Joost Snijder
@joostsnijder.bsky.social
a sort of scientist. viruses and antibodies. structure and biophysics. mass spec and cryoEM | Voorzitter SP Culemborg
LUX
open.spotify.com
November 10, 2025 at 9:02 AM
Reposted by Joost Snijder
New work from Tahirov x Lim collaboration! @qixianghe.bsky.social from my lab contributed the cryo-EM structures for this work. We are excited to help explain how anti-HSV drugs work and to guide their future development.
www.science.org/doi/10.1126/...
@unmc.bsky.social @uwbiochem.bsky.social
www.science.org/doi/10.1126/...
@unmc.bsky.social @uwbiochem.bsky.social
Structural basis of herpesvirus helicase-primase inhibition by pritelivir and amenamevir
Structural studies of HSV-1 helicase-primase revealed how pritelivir and amenamevir bind and block its helicase activity.
www.science.org
November 10, 2025 at 12:14 AM
New work from Tahirov x Lim collaboration! @qixianghe.bsky.social from my lab contributed the cryo-EM structures for this work. We are excited to help explain how anti-HSV drugs work and to guide their future development.
www.science.org/doi/10.1126/...
@unmc.bsky.social @uwbiochem.bsky.social
www.science.org/doi/10.1126/...
@unmc.bsky.social @uwbiochem.bsky.social
Reposted by Joost Snijder
Researchers immunized an alpaca and a llama with snake venoms, and combined some of the antibodies produced into a potent cocktail
go.nature.com/47QZkGc
go.nature.com/47QZkGc
Single antivenom protects against 17 different snakebites
Nature - Researchers immunized an alpaca and a llama with snake venoms, and combined some of the antibodies produced into a potent cocktail.
go.nature.com
November 1, 2025 at 10:38 AM
Researchers immunized an alpaca and a llama with snake venoms, and combined some of the antibodies produced into a potent cocktail
go.nature.com/47QZkGc
go.nature.com/47QZkGc
Reposted by Joost Snijder
🧪 🦠 Prefusion structure, evasion and neutralization of HSV-1 glycoprotein B www.nature.com/articles/s41...
Prefusion structure, evasion and neutralization of HSV-1 glycoprotein B - Nature Microbiology
Cryo-EM structures of the stabilized prefusion conformation of the glycoprotein B ectodomain—the HSV-1 entry machine—identify a prefusion-specific neutralizing antibody and reveal how prefusion glycop...
www.nature.com
November 8, 2025 at 3:37 AM
🧪 🦠 Prefusion structure, evasion and neutralization of HSV-1 glycoprotein B www.nature.com/articles/s41...
Reposted by Joost Snijder
🧬 Thrilled to share our latest paper in @natmicrobiol.nature.com 📄
A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think.
Our at-scale AI structure prediction gave a complementary perspective on viral evolution.
www.nature.com/articles/s41...
A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think.
Our at-scale AI structure prediction gave a complementary perspective on viral evolution.
www.nature.com/articles/s41...
Taxonomic expansion and reorganization of Flaviviridae - Nature Microbiology
Analysis of RNA polymerase hallmark gene phylogenies supported by protein structure relationships of flaviviruses and ‘flavi-like’ viruses underpins the taxonomic expansion and reorganization of Flavi...
www.nature.com
November 6, 2025 at 12:52 PM
🧬 Thrilled to share our latest paper in @natmicrobiol.nature.com 📄
A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think.
Our at-scale AI structure prediction gave a complementary perspective on viral evolution.
www.nature.com/articles/s41...
A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think.
Our at-scale AI structure prediction gave a complementary perspective on viral evolution.
www.nature.com/articles/s41...
Reposted by Joost Snijder
Glad to see our antibody design paper finally out in
@nature.com
(and congrats to lead authors and everyone involved )!
At Xaira we are excited about pushing antibody design further to bind harder targets and make drugs for unmet medical needs.
Paper:
www.nature.com/articles/s41...
@nature.com
(and congrats to lead authors and everyone involved )!
At Xaira we are excited about pushing antibody design further to bind harder targets and make drugs for unmet medical needs.
Paper:
www.nature.com/articles/s41...
November 5, 2025 at 8:20 PM
Glad to see our antibody design paper finally out in
@nature.com
(and congrats to lead authors and everyone involved )!
At Xaira we are excited about pushing antibody design further to bind harder targets and make drugs for unmet medical needs.
Paper:
www.nature.com/articles/s41...
@nature.com
(and congrats to lead authors and everyone involved )!
At Xaira we are excited about pushing antibody design further to bind harder targets and make drugs for unmet medical needs.
Paper:
www.nature.com/articles/s41...
Reposted by Joost Snijder
Now online! Generation of antigen-specific paired-chain antibodies using large language models
Generation of antigen-specific paired-chain antibodies using large language models
MAGE is a sequence-based protein language model designed to generate diverse human antibody sequences targeting various pathogens, including SARS-CoV-2, H5N1, and RSV-A. This AI-driven approach addresses traditional limitations by enabling efficient, target-agnostic antibody design with experimentally validated binding specificity.
dlvr.it
November 4, 2025 at 11:38 PM
Now online! Generation of antigen-specific paired-chain antibodies using large language models
Reposted by Joost Snijder
The Dutch Research Council (NWO) announced large investments in 11 (inter)national research infrastructures this week, and we are very happy that includes investments in our electron microscopy and mass spectrometry facilities, through projects EMPower and BioBeyond-NL:
www.nwo.nl/en/news/nati...
www.nwo.nl/en/news/nati...
National Roadmap: NWO invests 197 million euro in eleven Large-Scale Research Infrastructures | NWO
Eleven consortia from various scientific disciplines are set to launch projects of great value to science. But also to the economic and social prosperity of the Netherlands. For example, a consortium led by TU Delft will start work on a detailed virtual model of the Dutch energy system. In another project, a consortium of UMC Utrecht is developing an MRI scanner that can scan people in motion.
www.nwo.nl
November 5, 2025 at 10:35 AM
The Dutch Research Council (NWO) announced large investments in 11 (inter)national research infrastructures this week, and we are very happy that includes investments in our electron microscopy and mass spectrometry facilities, through projects EMPower and BioBeyond-NL:
www.nwo.nl/en/news/nati...
www.nwo.nl/en/news/nati...
Reposted by Joost Snijder
Reposted by Joost Snijder
“resolving power in a range of 600,000–800,000 for peptide ions across the whole m/z range, with a high repetition rate of 300 Hz (averaged to 0.5–4 Hz for enhanced dynamic range)”
Let’s see if Waters can make a big dent in the proteomics field with this
Let’s see if Waters can make a big dent in the proteomics field with this
A Novel Ultrahigh-Resolution Y-Injection Multireflecting Time-of-Flight Mass Spectrometer for Bottom-Up Proteomics #AC pubs.acs.org/doi/10.1021/...
A Novel Ultrahigh-Resolution Y-Injection Multireflecting Time-of-Flight Mass Spectrometer for Bottom-Up Proteomics
The first results of using a new type of ultrahigh-resolution mass analyzer based on a planar multipass time-of-flight mass spectrometer with periodic reflecting lenses (Y-MRT MS) for bottom-up whole-...
pubs.acs.org
November 4, 2025 at 11:20 AM
“resolving power in a range of 600,000–800,000 for peptide ions across the whole m/z range, with a high repetition rate of 300 Hz (averaged to 0.5–4 Hz for enhanced dynamic range)”
Let’s see if Waters can make a big dent in the proteomics field with this
Let’s see if Waters can make a big dent in the proteomics field with this
Reposted by Joost Snijder
Neutralizing antibodies against Chikungunya virus and structural elucidation of their mechanism of action pubmed.ncbi.nlm.nih.gov/41184282/ #cryoem
November 4, 2025 at 10:15 AM
Neutralizing antibodies against Chikungunya virus and structural elucidation of their mechanism of action pubmed.ncbi.nlm.nih.gov/41184282/ #cryoem
Reposted by Joost Snijder
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
www.uu.nl
November 4, 2025 at 7:14 AM
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
www.uu.nl/en/news/33-m...
Reposted by Joost Snijder
Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
www.uu.nl
November 3, 2025 at 4:47 PM
Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
Reposted by Joost Snijder
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
November 3, 2025 at 12:26 PM
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Reposted by Joost Snijder
Since early 2024 we have been working with @brukercorporation.bsky.social on the first prototype timsOmni instrument, integrating an Omnitrap into a timsTOF. Here we report for the first time on the use of this instrument for protein-centric antibody sequencing. See www.biorxiv.org/content/10.1...
October 31, 2025 at 7:07 PM
Since early 2024 we have been working with @brukercorporation.bsky.social on the first prototype timsOmni instrument, integrating an Omnitrap into a timsTOF. Here we report for the first time on the use of this instrument for protein-centric antibody sequencing. See www.biorxiv.org/content/10.1...
Reposted by Joost Snijder
We are excited to share the final program for the NVMS Fall Meeting on November 19, 2025, at the House of Connections in Groningen. Download the program here: www.nvms.nl/index.php/nv...
See you all there! 😀🧪✨
#NVMS #MassSpec #RUG #Science
See you all there! 😀🧪✨
#NVMS #MassSpec #RUG #Science
NVMS Fall Meeting 2025 – Program Announced! - NVMS
We are pleased to share the full program for the upcoming NVMS Fall Meeting, taking place on Wednesday, November 19, 2025, at the House of Connections in Groningen.
www.nvms.nl
October 30, 2025 at 3:46 PM
We are excited to share the final program for the NVMS Fall Meeting on November 19, 2025, at the House of Connections in Groningen. Download the program here: www.nvms.nl/index.php/nv...
See you all there! 😀🧪✨
#NVMS #MassSpec #RUG #Science
See you all there! 😀🧪✨
#NVMS #MassSpec #RUG #Science
Reposted by Joost Snijder
Excited to share a new paper led by @andreaslaustsen.bsky.social, Anne Ljungars, @tpjenkins.bsky.social, Shirin Ahmadi and Nick Burlet. It was a privelege to be a part of this amazing team!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites - Nature
A recombinant antivenom composed of eight nanobodies provides broad protection against venom-induced lethality and dermonecrosis in mice challenged with venoms from cobras, mambas and rinkha...
www.nature.com
October 30, 2025 at 8:47 AM
Excited to share a new paper led by @andreaslaustsen.bsky.social, Anne Ljungars, @tpjenkins.bsky.social, Shirin Ahmadi and Nick Burlet. It was a privelege to be a part of this amazing team!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Joost Snijder
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
mrc.tal.net/vx/appcentre...
Quick Check Needed
mrc.tal.net
October 29, 2025 at 9:17 AM
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
mrc.tal.net/vx/appcentre...
Reposted by Joost Snijder
Happy to announce the publication of our work exploring under-appreciated genetic diversity in the human IGHC region. Awesome work by @uddalok.bsky.social. So grateful for our amazing co-authors.
@williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social
www.cell.com/cell-genomic...
@williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social
www.cell.com/cell-genomic...
The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populations
Genetic variation within immunoglobulin heavy chain constant (IGHC) genes modulates
interactions between antibodies and other immune receptors and effector cells, directing
cell killing and the cleara...
www.cell.com
October 28, 2025 at 2:35 PM
Happy to announce the publication of our work exploring under-appreciated genetic diversity in the human IGHC region. Awesome work by @uddalok.bsky.social. So grateful for our amazing co-authors.
@williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social
www.cell.com/cell-genomic...
@williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social
www.cell.com/cell-genomic...
Reposted by Joost Snijder
New Title Alert: HADDOCK3- is the next generation integrative modeling software in the long-lasting HADDOCK project.
Learn more here: buff.ly/gInH6VV
#SBGrid #SBGridSoftware #StructuralBiology
Learn more here: buff.ly/gInH6VV
#SBGrid #SBGridSoftware #StructuralBiology
A brief introduction to HADDOCK3 — haddock3 3.0.0 documentation
HADDOCK3 is the next generation integrative modelling software in the long-lasting HADDOCK project. It represents a complete rethinking and rewriting of the HADDOCK2.X series, implementing a new way…
buff.ly
October 24, 2025 at 4:08 PM
New Title Alert: HADDOCK3- is the next generation integrative modeling software in the long-lasting HADDOCK project.
Learn more here: buff.ly/gInH6VV
#SBGrid #SBGridSoftware #StructuralBiology
Learn more here: buff.ly/gInH6VV
#SBGrid #SBGridSoftware #StructuralBiology
Reposted by Joost Snijder
Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET!
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.
October 24, 2025 at 8:11 AM
Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET!
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.
Reposted by Joost Snijder
Visualizing influenza A virus assembly by in situ cryo-electron tomography
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Visualizing influenza A virus assembly by in situ cryo-electron tomography - Nature Communications
Influenza A virus must package eight separate genomic segments, called viral ribonucleoproteins (vRNPs). Using in situ cryo-electron tomography, the authors visualize how vRNPs are clustered on cell m...
www.nature.com
October 23, 2025 at 2:01 PM
Visualizing influenza A virus assembly by in situ cryo-electron tomography
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Joost Snijder
Finally, just about 2 years after finishing the postdoc the last part of my work is finally online! We determined the structure of HSV-1 Origin Binding Protein, the viral initiator of DNA replication, by cryo-EM 🧪🧬🧶🧵 #cryoEM #structuralbiology
October 23, 2025 at 6:37 AM
Finally, just about 2 years after finishing the postdoc the last part of my work is finally online! We determined the structure of HSV-1 Origin Binding Protein, the viral initiator of DNA replication, by cryo-EM 🧪🧬🧶🧵 #cryoEM #structuralbiology