Albert Heck
@hecklab.bsky.social
Professor in Biomolecular Mass Spectrometry and Proteomics, Utrecht University, the Netherlands
Reposted by Albert Heck
#HUPO2025 interested in #topdownproteomics please come to join us in the Friends of HUPO reception 18:45-19:45 pm Westin Frontenac Ballroom Foyer 😀❄️ @nlkproteomics.bsky.social @proteoforms.bsky.social @jyates.bsky.social @hecklab.bsky.social #teammassspec
November 10, 2025 at 10:11 PM
#HUPO2025 interested in #topdownproteomics please come to join us in the Friends of HUPO reception 18:45-19:45 pm Westin Frontenac Ballroom Foyer 😀❄️ @nlkproteomics.bsky.social @proteoforms.bsky.social @jyates.bsky.social @hecklab.bsky.social #teammassspec
Every day’s commute on bike. Not every day is the same
November 5, 2025 at 6:46 AM
Every day’s commute on bike. Not every day is the same
Since early 2024 we have been working with @brukercorporation.bsky.social on the first prototype timsOmni instrument, integrating an Omnitrap into a timsTOF. Here we report for the first time on the use of this instrument for protein-centric antibody sequencing. See www.biorxiv.org/content/10.1...
October 31, 2025 at 7:07 PM
Since early 2024 we have been working with @brukercorporation.bsky.social on the first prototype timsOmni instrument, integrating an Omnitrap into a timsTOF. Here we report for the first time on the use of this instrument for protein-centric antibody sequencing. See www.biorxiv.org/content/10.1...
Reposted by Albert Heck
🔬 For more, delve into this paper published in Molecular & Cellular Proteomics ( @asbmbjournals.bsky.social): www.mcponline.org/article/S153....
Congratulations to @tkadava.bsky.social, @hecklab.bsky.social and colleagues on this fascinating work!
Congratulations to @tkadava.bsky.social, @hecklab.bsky.social and colleagues on this fascinating work!
October 31, 2025 at 6:37 PM
🔬 For more, delve into this paper published in Molecular & Cellular Proteomics ( @asbmbjournals.bsky.social): www.mcponline.org/article/S153....
Congratulations to @tkadava.bsky.social, @hecklab.bsky.social and colleagues on this fascinating work!
Congratulations to @tkadava.bsky.social, @hecklab.bsky.social and colleagues on this fascinating work!
Reposted by Albert Heck
For those who perform thermal proteome profiling (TPP) experiments, you might find this new data analysis approach (and open source Python software) useful. Developed by postdoc @jfhevler.bsky.social 🙏
arxiv.org/abs/2508.096...
arxiv.org/abs/2508.096...
Thermal Tracks: A Gaussian process-based framework for universal melting curve analysis enabling unconstrained hit identification in thermal proteome profiling experiments
Thermal Tracks is a Python-based statistical framework for analyzing protein thermal stability data that overcomes key limitations of existing thermal proteome profiling (TPP) work-flows. Unlike stand...
arxiv.org
October 24, 2025 at 10:18 PM
For those who perform thermal proteome profiling (TPP) experiments, you might find this new data analysis approach (and open source Python software) useful. Developed by postdoc @jfhevler.bsky.social 🙏
arxiv.org/abs/2508.096...
arxiv.org/abs/2508.096...
Reposted by Albert Heck
🧵(4/7)
🔬 We have put together a fascinating #Keynote #Speakers team:
• Prof. Albert Heck - @hecklab.bsky.social
• Dr. Hamish Stewart - @hamishs.bsky.social
• Prof. Olga Vitek - @olgavitek.bsky.social l
• Prof. Ron M.A. Heeren
🔬 We have put together a fascinating #Keynote #Speakers team:
• Prof. Albert Heck - @hecklab.bsky.social
• Dr. Hamish Stewart - @hamishs.bsky.social
• Prof. Olga Vitek - @olgavitek.bsky.social l
• Prof. Ron M.A. Heeren
October 15, 2025 at 5:18 AM
🧵(4/7)
🔬 We have put together a fascinating #Keynote #Speakers team:
• Prof. Albert Heck - @hecklab.bsky.social
• Dr. Hamish Stewart - @hamishs.bsky.social
• Prof. Olga Vitek - @olgavitek.bsky.social l
• Prof. Ron M.A. Heeren
🔬 We have put together a fascinating #Keynote #Speakers team:
• Prof. Albert Heck - @hecklab.bsky.social
• Dr. Hamish Stewart - @hamishs.bsky.social
• Prof. Olga Vitek - @olgavitek.bsky.social l
• Prof. Ron M.A. Heeren
Reposted by Albert Heck
My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology:
postdocs.stanford.edu/prospective/...
#TeamMassSpec #Proteomics #GPCR #Postdoc
postdocs.stanford.edu/prospective/...
#TeamMassSpec #Proteomics #GPCR #Postdoc
Open Postdoctoral position, faculty mentor Ruth Huttenhain | Office of Postdoctoral Affairs
postdocs.stanford.edu
October 2, 2025 at 6:27 PM
My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology:
postdocs.stanford.edu/prospective/...
#TeamMassSpec #Proteomics #GPCR #Postdoc
postdocs.stanford.edu/prospective/...
#TeamMassSpec #Proteomics #GPCR #Postdoc
Having a great time at msandm2025.org with a great bunch of people interesting in visualizing biomolecules, together with my co-chairs @joostsnijder.bsky.social @vixklen.bsky.social & Kyle Fort. Learning so much from all posters & lectures. We thanks all participants for joining us in Utrecht.
October 2, 2025 at 1:13 PM
Having a great time at msandm2025.org with a great bunch of people interesting in visualizing biomolecules, together with my co-chairs @joostsnijder.bsky.social @vixklen.bsky.social & Kyle Fort. Learning so much from all posters & lectures. We thanks all participants for joining us in Utrecht.
Reposted by Albert Heck
We’re hosting the MS+M conference in Utrecht today, lots of great talks ahead at the intersection of mass spec and microscopy. Here’s @hecklab.bsky.social kicking things off.
October 1, 2025 at 7:38 AM
We’re hosting the MS+M conference in Utrecht today, lots of great talks ahead at the intersection of mass spec and microscopy. Here’s @hecklab.bsky.social kicking things off.
Breaking barriers in the sensitive and accurate mass determination of large DNA plasmids by mass photometry: Molecular Therapy Nucleic Acids www.cell.com/molecular-th.... Even visualizing > 10 million Da plasmids by the incredible Eduard Ebberink
Breaking barriers in the sensitive and accurate mass determination of large DNA plasmids by mass photometry
Heck and colleagues developed a mass photometry-based method for accurate and fast
mass determination of plasmid DNA. Conventional mass photometry methods are not applicable
for large DNA particles; h...
www.cell.com
September 19, 2025 at 10:21 AM
Breaking barriers in the sensitive and accurate mass determination of large DNA plasmids by mass photometry: Molecular Therapy Nucleic Acids www.cell.com/molecular-th.... Even visualizing > 10 million Da plasmids by the incredible Eduard Ebberink
Preparations in full swing. Exciting program, looking forward to msandm2025.org and welcome our guests in Utrecht to discuss mass spectrometry, atomic force & electron microscopy and single molecule techniques
September 18, 2025 at 3:01 PM
Preparations in full swing. Exciting program, looking forward to msandm2025.org and welcome our guests in Utrecht to discuss mass spectrometry, atomic force & electron microscopy and single molecule techniques
Structural Insights Into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-Binding Protein Complexes With C4b and SAP - Molecular & Cellular Proteomics www.mcponline.org/article/S153.... See this work of @tkadava.bsky.social @utrechtuniversity.bsky.social artistically interpreted
September 5, 2025 at 5:42 AM
Structural Insights Into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-Binding Protein Complexes With C4b and SAP - Molecular & Cellular Proteomics www.mcponline.org/article/S153.... See this work of @tkadava.bsky.social @utrechtuniversity.bsky.social artistically interpreted
🕷️Spiders in your blood? Don’t worry, these are protein molecules of C4BP protein, part of your immune system. Just like real spiders, they grab prey with their “legs.” Watch them in action! Intrigued, check the paper of @tkadava.bsky.social doi.org/10.1016/j.mc... @bijvoet-centre.bsky.social
September 4, 2025 at 2:27 PM
🕷️Spiders in your blood? Don’t worry, these are protein molecules of C4BP protein, part of your immune system. Just like real spiders, they grab prey with their “legs.” Watch them in action! Intrigued, check the paper of @tkadava.bsky.social doi.org/10.1016/j.mc... @bijvoet-centre.bsky.social
Reposted by Albert Heck
Reposted by Albert Heck
Our graduate student, Holden Rogers and Marie Curie postdoc fellow, Boris Krichel, did a fantastic job presenting their research projects at #TDP2025👍👏😀
August 29, 2025 at 12:14 PM
Our graduate student, Holden Rogers and Marie Curie postdoc fellow, Boris Krichel, did a fantastic job presenting their research projects at #TDP2025👍👏😀
Reposted by Albert Heck
#TDP2025 @proteoforms.bsky.social a great opening session with fantastic talks! @nlkproteomics.bsky.social @joelooucla.bsky.social @hecklab.bsky.social @metamorpheus.bsky.social 👍thanks Hartmut for organizing the conference! 👏
August 26, 2025 at 3:54 PM
#TDP2025 @proteoforms.bsky.social a great opening session with fantastic talks! @nlkproteomics.bsky.social @joelooucla.bsky.social @hecklab.bsky.social @metamorpheus.bsky.social 👍thanks Hartmut for organizing the conference! 👏
Reposted by Albert Heck
🥁🥁🥁
The 51st Lorne Conference on Protein Structure and Function is officially live! After the resounding success of the 50th Lorne Conference in 2025 celebrating five decades of pioneering science and community, the legacy continues... 🏄🏖️🌞
February 8–12, 2026
Register here: www.lorneproteins.org
The 51st Lorne Conference on Protein Structure and Function is officially live! After the resounding success of the 50th Lorne Conference in 2025 celebrating five decades of pioneering science and community, the legacy continues... 🏄🏖️🌞
February 8–12, 2026
Register here: www.lorneproteins.org
August 21, 2025 at 4:38 AM
🥁🥁🥁
The 51st Lorne Conference on Protein Structure and Function is officially live! After the resounding success of the 50th Lorne Conference in 2025 celebrating five decades of pioneering science and community, the legacy continues... 🏄🏖️🌞
February 8–12, 2026
Register here: www.lorneproteins.org
The 51st Lorne Conference on Protein Structure and Function is officially live! After the resounding success of the 50th Lorne Conference in 2025 celebrating five decades of pioneering science and community, the legacy continues... 🏄🏖️🌞
February 8–12, 2026
Register here: www.lorneproteins.org
Reposted by Albert Heck
New plasma glycoproteomics method out of the @hecklab.bsky.social uses narrow-window DIA on Orbitrap Astral with Aurora Ultimate XT column. 50% more glycopeptide IDs vs. traditional approaches, with 181 glycoproteins detected across 7 orders of magnitude in just 10-40 minute runs.
bit.ly/45bDXhv
bit.ly/45bDXhv
Revolutionising plasma glycoproteomics with Orbitrap Astral and narrow-window DIA - IonOpticks
Jager et al.'s study into plasma glycoproteomics uses a 25 cm x 75 μm IonOpticks Aurora Ultimate 25x75 UHPLC column.
bit.ly
August 17, 2025 at 11:28 PM
New plasma glycoproteomics method out of the @hecklab.bsky.social uses narrow-window DIA on Orbitrap Astral with Aurora Ultimate XT column. 50% more glycopeptide IDs vs. traditional approaches, with 181 glycoproteins detected across 7 orders of magnitude in just 10-40 minute runs.
bit.ly/45bDXhv
bit.ly/45bDXhv
Reposted by Albert Heck
🕷️ Spiders from our blood 🕷️
Check out our new paper from @hecklab.bsky.social describing how the spider-like immune regulator C4BP interacts with its native binding partners.
🔗 www.mcponline.org/article/S153...
#MassSpec #StructuralBiology
Check out our new paper from @hecklab.bsky.social describing how the spider-like immune regulator C4BP interacts with its native binding partners.
🔗 www.mcponline.org/article/S153...
#MassSpec #StructuralBiology
Structural Insights into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-binding Protein Complexes with C4b and SAP
C4b-binding protein (C4BP) is an innate immune inhibitor found in serum. Human C4BP
adopts spider-like higher-order structures (HOS) formed by disulfide-linked C4BPα
and C4BPβ chains that non-covalent...
www.mcponline.org
August 4, 2025 at 9:26 AM
🕷️ Spiders from our blood 🕷️
Check out our new paper from @hecklab.bsky.social describing how the spider-like immune regulator C4BP interacts with its native binding partners.
🔗 www.mcponline.org/article/S153...
#MassSpec #StructuralBiology
Check out our new paper from @hecklab.bsky.social describing how the spider-like immune regulator C4BP interacts with its native binding partners.
🔗 www.mcponline.org/article/S153...
#MassSpec #StructuralBiology
Reposted by Albert Heck
We show that C4BP has two distinct binding modes, either involving a single “spider leg” or the entire spider-like structure wrapping around the target.
Thanks to everyone involved!
@victoryin.bsky.social, @hecklab.bsky.social, Jürgen, Johannes, Maryam, and Leendert
Thanks to everyone involved!
@victoryin.bsky.social, @hecklab.bsky.social, Jürgen, Johannes, Maryam, and Leendert
August 4, 2025 at 9:29 AM
We show that C4BP has two distinct binding modes, either involving a single “spider leg” or the entire spider-like structure wrapping around the target.
Thanks to everyone involved!
@victoryin.bsky.social, @hecklab.bsky.social, Jürgen, Johannes, Maryam, and Leendert
Thanks to everyone involved!
@victoryin.bsky.social, @hecklab.bsky.social, Jürgen, Johannes, Maryam, and Leendert
Reposted by Albert Heck
🤩 JOB ALERT 🤩 Come work with me and two cutting-edge LC-MS/MS systems at our brand new Mass Spectrometry Facility @iimcb.bsky.social in Warsaw! Apply here tinyurl.com/y47mzafa or send any questions my way. #TeamMassSpec please share widely!
Mass Spectrometry Technology Specialist, Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie, Warszawa
Job offer Mass Spectrometry Technology Specialist, Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie, Warszawa
tinyurl.com
July 31, 2025 at 3:01 PM
🤩 JOB ALERT 🤩 Come work with me and two cutting-edge LC-MS/MS systems at our brand new Mass Spectrometry Facility @iimcb.bsky.social in Warsaw! Apply here tinyurl.com/y47mzafa or send any questions my way. #TeamMassSpec please share widely!
Reposted by Albert Heck
confession: I often get excited by n=1 results.
July 31, 2025 at 5:32 PM
confession: I often get excited by n=1 results.
Reposted by Albert Heck
Special thanks to our keynote speakers: Alexander Makarov, Albert Heck(@hecklab.bsky.social), Kelly Stecker, Noortje de Haan & Ron Heeren.
And to the organising team: Corine Heuzer, Albert Heck, Pavel Sinitcyn(@sinitcyn.bsky.social) & the full MaxQuant team(@coxlab.bsky.social).
And to the organising team: Corine Heuzer, Albert Heck, Pavel Sinitcyn(@sinitcyn.bsky.social) & the full MaxQuant team(@coxlab.bsky.social).
July 28, 2025 at 2:29 PM
Special thanks to our keynote speakers: Alexander Makarov, Albert Heck(@hecklab.bsky.social), Kelly Stecker, Noortje de Haan & Ron Heeren.
And to the organising team: Corine Heuzer, Albert Heck, Pavel Sinitcyn(@sinitcyn.bsky.social) & the full MaxQuant team(@coxlab.bsky.social).
And to the organising team: Corine Heuzer, Albert Heck, Pavel Sinitcyn(@sinitcyn.bsky.social) & the full MaxQuant team(@coxlab.bsky.social).
Reposted by Albert Heck
📣 Save the date for the 51st Lorne Conference on Protein Structure and Function! ✨ Lorne, Victoria, Australia. We have a packed program and we'll be sharing all the details here - Like, Follow and Share - because friends don't let friends miss the epic Lorne Proteins 😊
www.lorneproteins.org
www.lorneproteins.org
July 25, 2025 at 11:30 AM
📣 Save the date for the 51st Lorne Conference on Protein Structure and Function! ✨ Lorne, Victoria, Australia. We have a packed program and we'll be sharing all the details here - Like, Follow and Share - because friends don't let friends miss the epic Lorne Proteins 😊
www.lorneproteins.org
www.lorneproteins.org
Reposted by Albert Heck
"You can literally lose who you are."
Institute Scholar Monther Abu‑Remaileh @abu-remaileh.bsky.social and team are working to uncover the role of lysosomes, our cells’ recycling centers, in degenerative brain disorders in order to identify a cure:
Institute Scholar Monther Abu‑Remaileh @abu-remaileh.bsky.social and team are working to uncover the role of lysosomes, our cells’ recycling centers, in degenerative brain disorders in order to identify a cure:
‘You can literally lose who you are’
Scientists in the lab of chemical engineer Monther Abu-Remaileh are uncovering the cellular functions that go awry in degenerative brain disorders and identifying therapies that could treat them.
news.stanford.edu
July 15, 2025 at 5:04 PM
"You can literally lose who you are."
Institute Scholar Monther Abu‑Remaileh @abu-remaileh.bsky.social and team are working to uncover the role of lysosomes, our cells’ recycling centers, in degenerative brain disorders in order to identify a cure:
Institute Scholar Monther Abu‑Remaileh @abu-remaileh.bsky.social and team are working to uncover the role of lysosomes, our cells’ recycling centers, in degenerative brain disorders in order to identify a cure: