Joost Snijder
@joostsnijder.bsky.social
a sort of scientist. viruses and antibodies. structure and biophysics. mass spec and cryoEM | Voorzitter SP Culemborg
Reposted by Joost Snijder
Structure-guided design of a targeted autoantibody degrader for neurologic disease pubmed.ncbi.nlm.nih.gov/41676581/ #cryoem
February 14, 2026 at 1:39 AM
Structure-guided design of a targeted autoantibody degrader for neurologic disease pubmed.ncbi.nlm.nih.gov/41676581/ #cryoem
Reposted by Joost Snijder
Development of a potent monoclonal antibody for treatment of human metapneumovirus infections pubmed.ncbi.nlm.nih.gov/41680141/ #cryoem
February 13, 2026 at 2:37 PM
Development of a potent monoclonal antibody for treatment of human metapneumovirus infections pubmed.ncbi.nlm.nih.gov/41680141/ #cryoem
Reposted by Joost Snijder
Mosquitoes like Aedes aegypti spread viruses that cause major global diseases. We decided to have a closer look at a family of mosquito carbohydrate-binding proteins involved in infecting these vector species. We found some unexpected things 😁
Preprint out now 🦟🦟🦟
www.biorxiv.org/content/10.6...
Preprint out now 🦟🦟🦟
www.biorxiv.org/content/10.6...
February 13, 2026 at 9:04 AM
Mosquitoes like Aedes aegypti spread viruses that cause major global diseases. We decided to have a closer look at a family of mosquito carbohydrate-binding proteins involved in infecting these vector species. We found some unexpected things 😁
Preprint out now 🦟🦟🦟
www.biorxiv.org/content/10.6...
Preprint out now 🦟🦟🦟
www.biorxiv.org/content/10.6...
Reposted by Joost Snijder
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?
Excited to share our latest work in @science.org on a new small polymerase.
1/n
Excited to share our latest work in @science.org on a new small polymerase.
1/n
A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
www.science.org
February 13, 2026 at 11:42 AM
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?
Excited to share our latest work in @science.org on a new small polymerase.
1/n
Excited to share our latest work in @science.org on a new small polymerase.
1/n
Reposted by Joost Snijder
Ooooh. Cool new paper on origins of life. A simple 45-nucleotide RNA molecule that can perfectly copy itself.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
www.science.org
February 13, 2026 at 2:19 AM
Ooooh. Cool new paper on origins of life. A simple 45-nucleotide RNA molecule that can perfectly copy itself.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Joost Snijder
Reposted by Joost Snijder
Some antibodies against Adenovirus pVII cross-react to platelet protein PF4, and the pathogenic autoantibodies all carry light chain K31E or K31D somatic hypermutation. So only individuals who expand one particular clonotype, and one specific SHM, during their response to AdV infection were at risk.
Five years after the rollout of Covid-19 vaccines started, it seems the mystery of why the Astra-Zeneca and J&J vaccines led to a rare but deadly side effect of unusual blood clots and bleeding has finally been solved.
It's a fascinating case of molecular mimicry that may help make vaccine safer.🧪
It's a fascinating case of molecular mimicry that may help make vaccine safer.🧪
Rare, dangerous side effects of some COVID-19 vaccines explained
“Groundbreaking” study uncovers why adenovirus-based shots caused life-threatening blood clots and bleeding in some people
www.science.org
February 12, 2026 at 7:43 AM
Some antibodies against Adenovirus pVII cross-react to platelet protein PF4, and the pathogenic autoantibodies all carry light chain K31E or K31D somatic hypermutation. So only individuals who expand one particular clonotype, and one specific SHM, during their response to AdV infection were at risk.
Reposted by Joost Snijder
Five years after the rollout of Covid-19 vaccines started, it seems the mystery of why the Astra-Zeneca and J&J vaccines led to a rare but deadly side effect of unusual blood clots and bleeding has finally been solved.
It's a fascinating case of molecular mimicry that may help make vaccine safer.🧪
It's a fascinating case of molecular mimicry that may help make vaccine safer.🧪
Rare, dangerous side effects of some COVID-19 vaccines explained
“Groundbreaking” study uncovers why adenovirus-based shots caused life-threatening blood clots and bleeding in some people
www.science.org
February 11, 2026 at 10:10 PM
Five years after the rollout of Covid-19 vaccines started, it seems the mystery of why the Astra-Zeneca and J&J vaccines led to a rare but deadly side effect of unusual blood clots and bleeding has finally been solved.
It's a fascinating case of molecular mimicry that may help make vaccine safer.🧪
It's a fascinating case of molecular mimicry that may help make vaccine safer.🧪
Reposted by Joost Snijder
Out now in Cell Systems: We develop a technique to visualize influenza A virus in live cells with single viral RNA resolution. Combined with precise readouts of viral transcription, we map the whole influenza A viral life cycle and identify key bottlenecks in infection.
www.cell.com/cell-systems...
www.cell.com/cell-systems...
Live-cell single-vRNP imaging identifies viral gene expression signatures that shape influenza infection heterogeneity
In this study, an imaging technology, “VISUN,” is developed that allows live-cell
visualization of unmodified influenza virus during infection with single-vRNP resolution.
Combining VISUN with multipl...
www.cell.com
February 12, 2026 at 7:45 AM
Out now in Cell Systems: We develop a technique to visualize influenza A virus in live cells with single viral RNA resolution. Combined with precise readouts of viral transcription, we map the whole influenza A viral life cycle and identify key bottlenecks in infection.
www.cell.com/cell-systems...
www.cell.com/cell-systems...
Reposted by Joost Snijder
It feels official now... www.sanquin.nl/en/researche...
Protein engineering and structural biology
To understand how proteins function, we need to know their three-dimensional structure. We use two techniques to determine such 3D structures of proteins and their complexes: X-ray crystallography and...
www.sanquin.nl
February 10, 2026 at 9:57 PM
It feels official now... www.sanquin.nl/en/researche...
Reposted by Joost Snijder
Structural determinants of broadly neutralizing human antibodies binding to morphological dengue virus variants. www.biorxiv.org/content/10.64898/2026.02.07.704521v1 #cryoem
February 9, 2026 at 8:10 AM
Structural determinants of broadly neutralizing human antibodies binding to morphological dengue virus variants. www.biorxiv.org/content/10.64898/2026.02.07.704521v1 #cryoem
Reposted by Joost Snijder
Look at this 🙂 #CryoEM
Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org
www.biorxiv.org/content/10.6...
Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org
www.biorxiv.org/content/10.6...
February 9, 2026 at 8:32 AM
Look at this 🙂 #CryoEM
Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org
www.biorxiv.org/content/10.6...
Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org
www.biorxiv.org/content/10.6...
Reposted by Joost Snijder
We studied how the glycan shield of alphaherpesvirus fusion protein gB mediates host co-receptor interactions. Great work by Sabrina, check it out!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
February 4, 2026 at 10:01 AM
We studied how the glycan shield of alphaherpesvirus fusion protein gB mediates host co-receptor interactions. Great work by Sabrina, check it out!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Joost Snijder
I am very pleased to announce that we have finalised the program for the @eupaproteomics.bsky.social Brixen Proteomics Summer School 2026 now also a @febsj.bsky.social advance lecture course.
www.brixenproteomics.org
www.brixenproteomics.org
In 2026 the established Brixen Proteomics Summer School
FEBS Advanced Lecture Course
www.brixenproteomics.org
February 6, 2026 at 10:04 AM
I am very pleased to announce that we have finalised the program for the @eupaproteomics.bsky.social Brixen Proteomics Summer School 2026 now also a @febsj.bsky.social advance lecture course.
www.brixenproteomics.org
www.brixenproteomics.org
Reposted by Joost Snijder
Congratulations to former LMB postdoc @mfpronker.bsky.social, who is launching his own independent research group at Sanquin Research where he'll use protein engineering and structural biology techniques to study important blood protein complexes.
Best of luck to you Matti!
#LMBAlumni
Best of luck to you Matti!
#LMBAlumni
February 5, 2026 at 1:04 PM
Congratulations to former LMB postdoc @mfpronker.bsky.social, who is launching his own independent research group at Sanquin Research where he'll use protein engineering and structural biology techniques to study important blood protein complexes.
Best of luck to you Matti!
#LMBAlumni
Best of luck to you Matti!
#LMBAlumni
Reposted by Joost Snijder
Nieuwe neussspray met antigriep antilichamen beschermt tegen verschillende subtypen van griep. www.nrc.nl/nieuws/2026/...
Met een neusspray is elke griep te voorkomen
Infectieziekte: Een breed werkende antistof in een neusspray beschermt tegen veel verschillende griepvirussen. Dat kan een belangrijk wapen worden bij een nieuwe pandemie.
www.nrc.nl
February 5, 2026 at 7:44 AM
Nieuwe neussspray met antigriep antilichamen beschermt tegen verschillende subtypen van griep. www.nrc.nl/nieuws/2026/...
Reposted by Joost Snijder
🌀 How do spirochete bacteria swim through thick fluids like champions?
We solved T. denticola flagella structure - asymmetric proteins expand one side, compress the other for perfect corkscrew motion!
@debnathghosal.bsky.social
🔗 doi.org/10.64898/202...
#StructuralBiology #CryoEM #Microbiology
We solved T. denticola flagella structure - asymmetric proteins expand one side, compress the other for perfect corkscrew motion!
@debnathghosal.bsky.social
🔗 doi.org/10.64898/202...
#StructuralBiology #CryoEM #Microbiology
February 5, 2026 at 6:37 AM
🌀 How do spirochete bacteria swim through thick fluids like champions?
We solved T. denticola flagella structure - asymmetric proteins expand one side, compress the other for perfect corkscrew motion!
@debnathghosal.bsky.social
🔗 doi.org/10.64898/202...
#StructuralBiology #CryoEM #Microbiology
We solved T. denticola flagella structure - asymmetric proteins expand one side, compress the other for perfect corkscrew motion!
@debnathghosal.bsky.social
🔗 doi.org/10.64898/202...
#StructuralBiology #CryoEM #Microbiology
Reposted by Joost Snijder
Influenza A virus infection perturbs host cell glycosylation https://www.biorxiv.org/content/10.64898/2026.02.02.703422v1
February 4, 2026 at 2:45 AM
Influenza A virus infection perturbs host cell glycosylation https://www.biorxiv.org/content/10.64898/2026.02.02.703422v1
Reposted by Joost Snijder
The glycan shield of alphaherpesvirus glycoprotein B modulates host co-receptor binding https://www.biorxiv.org/content/10.64898/2026.02.03.703472v1
February 4, 2026 at 2:45 AM
The glycan shield of alphaherpesvirus glycoprotein B modulates host co-receptor binding https://www.biorxiv.org/content/10.64898/2026.02.03.703472v1
We studied how the glycan shield of alphaherpesvirus fusion protein gB mediates host co-receptor interactions. Great work by Sabrina, check it out!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
February 4, 2026 at 10:01 AM
We studied how the glycan shield of alphaherpesvirus fusion protein gB mediates host co-receptor interactions. Great work by Sabrina, check it out!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Joost Snijder
A broadly protective antibody targeting gammaherpesvirus gB pubmed.ncbi.nlm.nih.gov/41629701/ #cryoem
February 3, 2026 at 2:45 PM
A broadly protective antibody targeting gammaherpesvirus gB pubmed.ncbi.nlm.nih.gov/41629701/ #cryoem
Reposted by Joost Snijder
Viral Infections Drive Functional Remodeling of Ribosome-Associated Proteins https://www.biorxiv.org/content/10.64898/2026.01.29.701737v1
January 30, 2026 at 3:18 AM
Viral Infections Drive Functional Remodeling of Ribosome-Associated Proteins https://www.biorxiv.org/content/10.64898/2026.01.29.701737v1
Reposted by Joost Snijder
This is finally out.
Very short take home. All the variation in spike that produced the immune escape characteristics of Omicron can occur in one single persistently infected individual over the period of a year.
This is why persistent infections matter
www.cell.com/cell-reports...
Very short take home. All the variation in spike that produced the immune escape characteristics of Omicron can occur in one single persistently infected individual over the period of a year.
This is why persistent infections matter
www.cell.com/cell-reports...
Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections
Snell et al. develop sequencing methodology to identify full-length spike haplotypes
and show that persistent SARS-CoV-2 infections drive divergent haplotype emergence,
accelerating viral evolution an...
www.cell.com
February 2, 2026 at 4:09 PM
This is finally out.
Very short take home. All the variation in spike that produced the immune escape characteristics of Omicron can occur in one single persistently infected individual over the period of a year.
This is why persistent infections matter
www.cell.com/cell-reports...
Very short take home. All the variation in spike that produced the immune escape characteristics of Omicron can occur in one single persistently infected individual over the period of a year.
This is why persistent infections matter
www.cell.com/cell-reports...
Reposted by Joost Snijder
Crystal structure of malaria parasite fusogen PfHAP2 domain 3 and nanobodies - unsolved mysteries galore! 🦟🦙💎
PfHAP2 is part of family of ancient fusogens involved in fertilisation processes in algae, plants to malaria parasites.
Check out the first crystal structure of PfHAP2 D3 and nanobodies
PfHAP2 is part of family of ancient fusogens involved in fertilisation processes in algae, plants to malaria parasites.
Check out the first crystal structure of PfHAP2 D3 and nanobodies
Crystal structure and nanobodies against domain 3 of the malaria parasite fusogen Plasmodium falciparum HAP2
Malaria parasites are transmitted to humans through a bite from an infected female Anopheles mosquito. Within the mosquito midgut, malaria parasite gametes are activated and undergo fertilisation. If ...
portlandpress.com
February 2, 2026 at 10:51 PM
Crystal structure of malaria parasite fusogen PfHAP2 domain 3 and nanobodies - unsolved mysteries galore! 🦟🦙💎
PfHAP2 is part of family of ancient fusogens involved in fertilisation processes in algae, plants to malaria parasites.
Check out the first crystal structure of PfHAP2 D3 and nanobodies
PfHAP2 is part of family of ancient fusogens involved in fertilisation processes in algae, plants to malaria parasites.
Check out the first crystal structure of PfHAP2 D3 and nanobodies
Reposted by Joost Snijder
Pfs48/45 nanobodies block malaria parasite transmission 🦟 and crystal structures provide structural insight to how they bind 💎
Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕
Please share widely- love to hear your feedback!
Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕
Please share widely- love to hear your feedback!
Pfs48/45 nanobodies block Plasmodium falciparum transmission
Author summary Malaria is spread when an infected Anopheles mosquito bites a human. Within the female Anopheles mosquito, malaria parasite fertilisation occurs in the mosquito midgut. If you inhibit p...
journals.plos.org
February 2, 2026 at 8:36 AM
Pfs48/45 nanobodies block malaria parasite transmission 🦟 and crystal structures provide structural insight to how they bind 💎
Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕
Please share widely- love to hear your feedback!
Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕
Please share widely- love to hear your feedback!