Joost Snijder
@joostsnijder.bsky.social
a sort of scientist. viruses and antibodies. structure and biophysics. mass spec and cryoEM | Voorzitter SP Culemborg
Reposted by Joost Snijder
Structural determinants of broadly neutralizing human antibodies binding to morphological dengue virus variants. www.biorxiv.org/content/10.64898/2026.02.07.704521v1 #cryoem
February 9, 2026 at 8:10 AM
Structural determinants of broadly neutralizing human antibodies binding to morphological dengue virus variants. www.biorxiv.org/content/10.64898/2026.02.07.704521v1 #cryoem
Reposted by Joost Snijder
Look at this 🙂 #CryoEM
Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org
www.biorxiv.org/content/10.6...
Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org
www.biorxiv.org/content/10.6...
February 9, 2026 at 8:32 AM
Look at this 🙂 #CryoEM
Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org
www.biorxiv.org/content/10.6...
Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org
www.biorxiv.org/content/10.6...
Reposted by Joost Snijder
We studied how the glycan shield of alphaherpesvirus fusion protein gB mediates host co-receptor interactions. Great work by Sabrina, check it out!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
February 4, 2026 at 10:01 AM
We studied how the glycan shield of alphaherpesvirus fusion protein gB mediates host co-receptor interactions. Great work by Sabrina, check it out!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Joost Snijder
I am very pleased to announce that we have finalised the program for the @eupaproteomics.bsky.social Brixen Proteomics Summer School 2026 now also a @febsj.bsky.social advance lecture course.
www.brixenproteomics.org
www.brixenproteomics.org
In 2026 the established Brixen Proteomics Summer School
FEBS Advanced Lecture Course
www.brixenproteomics.org
February 6, 2026 at 10:04 AM
I am very pleased to announce that we have finalised the program for the @eupaproteomics.bsky.social Brixen Proteomics Summer School 2026 now also a @febsj.bsky.social advance lecture course.
www.brixenproteomics.org
www.brixenproteomics.org
Reposted by Joost Snijder
Congratulations to former LMB postdoc @mfpronker.bsky.social, who is launching his own independent research group at Sanquin Research where he'll use protein engineering and structural biology techniques to study important blood protein complexes.
Best of luck to you Matti!
#LMBAlumni
Best of luck to you Matti!
#LMBAlumni
February 5, 2026 at 1:04 PM
Congratulations to former LMB postdoc @mfpronker.bsky.social, who is launching his own independent research group at Sanquin Research where he'll use protein engineering and structural biology techniques to study important blood protein complexes.
Best of luck to you Matti!
#LMBAlumni
Best of luck to you Matti!
#LMBAlumni
Reposted by Joost Snijder
Nieuwe neussspray met antigriep antilichamen beschermt tegen verschillende subtypen van griep. www.nrc.nl/nieuws/2026/...
Met een neusspray is elke griep te voorkomen
Infectieziekte: Een breed werkende antistof in een neusspray beschermt tegen veel verschillende griepvirussen. Dat kan een belangrijk wapen worden bij een nieuwe pandemie.
www.nrc.nl
February 5, 2026 at 7:44 AM
Nieuwe neussspray met antigriep antilichamen beschermt tegen verschillende subtypen van griep. www.nrc.nl/nieuws/2026/...
Reposted by Joost Snijder
🌀 How do spirochete bacteria swim through thick fluids like champions?
We solved T. denticola flagella structure - asymmetric proteins expand one side, compress the other for perfect corkscrew motion!
@debnathghosal.bsky.social
🔗 doi.org/10.64898/202...
#StructuralBiology #CryoEM #Microbiology
We solved T. denticola flagella structure - asymmetric proteins expand one side, compress the other for perfect corkscrew motion!
@debnathghosal.bsky.social
🔗 doi.org/10.64898/202...
#StructuralBiology #CryoEM #Microbiology
February 5, 2026 at 6:37 AM
🌀 How do spirochete bacteria swim through thick fluids like champions?
We solved T. denticola flagella structure - asymmetric proteins expand one side, compress the other for perfect corkscrew motion!
@debnathghosal.bsky.social
🔗 doi.org/10.64898/202...
#StructuralBiology #CryoEM #Microbiology
We solved T. denticola flagella structure - asymmetric proteins expand one side, compress the other for perfect corkscrew motion!
@debnathghosal.bsky.social
🔗 doi.org/10.64898/202...
#StructuralBiology #CryoEM #Microbiology
Reposted by Joost Snijder
Influenza A virus infection perturbs host cell glycosylation https://www.biorxiv.org/content/10.64898/2026.02.02.703422v1
February 4, 2026 at 2:45 AM
Influenza A virus infection perturbs host cell glycosylation https://www.biorxiv.org/content/10.64898/2026.02.02.703422v1
Reposted by Joost Snijder
The glycan shield of alphaherpesvirus glycoprotein B modulates host co-receptor binding https://www.biorxiv.org/content/10.64898/2026.02.03.703472v1
February 4, 2026 at 2:45 AM
The glycan shield of alphaherpesvirus glycoprotein B modulates host co-receptor binding https://www.biorxiv.org/content/10.64898/2026.02.03.703472v1
We studied how the glycan shield of alphaherpesvirus fusion protein gB mediates host co-receptor interactions. Great work by Sabrina, check it out!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
February 4, 2026 at 10:01 AM
We studied how the glycan shield of alphaherpesvirus fusion protein gB mediates host co-receptor interactions. Great work by Sabrina, check it out!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Joost Snijder
A broadly protective antibody targeting gammaherpesvirus gB pubmed.ncbi.nlm.nih.gov/41629701/ #cryoem
February 3, 2026 at 2:45 PM
A broadly protective antibody targeting gammaherpesvirus gB pubmed.ncbi.nlm.nih.gov/41629701/ #cryoem
Reposted by Joost Snijder
Viral Infections Drive Functional Remodeling of Ribosome-Associated Proteins https://www.biorxiv.org/content/10.64898/2026.01.29.701737v1
January 30, 2026 at 3:18 AM
Viral Infections Drive Functional Remodeling of Ribosome-Associated Proteins https://www.biorxiv.org/content/10.64898/2026.01.29.701737v1
Reposted by Joost Snijder
This is finally out.
Very short take home. All the variation in spike that produced the immune escape characteristics of Omicron can occur in one single persistently infected individual over the period of a year.
This is why persistent infections matter
www.cell.com/cell-reports...
Very short take home. All the variation in spike that produced the immune escape characteristics of Omicron can occur in one single persistently infected individual over the period of a year.
This is why persistent infections matter
www.cell.com/cell-reports...
Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections
Snell et al. develop sequencing methodology to identify full-length spike haplotypes
and show that persistent SARS-CoV-2 infections drive divergent haplotype emergence,
accelerating viral evolution an...
www.cell.com
February 2, 2026 at 4:09 PM
This is finally out.
Very short take home. All the variation in spike that produced the immune escape characteristics of Omicron can occur in one single persistently infected individual over the period of a year.
This is why persistent infections matter
www.cell.com/cell-reports...
Very short take home. All the variation in spike that produced the immune escape characteristics of Omicron can occur in one single persistently infected individual over the period of a year.
This is why persistent infections matter
www.cell.com/cell-reports...
Reposted by Joost Snijder
Crystal structure of malaria parasite fusogen PfHAP2 domain 3 and nanobodies - unsolved mysteries galore! 🦟🦙💎
PfHAP2 is part of family of ancient fusogens involved in fertilisation processes in algae, plants to malaria parasites.
Check out the first crystal structure of PfHAP2 D3 and nanobodies
PfHAP2 is part of family of ancient fusogens involved in fertilisation processes in algae, plants to malaria parasites.
Check out the first crystal structure of PfHAP2 D3 and nanobodies
Crystal structure and nanobodies against domain 3 of the malaria parasite fusogen Plasmodium falciparum HAP2
Malaria parasites are transmitted to humans through a bite from an infected female Anopheles mosquito. Within the mosquito midgut, malaria parasite gametes are activated and undergo fertilisation. If ...
portlandpress.com
February 2, 2026 at 10:51 PM
Crystal structure of malaria parasite fusogen PfHAP2 domain 3 and nanobodies - unsolved mysteries galore! 🦟🦙💎
PfHAP2 is part of family of ancient fusogens involved in fertilisation processes in algae, plants to malaria parasites.
Check out the first crystal structure of PfHAP2 D3 and nanobodies
PfHAP2 is part of family of ancient fusogens involved in fertilisation processes in algae, plants to malaria parasites.
Check out the first crystal structure of PfHAP2 D3 and nanobodies
Reposted by Joost Snijder
Pfs48/45 nanobodies block malaria parasite transmission 🦟 and crystal structures provide structural insight to how they bind 💎
Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕
Please share widely- love to hear your feedback!
Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕
Please share widely- love to hear your feedback!
Pfs48/45 nanobodies block Plasmodium falciparum transmission
Author summary Malaria is spread when an infected Anopheles mosquito bites a human. Within the female Anopheles mosquito, malaria parasite fertilisation occurs in the mosquito midgut. If you inhibit p...
journals.plos.org
February 2, 2026 at 8:36 AM
Pfs48/45 nanobodies block malaria parasite transmission 🦟 and crystal structures provide structural insight to how they bind 💎
Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕
Please share widely- love to hear your feedback!
Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕
Please share widely- love to hear your feedback!
Today is the big day! On my way to the Triple I community conference, looking forward to seeing all the great immunology, infection biology and immuno-oncology talks and posters. See you there!
www.uu.nl/en/research/...
www.uu.nl/en/research/...
Programme
Discover the programme of the Triple I Conference.
www.uu.nl
February 2, 2026 at 8:07 AM
Today is the big day! On my way to the Triple I community conference, looking forward to seeing all the great immunology, infection biology and immuno-oncology talks and posters. See you there!
www.uu.nl/en/research/...
www.uu.nl/en/research/...
Reposted by Joost Snijder
A highly potent and broadly accessible bispecific nanobody for the treatment of ebola virus infections
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
A highly potent and broadly accessible bispecific nanobody for the treatment of ebola virus infections
Author summary Ebola virus (EBOV) remains a significant global health threat, with current treatments providing only modest survival benefits and limited accessibility due to their dependence on injec...
journals.plos.org
February 2, 2026 at 3:48 AM
A highly potent and broadly accessible bispecific nanobody for the treatment of ebola virus infections
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Reposted by Joost Snijder
I am excited to share that I will be starting my lab @Sanquin-forlife Research in Amsterdam this month! Looking forward to do structural biology and use protein engineering to tackle important questions related to 🩸blood🩸 protein complexes in health and disease.
🧬🧫🔬🧪👨🔬
#cryoEM #xtallography
🧬🧫🔬🧪👨🔬
#cryoEM #xtallography
February 1, 2026 at 12:53 PM
I am excited to share that I will be starting my lab @Sanquin-forlife Research in Amsterdam this month! Looking forward to do structural biology and use protein engineering to tackle important questions related to 🩸blood🩸 protein complexes in health and disease.
🧬🧫🔬🧪👨🔬
#cryoEM #xtallography
🧬🧫🔬🧪👨🔬
#cryoEM #xtallography
Reposted by Joost Snijder
In de week dat ASML een winst van 10 miljard bekendmaakt en ING een winst van 6 miljard haalt het nieuwe kabinet de miljarden bij… de mensen.
Column! Vandaag zonder betaalmuur www.groene.nl/artikel/opto...
Column! Vandaag zonder betaalmuur www.groene.nl/artikel/opto...
De economische keuzes van het nieuwe kabinet zijn vooral goed voor het bedrijfsleven
Het regeerakkoord is een integrale vertaling van het rapport Wennink: zoveel mogelijk publiek geld richting bedrijven, en zoveel mogelijk regels voor bedrijven afschaffen.
www.groene.nl
January 31, 2026 at 9:21 AM
In de week dat ASML een winst van 10 miljard bekendmaakt en ING een winst van 6 miljard haalt het nieuwe kabinet de miljarden bij… de mensen.
Column! Vandaag zonder betaalmuur www.groene.nl/artikel/opto...
Column! Vandaag zonder betaalmuur www.groene.nl/artikel/opto...
Reposted by Joost Snijder
Build a paper model of dengue virus for WHO's World Neglected Tropical Diseases Day on January 30 #WorldNTDDay
pdb101.rcsb.org/lear...
More on dengue at Molecule of the Month: pdb101.rcsb.org/motm...
pdb101.rcsb.org/lear...
More on dengue at Molecule of the Month: pdb101.rcsb.org/motm...
PDB101: Learn: Paper Models: Dengue Virus
Atomic structures of dengue virus are giving new hope for creation of a vaccine
pdb101.rcsb.org
January 30, 2026 at 4:33 PM
Build a paper model of dengue virus for WHO's World Neglected Tropical Diseases Day on January 30 #WorldNTDDay
pdb101.rcsb.org/lear...
More on dengue at Molecule of the Month: pdb101.rcsb.org/motm...
pdb101.rcsb.org/lear...
More on dengue at Molecule of the Month: pdb101.rcsb.org/motm...
Reposted by Joost Snijder
FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social.
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...
Multiple protein structure alignment at scale with FoldMason
Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...
www.science.org
January 30, 2026 at 6:11 AM
FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social.
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...
Reposted by Joost Snijder
Now out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake!
rdcu.be/e1bBW
rdcu.be/e1bBW
Pre-assembly of biomolecular condensate seeds drives RSV replication
Nature - Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.
rdcu.be
January 28, 2026 at 8:38 PM
Now out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake!
rdcu.be/e1bBW
rdcu.be/e1bBW
Reposted by Joost Snijder
January is Cervical Cancer Awareness Month
Visit PDB-101 to learn how the capsid protein of papillomavirus is used in vaccines that prevent cervical cancer
Visit PDB-101 to learn how the capsid protein of papillomavirus is used in vaccines that prevent cervical cancer
PDB101: Molecule of the Month: Human Papillomavirus and Vaccines
The capsid protein of papillomavirus is used in vaccines that prevent cervical cancer.
pdb101.rcsb.org
January 28, 2026 at 5:22 PM
January is Cervical Cancer Awareness Month
Visit PDB-101 to learn how the capsid protein of papillomavirus is used in vaccines that prevent cervical cancer
Visit PDB-101 to learn how the capsid protein of papillomavirus is used in vaccines that prevent cervical cancer
Reposted by Joost Snijder
Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection.
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Population-scale sequencing resolves determinants of persistent EBV DNA - Nature
Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous di...
www.nature.com
January 28, 2026 at 5:07 PM
Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection.
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Reposted by Joost Snijder
Check out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3)
🔗 biorxiv.org/content/10.6...
🔗 biorxiv.org/content/10.6...
January 27, 2026 at 5:03 PM
Check out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3)
🔗 biorxiv.org/content/10.6...
🔗 biorxiv.org/content/10.6...