Gabriel Victora
@victora.bsky.social
B cell biologist at @rockefeller.edu and @hhmi.org. Opinions are my own.
www.germinal.center
www.germinal.center
Check out our latest preprint on the effects of antibody-mediated feedback on ongoing germinal center reactions, led by Alex Barbulescu and @janabilanovic.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Antibody-mediated feedback modulates interclonal competition in the germinal center
Serum antibodies from prior immune responses regulate B cell activation and germinal center (GC) access upon recall immunization. However, how antibodies produced by an ongoing immune response influen...
www.biorxiv.org
November 8, 2025 at 3:04 PM
Check out our latest preprint on the effects of antibody-mediated feedback on ongoing germinal center reactions, led by Alex Barbulescu and @janabilanovic.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Gabriel Victora
@biorxiv-immuno.bsky.social Identification of distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation
www.biorxiv.org/content/10.1...
@ucberkeleyofficial.bsky.social
www.biorxiv.org/content/10.1...
@ucberkeleyofficial.bsky.social
November 6, 2025 at 2:42 AM
@biorxiv-immuno.bsky.social Identification of distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation
www.biorxiv.org/content/10.1...
@ucberkeleyofficial.bsky.social
www.biorxiv.org/content/10.1...
@ucberkeleyofficial.bsky.social
Reposted by Gabriel Victora
@biorxivpreprint.bsky.social Lymphatic constraint of germinal centers optimizes protective antibody responses
www.biorxiv.org/content/10.1... @thelundlab.bsky.social
@nyulangone.bsky.social @carlanowosad.bsky.social
www.biorxiv.org/content/10.1... @thelundlab.bsky.social
@nyulangone.bsky.social @carlanowosad.bsky.social
November 6, 2025 at 2:48 AM
@biorxivpreprint.bsky.social Lymphatic constraint of germinal centers optimizes protective antibody responses
www.biorxiv.org/content/10.1... @thelundlab.bsky.social
@nyulangone.bsky.social @carlanowosad.bsky.social
www.biorxiv.org/content/10.1... @thelundlab.bsky.social
@nyulangone.bsky.social @carlanowosad.bsky.social
Reposted by Gabriel Victora
Our B cell Keystone is getting closer! Short talk abstracts and scholarship applications are due on November 13 - get to it! www.keystonesymposia.org/conferences/...
November 4, 2025 at 10:58 PM
Our B cell Keystone is getting closer! Short talk abstracts and scholarship applications are due on November 13 - get to it! www.keystonesymposia.org/conferences/...
Renewing my yearly bet on Cooper/Miller for the Nobels.
One might think that I would learn after being wrong so many times, but one would be mistaken.
laskerfoundation.org/winners/b-an...
One might think that I would learn after being wrong so many times, but one would be mistaken.
laskerfoundation.org/winners/b-an...
B and T cells—the organizing principle of the adaptive immune system - Lasker Foundation
For their discovery of the two distinct classes of lymphocytes, B and T cells – a monumental achievement that provided the organizing principle of the adaptive immune system and launched the course of...
laskerfoundation.org
October 4, 2025 at 1:43 PM
Renewing my yearly bet on Cooper/Miller for the Nobels.
One might think that I would learn after being wrong so many times, but one would be mistaken.
laskerfoundation.org/winners/b-an...
One might think that I would learn after being wrong so many times, but one would be mistaken.
laskerfoundation.org/winners/b-an...
@cyrilpedia.bsky.social is biased, I’ve grilled him too many steaks
If you want to deep dive in to immunology you could do worse than Gabriel's evolutionary landscaping
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Replaying germinal center evolution on a quantified affinity landscape
Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...
www.biorxiv.org
September 28, 2025 at 12:51 PM
@cyrilpedia.bsky.social is biased, I’ve grilled him too many steaks
Reposted by Gabriel Victora
Congratulations to all, especially Rockefeller's @veenapadmanaban.bsky.social, a research associate in
@sohailtavazoie.bsky.social's lab, and Maria Cecilia Campos Canesso, formerly a postdoc in @danmucida.bsky.social and @victora.bsky.social’s labs. A very well-deserved recognition!
@sohailtavazoie.bsky.social's lab, and Maria Cecilia Campos Canesso, formerly a postdoc in @danmucida.bsky.social and @victora.bsky.social’s labs. A very well-deserved recognition!
September 16, 2025 at 1:44 PM
Congratulations to all, especially Rockefeller's @veenapadmanaban.bsky.social, a research associate in
@sohailtavazoie.bsky.social's lab, and Maria Cecilia Campos Canesso, formerly a postdoc in @danmucida.bsky.social and @victora.bsky.social’s labs. A very well-deserved recognition!
@sohailtavazoie.bsky.social's lab, and Maria Cecilia Campos Canesso, formerly a postdoc in @danmucida.bsky.social and @victora.bsky.social’s labs. A very well-deserved recognition!
Reposted by Gabriel Victora
2/ Did adaptive immune cells learn to cooperate before the modern immune system existed? Awardee @affinityborn.bsky.social may redefine what's essential for immune memory & enable alternative immune architectures.
🥳 Congrats Dr. Wesemann! @harvardmed.bsky.social
🙏 #HFScout @victora.bsky.social
🥳 Congrats Dr. Wesemann! @harvardmed.bsky.social
🙏 #HFScout @victora.bsky.social
August 19, 2025 at 4:24 PM
2/ Did adaptive immune cells learn to cooperate before the modern immune system existed? Awardee @affinityborn.bsky.social may redefine what's essential for immune memory & enable alternative immune architectures.
🥳 Congrats Dr. Wesemann! @harvardmed.bsky.social
🙏 #HFScout @victora.bsky.social
🥳 Congrats Dr. Wesemann! @harvardmed.bsky.social
🙏 #HFScout @victora.bsky.social
Reposted by Gabriel Victora
In a new preprint we use deep learning on lineage trees to infer the functional form of the relationship between affinity and fitness that controls antibody evolution in germinal centers: arxiv.org/abs/2508.09871 🧵
Inference of germinal center evolutionary dynamics via simulation-based deep learning
B cells and the antibodies they produce are vital to health and survival, motivating research on the details of the mutational and evolutionary processes in the germinal centers (GC) from which mature...
arxiv.org
August 16, 2025 at 10:56 PM
In a new preprint we use deep learning on lineage trees to infer the functional form of the relationship between affinity and fitness that controls antibody evolution in germinal centers: arxiv.org/abs/2508.09871 🧵
Reposted by Gabriel Victora
In the minority here, but I think it would be refreshing and I'd appreciate reading a piece like "On the value of reductionist science".
While *incredibly* valuable, not everything *needs* -omics and the like, let alone when only done because it _can_ be done, with an illusion of mechanism.
While *incredibly* valuable, not everything *needs* -omics and the like, let alone when only done because it _can_ be done, with an illusion of mechanism.
June 26, 2025 at 1:46 PM
In the minority here, but I think it would be refreshing and I'd appreciate reading a piece like "On the value of reductionist science".
While *incredibly* valuable, not everything *needs* -omics and the like, let alone when only done because it _can_ be done, with an illusion of mechanism.
While *incredibly* valuable, not everything *needs* -omics and the like, let alone when only done because it _can_ be done, with an illusion of mechanism.
Reposted by Gabriel Victora
Oslo University's Johanne Tracey Jacobsen visited CCII this week & shared exciting progress in the application of cutting edge imaging techniques to decode dynamic T-B interactions in the Germinal Center.
#Immunology #GerminalCenter
www.jjacobsenlab.com
#Immunology #GerminalCenter
www.jjacobsenlab.com
July 4, 2025 at 2:50 AM
Oslo University's Johanne Tracey Jacobsen visited CCII this week & shared exciting progress in the application of cutting edge imaging techniques to decode dynamic T-B interactions in the Germinal Center.
#Immunology #GerminalCenter
www.jjacobsenlab.com
#Immunology #GerminalCenter
www.jjacobsenlab.com
Reposted by Gabriel Victora
Check it out, a great opportunity for people looking to start their own lab in Japan 👇
www.ccii.med.kyoto-u.ac.jp/en/careers-e...
www.ccii.med.kyoto-u.ac.jp/en/careers-e...
Open Positions｜Careers｜Center for Cancer Immunotherapy and Immunobiology
Open Positions
www.ccii.med.kyoto-u.ac.jp
July 2, 2025 at 6:32 AM
Check it out, a great opportunity for people looking to start their own lab in Japan 👇
www.ccii.med.kyoto-u.ac.jp/en/careers-e...
www.ccii.med.kyoto-u.ac.jp/en/careers-e...
Reposted by Gabriel Victora
Germinal center clonal diversity trees as a musical score, a great image to start @victora.bsky.social's CCII seminar, "Replaying germinal center evolution on a quantified affinity landscape"
#GerminalCenter #Immunology
www.ccii.med.kyoto-u.ac.jp/en/event/the...
#GerminalCenter #Immunology
www.ccii.med.kyoto-u.ac.jp/en/event/the...
July 2, 2025 at 2:42 AM
Germinal center clonal diversity trees as a musical score, a great image to start @victora.bsky.social's CCII seminar, "Replaying germinal center evolution on a quantified affinity landscape"
#GerminalCenter #Immunology
www.ccii.med.kyoto-u.ac.jp/en/event/the...
#GerminalCenter #Immunology
www.ccii.med.kyoto-u.ac.jp/en/event/the...
Reposted by Gabriel Victora
Following Daniel @danmucida.bsky.social's session, Angelina Bilate @rockefelleruniv.bsky.social discussed strategies to identify antigen specific T cells.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
July 1, 2025 at 9:48 PM
Following Daniel @danmucida.bsky.social's session, Angelina Bilate @rockefelleruniv.bsky.social discussed strategies to identify antigen specific T cells.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
With a little help from my friend
July 1, 2025 at 10:22 PM
With a little help from my friend
Reposted by Gabriel Victora
A great start to a 3-day workshop: Daniel & Angelina Bilate discussing with students & postdocs at @ccii-kyoto.bsky.social all the obstacles faced & strategies to overcome them (or, more drastically, the thorny topic of when to pull the plug on a project).
www.ccii.med.kyoto-u.ac.jp/en/event/wor...
www.ccii.med.kyoto-u.ac.jp/en/event/wor...
July 1, 2025 at 1:22 AM
A great start to a 3-day workshop: Daniel & Angelina Bilate discussing with students & postdocs at @ccii-kyoto.bsky.social all the obstacles faced & strategies to overcome them (or, more drastically, the thorny topic of when to pull the plug on a project).
www.ccii.med.kyoto-u.ac.jp/en/event/wor...
www.ccii.med.kyoto-u.ac.jp/en/event/wor...
Reposted by Gabriel Victora
Our streamlined Junior PI application process asks you to submit:
a cover letter;
a research plan;
a current curriculum vitae;
brief narrative summary of your main research achievements;
Contact information for three references
#Immunology #Immunotherapy
www.ccii.med.kyoto-u.ac.jp/en/careers-e...
a cover letter;
a research plan;
a current curriculum vitae;
brief narrative summary of your main research achievements;
Contact information for three references
#Immunology #Immunotherapy
www.ccii.med.kyoto-u.ac.jp/en/careers-e...
July 1, 2025 at 6:58 AM
Our streamlined Junior PI application process asks you to submit:
a cover letter;
a research plan;
a current curriculum vitae;
brief narrative summary of your main research achievements;
Contact information for three references
#Immunology #Immunotherapy
www.ccii.med.kyoto-u.ac.jp/en/careers-e...
a cover letter;
a research plan;
a current curriculum vitae;
brief narrative summary of your main research achievements;
Contact information for three references
#Immunology #Immunotherapy
www.ccii.med.kyoto-u.ac.jp/en/careers-e...
Great to be back for the last iteration of this great symposium. It will be missed!
I am so delighted to be in #Japan for this year's RIKEN IMS–JSI International Symposium on #Immunology! 🇯🇵
温かく迎えてくれた主催者に感謝する！
温かく迎えてくれた主催者に感謝する！
June 27, 2025 at 7:18 AM
Great to be back for the last iteration of this great symposium. It will be missed!
Reposted by Gabriel Victora
I'm stoked to have this long-term and highly collaborative effort out in the wild. We present an experimental evolution system to quantitatively study the rapid evolutionary dynamics of B-cell affinity maturation. These evolutionary mechanisms underpin antibody responses and immune memory formation.
June 7, 2025 at 11:30 PM
I'm stoked to have this long-term and highly collaborative effort out in the wild. We present an experimental evolution system to quantitatively study the rapid evolutionary dynamics of B-cell affinity maturation. These evolutionary mechanisms underpin antibody responses and immune memory formation.
Reposted by Gabriel Victora
Another tour de force by the Victora lab. A must read for germinal center aficionados. There goes the weekend!
Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Replaying germinal center evolution on a quantified affinity landscape
Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...
www.biorxiv.org
June 7, 2025 at 11:17 AM
Another tour de force by the Victora lab. A must read for germinal center aficionados. There goes the weekend!
Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Replaying germinal center evolution on a quantified affinity landscape
Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...
www.biorxiv.org
June 5, 2025 at 2:28 PM
Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Gabriel Victora
”replication crisis” has always been hyperbole. Scientists ALWAYS argued, called each other frauds, and eventually land on consensus. A lot of what van Leeuwenhoek observed in the late 1600s was NOT REPRODUCIBLE because nobody could make lenses like him. But he was right, about cells, and bacteria.
There is no "science-wide replication crisis" because every word in that phrase carries unfounded assumptions. 🧵
1. There is no evidence that progress has generally stalled in the sciences. Also, no one has actually tried to estimate replicability across fields.
1. There is no evidence that progress has generally stalled in the sciences. Also, no one has actually tried to estimate replicability across fields.
June 4, 2025 at 2:05 AM
”replication crisis” has always been hyperbole. Scientists ALWAYS argued, called each other frauds, and eventually land on consensus. A lot of what van Leeuwenhoek observed in the late 1600s was NOT REPRODUCIBLE because nobody could make lenses like him. But he was right, about cells, and bacteria.
Dear uLIPSTIC users,
We have been getting reports that, under some more inflammatory settings like TB or chronic LCMV infection, uLIPSTIC-expressing lymphocytes adoptively transferred into cre-negative uLIPSTIC hosts may be rejected at later timepoints (>1 wk).
We have been getting reports that, under some more inflammatory settings like TB or chronic LCMV infection, uLIPSTIC-expressing lymphocytes adoptively transferred into cre-negative uLIPSTIC hosts may be rejected at later timepoints (>1 wk).
May 29, 2025 at 7:13 PM
Dear uLIPSTIC users,
We have been getting reports that, under some more inflammatory settings like TB or chronic LCMV infection, uLIPSTIC-expressing lymphocytes adoptively transferred into cre-negative uLIPSTIC hosts may be rejected at later timepoints (>1 wk).
We have been getting reports that, under some more inflammatory settings like TB or chronic LCMV infection, uLIPSTIC-expressing lymphocytes adoptively transferred into cre-negative uLIPSTIC hosts may be rejected at later timepoints (>1 wk).
Reposted by Gabriel Victora
A collaborative study between the labs of @danmucida.bsky.social and @victora.bsky.social earlier this year showed how immune cells in the gut distinguish between food and harmful pathogens, shedding light on the origins of food allergies: bit.ly/4hyS18b
#FoodAllergyAwarenessWeek
#FoodAllergyAwarenessWeek
May 14, 2025 at 6:56 PM
A collaborative study between the labs of @danmucida.bsky.social and @victora.bsky.social earlier this year showed how immune cells in the gut distinguish between food and harmful pathogens, shedding light on the origins of food allergies: bit.ly/4hyS18b
#FoodAllergyAwarenessWeek
#FoodAllergyAwarenessWeek
Reposted by Gabriel Victora
New imaging from @victora.bsky.social's lab reveals a built-in safeguard that allows B cell populations to rapidly expand in germinal centers without introducing deleterious mutations. #RockefellerScience
New mechanism behind adaptive immunity revealed. It could impact how we design vaccines. - News
Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted...
www.rockefeller.edu
March 19, 2025 at 6:40 PM
New imaging from @victora.bsky.social's lab reveals a built-in safeguard that allows B cell populations to rapidly expand in germinal centers without introducing deleterious mutations. #RockefellerScience