HHMI
@hhmi-science.bsky.social
We invest in scientists at all career stages who make discoveries that advance human health for decades to come.
After 50 years in science, former #HHMIInvestigator David Clapham’s advice is simple: “You have to see problem-solving as fun.” From training with Nobel laureates to deepening our understanding of ion channels & leading at HHMI, he retires with a lasting legacy: hhmi.news/3O3kYji.
February 10, 2026 at 5:59 PM
After 50 years in science, former #HHMIInvestigator David Clapham’s advice is simple: “You have to see problem-solving as fun.” From training with Nobel laureates to deepening our understanding of ion channels & leading at HHMI, he retires with a lasting legacy: hhmi.news/3O3kYji.
What if the answers to Alzheimer’s & schizophrenia lie in glia, not neurons? Join “SciShow Field Trips” & our own Tangled Bank Studios inside #HHMIInvestigator Beth Stevens' lab to see how these long-ignored brain cells may help us better understand neurological diseases: bit.ly/4kjqU3R.
February 9, 2026 at 9:10 PM
What if the answers to Alzheimer’s & schizophrenia lie in glia, not neurons? Join “SciShow Field Trips” & our own Tangled Bank Studios inside #HHMIInvestigator Beth Stevens' lab to see how these long-ignored brain cells may help us better understand neurological diseases: bit.ly/4kjqU3R.
Kids who grow up in biodiverse environments tend to have fewer allergies—& now we know why. #HHMIInvestigator Ruslan Medzhitov & co have found early exposure to diverse microbes creates broad immune memory, & an antibody that helps block allergic reactions later in life: bit.ly/4rGC59h.
February 5, 2026 at 6:18 PM
Kids who grow up in biodiverse environments tend to have fewer allergies—& now we know why. #HHMIInvestigator Ruslan Medzhitov & co have found early exposure to diverse microbes creates broad immune memory, & an antibody that helps block allergic reactions later in life: bit.ly/4rGC59h.
🎶 Sound on! How does a young zebra finch's song connect to treating Parkinson's? #FreemanHrabowski Scholar Vikram Gadagkar & co have ID'd a dopamine-based neural signal in finches that could offer insights into motor learning in humans — esp. those w/conditions like Parkinson’s hhmi.news/4tndfNg
February 3, 2026 at 4:54 PM
🎶 Sound on! How does a young zebra finch's song connect to treating Parkinson's? #FreemanHrabowski Scholar Vikram Gadagkar & co have ID'd a dopamine-based neural signal in finches that could offer insights into motor learning in humans — esp. those w/conditions like Parkinson’s hhmi.news/4tndfNg
We're proud to join the Vilcek Foundation in recognizing HHMI Investigator Karolin Luger, whose dedication & groundbreaking nucleosome research has led to the development of innovative new drug treatments, including cancer medicines. hhmi.news/49VciEd @vilcekfoundation.bsky.social
February 2, 2026 at 5:05 PM
We're proud to join the Vilcek Foundation in recognizing HHMI Investigator Karolin Luger, whose dedication & groundbreaking nucleosome research has led to the development of innovative new drug treatments, including cancer medicines. hhmi.news/49VciEd @vilcekfoundation.bsky.social
CLOSING SOON: Applications for Group Leader roles at our Janelia Research Campus close Feb. 3! Have original, transformative ideas for experimental approaches in imaging, molecular engineering, protein chemistry, mass spectrometry, & beyond? Learn more: janelia.org/groupleader 🧪
January 30, 2026 at 6:16 PM
CLOSING SOON: Applications for Group Leader roles at our Janelia Research Campus close Feb. 3! Have original, transformative ideas for experimental approaches in imaging, molecular engineering, protein chemistry, mass spectrometry, & beyond? Learn more: janelia.org/groupleader 🧪
"SciShow Field Trips" & our own Tangled Bank Studios take you inside the lab of HHMI Investigator Feng Zhang. Known for engineering CRISPR-Cas9 for use in human cells, his next breakthrough could reach hard-to-access cells associated with conditions like ALS & Huntington's: bit.ly/49JomIt
January 28, 2026 at 10:14 PM
"SciShow Field Trips" & our own Tangled Bank Studios take you inside the lab of HHMI Investigator Feng Zhang. Known for engineering CRISPR-Cas9 for use in human cells, his next breakthrough could reach hard-to-access cells associated with conditions like ALS & Huntington's: bit.ly/49JomIt
Biosensors help scientists understand the brain & body like never before, but building one can take years. Researchers Alison Tebo & Srinivas Turaga at HHMI's Janelia Research Campus are using AI to build a tool that will vastly speed biosensor development for all scientists: hhmi.news/4rdhvNt
January 25, 2026 at 6:07 PM
Biosensors help scientists understand the brain & body like never before, but building one can take years. Researchers Alison Tebo & Srinivas Turaga at HHMI's Janelia Research Campus are using AI to build a tool that will vastly speed biosensor development for all scientists: hhmi.news/4rdhvNt
2/2: Hynes discovered key molecules involved in cell adhesion, driving a better understanding of development and cancer metastasis. Their enormous contributions to basic science and human health live on.
January 23, 2026 at 10:13 PM
2/2: Hynes discovered key molecules involved in cell adhesion, driving a better understanding of development and cancer metastasis. Their enormous contributions to basic science and human health live on.
1/2: It is with deep sadness that we share the passing of Joel Habener and Richard Hynes, members of the HHMI Investigator community for more than 3 decades. Habener's discoveries helped transform the treatment of diabetes, obesity, and related conditions.
January 23, 2026 at 10:13 PM
1/2: It is with deep sadness that we share the passing of Joel Habener and Richard Hynes, members of the HHMI Investigator community for more than 3 decades. Habener's discoveries helped transform the treatment of diabetes, obesity, and related conditions.
Science teacher & HHMI BioInteractive Ambassador Samuel Washington Jr. draws students in with more than textbooks. “At first, kids love science—bugs, their bodies, the outdoors—but if you don’t tap into that natural curiosity, they lose it." Via @neatoday.bsky.social bit.ly/4pD1w9W 📸Shea Kastriner
January 22, 2026 at 6:13 PM
Science teacher & HHMI BioInteractive Ambassador Samuel Washington Jr. draws students in with more than textbooks. “At first, kids love science—bugs, their bodies, the outdoors—but if you don’t tap into that natural curiosity, they lose it." Via @neatoday.bsky.social bit.ly/4pD1w9W 📸Shea Kastriner
Created using fluorescence microscopy, this stunning image of an animal cell showcases thin, web-like fibers called vimentin — a protein that provides mechanical stability to cells and tissues, despite a single vimentin being ~7000x smaller than the width of a human hair. 📸 @aaandmoore.bsky.social
January 20, 2026 at 9:57 PM
Created using fluorescence microscopy, this stunning image of an animal cell showcases thin, web-like fibers called vimentin — a protein that provides mechanical stability to cells and tissues, despite a single vimentin being ~7000x smaller than the width of a human hair. 📸 @aaandmoore.bsky.social
Driven by an experience familiar to many — watching parents age — HHMI Hanna Gray Fellow Melanie McReynolds wants to answer a fundamental question: How can we age healthier? The key may lie in better understanding NAD+ & how its levels decline as we grow older. Via @asbmb.bsky.social: bit.ly/45tDuHB
January 18, 2026 at 4:26 PM
Driven by an experience familiar to many — watching parents age — HHMI Hanna Gray Fellow Melanie McReynolds wants to answer a fundamental question: How can we age healthier? The key may lie in better understanding NAD+ & how its levels decline as we grow older. Via @asbmb.bsky.social: bit.ly/45tDuHB
12 years after unlocking the famously "undruggable" K-Ras protein — a discovery still driving treatments for cancers with notoriously poor survival rates — HHMI Investigator Kevan Shokat & team are charting new therapies to outmaneuver drug resistance: hhmi.news/3LwWaz5
@ucsanfrancisco.bsky.social
@ucsanfrancisco.bsky.social
New Ways to Target Hard-to-Treat Cancers | HHMI
HHMI Investigator Kevan Shokat is advancing Ras-targeted cancer therapies, overcoming drug resistance, and exploring preventive strategies.
hhmi.news
January 16, 2026 at 5:58 PM
12 years after unlocking the famously "undruggable" K-Ras protein — a discovery still driving treatments for cancers with notoriously poor survival rates — HHMI Investigator Kevan Shokat & team are charting new therapies to outmaneuver drug resistance: hhmi.news/3LwWaz5
@ucsanfrancisco.bsky.social
@ucsanfrancisco.bsky.social
Want to learn state-of-the-art deep learning techniques for microscopy image analysis? Apply by Jan. 15 to join us for a bootcamp at HHMI’s Janelia Research Campus. Gain hands-on experience with tools & frameworks you can use in your own research: bit.ly/4sqejiG 🧪
Deep Learning for Microscopy Image Analysis
Topics The following will be covered extensively during lectures, exercises, and project work: Image denoising and restoration (fully supervised and self-supervised) Image translation (e.g.,
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January 13, 2026 at 9:33 PM
Want to learn state-of-the-art deep learning techniques for microscopy image analysis? Apply by Jan. 15 to join us for a bootcamp at HHMI’s Janelia Research Campus. Gain hands-on experience with tools & frameworks you can use in your own research: bit.ly/4sqejiG 🧪
NYE fireworks < neurons expressing iGluSnFR3!
Developed at our Janelia Research Campus, iGluSnFR3 is a fluorescent sensor designed to rapidly detect & image glutamate — our brains' main chemical messenger — allowing researchers to observe (dazzling) neural communication as it happens. 🎆
Developed at our Janelia Research Campus, iGluSnFR3 is a fluorescent sensor designed to rapidly detect & image glutamate — our brains' main chemical messenger — allowing researchers to observe (dazzling) neural communication as it happens. 🎆
December 31, 2025 at 4:49 PM
NYE fireworks < neurons expressing iGluSnFR3!
Developed at our Janelia Research Campus, iGluSnFR3 is a fluorescent sensor designed to rapidly detect & image glutamate — our brains' main chemical messenger — allowing researchers to observe (dazzling) neural communication as it happens. 🎆
Developed at our Janelia Research Campus, iGluSnFR3 is a fluorescent sensor designed to rapidly detect & image glutamate — our brains' main chemical messenger — allowing researchers to observe (dazzling) neural communication as it happens. 🎆
When gene expression goes wrong, it can cause abnormal cellular growth, cancer, & more. HHMI Investigator Michelle Wang (Cornell University) & collaborators have discovered that nucleosomes—long thought to be obstacles to gene expression—actually help the process work more smoothly. bit.ly/4q9xA6e
Unexpected allies: DNA packaging aids gene expression | Cornell Chronicle
Researchers discovered that DNA packaging structures called nucleosomes, which have been traditionally seen as roadblocks for gene expression, actually help reduce torsional stress in DNA strands and facilitate genetic information decoding.
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December 27, 2025 at 5:15 PM
When gene expression goes wrong, it can cause abnormal cellular growth, cancer, & more. HHMI Investigator Michelle Wang (Cornell University) & collaborators have discovered that nucleosomes—long thought to be obstacles to gene expression—actually help the process work more smoothly. bit.ly/4q9xA6e
Our kind of annual tradition: Glucose + Tollens’ reagent + festive swirling = a chemical reaction that creates a thin layer of silver, loads of seasonal cheer, & ornaments worthy of being passed down for ... well, a few weeks at least. Happy holidays to all those who celebrate! ✨
December 24, 2025 at 3:48 PM
Our kind of annual tradition: Glucose + Tollens’ reagent + festive swirling = a chemical reaction that creates a thin layer of silver, loads of seasonal cheer, & ornaments worthy of being passed down for ... well, a few weeks at least. Happy holidays to all those who celebrate! ✨
Rising undergrad junior or senior? Last chance to apply! Applications close TOMORROW, Dec. 22, 11:59pm EST. 🧪
Our 9-week summer research experience includes hands-on lab work, a generous stipend, & mentorship from some of the nation’s top scientists. Learn more & apply at bit.ly/CechFellows.
Our 9-week summer research experience includes hands-on lab work, a generous stipend, & mentorship from some of the nation’s top scientists. Learn more & apply at bit.ly/CechFellows.
December 21, 2025 at 3:00 PM
Rising undergrad junior or senior? Last chance to apply! Applications close TOMORROW, Dec. 22, 11:59pm EST. 🧪
Our 9-week summer research experience includes hands-on lab work, a generous stipend, & mentorship from some of the nation’s top scientists. Learn more & apply at bit.ly/CechFellows.
Our 9-week summer research experience includes hands-on lab work, a generous stipend, & mentorship from some of the nation’s top scientists. Learn more & apply at bit.ly/CechFellows.
"Watching my students who didn’t really know if they wanted to do research turn around & fall in love with research … that’s been the most meaningful." — HHMI Postdoc Scientist Brea Manuel, '25 program mentor. 🧪
Rising junior or senior? *Applications close 11:59pm EST Dec. 22* ⏰❗bit.ly/CechFellows
Rising junior or senior? *Applications close 11:59pm EST Dec. 22* ⏰❗bit.ly/CechFellows
December 20, 2025 at 3:10 PM
"Watching my students who didn’t really know if they wanted to do research turn around & fall in love with research … that’s been the most meaningful." — HHMI Postdoc Scientist Brea Manuel, '25 program mentor. 🧪
Rising junior or senior? *Applications close 11:59pm EST Dec. 22* ⏰❗bit.ly/CechFellows
Rising junior or senior? *Applications close 11:59pm EST Dec. 22* ⏰❗bit.ly/CechFellows
(2/2): The researchers ID'd two subtypes of regulatory T cells in colorectal cancer — one that supports tumor growth, and one that restrains it. The findings could help improve immunotherapy treatment for patients with colorectal and other types of cancer.
December 19, 2025 at 8:29 PM
(2/2): The researchers ID'd two subtypes of regulatory T cells in colorectal cancer — one that supports tumor growth, and one that restrains it. The findings could help improve immunotherapy treatment for patients with colorectal and other types of cancer.
(1/2): HHMI Investigator Alexander Rudensky & collaborators at @mskcancercenter.bsky.social have solved a 20-year mystery: Why are high levels of regulatory #Tcells linked to better survival in colorectal cancer, when they’re usually indicative of poor outcomes in most other cancers? bit.ly/3MGn9IY
MSK Researchers Solve a Key Colorectal Cancer Mystery
A new MSK study finds that in colorectal cancer, not all regulatory T cells are created equal. One subtype suppresses cancer growth while another aids it. The findings could help improve immunotherapy...
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December 19, 2025 at 8:29 PM
(1/2): HHMI Investigator Alexander Rudensky & collaborators at @mskcancercenter.bsky.social have solved a 20-year mystery: Why are high levels of regulatory #Tcells linked to better survival in colorectal cancer, when they’re usually indicative of poor outcomes in most other cancers? bit.ly/3MGn9IY
“I feel being part of their life, being part of their career, is just priceless.” — HHMI Investigator Xin Chen, '25 Summer Undergraduate Research Program mentor 🧪
Rising junior or senior? Applications close 11:59pm Dec. 22! Explore a career in biological or biomedical research: bit.ly/CechFellows
Rising junior or senior? Applications close 11:59pm Dec. 22! Explore a career in biological or biomedical research: bit.ly/CechFellows
December 17, 2025 at 7:03 PM
“I feel being part of their life, being part of their career, is just priceless.” — HHMI Investigator Xin Chen, '25 Summer Undergraduate Research Program mentor 🧪
Rising junior or senior? Applications close 11:59pm Dec. 22! Explore a career in biological or biomedical research: bit.ly/CechFellows
Rising junior or senior? Applications close 11:59pm Dec. 22! Explore a career in biological or biomedical research: bit.ly/CechFellows
(2/2): This points to a potential strategy for using bacteria-targeting drugs to support healthier aging, & inspires a new way of thinking about drug development.
December 16, 2025 at 9:19 PM
(2/2): This points to a potential strategy for using bacteria-targeting drugs to support healthier aging, & inspires a new way of thinking about drug development.
(1/2): What if the bacteria living in our digestive tracts could produce compounds that help us live longer?
The Wang (Meng) Lab at HHMI's Janelia Research Campus has found a way to get gut microbes to produce metabolites that promote longevity in animals: hhmi.news/48QyPAm.
The Wang (Meng) Lab at HHMI's Janelia Research Campus has found a way to get gut microbes to produce metabolites that promote longevity in animals: hhmi.news/48QyPAm.
December 16, 2025 at 9:19 PM
(1/2): What if the bacteria living in our digestive tracts could produce compounds that help us live longer?
The Wang (Meng) Lab at HHMI's Janelia Research Campus has found a way to get gut microbes to produce metabolites that promote longevity in animals: hhmi.news/48QyPAm.
The Wang (Meng) Lab at HHMI's Janelia Research Campus has found a way to get gut microbes to produce metabolites that promote longevity in animals: hhmi.news/48QyPAm.