Matti Pronker
@mfpronker.bsky.social
Junior Director sdAb engineering at QVQ, structural biology, protein engineering, #cryoEM ❄️🔬, #crystallography 💎 - views are my own
Pinned
Matti Pronker
@mfpronker.bsky.social
· Jun 22
The final reviewed version of our FLAG/anti-FLAG M2 structure paper is now out fully open access in the Journal of Molecular Biology: www.sciencedirect.com/science/arti...
Many thanks to Wouter Beugelink, Els Sweep, Bert Janssen and @joostsnijder.bsky.social
Many thanks to Wouter Beugelink, Els Sweep, Bert Janssen and @joostsnijder.bsky.social
Reposted by Matti Pronker
The Wilkinson Lab is open for science! @mskcancercenter.bsky.social
🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)
🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)
Wilkinson Lab
We discover and study reverse transcriptases
wilkinsonlab.bio
October 31, 2025 at 7:00 PM
The Wilkinson Lab is open for science! @mskcancercenter.bsky.social
🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)
🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)
Reposted by Matti Pronker
The South Korean Ministry of Defense has awarded medals of merit to 11 officers for disobeying direct orders of superiors during the martial law fiasco, orders that they deemed to be contrary to the constitution and endangerment to democracy.
www.chosun.com/english/nati...
www.chosun.com/english/nati...
National Defense Ministry Honors 11 Soldiers for Refusing Illegal Orders
National Defense Ministry Honors 11 Soldiers for Refusing Illegal Orders Honored for rejecting illegal orders during martial law, Marine death probe
www.chosun.com
September 27, 2025 at 6:44 PM
The South Korean Ministry of Defense has awarded medals of merit to 11 officers for disobeying direct orders of superiors during the martial law fiasco, orders that they deemed to be contrary to the constitution and endangerment to democracy.
www.chosun.com/english/nati...
www.chosun.com/english/nati...
Disney cancels @jimmykimmel.com , I cancel Disney Plus, byebye!
September 18, 2025 at 1:13 PM
Disney cancels @jimmykimmel.com , I cancel Disney Plus, byebye!
Reposted by Matti Pronker
This year, for Postdoc Appreciation Week, could we please STOP referring to them as TRAINEES!
They are exceptionally qualified professionals, highly experienced researchers, mentors, educators, world-leading experts in their field, grownups with responsibilities, not interns!
They are exceptionally qualified professionals, highly experienced researchers, mentors, educators, world-leading experts in their field, grownups with responsibilities, not interns!
September 17, 2025 at 7:08 PM
This year, for Postdoc Appreciation Week, could we please STOP referring to them as TRAINEES!
They are exceptionally qualified professionals, highly experienced researchers, mentors, educators, world-leading experts in their field, grownups with responsibilities, not interns!
They are exceptionally qualified professionals, highly experienced researchers, mentors, educators, world-leading experts in their field, grownups with responsibilities, not interns!
As it's the season, 3 options for those wishing to cook pumpkin:
1. Suffer when trying to peel a raw pumpkin
2. Boil the pumpkin with skin on (skin comes of easily), suffer when trying to clean the pot later
3. Suffer when eating the awful pre-cut pumpkin (fridge or frozen) 🥴
1. Suffer when trying to peel a raw pumpkin
2. Boil the pumpkin with skin on (skin comes of easily), suffer when trying to clean the pot later
3. Suffer when eating the awful pre-cut pumpkin (fridge or frozen) 🥴
September 13, 2025 at 8:42 PM
As it's the season, 3 options for those wishing to cook pumpkin:
1. Suffer when trying to peel a raw pumpkin
2. Boil the pumpkin with skin on (skin comes of easily), suffer when trying to clean the pot later
3. Suffer when eating the awful pre-cut pumpkin (fridge or frozen) 🥴
1. Suffer when trying to peel a raw pumpkin
2. Boil the pumpkin with skin on (skin comes of easily), suffer when trying to clean the pot later
3. Suffer when eating the awful pre-cut pumpkin (fridge or frozen) 🥴
It seems trendy lately to have visualizations of 3D proteins structures generated by AI. These show very ugly artifacts, akin to AI pictures of humans with the wrong number of fingers. It is really not hard to make a visualization of a random protein structure using free software! #AI-slop
September 12, 2025 at 1:18 PM
It seems trendy lately to have visualizations of 3D proteins structures generated by AI. These show very ugly artifacts, akin to AI pictures of humans with the wrong number of fingers. It is really not hard to make a visualization of a random protein structure using free software! #AI-slop
Reposted by Matti Pronker
We are experiencing a period of remarkable technological advancement ( #CryoEM, #CRISPR, #alphafold, protein design) unparalleled in the past decade.
Keeping pace is challenging, continuously adapting to technological developments that may become obsolete by the time you've mastered them. 🤕
Keeping pace is challenging, continuously adapting to technological developments that may become obsolete by the time you've mastered them. 🤕
September 1, 2025 at 11:35 AM
We are experiencing a period of remarkable technological advancement ( #CryoEM, #CRISPR, #alphafold, protein design) unparalleled in the past decade.
Keeping pace is challenging, continuously adapting to technological developments that may become obsolete by the time you've mastered them. 🤕
Keeping pace is challenging, continuously adapting to technological developments that may become obsolete by the time you've mastered them. 🤕
Reposted by Matti Pronker
We sequenced the anti-RSV-F antibody 131-2a by mass spec and determined its epitope by cryoEM. New insights in postfusion specific binding and antigenic site I. Now published in ACS Infectious Diseases @pubs.acs.org.
pubs.acs.org/doi/10.1021/...
@xdh.bsky.social @hangryhobbit.bsky.social
pubs.acs.org/doi/10.1021/...
@xdh.bsky.social @hangryhobbit.bsky.social
July 22, 2025 at 11:33 AM
We sequenced the anti-RSV-F antibody 131-2a by mass spec and determined its epitope by cryoEM. New insights in postfusion specific binding and antigenic site I. Now published in ACS Infectious Diseases @pubs.acs.org.
pubs.acs.org/doi/10.1021/...
@xdh.bsky.social @hangryhobbit.bsky.social
pubs.acs.org/doi/10.1021/...
@xdh.bsky.social @hangryhobbit.bsky.social
Reposted by Matti Pronker
In Science, researchers detail a nanoscale-resolution reconstruction of a millimeter-scale fragment of human cerebral cortex, giving an unprecedented view into the structural organization of brain tissue at the supracellular, cellular, and subcellular levels. #WorldBrainDay scim.ag/3FvpAKy
July 22, 2025 at 2:07 PM
In Science, researchers detail a nanoscale-resolution reconstruction of a millimeter-scale fragment of human cerebral cortex, giving an unprecedented view into the structural organization of brain tissue at the supracellular, cellular, and subcellular levels. #WorldBrainDay scim.ag/3FvpAKy
Reposted by Matti Pronker
Preprint alert! With #PFAS contamination becoming an environmental crisis, we dared to engineer natural defluorinases towards degradation of (un)natural organofluorides. How? Check out our robust growth-based selection platform here: www.biorxiv.org/content/10.1... thanks to @mayerlab.bsky.social !
Engineering fluoroacetate dehalogenase by growth-based selections to degrade non-natural organofluorides
The widespread use of organofluorides in modern society has inadvertently led to the bioaccumulation of harmful pollutants, most prominently per- and polyfluorinated alkyl substances (PFAS). In princi...
www.biorxiv.org
July 17, 2025 at 9:38 AM
Preprint alert! With #PFAS contamination becoming an environmental crisis, we dared to engineer natural defluorinases towards degradation of (un)natural organofluorides. How? Check out our robust growth-based selection platform here: www.biorxiv.org/content/10.1... thanks to @mayerlab.bsky.social !
Reposted by Matti Pronker
Breng Nederland terug aan kop, investeer in wetenschap en innovatie. Want onze veiligheid, welvaart, gezondheid en democratische waarden zijn niet vanzelfsprekend. In aanloop naar de verkiezingen doet de KNAW die oproep aan de politieke partijen: www.knaw.nl/nieuws/breng...
July 10, 2025 at 9:50 AM
Breng Nederland terug aan kop, investeer in wetenschap en innovatie. Want onze veiligheid, welvaart, gezondheid en democratische waarden zijn niet vanzelfsprekend. In aanloop naar de verkiezingen doet de KNAW die oproep aan de politieke partijen: www.knaw.nl/nieuws/breng...
Cool visualization of MAG cis dimerisation and trans ganglioside binding at the axon-myelin interface by Krzyszlof Anklewicz, a bachelor student @utrechtuniversity.bsky.social. This structure was the main discovery of my PhD! Find the open access paper here: www.nature.com/articles/nco... #glycotime
June 23, 2025 at 11:10 AM
Cool visualization of MAG cis dimerisation and trans ganglioside binding at the axon-myelin interface by Krzyszlof Anklewicz, a bachelor student @utrechtuniversity.bsky.social. This structure was the main discovery of my PhD! Find the open access paper here: www.nature.com/articles/nco... #glycotime
Reposted by Matti Pronker
Latest preprint from the lab, many years in the making!
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
June 18, 2025 at 6:32 AM
Latest preprint from the lab, many years in the making!
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
Reposted by Matti Pronker
Four LAPD officers on horseback surround a man laying on the ground, trample him, and beat him with their polycarbonate "saber" batons.
June 9, 2025 at 3:39 AM
Four LAPD officers on horseback surround a man laying on the ground, trample him, and beat him with their polycarbonate "saber" batons.
Reposted by Matti Pronker
This is his only biography now
"Roughly 1,500 babies have been born HIV-positive every day since January 21, because Musk cut off their mothers’ medication." prospect.org/power/2025-0...
Go, Elon, and Never Darken Our Doors Again
The worst ultra-billionaire on Earth says he’s leaving government. Let’s hope he actually does it.
prospect.org
May 30, 2025 at 8:20 PM
This is his only biography now
Reposted by Matti Pronker
🇨🇦🚨Job Alert🚨🇨🇦
Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget)
U Toronto, Dept of Biochem/LabMedPath
*Was just told they're looking for a structural biologist using cryoEM* (related to infectious disease?)
Are you an established PI ready to move to 🇨🇦?
research.utoronto.ca/funding-oppo...
Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget)
U Toronto, Dept of Biochem/LabMedPath
*Was just told they're looking for a structural biologist using cryoEM* (related to infectious disease?)
Are you an established PI ready to move to 🇨🇦?
research.utoronto.ca/funding-oppo...
2026 Canada Excellence Research Chair Opportunities | Research & Innovation
research.utoronto.ca
May 31, 2025 at 12:46 PM
🇨🇦🚨Job Alert🚨🇨🇦
Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget)
U Toronto, Dept of Biochem/LabMedPath
*Was just told they're looking for a structural biologist using cryoEM* (related to infectious disease?)
Are you an established PI ready to move to 🇨🇦?
research.utoronto.ca/funding-oppo...
Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget)
U Toronto, Dept of Biochem/LabMedPath
*Was just told they're looking for a structural biologist using cryoEM* (related to infectious disease?)
Are you an established PI ready to move to 🇨🇦?
research.utoronto.ca/funding-oppo...
Next week will be the FEBS Advanced Lecture Course 'Emerging insights from structural biology into molecular mechanisms of diseases', where I will present new structural biology and protein engineering results at the 'Academia meets industry' session. Hope to see you there!
May 23, 2025 at 1:28 PM
Next week will be the FEBS Advanced Lecture Course 'Emerging insights from structural biology into molecular mechanisms of diseases', where I will present new structural biology and protein engineering results at the 'Academia meets industry' session. Hope to see you there!
Reposted by Matti Pronker
Liposome Encapsulation Enables Near-Native Cryo-EM Structural Determination by Shielding Macromolecules from Non-Physiological Interfaces www.biorxiv.org/content/10.1101/2025.05.06.652550v1 #cryoem
May 11, 2025 at 7:10 AM
Liposome Encapsulation Enables Near-Native Cryo-EM Structural Determination by Shielding Macromolecules from Non-Physiological Interfaces www.biorxiv.org/content/10.1101/2025.05.06.652550v1 #cryoem
Nice work on coronavirus HKU1-A spike opening by Min Jin et al.:
www.nature.com/articles/s41...
With a longer glycan and higher resolution structures, they nicely confirm our conclusions (www.nature.com/articles/s41...) and add new insights.
www.nature.com/articles/s41...
With a longer glycan and higher resolution structures, they nicely confirm our conclusions (www.nature.com/articles/s41...) and add new insights.
Human coronavirus HKU1 spike structures reveal the basis for sialoglycan specificity and carbohydrate-promoted conformational changes - Nature Communications
Sialoglycan receptor binding promotes the D2 domain up conformation in the HKU1 coronavirus spike protein. Here the authors show that this conformational change is driven fundamentally by the full str...
www.nature.com
May 7, 2025 at 11:01 AM
Nice work on coronavirus HKU1-A spike opening by Min Jin et al.:
www.nature.com/articles/s41...
With a longer glycan and higher resolution structures, they nicely confirm our conclusions (www.nature.com/articles/s41...) and add new insights.
www.nature.com/articles/s41...
With a longer glycan and higher resolution structures, they nicely confirm our conclusions (www.nature.com/articles/s41...) and add new insights.
Reposted by Matti Pronker
Excellent opportunity available for a motivated #postdoc to join @kellythd-nguyen.bsky.social’s group investigating the roles of histones in regulating telomerase using a multi-disciplinary approach.
More details: www.nature.com/naturecareer...
Apply by 04 MAY
#PostdocJobs #ScienceJobs
More details: www.nature.com/naturecareer...
Apply by 04 MAY
#PostdocJobs #ScienceJobs
April 16, 2025 at 8:16 AM
Excellent opportunity available for a motivated #postdoc to join @kellythd-nguyen.bsky.social’s group investigating the roles of histones in regulating telomerase using a multi-disciplinary approach.
More details: www.nature.com/naturecareer...
Apply by 04 MAY
#PostdocJobs #ScienceJobs
More details: www.nature.com/naturecareer...
Apply by 04 MAY
#PostdocJobs #ScienceJobs
Reposted by Matti Pronker
Air pollution has dropped significantly in #Paris in the last 15 years as a result of a deliberate strategy. Mayor @annehidalgo.bsky.social’s leadership has traded car space for green space, safe bike space, kid space.. and traded pollution for people.
Good trade.
Good trade.
April 10, 2025 at 12:17 AM
Air pollution has dropped significantly in #Paris in the last 15 years as a result of a deliberate strategy. Mayor @annehidalgo.bsky.social’s leadership has traded car space for green space, safe bike space, kid space.. and traded pollution for people.
Good trade.
Good trade.
MAR added DT
DT:
Covfefe
MAR removed DT from the group
DT:
Covfefe
MAR removed DT from the group
March 26, 2025 at 4:03 PM
MAR added DT
DT:
Covfefe
MAR removed DT from the group
DT:
Covfefe
MAR removed DT from the group