Sjors Scheres
@sjorsscheres.bsky.social
Joint Head of Structural Studies at @mrclmb.bsky.social. Develops & uses #cryoEM to study amyloids in neurodegeneration. #tau, #alphasynuclein, #opensoftware, #RELION. All opinions my own.
Reposted by Sjors Scheres
Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
November 6, 2025 at 3:46 PM
Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
Reposted by Sjors Scheres
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
www.uu.nl
November 4, 2025 at 7:14 AM
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
www.uu.nl/en/news/33-m...
At some point, Doppio will replace relion's gui. Already you can do more in Doppio than in relion! 🤩
We are pleased to announce Doppio version 1.4! Available here www.ccpem.ac.uk/software/dow...
Downloads – CCP-EM
www.ccpem.ac.uk
November 4, 2025 at 6:14 PM
At some point, Doppio will replace relion's gui. Already you can do more in Doppio than in relion! 🤩
Reposted by Sjors Scheres
Doppio is a great tool (more of a toolbelt actually) to go all the way from micrographs to deposition!! (and the more people using it, the greater it gets)
We are pleased to announce Doppio version 1.4! Available here www.ccpem.ac.uk/software/dow...
Downloads – CCP-EM
www.ccpem.ac.uk
November 4, 2025 at 5:46 PM
Doppio is a great tool (more of a toolbelt actually) to go all the way from micrographs to deposition!! (and the more people using it, the greater it gets)
🥳🥳🥳
Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
www.uu.nl
November 3, 2025 at 5:42 PM
🥳🥳🥳
Max is a fantastic scientist!! 🤩
The Wilkinson Lab is open for science! @mskcancercenter.bsky.social
🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)
🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)
Wilkinson Lab
We discover and study reverse transcriptases
wilkinsonlab.bio
October 31, 2025 at 7:01 PM
Max is a fantastic scientist!! 🤩
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
mrc.tal.net/vx/appcentre...
Quick Check Needed
mrc.tal.net
October 29, 2025 at 9:17 AM
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
mrc.tal.net/vx/appcentre...
Our amazing Sofia did it again! She previously won the Perutz Prize for best PhD thesis at the LMB; this year she has won the Joan Steitz Prize for best postdoctoral work. She is on the job market for an independent position. Any institute would be lucky to have her. 🥳
Congratulations to the 2025 recipients of the Perutz Student Prize and the Joan Steitz Postdoc Prize: Claudia De Miguel, @lucaschwarz.bsky.social, Tom Dendooven, Sofia Lövestam, Katerina Naydenva & Tomke Stürner.
Find out why they won here: www2.mrc-lmb.cam.ac.uk/lmb-prizes-2...
#LMBNews 👏
Find out why they won here: www2.mrc-lmb.cam.ac.uk/lmb-prizes-2...
#LMBNews 👏
October 28, 2025 at 5:26 PM
Our amazing Sofia did it again! She previously won the Perutz Prize for best PhD thesis at the LMB; this year she has won the Joan Steitz Prize for best postdoctoral work. She is on the job market for an independent position. Any institute would be lucky to have her. 🥳
Reposted by Sjors Scheres
We are looking to hire a postdoc to take this and other TDP-43 assay development forward! Please re-post!
October 24, 2025 at 8:58 PM
We are looking to hire a postdoc to take this and other TDP-43 assay development forward! Please re-post!
Reposted by Sjors Scheres
We are excited to share our latest work on GLIC published in @pnas.org, where we developed a #cryoEM data processing strategy that allowed us to isolate and reconstruct multiple asymmetric states, revealing detailed insights into the channel’s activation mechanism. tinyurl.com/mwtb4rpj
Asymmetric gating of a homopentameric ion channel GLIC revealed by cryo-EM | PNAS
Pentameric ligand-gated ion channels (pLGICs) are vital neurotransmitter receptors
that are key therapeutic targets for neurological disorders. Alt...
tinyurl.com
October 24, 2025 at 5:32 AM
We are excited to share our latest work on GLIC published in @pnas.org, where we developed a #cryoEM data processing strategy that allowed us to isolate and reconstruct multiple asymmetric states, revealing detailed insights into the channel’s activation mechanism. tinyurl.com/mwtb4rpj
Reposted by Sjors Scheres
Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
October 22, 2025 at 4:41 PM
Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
Reposted by Sjors Scheres
What do apple trees, Nobel Prizes, cows, and world-changing innovation all have in common? Well, they're all part of a new animated journey across one of Europe’s most extraordinary places, the Cambridge Biomedical Campus.
youtu.be/2K7Txdwb_k4
youtu.be/2K7Txdwb_k4
Welcome to the Cambridge Biomedical Campus
YouTube video by Cambridge Biomedical Campus
youtu.be
October 20, 2025 at 10:58 AM
What do apple trees, Nobel Prizes, cows, and world-changing innovation all have in common? Well, they're all part of a new animated journey across one of Europe’s most extraordinary places, the Cambridge Biomedical Campus.
youtu.be/2K7Txdwb_k4
youtu.be/2K7Txdwb_k4
Reposted by Sjors Scheres
You might like our lego @johninnescentre.bsky.social
October 18, 2025 at 2:13 PM
You might like our lego @johninnescentre.bsky.social
Reposted by Sjors Scheres
I’m pleased to announce that my Lego lab will officially be moving to this building should it be funded
October 17, 2025 at 2:52 PM
I’m pleased to announce that my Lego lab will officially be moving to this building should it be funded
I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗
beta.ideas.lego.com/product-idea...
beta.ideas.lego.com/product-idea...
Biological Laboratory | LEGO® Ideas
This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…
beta.ideas.lego.com
October 16, 2025 at 8:07 AM
I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗
beta.ideas.lego.com/product-idea...
beta.ideas.lego.com/product-idea...
Reposted by Sjors Scheres
the GNE headcrab went for its latest victim today, a wild @sjorsscheres.bsky.social…
Thankfully @przemekdut.bsky.social was there to save the day!
Thankfully @przemekdut.bsky.social was there to save the day!
October 10, 2025 at 3:35 AM
the GNE headcrab went for its latest victim today, a wild @sjorsscheres.bsky.social…
Thankfully @przemekdut.bsky.social was there to save the day!
Thankfully @przemekdut.bsky.social was there to save the day!
Reposted by Sjors Scheres
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
October 8, 2025 at 8:49 AM
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Below (by @landerlab.bsky.social) is the 2nd #cryosparc recipe on @biorxivpreprint.bsky.social in a month. I remain worried about closed-source software affecting progress in #cryoEM. We should develop new algorithms instead!
#OpenSoftwareAcceleratesScience
www.biorxiv.org/content/10.1...
#OpenSoftwareAcceleratesScience
www.biorxiv.org/content/10.1...
www.biorxiv.org
October 5, 2025 at 8:20 AM
Below (by @landerlab.bsky.social) is the 2nd #cryosparc recipe on @biorxivpreprint.bsky.social in a month. I remain worried about closed-source software affecting progress in #cryoEM. We should develop new algorithms instead!
#OpenSoftwareAcceleratesScience
www.biorxiv.org/content/10.1...
#OpenSoftwareAcceleratesScience
www.biorxiv.org/content/10.1...
Reposted by Sjors Scheres
184 years earlier than predicted, London has met the legal limits for toxic NO2 for the first time.
This historic milestone proves that bold action like expanding ULEZ works, protecting children’s health and giving millions cleaner air to breathe.
This historic milestone proves that bold action like expanding ULEZ works, protecting children’s health and giving millions cleaner air to breathe.
London Ulez reduced nitrogen dioxide to legal limit, mayor says
The mayor of London says the fall in airborne toxins is due to the Ultra low emission zone expansion.
www.bbc.co.uk
October 1, 2025 at 11:00 AM
184 years earlier than predicted, London has met the legal limits for toxic NO2 for the first time.
This historic milestone proves that bold action like expanding ULEZ works, protecting children’s health and giving millions cleaner air to breathe.
This historic milestone proves that bold action like expanding ULEZ works, protecting children’s health and giving millions cleaner air to breathe.
Finally someone speaking up! "Targeting refugees will do nothing to tackle [the UK's] structural issues or improve people’s lives". If you agree, why not send a signal and donate to Refugee Action today (donate.refugee-action.org.uk/page/99385/d...)?
www.theguardian.com/politics/202...
www.theguardian.com/politics/202...
Stop blaming migrants and tackle UK’s real problems, 100 charities tell home secretary
A letter warns Shabana Mahmood that ‘targeting refugees will do nothing to tackle’ problems with housing and the NHS
www.theguardian.com
September 29, 2025 at 6:35 AM
Finally someone speaking up! "Targeting refugees will do nothing to tackle [the UK's] structural issues or improve people’s lives". If you agree, why not send a signal and donate to Refugee Action today (donate.refugee-action.org.uk/page/99385/d...)?
www.theguardian.com/politics/202...
www.theguardian.com/politics/202...
Reposted by Sjors Scheres
Initial attempt at replicating in relion (parameters in next post). This is for Aca2-RNA, using a 100k subset of the 2D-classified particles (no prior 3D cleanup).
A 1-class ab initio in relion, then local refinement in relion (1.8deg searches+blush) gives a nominally 3.3Å map; 3.5 Å w/out blush.
A 1-class ab initio in relion, then local refinement in relion (1.8deg searches+blush) gives a nominally 3.3Å map; 3.5 Å w/out blush.
September 26, 2025 at 2:28 AM
Initial attempt at replicating in relion (parameters in next post). This is for Aca2-RNA, using a 100k subset of the 2D-classified particles (no prior 3D cleanup).
A 1-class ab initio in relion, then local refinement in relion (1.8deg searches+blush) gives a nominally 3.3Å map; 3.5 Å w/out blush.
A 1-class ab initio in relion, then local refinement in relion (1.8deg searches+blush) gives a nominally 3.3Å map; 3.5 Å w/out blush.
Reposted by Sjors Scheres
I can raise the issue to higher ups!
September 25, 2025 at 10:39 AM
I can raise the issue to higher ups!
I find that riding a bike also helps the mind for doing research on #Alzheimers disease! 😀
“Riding a bike is associated with a 19% lower risk of all-cause dementia and a 22% lower risk of Alzheimer’s disease, compared with taking nonactive travel modes such as a car, bus or train…” #ISOGG #DNA #epigenetics www.cnn.com/2025/09/20/h...
Cycling linked with lower dementia risk, study finds | CNN
Cycling instead of driving has been linked with a lower risk of dementia and Alzheimer’s disease, a large study has found.
www.cnn.com
September 25, 2025 at 7:45 AM
I find that riding a bike also helps the mind for doing research on #Alzheimers disease! 😀
Do you #PhD with us!
Calling all prospective PhD students! Why not consider the LMB for your PhD?
Applications are now open!
www2.mrc-lmb.cam.ac.uk/students/int...
General deadline: 2nd DEC
US Gates Scholarship deadline: 15th OCT
Applications are now open!
www2.mrc-lmb.cam.ac.uk/students/int...
General deadline: 2nd DEC
US Gates Scholarship deadline: 15th OCT
September 23, 2025 at 8:13 AM
Do you #PhD with us!