Sjors Scheres
@sjorsscheres.bsky.social
Joint Head of Structural Studies at @mrclmb.bsky.social. Develops & uses #cryoEM to study amyloids in neurodegeneration. #tau, #alphasynuclein, #opensoftware, #RELION. All opinions my own.
Reposted by Sjors Scheres
Looking to start your lab in generative biology / AI?
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
pls RT
tinyurl.com/GenGenFaculty
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
pls RT
tinyurl.com/GenGenFaculty
Group Leader - Generative Biology and AI
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
tinyurl.com
January 1, 2026 at 12:08 PM
Looking to start your lab in generative biology / AI?
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
pls RT
tinyurl.com/GenGenFaculty
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
pls RT
tinyurl.com/GenGenFaculty
A DVT after my trip to Berkeley early Oct wasn't great for the rest of the year, but happy to be back on the bike now. Still clocked 2.8 Mm in ~3 hrs/wk and with 25km height in 2025. Grateful to close the MTB year with my 76yo dad this afternoon. Looking forward to 2026! 🚴🚴🚴
December 31, 2025 at 5:48 PM
A DVT after my trip to Berkeley early Oct wasn't great for the rest of the year, but happy to be back on the bike now. Still clocked 2.8 Mm in ~3 hrs/wk and with 25km height in 2025. Grateful to close the MTB year with my 76yo dad this afternoon. Looking forward to 2026! 🚴🚴🚴
If Martin Kettle would have read the great book Humankind by @rutgerbregman.com, this story would not have come as a surprise. Anyway, it is good he realises that journalists, including himself, are partially to blame for our skewed understanding of society.
www.theguardian.com/commentisfre...
www.theguardian.com/commentisfre...
Need cheering up after a terrible year? I may have just the story you’re looking for | Martin Kettle
A single act of kindness reminded me that, despite so much evidence to the contrary, the better angels of our nature are not necessarily doomed, says Guardian columnist Martin Kettle
www.theguardian.com
December 28, 2025 at 9:41 AM
If Martin Kettle would have read the great book Humankind by @rutgerbregman.com, this story would not have come as a surprise. Anyway, it is good he realises that journalists, including himself, are partially to blame for our skewed understanding of society.
www.theguardian.com/commentisfre...
www.theguardian.com/commentisfre...
I much enjoyed reading this optimistic collection of data on how we deal with the climate crisis by data scientist @hannahritchie.bsky.social
Get off social media and treat yourself to some positivity. 🤗
Get off social media and treat yourself to some positivity. 🤗
December 28, 2025 at 9:29 AM
I much enjoyed reading this optimistic collection of data on how we deal with the climate crisis by data scientist @hannahritchie.bsky.social
Get off social media and treat yourself to some positivity. 🤗
Get off social media and treat yourself to some positivity. 🤗
Reposted by Sjors Scheres
CryoEM folks, If you want to handle huge STAR file efficiently in Python, please try starfile-rs!
github.com/hanjinliu/star…
Reading a motion data of a particle from a 15 MB file is just like this ↓🤩
github.com/hanjinliu/star…
Reading a motion data of a particle from a 15 MB file is just like this ↓🤩
December 23, 2025 at 2:52 PM
CryoEM folks, If you want to handle huge STAR file efficiently in Python, please try starfile-rs!
github.com/hanjinliu/star…
Reading a motion data of a particle from a 15 MB file is just like this ↓🤩
github.com/hanjinliu/star…
Reading a motion data of a particle from a 15 MB file is just like this ↓🤩
If 2025 feels overwhelming, I can highly recommend reading this insightful book by @rutgerbregman.com over the holidays. A radical view on humanity: most of us are pretty decent! 🤩
December 23, 2025 at 12:42 PM
If 2025 feels overwhelming, I can highly recommend reading this insightful book by @rutgerbregman.com over the holidays. A radical view on humanity: most of us are pretty decent! 🤩
Reposted by Sjors Scheres
We have an opening for a research support officer. Come and join us! Please share.
Are you an enthusiastic and ambitious scientist looking for a challenging project?
Come and join @kellythd-nguyen.bsky.social’s group as a Research Support Officer and help decipher the molecular mechanisms of telomere maintenance!
Apply by 11 JAN
www.jobs.ac.uk/job/DPU715/r...
Come and join @kellythd-nguyen.bsky.social’s group as a Research Support Officer and help decipher the molecular mechanisms of telomere maintenance!
Apply by 11 JAN
www.jobs.ac.uk/job/DPU715/r...
December 22, 2025 at 12:09 PM
We have an opening for a research support officer. Come and join us! Please share.
Reposted by Sjors Scheres
Excellent opportunity for a #postdoc to join Michel Goedert’s group, investigating the mechanisms which cause the formation of amyloid filaments in neurodegenerative diseases, in collaboration with @sjorsscheres.bsky.social’s group.
More details: www.nature.com/naturecareer...
Closes 04 JAN
More details: www.nature.com/naturecareer...
Closes 04 JAN
December 16, 2025 at 10:18 AM
Excellent opportunity for a #postdoc to join Michel Goedert’s group, investigating the mechanisms which cause the formation of amyloid filaments in neurodegenerative diseases, in collaboration with @sjorsscheres.bsky.social’s group.
More details: www.nature.com/naturecareer...
Closes 04 JAN
More details: www.nature.com/naturecareer...
Closes 04 JAN
Fantastic news! Core funded institutes are often a highly efficient way of doing impactful science. Good to speak with one voice. 🥳
The LMB is proud to be a founding member of the newly launched National Research Organisations (NRO) Group – a new alliance of 35 UK research centres dedicated to #MakingResearchMatter for people, communities & the economy.
Learn more: nrogroup.org
#NROGroup #LMBinthenews
Learn more: nrogroup.org
#NROGroup #LMBinthenews
December 10, 2025 at 10:08 PM
Fantastic news! Core funded institutes are often a highly efficient way of doing impactful science. Good to speak with one voice. 🥳
Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have.
mrc.tal.net/vx/mobile-0/...
mrc.tal.net/vx/mobile-0/...
Postdoctoral Scientist - Neurobiology - Dr Michel Goedert - LMB 2752 - Medical Research Council
Location: Cambridge. Vacancy: Postdoctoral Scientist - Neurobiology - Dr Michel Goedert - LMB 2752. Closing Date: 04/01/2026, 23:55
mrc.tal.net
December 10, 2025 at 2:28 PM
Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have.
mrc.tal.net/vx/mobile-0/...
mrc.tal.net/vx/mobile-0/...
Star student & postdoc Kiarash Jamali is setting up his own group at the Ellison institute in Oxford. Join him for the most exciting machine learning research in structural biology and beyond!! 🤩 #ProudPI
I’m excited to announce that I will be starting my research group on computational enzyme design at the Generative Biology Institute, Oxford, UK (@eitoxford.bsky.social)! PhD applications are open, deadline is Jan 8th (www.chem.ox.ac.uk/genbio-dtp). Email kiarash.jamali@eit.org with any questions!
GenBio DTP
Optional supporting text
www.chem.ox.ac.uk
December 9, 2025 at 7:55 PM
Star student & postdoc Kiarash Jamali is setting up his own group at the Ellison institute in Oxford. Join him for the most exciting machine learning research in structural biology and beyond!! 🤩 #ProudPI
It seems many AI researchers live in a perpetual rush to submit their work to the next conference, on a 3-month cycle. When do they think or explore the unknown? Impactful work often takes years.
www.theguardian.com/technology/2...
www.theguardian.com/technology/2...
Artificial intelligence research has a slop problem, academics say: ‘It’s a mess’
AI research in question as author claims to have written over 100 papers on AI that one expert calls a ‘disaster’
www.theguardian.com
December 7, 2025 at 8:22 AM
It seems many AI researchers live in a perpetual rush to submit their work to the next conference, on a 3-month cycle. When do they think or explore the unknown? Impactful work often takes years.
www.theguardian.com/technology/2...
www.theguardian.com/technology/2...
No lore for me. I thought I wanted to become a vet. In The Netherlands places to its only oversubscribed vet school were assigned in a lottery. Didn't get in and went to do chemistry instead. Had a lot of fun there and never looked back. 🤪
November 23, 2025 at 3:21 PM
No lore for me. I thought I wanted to become a vet. In The Netherlands places to its only oversubscribed vet school were assigned in a lottery. Didn't get in and went to do chemistry instead. Had a lot of fun there and never looked back. 🤪
The role of @ebi.embl.org in the deployment of AI in biology has been and will continue to be essential. They do biological data like no one else in the world.
The UK Government Department for Science, Innovation & Technology published its national AI for Science strategy.
We’re pleased that EMBL-EBI is highlighted for the strength of our data foundations and look forward to seeing how this strategy supports future discoveries.
www.gov.uk/government/p...
We’re pleased that EMBL-EBI is highlighted for the strength of our data foundations and look forward to seeing how this strategy supports future discoveries.
www.gov.uk/government/p...
November 22, 2025 at 9:36 AM
The role of @ebi.embl.org in the deployment of AI in biology has been and will continue to be essential. They do biological data like no one else in the world.
Reposted by Sjors Scheres
The LMB is deeply saddened to share that Martin Kyte, Senior Design Engineer in the Electronics Workshop, died suddenly on 3rd November 2025.
A popular and trusted member of the LMB for over 30 years, Martin will be sorely missed.
www2.mrc-lmb.cam.ac.uk/martin-kyte-...
#LMBNews
A popular and trusted member of the LMB for over 30 years, Martin will be sorely missed.
www2.mrc-lmb.cam.ac.uk/martin-kyte-...
#LMBNews
November 21, 2025 at 4:51 PM
The LMB is deeply saddened to share that Martin Kyte, Senior Design Engineer in the Electronics Workshop, died suddenly on 3rd November 2025.
A popular and trusted member of the LMB for over 30 years, Martin will be sorely missed.
www2.mrc-lmb.cam.ac.uk/martin-kyte-...
#LMBNews
A popular and trusted member of the LMB for over 30 years, Martin will be sorely missed.
www2.mrc-lmb.cam.ac.uk/martin-kyte-...
#LMBNews
Reposted by Sjors Scheres
I am delighted to share that our new manuscript is published as an online Pre-proof at the Journal of Biological Chemistry!! 🎉
www.jbc.org/article/S002...
www.jbc.org/article/S002...
Seeding biosensor cell line that reproduces the Alzheimer tau fold
The assembly of tau protein into amyloid filaments through templated seeding is believed
to underlie the propagation of pathology in neurodegenerative diseases, such as Alzheimer’s
disease (AD) and ot...
www.jbc.org
November 21, 2025 at 5:08 PM
I am delighted to share that our new manuscript is published as an online Pre-proof at the Journal of Biological Chemistry!! 🎉
www.jbc.org/article/S002...
www.jbc.org/article/S002...
Oh wow, this is 🤯 amazing: ~3-fold acceleration of running #relion on A100 GPUs for realistic single-particle refinement by the group of Guangwen Yang at @tsinghuauniversity.bsky.social
.
What a fantastic example of #OpenSoftwareAcceleratesScience, literally! 😍
dl.acm.org/doi/full/10....
.
What a fantastic example of #OpenSoftwareAcceleratesScience, literally! 😍
dl.acm.org/doi/full/10....
T2-RELION: Task Parallelism, Tensor Core Accelerated RELION for Cryo-EM 3D Reconstruction | Proceedings of the International Conference for High Performance Computing, Networking, Storage and Analysis
dl.acm.org
November 21, 2025 at 12:32 PM
Oh wow, this is 🤯 amazing: ~3-fold acceleration of running #relion on A100 GPUs for realistic single-particle refinement by the group of Guangwen Yang at @tsinghuauniversity.bsky.social
.
What a fantastic example of #OpenSoftwareAcceleratesScience, literally! 😍
dl.acm.org/doi/full/10....
.
What a fantastic example of #OpenSoftwareAcceleratesScience, literally! 😍
dl.acm.org/doi/full/10....
I wonder how extremely busy people ever get any work done.
November 20, 2025 at 7:40 PM
I wonder how extremely busy people ever get any work done.
Reposted by Sjors Scheres
Want to join the LMB as a PhD student in October 2026?
You’ve got two weeks left to apply!
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/students/int...
Applications close on 2nd December 2025.
You’ve got two weeks left to apply!
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/students/int...
Applications close on 2nd December 2025.
November 18, 2025 at 2:29 PM
Want to join the LMB as a PhD student in October 2026?
You’ve got two weeks left to apply!
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/students/int...
Applications close on 2nd December 2025.
You’ve got two weeks left to apply!
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/students/int...
Applications close on 2nd December 2025.
This study claims in vitro seeded assembly in brain homogenate is more disease-relevant than fibril extraction, without providing any evidence thereof. It also ignores ample data that in vitro seeding with aSyn may NOT template the structure of seeds. 😕
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
www.sciencedirect.com
November 17, 2025 at 8:21 AM
This study claims in vitro seeded assembly in brain homogenate is more disease-relevant than fibril extraction, without providing any evidence thereof. It also ignores ample data that in vitro seeding with aSyn may NOT template the structure of seeds. 😕
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Sjors Scheres
Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
November 6, 2025 at 3:46 PM
Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
Reposted by Sjors Scheres
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
www.uu.nl
November 4, 2025 at 7:14 AM
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
www.uu.nl/en/news/33-m...
At some point, Doppio will replace relion's gui. Already you can do more in Doppio than in relion! 🤩
We are pleased to announce Doppio version 1.4! Available here www.ccpem.ac.uk/software/dow...
Downloads – CCP-EM
www.ccpem.ac.uk
November 4, 2025 at 6:14 PM
At some point, Doppio will replace relion's gui. Already you can do more in Doppio than in relion! 🤩
Reposted by Sjors Scheres
Doppio is a great tool (more of a toolbelt actually) to go all the way from micrographs to deposition!! (and the more people using it, the greater it gets)
We are pleased to announce Doppio version 1.4! Available here www.ccpem.ac.uk/software/dow...
Downloads – CCP-EM
www.ccpem.ac.uk
November 4, 2025 at 5:46 PM
Doppio is a great tool (more of a toolbelt actually) to go all the way from micrographs to deposition!! (and the more people using it, the greater it gets)
🥳🥳🥳
Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
www.uu.nl
November 3, 2025 at 5:42 PM
🥳🥳🥳