Kelly Nguyen
@kellythd-nguyen.bsky.social
Group Leader @MRC_LMB /Structural Biologist/Biochemist. Amateur baker in free time #RNAworld #spliceosome #telomerase #telomeres #cryoEM #Xraycrystallography
Honored to be a finalist for the 2026 Blavanik Awards in the UK in Life Sciences. I’m grateful to past and present lab members, collaborators, colleagues and mentors, who made it possible. It’s even better to share this from
Vietnam while celebrating the Tet holidays with family.
Vietnam while celebrating the Tet holidays with family.
@kellythd-nguyen.bsky.social, Group Leader in the Structural Studies Division, has been announced as a Finalist in the 2026 Blavatnik Awards for her work on telomerase.
Congratulations to Kelly and to all the other Finalists!
Read more here: blavatnikawards.org/news/items/y...
#LMBintheNews
Congratulations to Kelly and to all the other Finalists!
Read more here: blavatnikawards.org/news/items/y...
#LMBintheNews
February 10, 2026 at 10:19 AM
Honored to be a finalist for the 2026 Blavanik Awards in the UK in Life Sciences. I’m grateful to past and present lab members, collaborators, colleagues and mentors, who made it possible. It’s even better to share this from
Vietnam while celebrating the Tet holidays with family.
Vietnam while celebrating the Tet holidays with family.
Reposted by Kelly Nguyen
Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!
www.biorxiv.org
February 6, 2026 at 11:20 AM
Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!
Reposted by Kelly Nguyen
🧬🌉Online @science.org Programmable genome editing in human cells using RNA-guided bridge recombinases | Science www.science.org/doi/10.1126/...
Programmable genome editing in human cells using RNA-guided bridge recombinases
Site-specific insertion of gene-sized DNA fragments remains an unmet need in the genome editing field. IS110-family serine recombinases have recently been shown to mediate programmable DNA recombinati...
www.science.org
February 6, 2026 at 12:12 AM
🧬🌉Online @science.org Programmable genome editing in human cells using RNA-guided bridge recombinases | Science www.science.org/doi/10.1126/...
Congratulations on the well-deserved honor Karolin!
February 2, 2026 at 8:05 PM
Congratulations on the well-deserved honor Karolin!
Reposted by Kelly Nguyen
Here is the official announcement. Now more than ever, acknowledging the contributions of immigrants is so important. Thank you @vilcekfoundation.bsky.social, and congrats to my fellow awardees. Can't wait to meet you all.
Join us in congratulating the winners of our 2026 Vilcek Foundation Prizes in Biomedical Science, Fashion & Culture, Fashion & Design, and Art History! This year, we awarded $850,000 to 14 immigrants and cultural leaders. https://vilcek.co/4aemyr2
February 2, 2026 at 6:37 PM
Here is the official announcement. Now more than ever, acknowledging the contributions of immigrants is so important. Thank you @vilcekfoundation.bsky.social, and congrats to my fellow awardees. Can't wait to meet you all.
Reposted by Kelly Nguyen
Now online! Hallmarks of cancer—Then and now, and beyond
Hallmarks of cancer—Then and now, and beyond
Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years of conceptual refinement into a multidimensional view of tumor biology. This review highlights how aberrant capabilities, enabling traits, microenvironmental players, and systemic interactions converge to drive tumorigenesis and proposes that mechanism-guided co-targeting of hallmarks may offer promising therapeutic strategies.
dlvr.it
January 30, 2026 at 11:38 PM
Now online! Hallmarks of cancer—Then and now, and beyond
Second PhDone from our lab. Congrats Seb! What a start to 2026, a paper out, a successful PhD defense, two new members and two visits from our collaborators Michael Stone and @janovictom.bsky.social! Can’t be more grateful but time for a short break with family in Vietnam 🇻🇳.
January 30, 2026 at 9:19 AM
Second PhDone from our lab. Congrats Seb! What a start to 2026, a paper out, a successful PhD defense, two new members and two visits from our collaborators Michael Stone and @janovictom.bsky.social! Can’t be more grateful but time for a short break with family in Vietnam 🇻🇳.
Reposted by Kelly Nguyen
New pre-print from the lab! Lead by Mariia Mikhova and in collaboration with Kefei Yu’s lab @msumgi.bsky.social we dug into the molecular mechanism of class switch recombination in B cells using simultaneous RNA and protein single-molecule imaging. 1/n
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 23, 2026 at 2:49 PM
New pre-print from the lab! Lead by Mariia Mikhova and in collaboration with Kefei Yu’s lab @msumgi.bsky.social we dug into the molecular mechanism of class switch recombination in B cells using simultaneous RNA and protein single-molecule imaging. 1/n
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Thank you very much Pleasantine!
January 23, 2026 at 9:18 PM
Thank you very much Pleasantine!
Excited to share our latest work on dissecting the mechanism of processive telomeric DNA synthesis by telomerase. Led by amazing PhD student Sebastian Balch in collaboration with lab members,@automnenine.bsky.social @rachael-kretsch.bsky.social,@rdaslab.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structures of nucleotide-bound human telomerase at several steps of its telomeric DNA repeat addition cycle - Nature Communications
To maintain genome stability, the specialised reverse transcriptase telomerase processively adds telomeric DNA repeats to chromosome ends. Here the authors reported structures of human telomerase at t...
www.nature.com
January 23, 2026 at 6:57 AM
Excited to share our latest work on dissecting the mechanism of processive telomeric DNA synthesis by telomerase. Led by amazing PhD student Sebastian Balch in collaboration with lab members,@automnenine.bsky.social @rachael-kretsch.bsky.social,@rdaslab.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kelly Nguyen
Tom Cech on RNA research in Davos (video): www.weforum.org/meetings/wor...
January 21, 2026 at 9:24 PM
Tom Cech on RNA research in Davos (video): www.weforum.org/meetings/wor...
Congratulations Dawid! Very excited for you!
January 21, 2026 at 1:30 PM
Congratulations Dawid! Very excited for you!
Reposted by Kelly Nguyen
We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)
January 6, 2026 at 3:16 PM
We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)
Reposted by Kelly Nguyen
🚨 Interdisciplinary PhD opportunity for graduates interested in DNA replication, chromatin biology, and cancer research. Please share with potential candidates.
We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) — a major driver of tumour evolution and therapy resistance.
tiny.cc/vilw001
#PhD #CancerResearch #GenomeStability #Chromatin
tiny.cc/vilw001
#PhD #CancerResearch #GenomeStability #Chromatin
PhD Studentship: Understanding How Centromere Replication Fails in Cancer Imperial College London & The Institute of Cancer Research (CRUK Convergence Science Centre) at Institute of Cancer Research o...
PhD Project - PhD Studentship: Understanding How Centromere Replication Fails in Cancer Imperial College London & The Institute of Cancer Research (CRUK Convergence Science Centre) at Institute of...
www.findaphd.com
December 31, 2025 at 9:52 AM
🚨 Interdisciplinary PhD opportunity for graduates interested in DNA replication, chromatin biology, and cancer research. Please share with potential candidates.
We have an opening for a research support officer. Come and join us! Please share.
Are you an enthusiastic and ambitious scientist looking for a challenging project?
Come and join @kellythd-nguyen.bsky.social’s group as a Research Support Officer and help decipher the molecular mechanisms of telomere maintenance!
Apply by 11 JAN
www.jobs.ac.uk/job/DPU715/r...
Come and join @kellythd-nguyen.bsky.social’s group as a Research Support Officer and help decipher the molecular mechanisms of telomere maintenance!
Apply by 11 JAN
www.jobs.ac.uk/job/DPU715/r...
December 22, 2025 at 12:09 PM
We have an opening for a research support officer. Come and join us! Please share.
Reposted by Kelly Nguyen
We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) — a major driver of tumour evolution and therapy resistance.
tiny.cc/vilw001
#PhD #CancerResearch #GenomeStability #Chromatin
tiny.cc/vilw001
#PhD #CancerResearch #GenomeStability #Chromatin
PhD Studentship: Understanding How Centromere Replication Fails in Cancer Imperial College London & The Institute of Cancer Research (CRUK Convergence Science Centre) at Institute of Cancer Research o...
PhD Project - PhD Studentship: Understanding How Centromere Replication Fails in Cancer Imperial College London & The Institute of Cancer Research (CRUK Convergence Science Centre) at Institute of...
www.findaphd.com
December 18, 2025 at 3:46 PM
We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) — a major driver of tumour evolution and therapy resistance.
tiny.cc/vilw001
#PhD #CancerResearch #GenomeStability #Chromatin
tiny.cc/vilw001
#PhD #CancerResearch #GenomeStability #Chromatin
Reposted by Kelly Nguyen
Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 16, 2025 at 4:29 PM
Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kelly Nguyen
📢 Telomere community: Registration and abstract submission are now open for the EMBO Workshop “Telomere function and maintenance in health and disease”, May 25–30, 2026, in Lazise, Italy 🇮🇹. Looking forward to an exciting meeting! Please re-post. meetings.embo.org/event/26-tel...
Telomere function and maintenance in health and disease
Telomeres are specialized structures that protect the ends of linear chromosomes in eukaryotes. Research in this area has revealed that telomere maintenance is critical for stem cell function and nor…
meetings.embo.org
December 15, 2025 at 5:57 PM
📢 Telomere community: Registration and abstract submission are now open for the EMBO Workshop “Telomere function and maintenance in health and disease”, May 25–30, 2026, in Lazise, Italy 🇮🇹. Looking forward to an exciting meeting! Please re-post. meetings.embo.org/event/26-tel...
Reposted by Kelly Nguyen
The Reck-Peterson lab at Weill Cornell Medicine is seeking a technician or staff scientist to work on Aspergillus projects. Broad background in fungal biology and techniques required. Bioinformatics skills preferred. Find out more at: reckpetersonlab.org.
December 14, 2025 at 4:27 PM
The Reck-Peterson lab at Weill Cornell Medicine is seeking a technician or staff scientist to work on Aspergillus projects. Broad background in fungal biology and techniques required. Bioinformatics skills preferred. Find out more at: reckpetersonlab.org.
Reposted by Kelly Nguyen
Happy to share a new preprint from our lab, uncovering "spooky action at a distance" - for RNA Polymerase II:
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Stalling of elongating Pol II triggers Ser7 phosphorylation in trans to drive transcription recovery
DNA is scattered with obstacles that stall RNA polymerase II (Pol II) and block the production of full-length transcripts. Two mechanisms are known to resolve stalled Pol II: transcription-coupled nuc...
www.biorxiv.org
December 9, 2025 at 10:13 PM
Happy to share a new preprint from our lab, uncovering "spooky action at a distance" - for RNA Polymerase II:
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Santa swung by our lab early. Wrap up an amazing 2025 and stay tuned for more exciting discoveries from this ⭐️ team in 2026.
December 12, 2025 at 11:15 AM
Santa swung by our lab early. Wrap up an amazing 2025 and stay tuned for more exciting discoveries from this ⭐️ team in 2026.
Reposted by Kelly Nguyen
Time for a new pre-print! How do dendritic cells control pore formation in their own endocytic compartments?
Our work shows that the unique transmembrane anchor of perforin-2 does not protect DC membranes, but instead it enables antigen escape during cross-presentation
doi.org/10.64898/202...
Our work shows that the unique transmembrane anchor of perforin-2 does not protect DC membranes, but instead it enables antigen escape during cross-presentation
doi.org/10.64898/202...
December 11, 2025 at 9:21 AM
Time for a new pre-print! How do dendritic cells control pore formation in their own endocytic compartments?
Our work shows that the unique transmembrane anchor of perforin-2 does not protect DC membranes, but instead it enables antigen escape during cross-presentation
doi.org/10.64898/202...
Our work shows that the unique transmembrane anchor of perforin-2 does not protect DC membranes, but instead it enables antigen escape during cross-presentation
doi.org/10.64898/202...
Reposted by Kelly Nguyen
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
SET1/MLL complexes control transcription independently of H3K4me3
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
www.biorxiv.org
December 11, 2025 at 6:09 AM
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Kelly Nguyen
Please RT‼️ #TenureTrack position @zmbh.uni-heidelberg.de one of the best #proteostasis research centres in the world. www.nature.com/naturecareer...
Tenure Track Professorship (W1 with Tenure Track to W3) in “Molecular Biology" (f/m/d) - Heidelberg job with Universität Heidelberg | 12850668
The Center for Molecular Biology of Heidelberg University (ZMBH) and the Faculty of Biosciences invite applications for a Tenure Track Professors...
www.nature.com
December 10, 2025 at 2:14 PM
Please RT‼️ #TenureTrack position @zmbh.uni-heidelberg.de one of the best #proteostasis research centres in the world. www.nature.com/naturecareer...
Reposted by Kelly Nguyen
Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have.
mrc.tal.net/vx/mobile-0/...
mrc.tal.net/vx/mobile-0/...
Postdoctoral Scientist - Neurobiology - Dr Michel Goedert - LMB 2752 - Medical Research Council
Location: Cambridge. Vacancy: Postdoctoral Scientist - Neurobiology - Dr Michel Goedert - LMB 2752. Closing Date: 04/01/2026, 23:55
mrc.tal.net
December 10, 2025 at 2:28 PM
Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have.
mrc.tal.net/vx/mobile-0/...
mrc.tal.net/vx/mobile-0/...