Ana Tufegdzic Vidakovic
@anatv.bsky.social
Group Leader at MRC Laboratory of Molecular Biology. Transcription, RNA Polymerase II, Ubiquitin
It was great fun collaborating with Scott Berry's lab, as always! @scottbscience.bsky.social @cftbla.bsky.social
Wonderful to see this work online 🧪 🔬 🧫! How cells respond to changes in RNA Pol II abundance 👇
Wonderful to see this work online 🧪 🔬 🧫! How cells respond to changes in RNA Pol II abundance 👇
What happens when you suddenly remove half of an essential enzyme from cells? 🤔
We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance.
Our lab's new preprint 👇
bit.ly/4pyPgax
We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance.
Our lab's new preprint 👇
bit.ly/4pyPgax
Hierarchical buffering of cellular RNA polymerase II pools maintains transcriptional homeostasis
RNA polymerase II (Pol II) abundance and transcriptional output are coordinated across diverse conditions to maintain mRNA homeostasis. To determine whether Pol II acts as a limiting factor for transc...
bit.ly
January 15, 2026 at 9:37 PM
It was great fun collaborating with Scott Berry's lab, as always! @scottbscience.bsky.social @cftbla.bsky.social
Wonderful to see this work online 🧪 🔬 🧫! How cells respond to changes in RNA Pol II abundance 👇
Wonderful to see this work online 🧪 🔬 🧫! How cells respond to changes in RNA Pol II abundance 👇
Reposted by Ana Tufegdzic Vidakovic
We have an opening for a research support officer. Come and join us! Please share.
Are you an enthusiastic and ambitious scientist looking for a challenging project?
Come and join @kellythd-nguyen.bsky.social’s group as a Research Support Officer and help decipher the molecular mechanisms of telomere maintenance!
Apply by 11 JAN
www.jobs.ac.uk/job/DPU715/r...
Come and join @kellythd-nguyen.bsky.social’s group as a Research Support Officer and help decipher the molecular mechanisms of telomere maintenance!
Apply by 11 JAN
www.jobs.ac.uk/job/DPU715/r...
December 22, 2025 at 12:09 PM
We have an opening for a research support officer. Come and join us! Please share.
Reposted by Ana Tufegdzic Vidakovic
Time for a new pre-print! How do dendritic cells control pore formation in their own endocytic compartments?
Our work shows that the unique transmembrane anchor of perforin-2 does not protect DC membranes, but instead it enables antigen escape during cross-presentation
doi.org/10.64898/202...
Our work shows that the unique transmembrane anchor of perforin-2 does not protect DC membranes, but instead it enables antigen escape during cross-presentation
doi.org/10.64898/202...
December 11, 2025 at 9:21 AM
Time for a new pre-print! How do dendritic cells control pore formation in their own endocytic compartments?
Our work shows that the unique transmembrane anchor of perforin-2 does not protect DC membranes, but instead it enables antigen escape during cross-presentation
doi.org/10.64898/202...
Our work shows that the unique transmembrane anchor of perforin-2 does not protect DC membranes, but instead it enables antigen escape during cross-presentation
doi.org/10.64898/202...
Reposted by Ana Tufegdzic Vidakovic
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
SET1/MLL complexes control transcription independently of H3K4me3
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
www.biorxiv.org
December 11, 2025 at 6:09 AM
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Happy to share a new preprint from our lab, uncovering "spooky action at a distance" - for RNA Polymerase II:
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Stalling of elongating Pol II triggers Ser7 phosphorylation in trans to drive transcription recovery
DNA is scattered with obstacles that stall RNA polymerase II (Pol II) and block the production of full-length transcripts. Two mechanisms are known to resolve stalled Pol II: transcription-coupled nuc...
www.biorxiv.org
December 9, 2025 at 10:13 PM
Happy to share a new preprint from our lab, uncovering "spooky action at a distance" - for RNA Polymerase II:
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
It is a privilege to join the international EMBO community and I look forward to meeting and exchanging ideas with fellow EMBO investigators! I am most grateful to my fantastic lab members who made this possible. 🧪🧫 🧬
Congratulations to the new cohort of 28 EMBO Young Investigators! They are joining an international network of more than 800 life scientists – Welcome!
Read the press release here:
https://www.embo.org/press-releases/twenty-eight-group-leaders-become-embo-young-investigators/
Read the press release here:
https://www.embo.org/press-releases/twenty-eight-group-leaders-become-embo-young-investigators/
December 2, 2025 at 1:25 PM
It is a privilege to join the international EMBO community and I look forward to meeting and exchanging ideas with fellow EMBO investigators! I am most grateful to my fantastic lab members who made this possible. 🧪🧫 🧬
Our dxChIP-seq protocol is now online! If you have a difficult chromatin target, you may want to give it a try (it also works for "easy" targets such as Pol II and histones).
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
November 11, 2025 at 3:30 PM
Our dxChIP-seq protocol is now online! If you have a difficult chromatin target, you may want to give it a try (it also works for "easy" targets such as Pol II and histones).
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
@mrclmb.bsky.social MRC LMB is looking for a new group leader in Chemical/Synthetic Biology. Come and join us in this fantastic institute! Core funding, amazing science all around you and great collaborative colleagues are just some of the highlights. Please share the news!
We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).
Research Group Leader in Chemical/Synthetic Biology at MRC Laboratory of Molecular Biology
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
www.jobs.ac.uk
August 4, 2025 at 8:01 PM
@mrclmb.bsky.social MRC LMB is looking for a new group leader in Chemical/Synthetic Biology. Come and join us in this fantastic institute! Core funding, amazing science all around you and great collaborative colleagues are just some of the highlights. Please share the news!
Looking forward to presenting at the Cambridge RNA club again! If you are interested in gene regulation and around Cambridge, stop by!
Ever wondered how RNA polymerase II gears up to tackle obstacles on DNA?
Turns out, cells have a preparation pathway, and it’s way cooler than we imagined!
Join us and @anatv.bsky.social on June 26th to discover how Pol II gets battle-ready! 💥🧪 #RNAClub
Turns out, cells have a preparation pathway, and it’s way cooler than we imagined!
Join us and @anatv.bsky.social on June 26th to discover how Pol II gets battle-ready! 💥🧪 #RNAClub
June 17, 2025 at 2:26 PM
Looking forward to presenting at the Cambridge RNA club again! If you are interested in gene regulation and around Cambridge, stop by!
Reposted by Ana Tufegdzic Vidakovic
~1 week left to register for the EMBO workshop on RNA meets protein decay! #EMBOrnaDecay
Come join us for a fun time and invigorating scientific discussions in Vienna!
meetings.embo.org/event/25-rna...
Come join us for a fun time and invigorating scientific discussions in Vienna!
meetings.embo.org/event/25-rna...
RNA meets protein decay
Establishing the composition of RNAs and proteins that defines the identities and functions of cells relies not only on the regulated biosynthesis of these molecules, but also equally importantly, on…
meetings.embo.org
March 24, 2025 at 2:15 PM
~1 week left to register for the EMBO workshop on RNA meets protein decay! #EMBOrnaDecay
Come join us for a fun time and invigorating scientific discussions in Vienna!
meetings.embo.org/event/25-rna...
Come join us for a fun time and invigorating scientific discussions in Vienna!
meetings.embo.org/event/25-rna...
The first PhD student of our lab, 5'-Ivan Shlamovitz, has passed his viva with flying colours! What a special moment! The whole lab (and many friends at the LMB) are proud! 👏😁
February 27, 2025 at 4:58 PM
The first PhD student of our lab, 5'-Ivan Shlamovitz, has passed his viva with flying colours! What a special moment! The whole lab (and many friends at the LMB) are proud! 👏😁
The first paper from our lab is online! A wonderful collaboration with @scottbscience.bsky.social lab. We discover that Pol II is extensively regulated by Ubiquitin at the beginning of the transcription cycle!
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription
Cacioppo, Gillis, Shlamovitz, Zeller, et al. show that CRL3ARMC5 ubiquitylates RNA Pol II at early stages of transcription as part of a major homeostatic RNA Pol II turnover mechanism. CRL3ARMC5 and the Integrator phosphatase act as complementary pathways, monitoring the quantity and quality of RNA Pol II complexes before they are licensed into elongation.
www.cell.com
December 11, 2024 at 5:19 PM
The first paper from our lab is online! A wonderful collaboration with @scottbscience.bsky.social lab. We discover that Pol II is extensively regulated by Ubiquitin at the beginning of the transcription cycle!
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...