Rob Klose
@robklose.bsky.social
Professor of Genetics
Department of Biochemistry
University of Oxford
kloselab.co.uk
Department of Biochemistry
University of Oxford
kloselab.co.uk
Reposted by Rob Klose
Join @stirlingchurchman.bsky.social,
@moffittlab.bsky.social, @saramostafavi.bsky.social, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.asp...
@moffittlab.bsky.social, @saramostafavi.bsky.social, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.asp...
December 29, 2025 at 9:01 AM
Join @stirlingchurchman.bsky.social,
@moffittlab.bsky.social, @saramostafavi.bsky.social, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.asp...
@moffittlab.bsky.social, @saramostafavi.bsky.social, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.asp...
Reposted by Rob Klose
So proud of my former PhD student @tadasu443.bsky.social for starting his own lab at @umassamherst.bsky.social ! Wishing him all the best in this exciting new chapter. Looking forward to his future discoveries! 🎉🧬
I launched my lab at UMass Amherst this fall. We study the mechanisms of meiotic homolog pairing using advanced live‑cell and super‑resolution imaging. Currently in budding yeast, with plans to expand to other eukaryotes. #Chromosome #Meiosis #Mitosis
www.umass.edu/biology/abou...
www.umass.edu/biology/abou...
December 28, 2025 at 10:20 AM
So proud of my former PhD student @tadasu443.bsky.social for starting his own lab at @umassamherst.bsky.social ! Wishing him all the best in this exciting new chapter. Looking forward to his future discoveries! 🎉🧬
Reposted by Rob Klose
I ate two million pretzels in my life and this is a first
December 27, 2025 at 4:08 PM
I ate two million pretzels in my life and this is a first
Reposted by Rob Klose
Excited to share new manuscript on histone acylations, exploring how H4K16 acylations regulate inter and intranucleosomal interactions and how they confer resilience to metabolic challenges in vivo. Thanks to all authors +1 author @sandrani.bsky.social Enjoy 👇👇
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations
Histone modifications play crucial roles in genome function. However, how chromatin integrates physiological and metabolic responses at the molecular …
www.sciencedirect.com
December 19, 2025 at 5:17 PM
Excited to share new manuscript on histone acylations, exploring how H4K16 acylations regulate inter and intranucleosomal interactions and how they confer resilience to metabolic challenges in vivo. Thanks to all authors +1 author @sandrani.bsky.social Enjoy 👇👇
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Rob Klose
Nice paper from @robertife.bsky.social on how metabolism-induced H4K16 acylations correlate with (and may cause) chromatin opening through disruption of tail-acidic patch internucleosomal interactions.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations
Nitsch et al. show that short-chain acylations of histone H4K16, acetylation (C2),
propionylation (C3), and butyrylation (C4) modulate chromatin structure in vitro.
These effects can translate in vivo...
www.cell.com
December 27, 2025 at 6:13 AM
Nice paper from @robertife.bsky.social on how metabolism-induced H4K16 acylations correlate with (and may cause) chromatin opening through disruption of tail-acidic patch internucleosomal interactions.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Rob Klose
Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)
Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo
Enhancers control tissue-specific gene expression across metazoans. Although deep learning has enabled enhancer prediction and design in mammalian cell lines and invertebrate systems, it remains uncle...
www.biorxiv.org
December 24, 2025 at 3:06 PM
Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)
Reposted by Rob Klose
Congratulations Rob and team. Elegant! As usual! 👌🔝
December 23, 2025 at 8:20 PM
Congratulations Rob and team. Elegant! As usual! 👌🔝
Reposted by Rob Klose
Agreed. We need to change the system
December 23, 2025 at 11:24 AM
Agreed. We need to change the system
Seems like such a waste of funds. Preprint and post publication peer review would cut out the middle man.
Next generation open access??
www.jisc.ac.uk/news/all/lan...
www.jisc.ac.uk/news/all/lan...
Landmark publishing agreements for UK universities - Jisc
www.jisc.ac.uk
December 23, 2025 at 9:37 AM
Seems like such a waste of funds. Preprint and post publication peer review would cut out the middle man.
Reposted by Rob Klose
And here the EPFL news actu.epfl.ch/news/how-cel...
December 23, 2025 at 7:44 AM
And here the EPFL news actu.epfl.ch/news/how-cel...
Reposted by Rob Klose
What happens between
Manuscript submission date
&
Manuscript acceptance date
Manuscript submission date
&
Manuscript acceptance date
December 23, 2025 at 6:46 AM
What happens between
Manuscript submission date
&
Manuscript acceptance date
Manuscript submission date
&
Manuscript acceptance date
Reposted by Rob Klose
🚨Our story is published! Same bones but + dissection of MERVL’s role integrating signals from #ZGA factors, & + about pathological DUX4 activation of NOXA #TEsky. Thanks to all revs for their helpful comments improving the ms. Even #rev3 - until they ghosted us 😜
www.science.org/doi/epdf/10....
www.science.org/doi/epdf/10....
December 22, 2025 at 12:32 PM
🚨Our story is published! Same bones but + dissection of MERVL’s role integrating signals from #ZGA factors, & + about pathological DUX4 activation of NOXA #TEsky. Thanks to all revs for their helpful comments improving the ms. Even #rev3 - until they ghosted us 😜
www.science.org/doi/epdf/10....
www.science.org/doi/epdf/10....
Reposted by Rob Klose
Intrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway.
And found a hidden RNA-decay axis from Piwi to the RNA exosome.
And found a hidden RNA-decay axis from Piwi to the RNA exosome.
RNA decay via the nuclear exosome is essential for piwi-mediated transposon silencing https://www.biorxiv.org/content/10.64898/2025.12.16.694471v1
December 22, 2025 at 6:14 PM
Intrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway.
And found a hidden RNA-decay axis from Piwi to the RNA exosome.
And found a hidden RNA-decay axis from Piwi to the RNA exosome.
Reposted by Rob Klose
We have an opening for a research support officer. Come and join us! Please share.
Are you an enthusiastic and ambitious scientist looking for a challenging project?
Come and join @kellythd-nguyen.bsky.social’s group as a Research Support Officer and help decipher the molecular mechanisms of telomere maintenance!
Apply by 11 JAN
www.jobs.ac.uk/job/DPU715/r...
Come and join @kellythd-nguyen.bsky.social’s group as a Research Support Officer and help decipher the molecular mechanisms of telomere maintenance!
Apply by 11 JAN
www.jobs.ac.uk/job/DPU715/r...
December 22, 2025 at 12:09 PM
We have an opening for a research support officer. Come and join us! Please share.
Reposted by Rob Klose
The discovery of the first kinetochore proteins (CENP-A, CENP-B, CENP-C) was reported by Bill Earnshaw and Naomi Rothfield in 1985 in Chromosoma. Forty years later, Chromosoma/Chromosome Research has published a special issue (most articles are open access)
link.springer.com/collections/...
link.springer.com/collections/...
40 years of CENP-A
In 1985, Earnshaw and Rothfield published in Chromosoma a landmark discovery of the centromere-specific protein CENP-A. Subsequent research has shown that ...
link.springer.com
December 22, 2025 at 10:09 AM
The discovery of the first kinetochore proteins (CENP-A, CENP-B, CENP-C) was reported by Bill Earnshaw and Naomi Rothfield in 1985 in Chromosoma. Forty years later, Chromosoma/Chromosome Research has published a special issue (most articles are open access)
link.springer.com/collections/...
link.springer.com/collections/...
Reposted by Rob Klose
Excited to share the final version of our study on Nematostella cell type regulatory programs. Part of our @erc.europa.eu StG project, this was a challenging 5-year effort extraodinarily led by @aelek.bsky.social and @martaig.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Decoding cnidarian cell type gene regulation - Nature Ecology & Evolution
This study reconstructs the gene regulatory networks that define cell types in the sea anemone Nematostella vectensis, providing a valuable resource for comparative regulatory genomics and the evoluti...
www.nature.com
December 22, 2025 at 10:12 AM
Excited to share the final version of our study on Nematostella cell type regulatory programs. Part of our @erc.europa.eu StG project, this was a challenging 5-year effort extraodinarily led by @aelek.bsky.social and @martaig.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Rob Klose
Happy holidays from the @flurylab.bsky.social!🎉 A year with a lot of firsts: first PhD students, first Postdoc, first grant & first farewells - and a first lab move, too! Thanks to my amazing team for the hard work & curiosity!💪🧐👥 Can't wait to tackle more firsts (& seconds) in the coming year(s)!🙌🤩
December 21, 2025 at 10:27 PM
Happy holidays from the @flurylab.bsky.social!🎉 A year with a lot of firsts: first PhD students, first Postdoc, first grant & first farewells - and a first lab move, too! Thanks to my amazing team for the hard work & curiosity!💪🧐👥 Can't wait to tackle more firsts (& seconds) in the coming year(s)!🙌🤩
Reposted by Rob Klose
A thread on our latest paper from the Whitehouse lab
Hi all!
We developed CAD-C to map chromatin organization at high res in yeast. It revealed an unexpected tight alignment: nucleosomes covering the same sequence tend to be associated across sister chromatids.
www.biorxiv.org/content/10.6...
#3DGenome #chromatin #Cohesin #centromere
We developed CAD-C to map chromatin organization at high res in yeast. It revealed an unexpected tight alignment: nucleosomes covering the same sequence tend to be associated across sister chromatids.
www.biorxiv.org/content/10.6...
#3DGenome #chromatin #Cohesin #centromere
CAD-C reveals centromere pairing and near-perfect alignment of sister chromatids
Three-dimensional (3D) genome organization plays a central role in gene regulation, chromatin folding, and genome stability. Although chromosome-conformation capture (3C)-derived methods have revoluti...
www.biorxiv.org
December 20, 2025 at 5:11 PM
A thread on our latest paper from the Whitehouse lab
Reposted by Rob Klose
ending (almost) the academic year by accepting a ms for publication in @dev-journal.bsky.social (I'm an editor). A nice stocking stuffer for these folks...
December 20, 2025 at 2:31 AM
ending (almost) the academic year by accepting a ms for publication in @dev-journal.bsky.social (I'm an editor). A nice stocking stuffer for these folks...
Reposted by Rob Klose
This is now a published peer-reviewed paper, in which we show, for the first time (to my knowledge) an interaction and co-operation between SALL4 and BAF (SWI/SNF). Together, they induce neural crest fate early on, by priming thousands of enhancers in the neuroectoderm.
doi.org/10.1242/dev....
doi.org/10.1242/dev....
December 19, 2025 at 12:48 PM
This is now a published peer-reviewed paper, in which we show, for the first time (to my knowledge) an interaction and co-operation between SALL4 and BAF (SWI/SNF). Together, they induce neural crest fate early on, by priming thousands of enhancers in the neuroectoderm.
doi.org/10.1242/dev....
doi.org/10.1242/dev....
Reposted by Rob Klose
I'm excited to participate in the upcoming Wellcome conference on synthetic biology 🛠️🧬 with a great lineup of speakers! It's still possible to sign up, as the abstract deadline has been extended until January 5th 📄 - join us!
Meet our speakers for #SynBio26 🌟
Field experts will provide fascinating insights on how synthetic based-biology innovations are transforming human health and planetary sustainability.
Submit an abstract by 1 December 2025 - bursaries available
📎 bit.ly/43nlbBW
#ALife ⚙️🧫
Field experts will provide fascinating insights on how synthetic based-biology innovations are transforming human health and planetary sustainability.
Submit an abstract by 1 December 2025 - bursaries available
📎 bit.ly/43nlbBW
#ALife ⚙️🧫
December 19, 2025 at 1:28 PM
I'm excited to participate in the upcoming Wellcome conference on synthetic biology 🛠️🧬 with a great lineup of speakers! It's still possible to sign up, as the abstract deadline has been extended until January 5th 📄 - join us!
Reposted by Rob Klose
🎄🌟 Season’s greetings from the entire team of the Max Planck Institute of Immunobiology and Epigenetics in Freiburg … with a few impressions from our Winter Cookie Fair on December 11. ❄️
We wish you Happy Holidays and best wishes for 2026!
We wish you Happy Holidays and best wishes for 2026!
December 19, 2025 at 10:02 AM
🎄🌟 Season’s greetings from the entire team of the Max Planck Institute of Immunobiology and Epigenetics in Freiburg … with a few impressions from our Winter Cookie Fair on December 11. ❄️
We wish you Happy Holidays and best wishes for 2026!
We wish you Happy Holidays and best wishes for 2026!
Reposted by Rob Klose
💡 New paper out in @natcellbio.nature.com 💥💥💥🚀🚀🚀 We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation well beyond early development, in differentiated, non-dividing cells and in vivo post implantation embryos 👇👇👇👇
Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
Escape from X inactivation is directly modulated by Xist noncoding RNA
Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...
rdcu.be
December 15, 2025 at 6:52 PM
💡 New paper out in @natcellbio.nature.com 💥💥💥🚀🚀🚀 We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation well beyond early development, in differentiated, non-dividing cells and in vivo post implantation embryos 👇👇👇👇
Reposted by Rob Klose
Applications for our international #PhD program open until 11th Jan. Come work with us @uoe-igc.bsky.social and @hannahlong.bsky.social to understand DNMT3B in ICF syndrome or with our wonderful colleagues.
Details here:
institute-genetics-cancer.ed.ac.uk/igc-graduate...
#epigenetics Please repost 🙏
Details here:
institute-genetics-cancer.ed.ac.uk/igc-graduate...
#epigenetics Please repost 🙏
December 19, 2025 at 10:31 AM
Applications for our international #PhD program open until 11th Jan. Come work with us @uoe-igc.bsky.social and @hannahlong.bsky.social to understand DNMT3B in ICF syndrome or with our wonderful colleagues.
Details here:
institute-genetics-cancer.ed.ac.uk/igc-graduate...
#epigenetics Please repost 🙏
Details here:
institute-genetics-cancer.ed.ac.uk/igc-graduate...
#epigenetics Please repost 🙏
Reposted by Rob Klose
I think this is likely, at least in steady state. They may be more important in cell lineage or cell state changes, but overall they seem to do very little for gene expression. E/P interactions seem to form before, and independently from, TADs, after mitosis
December 19, 2025 at 1:48 AM
I think this is likely, at least in steady state. They may be more important in cell lineage or cell state changes, but overall they seem to do very little for gene expression. E/P interactions seem to form before, and independently from, TADs, after mitosis