Rob Klose
@robklose.bsky.social
Professor of Genetics
Department of Biochemistry
University of Oxford
kloselab.co.uk
Department of Biochemistry
University of Oxford
kloselab.co.uk
Reposted by Rob Klose
Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now?
www.nature.com/articles/s41...
More functional data, many thousands of words removed, and a few other updates from last year's preprint.
www.nature.com/articles/s41...
More functional data, many thousands of words removed, and a few other updates from last year's preprint.
February 12, 2026 at 11:22 AM
Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now?
www.nature.com/articles/s41...
More functional data, many thousands of words removed, and a few other updates from last year's preprint.
www.nature.com/articles/s41...
More functional data, many thousands of words removed, and a few other updates from last year's preprint.
Reposted by Rob Klose
Please join Andreas Ladurner and me for the GRC Chromatin Structure and Function conference to be held near Barcelona Spain from May 31-June 5! We accepting abstracts for posters and talks. The meeting is preceded by an awesome GRS. Learn more in our video below and apply www.grc.org/chromatin-st...
February 12, 2026 at 2:03 PM
Please join Andreas Ladurner and me for the GRC Chromatin Structure and Function conference to be held near Barcelona Spain from May 31-June 5! We accepting abstracts for posters and talks. The meeting is preceded by an awesome GRS. Learn more in our video below and apply www.grc.org/chromatin-st...
Reposted by Rob Klose
New Preprint www.biorxiv.org/content/10.6... from our lab - work by (now) Dr. Feyza Polat Haas with fabulous contributions from many. We show that mammals have a 💪 POWER-Spliceoeome in the 🧠 optimized for metabolic functions. This happens because SNRPB (SmB) is replaced by its paralogue SNRPN (SmN).
www.biorxiv.org
February 12, 2026 at 5:36 AM
New Preprint www.biorxiv.org/content/10.6... from our lab - work by (now) Dr. Feyza Polat Haas with fabulous contributions from many. We show that mammals have a 💪 POWER-Spliceoeome in the 🧠 optimized for metabolic functions. This happens because SNRPB (SmB) is replaced by its paralogue SNRPN (SmN).
Reposted by Rob Klose
Come join us for a great week of science in Dublin this summer! @brianstrahl.bsky.social @vanrechemlab.bsky.social @bonalditiziana.bsky.social @garcialabms.bsky.social @metorrespadilla.bsky.social
January 9, 2026 at 2:48 PM
Come join us for a great week of science in Dublin this summer! @brianstrahl.bsky.social @vanrechemlab.bsky.social @bonalditiziana.bsky.social @garcialabms.bsky.social @metorrespadilla.bsky.social
Reposted by Rob Klose
Particularly excited to announce "In Formation"
👉Vernissage 17h00 Munich *5th of July* @Muffatwerk
1st exhibition of Art&Science work from 4 artists, including annadumitriu.co.uk + @replifate.bsky.social Helen Pynor,Solveig Lill & Pei-Ying Lin
replifate.eu/event/in-for...
😇STAY TUNED 4more info
👉Vernissage 17h00 Munich *5th of July* @Muffatwerk
1st exhibition of Art&Science work from 4 artists, including annadumitriu.co.uk + @replifate.bsky.social Helen Pynor,Solveig Lill & Pei-Ying Lin
replifate.eu/event/in-for...
😇STAY TUNED 4more info
Events for February 2026
We are thrilled to announce In Formation, the first exhibition featuring work from four artist-in-residence projects that bring art into the heart of scientific stem cell and epigenetics research. ...
replifate.eu
February 11, 2026 at 10:10 AM
Particularly excited to announce "In Formation"
👉Vernissage 17h00 Munich *5th of July* @Muffatwerk
1st exhibition of Art&Science work from 4 artists, including annadumitriu.co.uk + @replifate.bsky.social Helen Pynor,Solveig Lill & Pei-Ying Lin
replifate.eu/event/in-for...
😇STAY TUNED 4more info
👉Vernissage 17h00 Munich *5th of July* @Muffatwerk
1st exhibition of Art&Science work from 4 artists, including annadumitriu.co.uk + @replifate.bsky.social Helen Pynor,Solveig Lill & Pei-Ying Lin
replifate.eu/event/in-for...
😇STAY TUNED 4more info
Reposted by Rob Klose
I’ll be there 😃! Can’t wait, should be an outstanding conference!
Come join us for a great week of science in Dublin this summer! @brianstrahl.bsky.social @vanrechemlab.bsky.social @bonalditiziana.bsky.social @garcialabms.bsky.social @metorrespadilla.bsky.social
February 11, 2026 at 7:35 PM
I’ll be there 😃! Can’t wait, should be an outstanding conference!
Reposted by Rob Klose
We are in EMBO J. See DNA and non-octameric nucleosome-like particles in situ
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Direct visualization and tracing of chromatin folding in the Drosophila embryo - The EMBO Journal
Chromatin organization, through the assembly of DNA with histones and the folding of nucleosome chains, regulates DNA accessibility for transcription, DNA replication and repair. Although models deriv...
link.springer.com
February 10, 2026 at 3:44 PM
We are in EMBO J. See DNA and non-octameric nucleosome-like particles in situ
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Rob Klose
Fascinating cryo-ET study! 🔬🧬
We can now trace strings of nucleosomes directly in cells.
Congratulations to the @eltsovmikhail.bsky.social team! 🎉
We can now trace strings of nucleosomes directly in cells.
Congratulations to the @eltsovmikhail.bsky.social team! 🎉
We are in EMBO J. See DNA and non-octameric nucleosome-like particles in situ
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Direct visualization and tracing of chromatin folding in the Drosophila embryo - The EMBO Journal
Chromatin organization, through the assembly of DNA with histones and the folding of nucleosome chains, regulates DNA accessibility for transcription, DNA replication and repair. Although models deriv...
link.springer.com
February 11, 2026 at 8:55 AM
Fascinating cryo-ET study! 🔬🧬
We can now trace strings of nucleosomes directly in cells.
Congratulations to the @eltsovmikhail.bsky.social team! 🎉
We can now trace strings of nucleosomes directly in cells.
Congratulations to the @eltsovmikhail.bsky.social team! 🎉
Reposted by Rob Klose
Let’s celebrate women and girls in scientific research! Often underestimated, women drive research in biomedical sciences both intellectually and at the bench. Research should be a “gender-blind” endeavor, but rarely is. Stop bigotry ! Stop unconscious bias ! Go women & girls!
February 11, 2026 at 8:58 AM
Let’s celebrate women and girls in scientific research! Often underestimated, women drive research in biomedical sciences both intellectually and at the bench. Research should be a “gender-blind” endeavor, but rarely is. Stop bigotry ! Stop unconscious bias ! Go women & girls!
Reposted by Rob Klose
Happy International Day of Women and Girls in Science! 🧪 Don't forget to send in your nominations for the FEBS | EMBO #WomenInScience Award.
Deadline: 15 May
Read more:
https://www.embo.org/the-embo-communities/febsembo-women-in-science-awardees/nominate-for-the-women-in-science-award/
#award
Deadline: 15 May
Read more:
https://www.embo.org/the-embo-communities/febsembo-women-in-science-awardees/nominate-for-the-women-in-science-award/
#award
February 11, 2026 at 8:35 AM
Happy International Day of Women and Girls in Science! 🧪 Don't forget to send in your nominations for the FEBS | EMBO #WomenInScience Award.
Deadline: 15 May
Read more:
https://www.embo.org/the-embo-communities/febsembo-women-in-science-awardees/nominate-for-the-women-in-science-award/
#award
Deadline: 15 May
Read more:
https://www.embo.org/the-embo-communities/febsembo-women-in-science-awardees/nominate-for-the-women-in-science-award/
#award
Wow, congratulations Kelly! Well deserved!
February 11, 2026 at 6:07 AM
Wow, congratulations Kelly! Well deserved!
Reposted by Rob Klose
Honored to be a finalist for the 2026 Blavanik Awards in the UK in Life Sciences. I’m grateful to past and present lab members, collaborators, colleagues and mentors, who made it possible. It’s even better to share this from
Vietnam while celebrating the Tet holidays with family.
Vietnam while celebrating the Tet holidays with family.
@kellythd-nguyen.bsky.social, Group Leader in the Structural Studies Division, has been announced as a Finalist in the 2026 Blavatnik Awards for her work on telomerase.
Congratulations to Kelly and to all the other Finalists!
Read more here: blavatnikawards.org/news/items/y...
#LMBintheNews
Congratulations to Kelly and to all the other Finalists!
Read more here: blavatnikawards.org/news/items/y...
#LMBintheNews
February 10, 2026 at 10:19 AM
Honored to be a finalist for the 2026 Blavanik Awards in the UK in Life Sciences. I’m grateful to past and present lab members, collaborators, colleagues and mentors, who made it possible. It’s even better to share this from
Vietnam while celebrating the Tet holidays with family.
Vietnam while celebrating the Tet holidays with family.
Reposted by Rob Klose
View of the @britishlibrary.bsky.social from my hotel. A long day again, but a good day
February 10, 2026 at 10:13 PM
View of the @britishlibrary.bsky.social from my hotel. A long day again, but a good day
Reposted by Rob Klose
My student Aoi Otsuka ’s PhD work is now officially published @csf-jscb.bsky.social! 🔬 Single-nucleosome imaging uncovers biphasic local chromatin dynamics in an oncogene-inducible human carcinogenesis model (1–3 d: same, 5–7 d: ↑, back by week 4). Congrats! www.jstage.jst.go.jp/article/csf/...
February 10, 2026 at 1:19 PM
My student Aoi Otsuka ’s PhD work is now officially published @csf-jscb.bsky.social! 🔬 Single-nucleosome imaging uncovers biphasic local chromatin dynamics in an oncogene-inducible human carcinogenesis model (1–3 d: same, 5–7 d: ↑, back by week 4). Congrats! www.jstage.jst.go.jp/article/csf/...
Reposted by Rob Klose
We go live!!!
Join us Munich July5-7th to hear exciting research on #Replication by leaders in the field
AND !! registration is FREE 🥳 (but mandatory) - we hope to see many in Munich 🍺 @helmholtzmunich.bsky.social
@replifate.bsky.social @epicrossborders.bsky.social
replifate.eu/event/meetin...
Join us Munich July5-7th to hear exciting research on #Replication by leaders in the field
AND !! registration is FREE 🥳 (but mandatory) - we hope to see many in Munich 🍺 @helmholtzmunich.bsky.social
@replifate.bsky.social @epicrossborders.bsky.social
replifate.eu/event/meetin...
Events for February 2026
06-07 July 2026 | Munich, GermanyDNA Replication and Its Impact on Genome and Chromatin MaintenanceWe are RepliFate, a European Training Doctoral Network dedicated to understanding how DNA replication...
replifate.eu
February 9, 2026 at 1:29 PM
We go live!!!
Join us Munich July5-7th to hear exciting research on #Replication by leaders in the field
AND !! registration is FREE 🥳 (but mandatory) - we hope to see many in Munich 🍺 @helmholtzmunich.bsky.social
@replifate.bsky.social @epicrossborders.bsky.social
replifate.eu/event/meetin...
Join us Munich July5-7th to hear exciting research on #Replication by leaders in the field
AND !! registration is FREE 🥳 (but mandatory) - we hope to see many in Munich 🍺 @helmholtzmunich.bsky.social
@replifate.bsky.social @epicrossborders.bsky.social
replifate.eu/event/meetin...
Looks great Lucas and team!
February 9, 2026 at 10:04 PM
Looks great Lucas and team!
Reposted by Rob Klose
🧪✨ Introducing BenchAid🧪! Our new molecular biology AI agent is live at benchaid.farnunglab.com. Over the last months, we built BenchAid🧪 to streamline many of our bench workflows to help move our lab faster. Try it out!
February 9, 2026 at 9:27 PM
🧪✨ Introducing BenchAid🧪! Our new molecular biology AI agent is live at benchaid.farnunglab.com. Over the last months, we built BenchAid🧪 to streamline many of our bench workflows to help move our lab faster. Try it out!
Reposted by Rob Klose
For once an article about the "how to get to Rome" and not "Rome" itself. Collaboration with my "partner-in-crime" @felibas.bsky.social has been a key ingredient of my research over the years. Sara Miller at Molecular Cell spoke with us of how we got there and what we think about collaborations.
February 9, 2026 at 8:25 PM
For once an article about the "how to get to Rome" and not "Rome" itself. Collaboration with my "partner-in-crime" @felibas.bsky.social has been a key ingredient of my research over the years. Sara Miller at Molecular Cell spoke with us of how we got there and what we think about collaborations.
Reposted by Rob Klose
🚨Preprint alert🚨 How does chromatin “architecture” form at CTCF sites? Our new preprint with @voslab.org and @andersshansen.bsky.social shows CTCF dimerization promotes nucleosome oligomerization on chromatin. tinyurl.com/CTCF-nucleos...
February 9, 2026 at 3:04 PM
🚨Preprint alert🚨 How does chromatin “architecture” form at CTCF sites? Our new preprint with @voslab.org and @andersshansen.bsky.social shows CTCF dimerization promotes nucleosome oligomerization on chromatin. tinyurl.com/CTCF-nucleos...
Reposted by Rob Klose
🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...
February 9, 2026 at 12:54 PM
🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...
Reposted by Rob Klose
One week left to apply for the postdoc position at MRC-LMB in Cambridge. Join our team for an exciting project on transcription-coupled splicing to understand human gene regulation 🧬 Feel free to get in touch directly
#postdoc #cryoEM #biochemistry
#postdoc #cryoEM #biochemistry
February 5, 2026 at 12:06 PM
One week left to apply for the postdoc position at MRC-LMB in Cambridge. Join our team for an exciting project on transcription-coupled splicing to understand human gene regulation 🧬 Feel free to get in touch directly
#postdoc #cryoEM #biochemistry
#postdoc #cryoEM #biochemistry
Congratulations Lluis and team. Looks very interesting!
February 6, 2026 at 8:19 PM
Congratulations Lluis and team. Looks very interesting!
Reposted by Rob Klose
Very excited to share our new Molecular Cell paper on missense mutations in Polycomb genes and how they can disrupt chromatin regulation to drive neurodevelopmental disorders. A huge thank you to everyone involved, and to our amazing collaborators!
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders
Borges, González-Blanco, Arigela, et al. report new missense mutations in the PRC1
genes RNF2 and RING1 in individuals with neurodevelopmental disorders. Functional
dissection of a deleterious variant...
www.cell.com
February 6, 2026 at 4:09 PM
Very excited to share our new Molecular Cell paper on missense mutations in Polycomb genes and how they can disrupt chromatin regulation to drive neurodevelopmental disorders. A huge thank you to everyone involved, and to our amazing collaborators!
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...