Rob Klose
@robklose.bsky.social
Professor of Genetics
Department of Biochemistry
University of Oxford
kloselab.co.uk
Department of Biochemistry
University of Oxford
kloselab.co.uk
Reposted by Rob Klose
open postdoc call in our friendly neighborgroup with Esben Lorentzen. Higly recommed🌟:
www.au.dk/om/stillinge...
www.au.dk/om/stillinge...
Postdoctoral Position in Structural and mechanistic investigation of the ciliary trafficking machinery bound to cargo, Denmark - Ledig stilling på Aarhus Universitet
Ledig stilling ved Institut for Molekylærbiologi og Genetik - Proteinvidenskab, Aarhus Universitet
www.au.dk
November 24, 2025 at 8:13 AM
open postdoc call in our friendly neighborgroup with Esben Lorentzen. Higly recommed🌟:
www.au.dk/om/stillinge...
www.au.dk/om/stillinge...
Reposted by Rob Klose
The entrance to the 3-storey bike parking garage at Utrecht Central holding 12,500 bicycles. It’s free for the first 24 hours, linked to the station, and used by tens of thousands every day. This is what happens when a country treats bikes as real transport infrastructure, not an afterthought.
November 22, 2025 at 7:08 PM
The entrance to the 3-storey bike parking garage at Utrecht Central holding 12,500 bicycles. It’s free for the first 24 hours, linked to the station, and used by tens of thousands every day. This is what happens when a country treats bikes as real transport infrastructure, not an afterthought.
Reposted by Rob Klose
Last call! Applications for the @crg.eu International PhD Programme 2025 in beautiful Barcelona close next week! Join us and our inspiring colleagues at the CRG - an exceptional environment for discovery, creativity, and scientific growth.
Apply here: www.crg.eu/en/content/t...
Apply here: www.crg.eu/en/content/t...
November 22, 2025 at 1:36 PM
Last call! Applications for the @crg.eu International PhD Programme 2025 in beautiful Barcelona close next week! Join us and our inspiring colleagues at the CRG - an exceptional environment for discovery, creativity, and scientific growth.
Apply here: www.crg.eu/en/content/t...
Apply here: www.crg.eu/en/content/t...
Reposted by Rob Klose
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
November 21, 2025 at 5:37 PM
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
Reposted by Rob Klose
Yesterday’s lab lunch felt really special. We took a moment to celebrate new papers, promotions, fresh faces in the lab—and, most of all, friendship. Grateful for this team. We’re stronger than ever.
November 22, 2025 at 12:20 PM
Yesterday’s lab lunch felt really special. We took a moment to celebrate new papers, promotions, fresh faces in the lab—and, most of all, friendship. Grateful for this team. We’re stronger than ever.
Reposted by Rob Klose
Last few days to apply for this PhD project in our lab. Mix of biochemistry and structural biology, DNA replication and ubiquitin signalling. Get in touch if interested. Full application through official university portal. Deadline on 27th of November!
Fully-funded 4-years competitive PhD project in our lab (MIBTP-doctoral-training-programme. p97 unfoldase functions during DNA replication. Open to UK/international candidates. Please get in touch for informal enquiries. Deadline 27th of November. Please share.
warwick.ac.uk/fac/cross_fa...
warwick.ac.uk/fac/cross_fa...
Professor Aga Gambus
Professor Aga Gambus
warwick.ac.uk
November 22, 2025 at 8:44 AM
Last few days to apply for this PhD project in our lab. Mix of biochemistry and structural biology, DNA replication and ubiquitin signalling. Get in touch if interested. Full application through official university portal. Deadline on 27th of November!
Reposted by Rob Klose
The Brixen Summer School is back and is, as usual, building up a strong speaker list. Thank you @eupaproteomics.bsky.social @thermofishersci.bsky.social @biognosys.bsky.social @ionopticks.bsky.social @evosep.bsky.social for support!
November 21, 2025 at 9:54 AM
The Brixen Summer School is back and is, as usual, building up a strong speaker list. Thank you @eupaproteomics.bsky.social @thermofishersci.bsky.social @biognosys.bsky.social @ionopticks.bsky.social @evosep.bsky.social for support!
Reposted by Rob Klose
Very proud of our new paper! Great job @mweilert.bsky.social, our experimentalists and modeling collaborator Rosa Martinez-Corral. It was fun to see the story grow and get feedback from various experts. Thank you all!
We are pleased to announce a new preprint by @mlweilert.bsky.social: “Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs” (www.biorxiv.org/content/10.1...). See summary and longer recap below:
(TLDR; low-affinity motifs matter as pioneers!)
(TLDR; low-affinity motifs matter as pioneers!)
Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs
Low-affinity transcription factor (TF) motifs are an important element of the cis-regulatory code, yet they are notoriously difficult to map and mechanistically incompletely understood, limiting our a...
www.biorxiv.org
November 19, 2025 at 11:38 PM
Very proud of our new paper! Great job @mweilert.bsky.social, our experimentalists and modeling collaborator Rosa Martinez-Corral. It was fun to see the story grow and get feedback from various experts. Thank you all!
Reposted by Rob Klose
Dead Sperm Whale on Nantucket Is Too Big to Move, for Now
www.nytimes.com
November 20, 2025 at 9:46 PM
Reposted by Rob Klose
1/ I’m very excited to share my postdoc work with @kseskv.bsky.social, in collaboration with @oligriffith.bsky.social. We explore embryonic DNA methylation reprogramming in the fat-tailed dunnart, an Australian marsupial 🦘🌏 www.biorxiv.org/content/10.1...
www.biorxiv.org
November 12, 2025 at 2:57 AM
1/ I’m very excited to share my postdoc work with @kseskv.bsky.social, in collaboration with @oligriffith.bsky.social. We explore embryonic DNA methylation reprogramming in the fat-tailed dunnart, an Australian marsupial 🦘🌏 www.biorxiv.org/content/10.1...
Reposted by Rob Klose
To probe gene-scale chromatin physics, we built 96-mer (20 kb) arrays with defined histone marks. Combining single-molecule tracking, AFM imaging, and developing in vitro Hi-C, we saw how specific modifications dictate chromatin structure and dynamics. www.science.org/doi/10.1126/...
Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture
Reconstituting 20-kb chromatin shows that tuning acetylation alone reshapes its folding, dynamics, and contact domain formation.
www.science.org
November 20, 2025 at 7:46 AM
To probe gene-scale chromatin physics, we built 96-mer (20 kb) arrays with defined histone marks. Combining single-molecule tracking, AFM imaging, and developing in vitro Hi-C, we saw how specific modifications dictate chromatin structure and dynamics. www.science.org/doi/10.1126/...
Reposted by Rob Klose
piRNA-directed DNA methylation may not be a mammalian invention, but can already be found in the germline of axolotl salamanders
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....
November 13, 2025 at 11:54 AM
piRNA-directed DNA methylation may not be a mammalian invention, but can already be found in the germline of axolotl salamanders
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....
Reposted by Rob Klose
This was incredible. Think you know about how we interact with bacteria? Think again. Some really eye-opening stuff here- including how our gut bacteria can influence our personalities.
youtu.be/Q8Yew7XanNo
youtu.be/Q8Yew7XanNo
November 19, 2025 at 8:00 PM
This was incredible. Think you know about how we interact with bacteria? Think again. Some really eye-opening stuff here- including how our gut bacteria can influence our personalities.
youtu.be/Q8Yew7XanNo
youtu.be/Q8Yew7XanNo
Reposted by Rob Klose
Understanding bioRxiv/medRxiv DOIs. How openRxiv assigns them, a changing prefix, and the embedded priority date in citations openrxiv.org/dois-for-pre...
Understanding DOIs for preprints: how openRxiv assigns and manages persistent identifiers - openRxiv
Digital object identifiers (DOIs) are a class of persistent identifier (PID) assigned to an object to ensure that it can always be uniquely identified and, ideally, accessed reliably. Each DOI is a un...
openrxiv.org
November 19, 2025 at 7:40 PM
Understanding bioRxiv/medRxiv DOIs. How openRxiv assigns them, a changing prefix, and the embedded priority date in citations openrxiv.org/dois-for-pre...
Reposted by Rob Klose
Fun week for DNA methylation research! Here is a thread of three cool papers that came out, all with an evolution angle. And a bonus 4th that examines DNAme/PcG interplay (certainly an interest for our lab!) #Epigenetics
November 19, 2025 at 9:48 AM
Fun week for DNA methylation research! Here is a thread of three cool papers that came out, all with an evolution angle. And a bonus 4th that examines DNAme/PcG interplay (certainly an interest for our lab!) #Epigenetics
Reposted by Rob Klose
And such a cool fantastic and interesting set of discoveries.
a cartoon of a chef with a needle in his mouth is playing at 4:32
ALT: a cartoon of a chef with a needle in his mouth is playing at 4:32
media.tenor.com
November 19, 2025 at 5:42 AM
And such a cool fantastic and interesting set of discoveries.
Reposted by Rob Klose
Why LLPS Scaffolds Cannot Exist – A Thermodynamic Thread
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
November 19, 2025 at 5:48 AM
Why LLPS Scaffolds Cannot Exist – A Thermodynamic Thread
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
If you consider arguments logical, please share. Else please expose logical faults
🧵👇
Reposted by Rob Klose
It's always special when you find your own paper in the table of contents of the journal 😍
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
November 18, 2025 at 4:11 PM
It's always special when you find your own paper in the table of contents of the journal 😍
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
Reposted by Rob Klose
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
November 18, 2025 at 10:18 AM
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
Reposted by Rob Klose
Our new preprint is online! Viruses, bacteria and parasites use effector proteins to evade immunity and rewire host cell pathways. Together with @AlexanderStark8, we wondered if we could systematically map what these effectors, regardless of their origin, do in human cells. 1/8
www.biorxiv.org
November 18, 2025 at 3:57 PM
Our new preprint is online! Viruses, bacteria and parasites use effector proteins to evade immunity and rewire host cell pathways. Together with @AlexanderStark8, we wondered if we could systematically map what these effectors, regardless of their origin, do in human cells. 1/8
Reposted by Rob Klose
Calling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our ’26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows
Summer Undergraduate Research Experience | HHMI
The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.
bit.ly
November 18, 2025 at 2:44 PM
Calling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our ’26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows
Reposted by Rob Klose
Want to join the LMB as a PhD student in October 2026?
You’ve got two weeks left to apply!
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/students/int...
Applications close on 2nd December 2025.
You’ve got two weeks left to apply!
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/students/int...
Applications close on 2nd December 2025.
November 18, 2025 at 2:29 PM
Want to join the LMB as a PhD student in October 2026?
You’ve got two weeks left to apply!
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/students/int...
Applications close on 2nd December 2025.
You’ve got two weeks left to apply!
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/students/int...
Applications close on 2nd December 2025.
Reposted by Rob Klose
Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
www.biorxiv.org
November 18, 2025 at 2:51 PM
Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
Reposted by Rob Klose
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics
Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.
www.nature.com
November 18, 2025 at 12:00 PM
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9