Maxim Greenberg
@maxvcg.bsky.social
Group leader at Institut Jacques Monod. When I say "epigenetics" what I really mean is "DNA methylation".
www.maximgreenberglab.com
www.maximgreenberglab.com
Reposted by Maxim Greenberg
Activator-promoter compatibility in mammals - Hcfc1 is a key and intrinsically CGI-promoter-specific co-activator that cannot activate non-CGI promoters. Lead by @nemcko.bsky.social & Kevin Sabath in collab. with @plaschkalab.bsky.social @impvienna.bsky.social www.biorxiv.org/content/10.6... (1/2)
Activator-promoter compatibility in mammals: a CpG-Island-specific co-activator directly bridges transcription factors to TFIID
Transcription from CpG island (CGI) promoters controls the expression of two-thirds of mammalian genes, yet despite their prevalence, it remains unknown whether CGI-specific co-activators with intrins...
www.biorxiv.org
December 30, 2025 at 8:02 AM
Activator-promoter compatibility in mammals - Hcfc1 is a key and intrinsically CGI-promoter-specific co-activator that cannot activate non-CGI promoters. Lead by @nemcko.bsky.social & Kevin Sabath in collab. with @plaschkalab.bsky.social @impvienna.bsky.social www.biorxiv.org/content/10.6... (1/2)
Reposted by Maxim Greenberg
Not that long ago, in vivo mouse enhancer design was a dream. Today, it's a reality! Using transfer deep learning to design de novo synthetic embryonic enhancers active in the heart, limb, and CNS. Great collab with @alex-stark.bsky.social lab! @ucibiosci.bsky.social @impvienna.bsky.social
December 24, 2025 at 3:51 PM
Not that long ago, in vivo mouse enhancer design was a dream. Today, it's a reality! Using transfer deep learning to design de novo synthetic embryonic enhancers active in the heart, limb, and CNS. Great collab with @alex-stark.bsky.social lab! @ucibiosci.bsky.social @impvienna.bsky.social
Love this paper from @evahoermanseder.bsky.social and team; great to see it out. This is definitely "epigenetics" by any definition, but I wonder if it's premarking for activation or protecting against stable silence (i.e, DNAme), similar to Dppa2/4 targets in mammals www.nature.com/articles/s41...
Pre-marking chromatin with H3K4 methylation is required for accurate zygotic genome activation and development - Nature Communications
H3K4 methylation is required for defining active chromatin states in Xenopus embryos, ensuring faithful zygotic genome activation and successful embryonic development.
www.nature.com
December 24, 2025 at 12:02 PM
Love this paper from @evahoermanseder.bsky.social and team; great to see it out. This is definitely "epigenetics" by any definition, but I wonder if it's premarking for activation or protecting against stable silence (i.e, DNAme), similar to Dppa2/4 targets in mammals www.nature.com/articles/s41...
Reposted by Maxim Greenberg
A human embryo implantation model from the @Rugg-Gunn Lab
*key for understanding the early extraembryonic-maternal interactions
Congrats to everyone involved! It’s been great to see this project develop. Huge credit to the @babrahaminst.bsky.social authors 🥂🍾
www.cell.com/cell/fulltex...
*key for understanding the early extraembryonic-maternal interactions
Congrats to everyone involved! It’s been great to see this project develop. Huge credit to the @babrahaminst.bsky.social authors 🥂🍾
www.cell.com/cell/fulltex...
December 24, 2025 at 8:45 AM
A human embryo implantation model from the @Rugg-Gunn Lab
*key for understanding the early extraembryonic-maternal interactions
Congrats to everyone involved! It’s been great to see this project develop. Huge credit to the @babrahaminst.bsky.social authors 🥂🍾
www.cell.com/cell/fulltex...
*key for understanding the early extraembryonic-maternal interactions
Congrats to everyone involved! It’s been great to see this project develop. Huge credit to the @babrahaminst.bsky.social authors 🥂🍾
www.cell.com/cell/fulltex...
Reposted by Maxim Greenberg
Helene was so giving to others about her battle, and went through to make it into maybe the top 1% of survivors of pancreatic cancer, before succumbing Dec 19, 2025 all while losing her father to it. She supported @letswinpc.org and the family asks for you to consider supporting them as well.💔
Pancreatic cancer survivor Helene Andrews-Polymenis and Dr. John Chabot discuss strategies for preparing for a Whipple procedure.
Preparing for a Whipple Procedure: A Roadmap for Patients and Caregivers
Pancreatic cancer survivor Helene Andrews-Polymenis and Dr. John Chabot discuss strategies for preparing for a Whipple procedure.
buff.ly
December 22, 2025 at 8:28 PM
Helene was so giving to others about her battle, and went through to make it into maybe the top 1% of survivors of pancreatic cancer, before succumbing Dec 19, 2025 all while losing her father to it. She supported @letswinpc.org and the family asks for you to consider supporting them as well.💔
Reposted by Maxim Greenberg
Happy to share two BioRxiv manuscripts from our lab. One on genetic Argonaute interaction and unexpected non-correlation between small RNAs and their targets:
doi.org/10.64898/202...
The second on IDR processing and IDR-mediated Argonaute loading control:
doi.org/10.64898/202...
Merry Xmas😊
doi.org/10.64898/202...
The second on IDR processing and IDR-mediated Argonaute loading control:
doi.org/10.64898/202...
Merry Xmas😊
December 22, 2025 at 2:06 PM
Happy to share two BioRxiv manuscripts from our lab. One on genetic Argonaute interaction and unexpected non-correlation between small RNAs and their targets:
doi.org/10.64898/202...
The second on IDR processing and IDR-mediated Argonaute loading control:
doi.org/10.64898/202...
Merry Xmas😊
doi.org/10.64898/202...
The second on IDR processing and IDR-mediated Argonaute loading control:
doi.org/10.64898/202...
Merry Xmas😊
Reposted by Maxim Greenberg
Have you ever wondered what difference it makes to have 1 or 2 X chromosomes in your cells?
✨ I’m excited to share that our paper is now out!
Looking for some X-mas content featuring an actual X? 🎄 Here’s the paper: 👉 www.cell.com/current-biol...
✨ I’m excited to share that our paper is now out!
Looking for some X-mas content featuring an actual X? 🎄 Here’s the paper: 👉 www.cell.com/current-biol...
X chromosome dosage in respiratory stem cells is critical for post-embryonic development and survival
Tournière et al. uncover the biological roles of sex chromosome dosage compensation,
showing it is broadly dispensable except in the respiratory system during metamorphosis,
where X chromosome dose de...
www.cell.com
December 22, 2025 at 4:10 PM
Have you ever wondered what difference it makes to have 1 or 2 X chromosomes in your cells?
✨ I’m excited to share that our paper is now out!
Looking for some X-mas content featuring an actual X? 🎄 Here’s the paper: 👉 www.cell.com/current-biol...
✨ I’m excited to share that our paper is now out!
Looking for some X-mas content featuring an actual X? 🎄 Here’s the paper: 👉 www.cell.com/current-biol...
Reposted by Maxim Greenberg
Our latest publication in #BiologyofReproduction (@ssrepro.bsky.social) is out! We review current evidence of paternal diet on sperm epigenome, embryo dev, and placenta health. Interesting multidisciplinary perspectives from coauthors (only @juliecocquet.bsky.social on 🦋)
tinyurl.com/biolre-ioaf264
tinyurl.com/biolre-ioaf264
Uneven impacts: how male diet modulates the sperm epigenome and impacts embryo development and pregnancy health†
Paternal preconceptional nutrition can influence offspring development and long-term health. Emerging evidence shows that altered paternal diets modify spe
academic.oup.com
December 22, 2025 at 11:43 AM
Our latest publication in #BiologyofReproduction (@ssrepro.bsky.social) is out! We review current evidence of paternal diet on sperm epigenome, embryo dev, and placenta health. Interesting multidisciplinary perspectives from coauthors (only @juliecocquet.bsky.social on 🦋)
tinyurl.com/biolre-ioaf264
tinyurl.com/biolre-ioaf264
Reposted by Maxim Greenberg
I'm excited to participate in the upcoming Wellcome conference on synthetic biology 🛠️🧬 with a great lineup of speakers! It's still possible to sign up, as the abstract deadline has been extended until January 5th 📄 - join us!
Meet our speakers for #SynBio26 🌟
Field experts will provide fascinating insights on how synthetic based-biology innovations are transforming human health and planetary sustainability.
Submit an abstract by 1 December 2025 - bursaries available
📎 bit.ly/43nlbBW
#ALife ⚙️🧫
Field experts will provide fascinating insights on how synthetic based-biology innovations are transforming human health and planetary sustainability.
Submit an abstract by 1 December 2025 - bursaries available
📎 bit.ly/43nlbBW
#ALife ⚙️🧫
December 19, 2025 at 1:28 PM
I'm excited to participate in the upcoming Wellcome conference on synthetic biology 🛠️🧬 with a great lineup of speakers! It's still possible to sign up, as the abstract deadline has been extended until January 5th 📄 - join us!
Reposted by Maxim Greenberg
This is now a published peer-reviewed paper, in which we show, for the first time (to my knowledge) an interaction and co-operation between SALL4 and BAF (SWI/SNF). Together, they induce neural crest fate early on, by priming thousands of enhancers in the neuroectoderm.
doi.org/10.1242/dev....
doi.org/10.1242/dev....
December 19, 2025 at 12:48 PM
This is now a published peer-reviewed paper, in which we show, for the first time (to my knowledge) an interaction and co-operation between SALL4 and BAF (SWI/SNF). Together, they induce neural crest fate early on, by priming thousands of enhancers in the neuroectoderm.
doi.org/10.1242/dev....
doi.org/10.1242/dev....
Reposted by Maxim Greenberg
Do you want to play a key role in running a cutting-edge stem cell and embryology lab at reNEW @ucph.bsky.social ? We’re hiring a Lab Manager to support our team and help with stem cell and animal work. Apply before Feb. 1st : rb.gy/d5uf17
Academic employee for Research Group, Dept. of Biomedical Sciences, reNEW
rb.gy
December 17, 2025 at 12:53 PM
Do you want to play a key role in running a cutting-edge stem cell and embryology lab at reNEW @ucph.bsky.social ? We’re hiring a Lab Manager to support our team and help with stem cell and animal work. Apply before Feb. 1st : rb.gy/d5uf17
Reposted by Maxim Greenberg
I couldn't resist using the very festive-looking cover art from my book as a holiday card (image attribution to follow).
December 18, 2025 at 3:01 PM
I couldn't resist using the very festive-looking cover art from my book as a holiday card (image attribution to follow).
The famous CNRS "concours" competition for tenured research positions is open 👇
Vous avez l’ambition de faire bouger la science ? #RejoignezleCNRS 🫵
Jusqu’au 12 janvier 2026, le #CNRS recrute ses futurs chercheurs et chercheuses !
👉 carrieres.cnrs.fr/concours-ext...
#Recrutement
Jusqu’au 12 janvier 2026, le #CNRS recrute ses futurs chercheurs et chercheuses !
👉 carrieres.cnrs.fr/concours-ext...
#Recrutement
December 18, 2025 at 9:29 AM
The famous CNRS "concours" competition for tenured research positions is open 👇
"Higher intake of high-fat cheese and high-fat cream was associated with a lower risk of all-cause dementia."
Results of a 25-year prospective study of ~27,000 participants.
The purported benefit was not linked to APOE4 carriers or low-fat cheese intake
www.neurology.org/doi/full/10....
Results of a 25-year prospective study of ~27,000 participants.
The purported benefit was not linked to APOE4 carriers or low-fat cheese intake
www.neurology.org/doi/full/10....
December 18, 2025 at 8:50 AM
Reposted by Maxim Greenberg
My lab is hiring a postdoc (ERC funded)! If you're interested, get in touch!
December 18, 2025 at 8:36 AM
My lab is hiring a postdoc (ERC funded)! If you're interested, get in touch!
Reposted by Maxim Greenberg
It was a pleasure to write this News & Views article for the 4D Nucleome flagship article: www.nature.com/articles/d41...
With great editorial support from @hollyasmith.bsky.social!
Read the 4D Nucleome paper here: www.nature.com/articles/s41...
With great editorial support from @hollyasmith.bsky.social!
Read the 4D Nucleome paper here: www.nature.com/articles/s41...
Systematic maps reveal how human chromosomes are organized
Our genomes are highly structured, which facilitates gene regulation. An ambitious project has catalogued the organization of DNA in the nuclei of human cells.
www.nature.com
December 17, 2025 at 10:16 PM
It was a pleasure to write this News & Views article for the 4D Nucleome flagship article: www.nature.com/articles/d41...
With great editorial support from @hollyasmith.bsky.social!
Read the 4D Nucleome paper here: www.nature.com/articles/s41...
With great editorial support from @hollyasmith.bsky.social!
Read the 4D Nucleome paper here: www.nature.com/articles/s41...
Lab goal: get to VV
Wow this is a seriously serious supplementary figure from @cellpress.bsky.social today. Panels A through UU.
I get that Cell likes to minimize the number of supplementary figures. But is this really what is happening here?
www.cell.com/cell/fulltex...
I get that Cell likes to minimize the number of supplementary figures. But is this really what is happening here?
www.cell.com/cell/fulltex...
December 17, 2025 at 1:52 PM
Lab goal: get to VV
Reposted by Maxim Greenberg
Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
Escape from X inactivation is directly modulated by Xist noncoding RNA
Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...
rdcu.be
December 15, 2025 at 4:22 PM
Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
Reposted by Maxim Greenberg
We’re hiring 4 roles at UWA's Plant Synbio Innovation Centre: Facility Manager + 3 Postdocs (single-cell genomics/screening; molecular tools; construct prototyping). Apply by Jan 20 bit.ly/4qfoftG bit.ly/3MFgD59 bit.ly/4pFT6jf bit.ly/48VkgLw
December 16, 2025 at 5:23 AM
We’re hiring 4 roles at UWA's Plant Synbio Innovation Centre: Facility Manager + 3 Postdocs (single-cell genomics/screening; molecular tools; construct prototyping). Apply by Jan 20 bit.ly/4qfoftG bit.ly/3MFgD59 bit.ly/4pFT6jf bit.ly/48VkgLw
Reposted by Maxim Greenberg
Very happy with the final version of this work showing menin-MLL is a vulnerability in liver cancer and an interesting re-localization of NF-Y in response to menin inhibition. Menin-MLL1 complex cooperates with NF-Y to promote hepatocellular carcinoma survival: Cell Reports doi.org/10.1016/j.ce...
Redirecting
doi.org
December 15, 2025 at 2:54 PM
Very happy with the final version of this work showing menin-MLL is a vulnerability in liver cancer and an interesting re-localization of NF-Y in response to menin inhibition. Menin-MLL1 complex cooperates with NF-Y to promote hepatocellular carcinoma survival: Cell Reports doi.org/10.1016/j.ce...
Reposted by Maxim Greenberg
absolutely losing it at my 14yo's biology homework
December 15, 2025 at 2:02 AM
absolutely losing it at my 14yo's biology homework
Reposted by Maxim Greenberg
@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/
Dynamic evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammals
The Polycomb Repressive Complex 2 (PRC2) is an ancient, conserved chromatin-interacting complex that controls gene expression, facilitating differentiation and cellular identity during development. It...
www.biorxiv.org
December 13, 2025 at 10:08 PM
@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/
We watched It's A Wonderful Life last night (1st time my wife and kids had seen it). Of course, everyone loved it. The message of fighting corporate greed for workers to have a nice life felt very resonant. It also reminded me of this amazing lost ending from SNL 😂 www.youtube.com/watch?v=vw89...
It's a Wonderful Life: The Lost Ending - SNL
YouTube video by Saturday Night Live
www.youtube.com
December 13, 2025 at 8:24 AM
We watched It's A Wonderful Life last night (1st time my wife and kids had seen it). Of course, everyone loved it. The message of fighting corporate greed for workers to have a nice life felt very resonant. It also reminded me of this amazing lost ending from SNL 😂 www.youtube.com/watch?v=vw89...
Reposted by Maxim Greenberg
Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample?
Yes, one can. with CUT&ID ✂️🪪
Spearheaded — singlehandedly — by @annanordin.bsky.social
No need of transgenesis, cloning and overexpression.
Check it out, it's fast and its works.
Yes, one can. with CUT&ID ✂️🪪
Spearheaded — singlehandedly — by @annanordin.bsky.social
No need of transgenesis, cloning and overexpression.
Check it out, it's fast and its works.
December 13, 2025 at 7:00 AM
Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample?
Yes, one can. with CUT&ID ✂️🪪
Spearheaded — singlehandedly — by @annanordin.bsky.social
No need of transgenesis, cloning and overexpression.
Check it out, it's fast and its works.
Yes, one can. with CUT&ID ✂️🪪
Spearheaded — singlehandedly — by @annanordin.bsky.social
No need of transgenesis, cloning and overexpression.
Check it out, it's fast and its works.
Go work with Duncan!
Last few days to apply for this #PhD project!
December 12, 2025 at 1:25 PM
Go work with Duncan!