Marnie Blewitt
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marnieblewitt.bsky.social
Marnie Blewitt
@marnieblewitt.bsky.social
Deputy Director at WEHI, Melbourne Australia.
Lab head studying epigenetic control, in the context of X inactivation, genomic imprinting, SMCHD1, Prader Willi Syndrome, FSHD.
Mum, wife, beach lover.
Reposted by Marnie Blewitt
Do you want to play a key role in running a cutting-edge stem cell and embryology lab at reNEW @ucph.bsky.social ? We’re hiring a Lab Manager to support our team and help with stem cell and animal work. Apply before Feb. 1st : rb.gy/d5uf17
Academic employee for Research Group, Dept. of Biomedical Sciences, reNEW
rb.gy
December 17, 2025 at 12:53 PM
Reposted by Marnie Blewitt
UBC and BC Cancer are recruiting a cancer stem cell faculty member at the Associate Professor or Professor rank for the new Connie Eaves Chair in Cancer Stem Cell Research. A great position recognizing a giant in the field. Please share. #Vancouver
ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
Associate Professor (tenure) or Professor (tenure) Dr. Connie Eaves Chair in Cancer Stem Cell Research
Academic Job Category Faculty Bargaining Job Title Associate Professor (tenure) or Professor (tenure) Dr. Connie Eaves Chair in Cancer Stem Cell Research Department School of Biomedical Engineering | ...
ubc.wd10.myworkdayjobs.com
December 18, 2025 at 11:19 PM
Reposted by Marnie Blewitt
Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n
www.science.org/doi/10.1126/...
Cohesin drives chromatin scanning during the RAD51-mediated homology search
Cohesin folds genomes into chromatin loops, the roles of which are under debate. We found that double-strand breaks (DSBs) induce de novo formation of chromatin loops in human cells, with the loop bas...
www.science.org
December 4, 2025 at 9:50 PM
Reposted by Marnie Blewitt
Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
Escape from X inactivation is directly modulated by Xist noncoding RNA
Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...
rdcu.be
December 15, 2025 at 4:22 PM
Reposted by Marnie Blewitt
💡 New paper out in @natcellbio.nature.com 💥💥💥🚀🚀🚀 We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation well beyond early development, in differentiated, non-dividing cells and in vivo post implantation embryos 👇👇👇👇
December 15, 2025 at 6:52 PM
Reposted by Marnie Blewitt
🚨 Want to do a #Phd using high-throughput mutagenesis and CRISPR screens to understand how gene body methylation impacts transcription in collaboration with Greg Kudla's group? Do apply, deadline in a week! www.findaphd.com/phds/project...
Deadline 15th December 2025
#epigenetics Please share 🙏
www.findaphd.com
December 8, 2025 at 9:33 AM
Reposted by Marnie Blewitt
𝐍𝐞𝐰 𝐩𝐫𝐞𝐩𝐫𝐢𝐧𝐭 𝐚𝐥𝐞𝐫𝐭! 🎉
“𝐗𝐈𝐒𝐓 𝐃𝐫𝐢𝐯𝐞𝐬 𝐗-𝐂𝐡𝐫𝐨𝐦𝐨𝐬𝐨𝐦𝐞 𝐈𝐧𝐚𝐜𝐭𝐢𝐯𝐚𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐒𝐚𝐟𝐞𝐠𝐮𝐚𝐫𝐝𝐬 𝐅𝐞𝐦𝐚𝐥𝐞 𝐄𝐱𝐭𝐫𝐚𝐞𝐦𝐛𝐫𝐲𝐨𝐧𝐢𝐜 𝐂𝐞𝐥𝐥𝐬 𝐢𝐧 𝐇𝐮𝐦𝐚𝐧𝐬” 𝐢𝐬 𝐧𝐨𝐰 𝐨𝐧 𝐛𝐢𝐨𝐑𝐱𝐢𝐯!
www.biorxiv.org/content/10.1...
XIST Drives X-Chromosome Inactivation and Safeguards Female Extraembryonic Cells in Humans
Dosage compensation of sex chromosomes through X-chromosome inactivation (XCI) is required for mice extra-embryonic tissue growth and embryo development. The species specificity in mechanisms and timi...
www.biorxiv.org
November 25, 2025 at 4:37 PM
Reposted by Marnie Blewitt
We are excited to share our new preprint:

SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.

www.biorxiv.org/content/10.64898/2025.12.01.691499v1
December 3, 2025 at 6:53 PM
Reposted by Marnie Blewitt
🚨 Multiple #PhD opportunities for lab or computational applicants. Do you want to understand the molecular basis of #epigenetic dysfunction in human disease?
Come work with our group at the fantastic, collaborative @uoe-igc.bsky.social in a beautiful, liveable city.
🧵 1/4
Please repost 🙏
November 25, 2025 at 9:15 AM
Reposted by Marnie Blewitt
Project 2: Use human ES cells to determine exactly how DNMT3B mutations cause ICF1 syndrome. Collaboration with @hannahlong.bsky.social:
institute-genetics-cancer.ed.ac.uk/igc-graduate...
Deadline 11th January 2026
This scheme is flexible if you are interested in other projects.
🧵 3/4
November 25, 2025 at 9:15 AM
Reposted by Marnie Blewitt
📣 SAVE THE DATE
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
November 17, 2025 at 11:39 AM
Reposted by Marnie Blewitt
Keen to use an open source workflow for nanobody discovery? Check out Alpseq 🦙

Alpseq’s diversity analysis, enrichment counts & clustering allow different approaches for nanobody selection

Great collab with bioinformaticians @qgouil.bsky.social Kathleen Zeglinski

www.biorxiv.org/content/10.1...
alpseq: an open-source workflow to turbocharge nanobody discovery with high-throughput sequencing
Nanobodies have emerged as promising tools for many biotechnological applications due to their small size, high stability, and remarkable binding specificity. Next-Generation Sequencing (NGS) enables ...
www.biorxiv.org
October 27, 2025 at 3:18 AM
Reposted by Marnie Blewitt
⏳Three days to go until #AusUb2025! What is Grant Dewson most looking forward to in the upcoming Ubiquitin Summit? 🤔 Perhaps the speakers? Perhaps the free coffee ☕️? Or perhaps the very British prospect of cloudy, sunless days at the beach☁️? Watch the video to find out!
November 17, 2025 at 5:07 AM
Reposted by Marnie Blewitt
⏳Four days to go until #AusUb2025! Check out the video below to hear some conference tips and tricks from our committee chair David Komander (and some potentially controversial interest rankings!?!?).

More interviews to come in the next few days so watch this space 😉
November 16, 2025 at 12:25 PM
Reposted by Marnie Blewitt
Great work from the lab of @jojdavies.bsky.social

Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions

www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
Li et al. apply base-pair resolution Micro Capture-C ultra to map chromatin contacts between individual motifs within cis-regulatory elements and reveal a unified model of biophysically mediated enhan...
www.cell.com
November 17, 2025 at 6:55 AM
Reposted by Marnie Blewitt
The Medical Research Future Fund (MRFF) funds medical research in Australia. Only half the funds have been released. If you're an Australian and able to vote please use the form below to email your local MP to release the full amount of the MRFF
aamri.org.au/mrff/
Half the Funding. Half the Future. - AAMRI
The Medical Research Future Fund (MRFF) was designed to deliver $1 billion each year in new, lifesaving funding for medical research. We know through financial modelling that the full amount can be re...
aamri.org.au
November 16, 2025 at 9:14 PM
Reposted by Marnie Blewitt
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨

#PhD #3DGenome
November 15, 2025 at 9:53 AM
Reposted by Marnie Blewitt
Last chance! Early bird rates and oral presentation abstract submissions for Lorne Genome 𝐞𝐧𝐝 𝐍𝐨𝐯𝐞𝐦𝐛𝐞𝐫 𝟕𝐭𝐡, 𝟐𝟎𝟐𝟓 - only one week away: https://www.lornegenome.org/registrations

We have a fantastic lineup of national and international speakers: https://www.lornegenome.org/speakers. Join us!
Speakers — Lorne Genome
No description found
www.lornegenome.org
October 30, 2025 at 9:30 PM
Reposted by Marnie Blewitt
WEHI stands behind the @aamri.bsky.social campaign to strengthen the sector and secure the future of medical research.

Join the call to release the full MRFF and support our scientists to keep saving lives.

Find out more: www.aamri.org.au/mrff

#releasethefullmrff
October 31, 2025 at 12:02 AM
Reposted by Marnie Blewitt
Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....
October 27, 2025 at 11:49 AM
Reposted by Marnie Blewitt
If you are a computational biologist come, apply and join Howard & Klose lab in a joint Norwich-Oxford collaboration on chromatin dynamics!
VACANCY - We have an opportunity for a Postdoctoral Researcher to join the Howard Group, working to develop computational models of epigenetic dynamics in the Polycomb system.

www.jic.ac.uk/vacancies/po...

Closing date - 9 November 2025
Salary - £37,500 - £45,350
Contract - 36 months, full-time
Postdoctoral Researcher (Howard Group) | John Innes Centre
An exciting opportunity has arisen for a Postdoctoral Researcher to join the Howard Group at the John Innes Centre, working on cutting-edge science in the field of Computational and Systems Biology.
www.jic.ac.uk
October 8, 2025 at 10:44 AM
Reposted by Marnie Blewitt
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
October 8, 2025 at 9:45 PM
Reposted by Marnie Blewitt
📢We're #hiring Group Leaders!

Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning.

🔹5-year renewable appointment
🔹Pioneer new tools & approaches
🔹Collaborate across disciplines

Apply by Nov. 4👉 https://janelia.link/groupleader
August 26, 2025 at 7:00 PM
Reposted by Marnie Blewitt
We’re expanding our Partner Laboratory Network Steering Committee! 🎉

Thrilled to welcome Lisa Butler, Edwina McGlinn, @ijayas.bsky.social, Amee George, @ryanlister.bsky.social & Denise Doolan to our #leadership team - strengthening national & international collab'n in life sciences.

bit.ly/4gFxzDE
EMBL Australia expands Steering Committee to strengthen national collaboration | EMBL Australia
EMBL Australia is pleased to announce the expansion of its Partner Laboratory Network Steering Committee, welcoming new senior representatives from leading research institutions across the country. Th...
bit.ly
September 22, 2025 at 6:06 AM
Reposted by Marnie Blewitt
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene | Science www.science.org/doi/10.1126/...
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
www.science.org
September 23, 2025 at 9:04 AM