Alberto Marin
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albertomarin.bsky.social
Alberto Marin
@albertomarin.bsky.social
66 followers 34 following 40 posts
Postdoctoral fellow. Labs of Taekjip Ha and Ralph Scully, Harvard Medical School.
DNA repair in time and space.
Biophysics of genome integrity.
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Reposted by Alberto Marin
science.org
Extrusive and cohesive cohesin cooperate to repair double-strand breaks in DNA.

Learn more in a new #SciencePerspective: https://scim.ag/3XKbhb6
A tale of two forms of cohesin in DNA repair
Extrusive and cohesive cohesin cooperate to repair double-strand breaks in DNA
scim.ag
December 13, 2025 at 9:15 PM
albertomarin.bsky.social
Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n
www.science.org/doi/10.1126/...
Cohesin drives chromatin scanning during the RAD51-mediated homology search
Cohesin folds genomes into chromatin loops, the roles of which are under debate. We found that double-strand breaks (DSBs) induce de novo formation of chromatin loops in human cells, with the loop bas...
www.science.org
December 4, 2025 at 9:50 PM
albertomarin.bsky.social
1/n
Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv!
www.biorxiv.org/content/10.1...
Cohesin drives chromatin scanning during the RAD51-mediated homology search.
Cohesin folds genomes into chromatin loops, whose roles are under debate. We report that double strand breaks (DSB) induce de novo formation of chromatin loops, with the break positioned at the loop b...
www.biorxiv.org
February 13, 2025 at 1:16 AM