María Mariner
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mariamafau.bsky.social
María Mariner
@mariamafau.bsky.social
250 followers 520 following 26 posts
Postdoctoral researcher at @radaiglesiaslab.bsky.social | Developmental genomics | Prelighter (The Company of Biologists) | Artistic & Creative | Passionate about visual storytelling and design
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mariamafau.bsky.social
María Mariner @mariamafau.bsky.social · Jul 24
Thrilled to share the story stemming from my PhD!
We used mESC neural differentiation, genome editing and bulk & single-cell approaches to uncover how ZIC2 controls early neural fate by playing a dual and sequential regulatory role as a promiscous pioneer and a selective lineage-specific activator.
Reposted by María Mariner
triggerloop.bsky.social
This is a fascinating paper that reveals defined and clear mechanism for a phenomenon that for some seemed unbelievable- the up regulation of genes paralogous to those with specific types of inactivating mutations. This is called transcriptional adaptation 1/ www.science.org/doi/10.1126/...
Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation
Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...
www.science.org
February 16, 2026 at 2:24 AM
Reposted by María Mariner
mads100tist.bsky.social
This graph basically shows that the MSCA are, as of now, useless unless the EU governance does something about it 🧪
A graph titled "MSCA Postdoctoral Fellowships: section EF-LIF". The graph shows the scores between 70 and 100 over the years 2022, 2023, 2024 and 2025. The years 22, 23 and 24 show a relatively flat normal distribution that peaks at around 90ish and drops at both ends, more dramatically at 95+. The year 25, however, is very different: significant drop at the ends with a dramatic increase at ~95 (going from around 25 to 60ish %)
February 11, 2026 at 9:42 AM
Reposted by María Mariner
lenakutscher.bsky.social
Excited to share our preprint on our new multi-omic atlas of human hindbrain development. Led by postdoc Piyush Joshi, in collaboration with @kaessmannlab.bsky.social and Pfister labs, our atlas represents the first comprehensive view of human hindbrain development. www.biorxiv.org/content/10.6...
Brain with puzzle overlay to show that our study provides missing pieces of the puzzle of human brain development by delivering the most comprehensive picture of hindbrain development to date. We have strived to go beyond just another multi-omics atlas to gain deep insights by: 1. Meticulously annotating cell clusters 2. Extracting regulatory programs in terms of coordinated gene sets and accessible regulatory elements 3. Using deep learning to identify regulatory syntax 4. Resolving context-specific TF activity
February 10, 2026 at 7:04 AM
Reposted by María Mariner
surfinnurd.bsky.social
Final version of our paper now published.
elifesciences.org/articles/109...

Take homes:
CHD4/NuRD directly limits transcription factor residence times. At active enhancers this keeps them working efficiently. At inactive enhancers it prevents TFs from getting a foothold and causing activation. 1/n
The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements
CHD4 directly limits transcription factor binding to chromatin, which prevents activation of silent or cryptic enhancers but facilitates activity of active enhancers.
elifesciences.org
February 4, 2026 at 8:17 AM
Reposted by María Mariner
hannahlong.bsky.social
📣 I'm excited to share our latest preprint!

We adapt and characterise a neurosphere-based CNCC differentiation protocol, and demonstrate utility for quantitative phenotyping and craniofacial disease modelling! 🧫

Read about Array-CNCC here:
www.biorxiv.org/content/10.6...

@uoe-igc.bsky.social
January 28, 2026 at 2:37 PM
Reposted by María Mariner
ibv-csic.bsky.social
Bioinformatician Position Open at the Evolutionary and Functional Genomics Lab @ibb-botanic.bsky.social and Nuria Flames' group @ibv-csic.bsky.social
If you are interested, please send a CV and a short motivation letter to nflames@ibv.csic.es with the subject “Bioinfo position 2026” before 27/02/26
January 28, 2026 at 2:00 PM
Reposted by María Mariner
sproullab.bsky.social
Applications for our international #PhD program open until 11th Jan. Come work with us @uoe-igc.bsky.social and @hannahlong.bsky.social to understand DNMT3B in ICF syndrome or with our wonderful colleagues.
Details here:
institute-genetics-cancer.ed.ac.uk/igc-graduate...
#epigenetics Please repost 🙏
December 19, 2025 at 10:31 AM
mariamafau.bsky.social
Mi top 1 de #ESDLB 2025. Qué (casi) 3h de disfrute! Bioética y "Ser Científico" pasando por xenotransplantes, OMGs y (mi parte fav) Labradores simpáticos 🦮 y Síndrome de Williams! @lluismontoliu.bsky.social en youtu.be/uZGrvNpMCGM?...
La Modificación Genética en Personas, Animales y Plantas | Lluis Montoliu #ESDLB Cap.605
YouTube video by El Sentido De La Birra con Ricardo Moya
youtu.be
December 14, 2025 at 1:40 PM
Reposted by María Mariner
lazaroillustration.bsky.social
Probably the ugliest animal I've been requested to illustrate so far... and so beautiful at the same time :) So much fun to draw!
#bats #sciart #art
Line sketches of Centurio senex
December 12, 2025 at 9:44 AM
Reposted by María Mariner
fnucleosome.bsky.social
🧬🎉Join us on Dec 17th for our last session of 2025! 🎉🧬Two fantastic talks on transcriptional regulation:
🔬JB Lalanne on developmental enhancers (and starting a lab in 2025?)
🔬 @rberrens.bsky.social on transposable elements in development
📋Register here: us06web.zoom.us/webinar/regi...
December 11, 2025 at 6:54 PM
Reposted by María Mariner
nature.com
A stem-cell-based monkey embryo model that self-organizes into a comprehensive body plan could lead the way to more-sophisticated models of early human development

go.nature.com/48yxsG6
Primate embryo model leaps across developmental boundaries
A stem-cell-based monkey embryo model that self-organizes into a comprehensive body plan could lead the way to more-sophisticated models of early human development.
go.nature.com
December 4, 2025 at 8:37 AM
Reposted by María Mariner
molgen.mpg.de
Want to analyze the role of endogenous retroviruses in early human development or investigate their regulation in pluripotency and early development for your PhD?

Join the lab of @fueyoraquel.bsky.social via the IMPRS-BAC #gradschool!

👉 www.molgen.mpg.de/5094682/Fuey...
November 27, 2025 at 2:06 PM
Reposted by María Mariner
fnucleosome.bsky.social
🔔Join us next Wednesday for #FragileNucleosome! 2 fantastic talks on chromatin regulation:🔬 @mariamafau.bsky.social on ZIC2's dual role in neural induction 🔬 @jhenninger.bsky.social on how RNA-binding proteins drive transcription
📋Register here for the entire series: us06web.zoom.us/webinar/regi...
November 26, 2025 at 10:16 AM
Reposted by María Mariner
fnucleosome.bsky.social
Do you have an exciting new chromatin/transcription story that you'd like to share with the #FN community?

Fill out this form to be considered for a talk in our Jan-June 2026 schedule! forms.gle/TBi38UgYxPAB...

Please repost and share!
Application to speak in the Fragile Nucleosome series
Thank you for your interest in our seminar series! We use a variety of different session formats but, in general, trainees can plan for a ~15 min talk + 5min Q/A and PIs can plan for a ~25min talk +...
forms.gle
November 24, 2025 at 1:50 PM
Reposted by María Mariner
alex-stark.bsky.social
Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
www.biorxiv.org
November 18, 2025 at 2:51 PM
Reposted by María Mariner
molgen.mpg.de
IMPRS-BAC #gradschool: Our new groupleader @sedonamurphy.bsky.social has an open PhD project in her lab. Topic: Spatial feedback between epigenetic regulation and chromatin regulation. Apply by Jan 7, 2026!
👉 www.molgen.mpg.de/5091778/Murp...
November 18, 2025 at 4:05 PM
Reposted by María Mariner
fnucleosome.bsky.social
🔔This Wednesday , in #FragileNucleosome seminar, we are excited to host @ishtiaqueh.bsky.social of Pastor lab and Prof. Sarah Teichmann, @teichlab.bsky.social, to tell us about their exciting studies!
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
November 18, 2025 at 9:43 AM
mariamafau.bsky.social
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨

#PhD #3DGenome
November 15, 2025 at 9:53 AM
Reposted by María Mariner
radaiglesiaslab.bsky.social
OFERTA DE EMPLEO (por favor difundir):

Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas
👇
November 6, 2025 at 5:24 PM
Reposted by María Mariner
molgen.mpg.de
2nd Meeting on Early Embryogenesis and Epigenetics
16 - 18 Feb 2026 at MPI for Molecular Genetics, Berlin
with support by the Weizmann Institute for Science.
Early bird registration until 30 Sep - register now👇
www.molgen.mpg.de/embryo2026
Save-the-date information: New approaches to Early embryogenesis & epigenetics February 16 - 18 2026 Max Planck Institute for Molecular Genetics, Berlin, Germany
September 26, 2025 at 1:09 PM
Reposted by María Mariner
pedroprocha.bsky.social
🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
Job add showing the lab logo and the following text: WHAT WE OFFER Fully-funded fellowships up to five years Opportunity to start your own research program or lead ongoing projects. Large, diverse and extraordinary scientific network at the NIH/Bethesda campus. Working at NIH offers the possibility of living in a diverse, liberal and vibrant city: Washington DC Or in a calm residential area with great schools and good affordable housing: Bethesda and Rockville. WHO YOU ARE You share our enthusiasm for epigenetics, gene regulation, nuclear organization and mouse development. You have PhD-experience in one or more of the following: mouse development, mouse genetics, epigenetics, or computational biology.
September 8, 2025 at 3:15 PM
Reposted by María Mariner
socdevbio.bsky.social
Axolotl (Ambystoma mexicanum)🦎 can regrow limbs, tail, spinal cord, heart, and even parts of its brain. Axolotls are champions of regeneration and also shed light on limb patterning, wound healing, and developmental plasticity. Image from Prayag Murawala #ModelMonday #DevBio
September 2, 2025 at 12:11 AM
mariamafau.bsky.social
Honoured to be part of this awesome lineup 😍! @fnucleosome.bsky.social thanks for the opportunity! A very exciting Fall Season is about to start, I wouldn't miss it 😌🧬
fnucleosome.bsky.social FragileNucleosome @fnucleosome.bsky.social · Sep 1
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!

register here for the entire series: us06web.zoom.us/webinar/regi...
Fragile Nucleosome Fall Seminars: September 10 Grace Bower, Kvon Lab @ UC Irvine, USA Jennifer Phillips-Cremins, UPenn, USA September 24 Ali Wilkening, Sanulli Lab @ Stanford, USA Juanma Schvartzman, Columbia University, USA October 8 Sanim Rahman, Greenberg Lab @ UPenn, USA Alex Federation, Talus Bio, USA October 22 Alice Laigle, Croll Lab @ University of Neuchâtel, Switzerland Seungsoo Kim, UC Irvine, USA November 5 Hannah Long, University of Edinburgh, UK Jeff Vierstra, Altius Institute, USA November 19 Ishtiaque Hossain, Pastor Lab @ McGill, Canada Sarah Teichmann, University of Cambridge, UK December 3 María Mariner Faulí, Rada Iglesias Lab @ IBBTEC, Spain Jonathan Henninger, Carnegie Mellon, USA December 17 Rebecca Berrens, Oxford University, UK Jean-Benoit Lalanne, University of Montreal, Canada
September 2, 2025 at 8:56 AM
Reposted by María Mariner
kprummel.bsky.social
We are searching for a research technician in our group at EMBL Heidelberg! 🧫🧬🔬

For more details, see the ad. Please reach out in case of any questions.

The position is ideally filled by October 1.

embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Research Technician
We are looking for a highly motivated research technician to join the Zaugg group at EMBL Heidelberg, an interdisciplinary team of experimental and computational scientists. Our research combines larg...
embl.wd103.myworkdayjobs.com
September 1, 2025 at 7:37 AM
Reposted by María Mariner
radaiglesiaslab.bsky.social
#Preprint alert! 📣

We are thrilled to share the work led by Lara Zorro-Shahidian and Lucio di Filippo, in which we show that #MLL2 controls gene expression in both #ESC and upon #differentiation by facilitating the #enhancer like activity of #LINE1 elements

www.biorxiv.org/cgi/content/...
MLL2 facilitates long-range gene regulation through LINE1 elements
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 d...
www.biorxiv.org
August 13, 2025 at 5:54 AM