Hannah Long
@hannahlong.bsky.social
Group Leader @mrc_hgu investigating gene regulation in development & human disease
Pinned
📣 I'm excited to share our latest preprint!
We adapt and characterise a neurosphere-based CNCC differentiation protocol, and demonstrate utility for quantitative phenotyping and craniofacial disease modelling! 🧫
Read about Array-CNCC here:
www.biorxiv.org/content/10.6...
@uoe-igc.bsky.social
We adapt and characterise a neurosphere-based CNCC differentiation protocol, and demonstrate utility for quantitative phenotyping and craniofacial disease modelling! 🧫
Read about Array-CNCC here:
www.biorxiv.org/content/10.6...
@uoe-igc.bsky.social
Reposted by Hannah Long
SS18::SSX activates Polycomb target genes without BAF ❌
Instead, transcription relies on EP300 via the SS18 QPGY domain
www.biorxiv.org/content/10.6...
➡️ Coactivator targeting emerges as a new therapeutic strategy in synovial sarcoma 🎯
Team work from @banitolab.bsky.social and @uoe-igc.bsky.social
Instead, transcription relies on EP300 via the SS18 QPGY domain
www.biorxiv.org/content/10.6...
➡️ Coactivator targeting emerges as a new therapeutic strategy in synovial sarcoma 🎯
Team work from @banitolab.bsky.social and @uoe-igc.bsky.social
www.biorxiv.org
January 28, 2026 at 10:20 AM
SS18::SSX activates Polycomb target genes without BAF ❌
Instead, transcription relies on EP300 via the SS18 QPGY domain
www.biorxiv.org/content/10.6...
➡️ Coactivator targeting emerges as a new therapeutic strategy in synovial sarcoma 🎯
Team work from @banitolab.bsky.social and @uoe-igc.bsky.social
Instead, transcription relies on EP300 via the SS18 QPGY domain
www.biorxiv.org/content/10.6...
➡️ Coactivator targeting emerges as a new therapeutic strategy in synovial sarcoma 🎯
Team work from @banitolab.bsky.social and @uoe-igc.bsky.social
Reposted by Hannah Long
Array-CNCC: precise aggregation and arrayed plating facilitate quantitative phenotyping of human cranial neural crest cells and craniofacial disease modelling https://www.biorxiv.org/content/10.64898/2026.01.18.696654v1
January 19, 2026 at 8:30 AM
Array-CNCC: precise aggregation and arrayed plating facilitate quantitative phenotyping of human cranial neural crest cells and craniofacial disease modelling https://www.biorxiv.org/content/10.64898/2026.01.18.696654v1
📣 I'm excited to share our latest preprint!
We adapt and characterise a neurosphere-based CNCC differentiation protocol, and demonstrate utility for quantitative phenotyping and craniofacial disease modelling! 🧫
Read about Array-CNCC here:
www.biorxiv.org/content/10.6...
@uoe-igc.bsky.social
We adapt and characterise a neurosphere-based CNCC differentiation protocol, and demonstrate utility for quantitative phenotyping and craniofacial disease modelling! 🧫
Read about Array-CNCC here:
www.biorxiv.org/content/10.6...
@uoe-igc.bsky.social
January 28, 2026 at 2:37 PM
📣 I'm excited to share our latest preprint!
We adapt and characterise a neurosphere-based CNCC differentiation protocol, and demonstrate utility for quantitative phenotyping and craniofacial disease modelling! 🧫
Read about Array-CNCC here:
www.biorxiv.org/content/10.6...
@uoe-igc.bsky.social
We adapt and characterise a neurosphere-based CNCC differentiation protocol, and demonstrate utility for quantitative phenotyping and craniofacial disease modelling! 🧫
Read about Array-CNCC here:
www.biorxiv.org/content/10.6...
@uoe-igc.bsky.social
🎉 Many congratulations to Kasia Milto who successfully defended her thesis last week! It was so wonderful to have Kasia as the first PhD student in the lab, and to co-supervise with Jenny Nichols. So proud!
@km-milto.bsky.social
@uoe-igc.bsky.social
@km-milto.bsky.social
@uoe-igc.bsky.social
January 26, 2026 at 3:38 PM
🎉 Many congratulations to Kasia Milto who successfully defended her thesis last week! It was so wonderful to have Kasia as the first PhD student in the lab, and to co-supervise with Jenny Nichols. So proud!
@km-milto.bsky.social
@uoe-igc.bsky.social
@km-milto.bsky.social
@uoe-igc.bsky.social
Reposted by Hannah Long
Super line-up of chromatin, epigenetics and gene regulation speakers coming your way from @aicc-ireland.bsky.social over the next 5 months!
After a short break in our webinars we are delighted to be back up & running this month!
First up, on Jan 30th we will be joined by @lucas.farnunglab.com from @harvardmed.bsky.social 🔬
Shortly after, on Feb 13th we will be hosting @heardlab.bsky.social from @crick.ac.uk 🧬
Registration details 👇
First up, on Jan 30th we will be joined by @lucas.farnunglab.com from @harvardmed.bsky.social 🔬
Shortly after, on Feb 13th we will be hosting @heardlab.bsky.social from @crick.ac.uk 🧬
Registration details 👇
January 15, 2026 at 3:19 PM
Super line-up of chromatin, epigenetics and gene regulation speakers coming your way from @aicc-ireland.bsky.social over the next 5 months!
Reposted by Hannah Long
Latest from our lab: dx.plos.org/10.1371/jour... Congratulations to Veronika for leading this work to model cis-regulatory dynamics in F1s using single-cell allelic data
ASPEN: Robust detection of allelic dynamics in single cell RNA-seq
Author summary One powerful way to study regulation is to examine hybrids between two inbred species, where each gene has two distinct parental copies, or alleles. Measuring how much each allele is ex...
dx.plos.org
December 20, 2025 at 6:36 AM
Latest from our lab: dx.plos.org/10.1371/jour... Congratulations to Veronika for leading this work to model cis-regulatory dynamics in F1s using single-cell allelic data
Reposted by Hannah Long
Applications for our international #PhD program open until 11th Jan. Come work with us @uoe-igc.bsky.social and @hannahlong.bsky.social to understand DNMT3B in ICF syndrome or with our wonderful colleagues.
Details here:
institute-genetics-cancer.ed.ac.uk/igc-graduate...
#epigenetics Please repost 🙏
Details here:
institute-genetics-cancer.ed.ac.uk/igc-graduate...
#epigenetics Please repost 🙏
December 19, 2025 at 10:31 AM
Applications for our international #PhD program open until 11th Jan. Come work with us @uoe-igc.bsky.social and @hannahlong.bsky.social to understand DNMT3B in ICF syndrome or with our wonderful colleagues.
Details here:
institute-genetics-cancer.ed.ac.uk/igc-graduate...
#epigenetics Please repost 🙏
Details here:
institute-genetics-cancer.ed.ac.uk/igc-graduate...
#epigenetics Please repost 🙏
Reposted by Hannah Long
Excited to share our work at @natcomms.nature.com
We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq.
SCP will revolutionise immunology, this is just the start
We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq.
SCP will revolutionise immunology, this is just the start
December 15, 2025 at 8:09 PM
Excited to share our work at @natcomms.nature.com
We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq.
SCP will revolutionise immunology, this is just the start
We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq.
SCP will revolutionise immunology, this is just the start
Reposted by Hannah Long
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
SET1/MLL complexes control transcription independently of H3K4me3
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
www.biorxiv.org
December 11, 2025 at 6:09 AM
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Hannah Long
JASPAR 2026 is out 🎉
The new release massively expands the TF motif collections and adds a dedicated DeepLearning collection of motifs learned from deep learning models.
Database: jaspar.elixir.no
Paper (NAR): doi.org/10.1093/nar/...
🧵1/2
The new release massively expands the TF motif collections and adds a dedicated DeepLearning collection of motifs learned from deep learning models.
Database: jaspar.elixir.no
Paper (NAR): doi.org/10.1093/nar/...
🧵1/2
JASPAR: An open-access database of transcription factor binding profiles
JASPAR is the largest open-access database of curated and non-redundant transcription factor (TF) binding profiles from six different taxonomic groups.
jaspar.elixir.no
December 3, 2025 at 2:43 PM
JASPAR 2026 is out 🎉
The new release massively expands the TF motif collections and adds a dedicated DeepLearning collection of motifs learned from deep learning models.
Database: jaspar.elixir.no
Paper (NAR): doi.org/10.1093/nar/...
🧵1/2
The new release massively expands the TF motif collections and adds a dedicated DeepLearning collection of motifs learned from deep learning models.
Database: jaspar.elixir.no
Paper (NAR): doi.org/10.1093/nar/...
🧵1/2
Reposted by Hannah Long
We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen.
1/n
1/n
Intro to Bedder – The Quinlan Lab
quinlanlab.org
December 2, 2025 at 2:28 AM
Reposted by Hannah Long
Don’t miss out on this opportunity- come and join us at the Oxford Organoid Hub working under the MRC-BHF REACT programme! If you love in vitro 3D models, the ❤️ and regenerative therapies, this is for you - apply by 18 Dec @oxforddpag.bsky.social @idrm.ox.ac.uk @rdm.ox.ac.uk
Some good news, myself and @simoesfilipa.bsky.social are advertising for a post-doctoral researcher to join us at the Oxford Organoid hub: tinyurl.com/OOHJob
Come and join us to develop novel human organoid systems as part of the MRC/BHF CRE in advanced cardiac therapies.
Come and join us to develop novel human organoid systems as part of the MRC/BHF CRE in advanced cardiac therapies.
November 30, 2025 at 11:02 PM
Don’t miss out on this opportunity- come and join us at the Oxford Organoid Hub working under the MRC-BHF REACT programme! If you love in vitro 3D models, the ❤️ and regenerative therapies, this is for you - apply by 18 Dec @oxforddpag.bsky.social @idrm.ox.ac.uk @rdm.ox.ac.uk
Reposted by Hannah Long
Project 2: Use human ES cells to determine exactly how DNMT3B mutations cause ICF1 syndrome. Collaboration with @hannahlong.bsky.social:
institute-genetics-cancer.ed.ac.uk/igc-graduate...
Deadline 11th January 2026
This scheme is flexible if you are interested in other projects.
🧵 3/4
institute-genetics-cancer.ed.ac.uk/igc-graduate...
Deadline 11th January 2026
This scheme is flexible if you are interested in other projects.
🧵 3/4
November 25, 2025 at 9:15 AM
Project 2: Use human ES cells to determine exactly how DNMT3B mutations cause ICF1 syndrome. Collaboration with @hannahlong.bsky.social:
institute-genetics-cancer.ed.ac.uk/igc-graduate...
Deadline 11th January 2026
This scheme is flexible if you are interested in other projects.
🧵 3/4
institute-genetics-cancer.ed.ac.uk/igc-graduate...
Deadline 11th January 2026
This scheme is flexible if you are interested in other projects.
🧵 3/4
Reposted by Hannah Long
🚨 Multiple #PhD opportunities for lab or computational applicants. Do you want to understand the molecular basis of #epigenetic dysfunction in human disease?
Come work with our group at the fantastic, collaborative @uoe-igc.bsky.social in a beautiful, liveable city.
🧵 1/4
Please repost 🙏
Come work with our group at the fantastic, collaborative @uoe-igc.bsky.social in a beautiful, liveable city.
🧵 1/4
Please repost 🙏
November 25, 2025 at 9:15 AM
🚨 Multiple #PhD opportunities for lab or computational applicants. Do you want to understand the molecular basis of #epigenetic dysfunction in human disease?
Come work with our group at the fantastic, collaborative @uoe-igc.bsky.social in a beautiful, liveable city.
🧵 1/4
Please repost 🙏
Come work with our group at the fantastic, collaborative @uoe-igc.bsky.social in a beautiful, liveable city.
🧵 1/4
Please repost 🙏
Reposted by Hannah Long
Very pleased to share our latest paper published in Cell:
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants: Cell www.cell.com/cell/fulltex...
@cellpress.bsky.social, @cp-cell.bsky.social, @ruizhideng.bsky.social #enhancer
here is a thread about our findings:
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants: Cell www.cell.com/cell/fulltex...
@cellpress.bsky.social, @cp-cell.bsky.social, @ruizhideng.bsky.social #enhancer
here is a thread about our findings:
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants
BRAIN-MAGNET, a convolutional neural network trained on 148,198 functionally tested
non-coding regulatory elements, predicts enhancer activity directly from DNA sequence
and identifies nucleotides ess...
www.cell.com
November 20, 2025 at 9:38 AM
Very pleased to share our latest paper published in Cell:
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants: Cell www.cell.com/cell/fulltex...
@cellpress.bsky.social, @cp-cell.bsky.social, @ruizhideng.bsky.social #enhancer
here is a thread about our findings:
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants: Cell www.cell.com/cell/fulltex...
@cellpress.bsky.social, @cp-cell.bsky.social, @ruizhideng.bsky.social #enhancer
here is a thread about our findings:
Reposted by Hannah Long
Researchers have identified gene-regulatory variants that might have contributed to Neanderthals’ beefy jaws — offering a window on how the human face developed
go.nature.com/3Ke6StJ
go.nature.com/3Ke6StJ
Neanderthal DNA reveals how human faces form
Subtle genomic variations between humans and Neanderthals provide clues to how DNA shapes our facial features.
go.nature.com
November 20, 2025 at 5:07 PM
Researchers have identified gene-regulatory variants that might have contributed to Neanderthals’ beefy jaws — offering a window on how the human face developed
go.nature.com/3Ke6StJ
go.nature.com/3Ke6StJ
Congratulations!
It's always special when you find your own paper in the table of contents of the journal 😍
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
November 19, 2025 at 11:56 AM
Congratulations!
Reposted by Hannah Long
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
November 15, 2025 at 9:53 AM
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Reposted by Hannah Long
Join us for our free inaugural lecture & drinks reception. @jorisveltman.bsky.social will talk about the genetic causes of rare disorders such as reproductive disorders & Charlie Lees will tell the 20‑year story of change in IBD.
More info & register👉 bit.ly/3J766hJ
@cmvm-edinburghuni.bsky.social
More info & register👉 bit.ly/3J766hJ
@cmvm-edinburghuni.bsky.social
November 5, 2025 at 10:28 AM
Join us for our free inaugural lecture & drinks reception. @jorisveltman.bsky.social will talk about the genetic causes of rare disorders such as reproductive disorders & Charlie Lees will tell the 20‑year story of change in IBD.
More info & register👉 bit.ly/3J766hJ
@cmvm-edinburghuni.bsky.social
More info & register👉 bit.ly/3J766hJ
@cmvm-edinburghuni.bsky.social
Reposted by Hannah Long
Neanderthal DNA enhances our understanding of face development
This Research Highlight showcases the work from Hannah Long @hannahlong.bsky.social, Kirsty Uttley @kirstyuttley.bsky.social, Hannah Jüllig @hannahjuellig.bsky.social and colleagues: journals.biologists.com/dev/article/...
This Research Highlight showcases the work from Hannah Long @hannahlong.bsky.social, Kirsty Uttley @kirstyuttley.bsky.social, Hannah Jüllig @hannahjuellig.bsky.social and colleagues: journals.biologists.com/dev/article/...
November 10, 2025 at 1:04 PM
Neanderthal DNA enhances our understanding of face development
This Research Highlight showcases the work from Hannah Long @hannahlong.bsky.social, Kirsty Uttley @kirstyuttley.bsky.social, Hannah Jüllig @hannahjuellig.bsky.social and colleagues: journals.biologists.com/dev/article/...
This Research Highlight showcases the work from Hannah Long @hannahlong.bsky.social, Kirsty Uttley @kirstyuttley.bsky.social, Hannah Jüllig @hannahjuellig.bsky.social and colleagues: journals.biologists.com/dev/article/...
Reposted by Hannah Long
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by Hannah Long
To learn more about how this story developed and the researchers behind it, we talked to co-first authors Kirsty Uttley and Hannah Jüllig, as well as corresponding author, Hannah Long
doi.org/10.1242/dev....
doi.org/10.1242/dev....
November 10, 2025 at 1:04 PM
To learn more about how this story developed and the researchers behind it, we talked to co-first authors Kirsty Uttley and Hannah Jüllig, as well as corresponding author, Hannah Long
doi.org/10.1242/dev....
doi.org/10.1242/dev....
Reposted by Hannah Long
Excited to share our new paper out today in Development! Check out Hannah’s fantastic post below for a summary of the findings ✨
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 2:37 PM
Excited to share our new paper out today in Development! Check out Hannah’s fantastic post below for a summary of the findings ✨
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 11:11 AM
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
Reposted by Hannah Long
We recently reported that promoter competition can contribute to the robust insulation of gene regulatory domains (www.nature.com/articles/s41...).
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇
November 6, 2025 at 6:37 PM
We recently reported that promoter competition can contribute to the robust insulation of gene regulatory domains (www.nature.com/articles/s41...).
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇