Nature Reviews Genetics, Published online: 10 November 2025; doi:10.1038/s41576-025-00913-3In this Tools of the Trade article, Shaoqian Ma discusses scFLUENT-seq, a method that enables quantitative, genome-wide analysis of nascent transcription in single cells.

Nature Reviews Genetics, Published online: 03 November 2025; doi:10.1038/s41576-025-00909-zMicrobial genomics can improve our understanding of antimicrobial resistance dynamics across ecosystems. In this Comment, Kathryn Holt emphasizes the interconnectedness of human, animal and environmental health and calls for greater integration of microbial genomic data through robust analytical frameworks to unravel the complexity of antimicrobial resistance dynamics.

Nature Reviews Genetics, Published online: 17 October 2025; doi:10.1038/s41576-025-00899-yMorris discusses how single-cell genomics and computational tools expose failure points in reprogramming and guide protocols that improve the fidelity, maturity and purity of engineered cells, advancing their use in regenerative medicine and disease modelling.

Nature Reviews Genetics, Published online: 16 October 2025; doi:10.1038/s41576-025-00906-2Microorganisms are central to climate stability, food security and biodiversity, yet they remain absent from global sustainability frameworks. In this Comment, Nicole Webster highlights the power of eco-evolutionary genomics in transforming sustainability science and calls for the inclusion of microbes in global policies.

Nature Reviews Genetics, Published online: 06 November 2025; doi:10.1038/s41576-025-00904-4In this Review, Chen et al. discuss how the advancement and integration of large-scale genetic resources, multi-omics data and sophisticated computational tools are improving drug development pipelines.

Nature Reviews Genetics, Published online: 30 October 2025; doi:10.1038/s41576-025-00911-5In this Journal Club, Luis Orellana recalls a 2005 publication by Konstantinidis and Tiedje that introduced average nucleotide identity as a sequence-based metric to determine the relatedness between two genomes, which helped to operationally define bacterial species.

Nature Reviews Genetics, Published online: 04 November 2025; doi:10.1038/s41576-025-00903-5Kay et al. review evidence that parental care, and more complex social behaviour based on parental care, evolved in multiple species through the repeated co-option of members of a pleiotropic molecular network regulating the ancestral processes of feeding, growth and reproduction.

Nature Reviews Genetics, Published online: 03 November 2025; doi:10.1038/s41576-025-00909-zMicrobial genomics can improve our understanding of antimicrobial resistance dynamics across ecosystems. In this Comment, Kathryn Holt emphasizes the interconnectedness of human, animal and environmental health and calls for greater integration of microbial genomic data through robust analytical frameworks to unravel the complexity of antimicrobial resistance dynamics.

Nature Reviews Genetics, Published online: 03 November 2025; doi:10.1038/s41576-025-00914-2In this Journal Club, Peter Koo reflects on the 2021 publication of Enformer and its impact on the use of deep learning for modelling the regulatory genome.

Nature Reviews Genetics, Published online: 10 October 2025; doi:10.1038/s41576-025-00900-8This article reviews the current state of implementation of polygenic risk scores in the clinical setting, highlights key challenges and outlines future directions for the use of such scores to improve disease risk prediction and to enable personalized prevention.

Nature Reviews Genetics, Published online: 30 October 2025; doi:10.1038/s41576-025-00910-6Jaime Martinez-Urtaza reflects on two papers by Smith et al., who found that bacteria exist along a continuum from clonal to recombining populations, and introduced the concept of an ‘epidemic’ microbial population structure.

Nature Reviews Genetics, Published online: 30 October 2025; doi:10.1038/s41576-025-00911-5In this Journal Club, Luis Orellana recalls a 2005 publication by Konstantinidis and Tiedje that introduced average nucleotide identity as a sequence-based metric to determine the relatedness between two genomes, which helped to operationally define bacterial species.

Nature Reviews Genetics, Published online: 22 October 2025; doi:10.1038/s41576-025-00905-3Jean Fan recounts a 2015 paper by Martincorena et al. that revealed oncogenic mutations in normal tissues, also highlighting how the latest spatial technologies can now be used to study the spatial contextual impact of these mutations.

Nature Reviews Genetics, Published online: 08 October 2025; doi:10.1038/s41576-025-00896-1Recent advances in forensic genetics have improved the range, precision and reliability of forensic information obtainable from biological trace material. The author reviews how non-targeted and targeted omics approaches and methods are improving crime scene analyses being applied for the identification of perpetrators and their relatives or victims, the prediction of phenotypic traits, and the determination of trace characteristics.

Nature Reviews Genetics, Published online: 07 October 2025; doi:10.1038/s41576-025-00902-6In this Journal Club, Tzachi Hagai highlights a 2005 paper by Sawyer et al. that tested the functional relationship of evolutionary changes in immune genes with infection outcomes.

Nature Reviews Genetics, Published online: 17 October 2025; doi:10.1038/s41576-025-00899-yMorris discusses how single-cell genomics and computational tools expose failure points in reprogramming and guide protocols that improve the fidelity, maturity and purity of engineered cells, advancing their use in regenerative medicine and disease modelling.

Nature Reviews Genetics, Published online: 16 October 2025; doi:10.1038/s41576-025-00906-2Microorganisms are central to climate stability, food security and biodiversity, yet they remain absent from global sustainability frameworks. In this Comment, Nicole Webster highlights the power of eco-evolutionary genomics in transforming sustainability science and calls for the inclusion of microbes in global policies.

Nature Reviews Genetics, Published online: 22 October 2025; doi:10.1038/s41576-025-00905-3Jean Fan recounts a 2015 paper by Martincorena et al. that revealed oncogenic mutations in normal tissues, also highlighting how the latest spatial technologies can now be used to study the spatial contextual impact of these mutations.

Nature Reviews Genetics, Published online: 01 October 2025; doi:10.1038/s41576-025-00901-7Sara Suliman describes a seminal 2013 publication by Comas et al. that investigated the origins of the tuberculosis-causing bacteria and its coevolution with diverse human populations.

Nature Reviews Genetics, Published online: 30 September 2025; doi:10.1038/s41576-025-00892-5Spatial omics has empowered the discovery of developmental and disease-associated molecular signatures, cell states and multicellular niches, as well as the evaluation of disease heterogeneity within and across organs. The authors review spatially resolved molecular changes across diseases and discuss the potential of spatial multi-omics for clinical applications, including the recent impact of artificial intelligence.

Nature Reviews Genetics, Published online: 26 September 2025; doi:10.1038/s41576-025-00898-zGerald Mboowa reflects on the dual legacy of a 2021 study by Frangoul et al., which demonstrated safe and effective CRISPR-based editing to treat sickle-cell disease and β-thalassemia, as both a triumph of modern science and a call to action for global health.

Nature Reviews Genetics, Published online: 17 October 2025; doi:10.1038/s41576-025-00899-yMorris discusses how single-cell genomics and computational tools expose failure points in reprogramming and guide protocols that improve the fidelity, maturity and purity of engineered cells, advancing their use in regenerative medicine and disease modelling.

Nature Reviews Genetics, Published online: 10 October 2025; doi:10.1038/s41576-025-00900-8This article reviews the current state of implementation of polygenic risk scores in the clinical setting, highlights key challenges and outlines future directions for the use of such scores to improve disease risk prediction and to enable personalized prevention.