Nature Reviews Genetics, Published online: 02 January 2026; doi:10.1038/s41576-025-00927-xIn this Tools of the Trade article, Moritz Schaefer introduces CellWhisperer, a multimodal machine learning model and software tool for the chat-based interrogation of single-cell RNA sequencing datasets.

Nature Reviews Genetics, Published online: 02 January 2026; doi:10.1038/s41576-025-00920-4Causal and mechanistic modelling strategies, which aim to infer cause–effect relationships, provide insights into cellular responses to perturbations. The authors review computational approaches that harness machine learning and single-cell data to advance our understanding of cellular heterogeneity and causal mechanisms in biological systems.

Nature Reviews Genetics, Published online: 03 December 2025; doi:10.1038/s41576-025-00912-4Ancient DNA techniques are being applied to study increasingly diverse pathogens of the past. The authors review the latest insights into pathogen–host coevolution, zoonotic events and the spread of pathogens, all while highlighting the importance of a One Health approach to this research.

Nature Reviews Genetics, Published online: 15 December 2025; doi:10.1038/s41576-025-00917-zMicrobial genomics has yielded transformative insights into the ecology and evolution of microorganisms. Nature Reviews Genetics presents a Focus issue that explores how genomic approaches reveal microbial dynamics across ecological and evolutionary contexts.

Nature Reviews Genetics, Published online: 01 December 2025; doi:10.1038/s41576-025-00924-0In this Tools of the Trade article, Shubham Khetan presents PADIT-seq (protein affinity to DNA by in vitro transcription and RNA sequencing), which enables the reliable identification of low-affinity DNA binding sites for transcription factors.

Nature Reviews Genetics, Published online: 28 November 2025; doi:10.1038/s41576-025-00918-yEngelberts and Tyson discuss the potential and challenges of microbial single-cell genomics, emphasizing the integration of single-cell omics and meta-omics data as a promising opportunity to reveal the ecological and evolutionary processes that shape microbial communities.

Nature Reviews Genetics, Published online: 28 November 2025; doi:10.1038/s41576-025-00908-0Genome-wide association studies of increasing scale have revealed the prevalence of pleiotropic genetic variants that affect multiple traits. In this Review, the authors overview the statistical methods and approaches used to identify these pleiotropic genetic variants and dissect how they contribute to shared mechanisms of diseases.

Nature Reviews Genetics - Advances in long-read sequencing are driving the implementation of these technologies for transcriptome profiling. The authors provide a comprehensive guide to long-read...

Nature Reviews Genetics, Published online: 15 December 2025; doi:10.1038/s41576-025-00917-zMicrobial genomics has yielded transformative insights into the ecology and evolution of microorganisms. Nature Reviews Genetics presents a Focus issue that explores how genomic approaches reveal microbial dynamics across ecological and evolutionary contexts.

Nature Reviews Genetics - Ancient DNA techniques are being applied to study increasingly diverse pathogens of the past. The authors review the latest insights into pathogen–host coevolution,...

Viral pathogen evolution and global health

Recent genomic approaches are providing unprecedented opportunity to disentangle how genotype and environment affect organismal traits. The authors review the role of epigenetic variation in mediating...

Nature Reviews Genetics, Published online: 03 December 2025; doi:10.1038/s41576-025-00912-4Ancient DNA techniques are being applied to study increasingly diverse pathogens of the past. The authors review the latest insights into pathogen–host coevolution, zoonotic events and the spread of pathogens, all while highlighting the importance of a One Health approach to this research.

This article reviews the current state of implementation of polygenic risk scores in the clinical setting, highlights key challenges and outlines future directions for the use of such scores to improve disease risk prediction and to enable personalized prevention.

Nature Reviews Genetics, Published online: 11 April 2025; doi:10.1038/s41576-025-00836-zPost-transcriptional splicing has emerged as a key layer of gene expression regulation but is challenging to differentiate from co-transcriptional splicing. The authors review methodologies to detect post-transcriptional splicing, the mechanisms controlling splicing timing and how the temporal regulation of splicing affects gene expression.

Nature Reviews Genetics, Published online: 18 November 2025; doi:10.1038/s41576-025-00907-1CRISPR-based genome editing has revolutionized biotechnology, enabling precise DNA modifications for research and therapy. The authors review how artificial intelligence, including deep learning, is advancing genome editing by improving guide RNA design, editor protein engineering, novel effector discovery and predicting editing outcomes.

Nature Reviews Genetics, Published online: 18 November 2025; doi:10.1038/s41576-025-00919-xIn this Journal Club, Nozomu Yachie recalls a 1999 paper by Pellegrini, Marcotte and colleagues that demonstrated how functional information, such as protein--protein interactions, could be revealed through patterns of genetic diversity across species.

Nature Reviews Genetics, Published online: 01 December 2025; doi:10.1038/s41576-025-00924-0In this Tools of the Trade article, Shubham Khetan presents PADIT-seq (protein affinity to DNA by in vitro transcription and RNA sequencing), which enables the reliable identification of low-affinity DNA binding sites for transcription factors.

Nature Reviews Genetics, Published online: 28 November 2025; doi:10.1038/s41576-025-00908-0Genome-wide association studies of increasing scale have revealed the prevalence of pleiotropic genetic variants that affect multiple traits. In this Review, the authors overview the statistical methods and approaches used to identify these pleiotropic genetic variants and dissect how they contribute to shared mechanisms of diseases.