Mike Inouye
@mikeinouye.bsky.social
Computational biologist. Geriatric Millennial. Professor, University of Cambridge. Director of Data Sciences, Baker Heart & Diabetes Institute. British | Australian | American.
www.inouyelab.org | Cambridge, UK
www.inouyelab.org | Cambridge, UK
Reposted by Mike Inouye
“Integrating perturbational screens, eQTL, and GWAS data identifies mediating genes for complex traits”
Very nice @medrxivpreprint.bsky.social study by @zeyunlu.bsky.social @sashagusevposts.bsky.social & colleagues 🧪🧬
www.medrxiv.org/content/10.6...
Very nice @medrxivpreprint.bsky.social study by @zeyunlu.bsky.social @sashagusevposts.bsky.social & colleagues 🧪🧬
www.medrxiv.org/content/10.6...
Integrating perturbational screens, eQTL, and GWAS data identifies mediating genes for complex traits
Most current GWAS-eQTL approaches prioritize genes whose mediating effects on complex traits act through cis-regulation, while trans-acting genes remain largely underexplored. Recent perturbational sc...
www.medrxiv.org
January 6, 2026 at 7:24 AM
“Integrating perturbational screens, eQTL, and GWAS data identifies mediating genes for complex traits”
Very nice @medrxivpreprint.bsky.social study by @zeyunlu.bsky.social @sashagusevposts.bsky.social & colleagues 🧪🧬
www.medrxiv.org/content/10.6...
Very nice @medrxivpreprint.bsky.social study by @zeyunlu.bsky.social @sashagusevposts.bsky.social & colleagues 🧪🧬
www.medrxiv.org/content/10.6...
Reposted by Mike Inouye
Federal health officials slash recommended childhood vaccinations under Trump’s directive www.statnews.com/2026/01/05/c... via @statnews.com
Federal health officials slash recommended childhood vaccinations under Trump’s directive
The number of recommended childhood shots drops from 17 to 11.
www.statnews.com
January 5, 2026 at 7:07 PM
Federal health officials slash recommended childhood vaccinations under Trump’s directive www.statnews.com/2026/01/05/c... via @statnews.com
Reposted by Mike Inouye
Researchers from the Quadram Institute have come together to develop a new open access book filled with cutting-edge methods and protocols to ensure best practice in microbiome research.
New book shares Quadram’s Best Practice in Microbiome Research - Quadram Institute
Researchers from the Quadram Institute have developed an open access book to help ensure best practice in microbiome research.
buff.ly
January 4, 2026 at 12:00 PM
Researchers from the Quadram Institute have come together to develop a new open access book filled with cutting-edge methods and protocols to ensure best practice in microbiome research.
Thoroughly enjoying this sub, especially 'Western Scandinavia' www.reddit.com/r/AskTheWorl...
From the AskTheWorld community on Reddit: Would you rather live in the US or in the UK?
Explore this post and more from the AskTheWorld community
www.reddit.com
January 3, 2026 at 12:33 AM
Thoroughly enjoying this sub, especially 'Western Scandinavia' www.reddit.com/r/AskTheWorl...
Reposted by Mike Inouye
People age 70+ should not be taking aspirin at any dose for prevention. Results of randomized trials show higher risk of all-cause mortality, major bleeding events and deaths from cancer. p 153, SUPER AGERS book
January 1, 2026 at 10:12 PM
People age 70+ should not be taking aspirin at any dose for prevention. Results of randomized trials show higher risk of all-cause mortality, major bleeding events and deaths from cancer. p 153, SUPER AGERS book
Reposted by Mike Inouye
New @science.org today
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation
Somatic mutations that increase the fitness of hematopoietic stem cells (HSCs) drive their expansion in clonal hematopoiesis (CH) and predispose individuals to blood cancers. Population variation in t...
science.org
January 1, 2026 at 7:03 PM
New @science.org today
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
So yea, opened up my work laptop to a macOS recovery screen and uni IT doesnt open again until Jan 2… if anyone’s expecting anything from me in the near future, it’s gonna take a while (longer than usual) 🤷🏻♂️
December 27, 2025 at 9:00 PM
So yea, opened up my work laptop to a macOS recovery screen and uni IT doesnt open again until Jan 2… if anyone’s expecting anything from me in the near future, it’s gonna take a while (longer than usual) 🤷🏻♂️
Reposted by Mike Inouye
…and we don’t have this matrix at good completeness & precision, despite many efforts (including our own 👇). Hopefully we will in not too distant future, but given the difficulty of this task, I’m not holding my breath regarding virtual cells. pubmed.ncbi.nlm.nih.gov/41173850/
Large-scale causal discovery using interventional data sheds light on gene network structure in k562 cells - PubMed
Inference of directed biological networks is an important but notoriously challenging problem. The recent proliferation of large-scale CRISPR perturbation data provides a new opportunity to tackle this problem by leveraging the transcriptional response to the presence of a gene-targeting guide. Here …
pubmed.ncbi.nlm.nih.gov
December 27, 2025 at 4:58 PM
…and we don’t have this matrix at good completeness & precision, despite many efforts (including our own 👇). Hopefully we will in not too distant future, but given the difficulty of this task, I’m not holding my breath regarding virtual cells. pubmed.ncbi.nlm.nih.gov/41173850/
The senior university is a wonderful idea and widely implementable. Can't help but agree that such institutions are democratically important. www.theguardian.com/world/2025/d...
‘Keeps your mind alert’: older Swedes reap the benefits of learning for pleasure
Retirees with ‘fantastic hunger for education’ taking part in university organised events in record numbers
www.theguardian.com
December 26, 2025 at 6:42 AM
The senior university is a wonderful idea and widely implementable. Can't help but agree that such institutions are democratically important. www.theguardian.com/world/2025/d...
Reposted by Mike Inouye
Congrats @jeffgroh.bsky.social et al. Some avocado trees open female-phase flowers in the morning & then male in afternoon. Others show complementary pattern (m->f), to synchronize pollination of two types. Jeff show this to be a >45Mya polymorphism at a transcription factor across 100s of species.
Balanced polymorphism in a floral transcription factor underlies an ancient rhythm of daily sex alternation in avocado https://www.biorxiv.org/content/10.64898/2025.12.22.695989v1
December 25, 2025 at 6:47 PM
Congrats @jeffgroh.bsky.social et al. Some avocado trees open female-phase flowers in the morning & then male in afternoon. Others show complementary pattern (m->f), to synchronize pollination of two types. Jeff show this to be a >45Mya polymorphism at a transcription factor across 100s of species.
Reposted by Mike Inouye
This story is absolutely wild. Did you know that avocados change sex over the course of a day? And that it's controlled by a single ancient balanced polymorphism? This is flat our crazy
Balanced polymorphism in a floral transcription factor underlies an ancient rhythm of daily sex alternation in avocado https://www.biorxiv.org/content/10.64898/2025.12.22.695989v1
December 25, 2025 at 6:33 AM
This story is absolutely wild. Did you know that avocados change sex over the course of a day? And that it's controlled by a single ancient balanced polymorphism? This is flat our crazy
Every british parent now beyond exhaustion, furiously stuffing stockings, shoving pressies under trees, scarfing cookies that have been meticulously laid out, and chucking 'reindeer food' in the outside bin... 🎅🏼🥃
December 24, 2025 at 9:44 PM
Every british parent now beyond exhaustion, furiously stuffing stockings, shoving pressies under trees, scarfing cookies that have been meticulously laid out, and chucking 'reindeer food' in the outside bin... 🎅🏼🥃
Reposted by Mike Inouye
Japan is joining Horizon Europe, the EU’s flagship research and innovation programme.
Openness and international cooperation can shape a bright future for science and technology.
Through science, we can build bridges, strengthen competitiveness, and accelerate the green and digital transitions.
Openness and international cooperation can shape a bright future for science and technology.
Through science, we can build bridges, strengthen competitiveness, and accelerate the green and digital transitions.
December 22, 2025 at 9:53 AM
Japan is joining Horizon Europe, the EU’s flagship research and innovation programme.
Openness and international cooperation can shape a bright future for science and technology.
Through science, we can build bridges, strengthen competitiveness, and accelerate the green and digital transitions.
Openness and international cooperation can shape a bright future for science and technology.
Through science, we can build bridges, strengthen competitiveness, and accelerate the green and digital transitions.
"Most top achievers (Nobel laureates and world-class musicians, athletes, chess players) demonstrated lower performance than many peers during their early years. Across the highest adult performance, peak performance is negatively correlated with early performance" www.science.org/doi/10.1126/...
Recent discoveries on the acquisition of the highest levels of human performance
Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...
www.science.org
December 20, 2025 at 6:30 AM
"Most top achievers (Nobel laureates and world-class musicians, athletes, chess players) demonstrated lower performance than many peers during their early years. Across the highest adult performance, peak performance is negatively correlated with early performance" www.science.org/doi/10.1126/...
Reposted by Mike Inouye
We did a deep dive into aortic stenosis genetics, and took first steps to understand the genetics behind normal human variation in flow across the aortic valve.
We’re excited to share our new Nature Genetics paper examining the genetic architecture of aortic valve function and aortic stenosis. We used deep learning of cardiac MRI and MTAG to study disease biology long before clinical diagnosis.
nature.com/articles/s41...
1/10
nature.com/articles/s41...
1/10
December 19, 2025 at 11:11 PM
We did a deep dive into aortic stenosis genetics, and took first steps to understand the genetics behind normal human variation in flow across the aortic valve.
Reposted by Mike Inouye
This headline is wrong and misleading, and the brief text below it is not much better. Whatever might constitute a full explanation of the differences between sapiens and other hominins, we remain confident that 'genes' will be central to it.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Genes don’t explain what made humans different
Tiny genetic variations between humans, Neanderthals and Denisovans might not be all they were cracked up to be.
www.nature.com
December 19, 2025 at 11:55 AM
This headline is wrong and misleading, and the brief text below it is not much better. Whatever might constitute a full explanation of the differences between sapiens and other hominins, we remain confident that 'genes' will be central to it.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Mike Inouye
"The only kind of thinking that matters in science is structured thinking. The only way to give structure and substance to your thoughts is to write them down. Writing. Is. Thinking."
Thinking about this in the context of AI tools....
Thinking about this in the context of AI tools....
An open letter to graduate students and other procrastinators: it’s time to write - Nature Biotechnology
Nature Biotechnology - An open letter to graduate students and other procrastinators: it’s time to write
www.nature.com
March 25, 2025 at 2:46 PM
"The only kind of thinking that matters in science is structured thinking. The only way to give structure and substance to your thoughts is to write them down. Writing. Is. Thinking."
Thinking about this in the context of AI tools....
Thinking about this in the context of AI tools....
Reposted by Mike Inouye
And it's a whopper of an issue!
📢 Our January issue is live and it's a special one🦠🧫! Featuring a range of article types, including Reviews, Comments and Journal Club articles, this Focus issue explores the insights gained from the application of microbial genomics within ecological and evolutionary contexts go.nature.com/3MNmsgR
December 16, 2025 at 6:56 PM
And it's a whopper of an issue!
Reposted by Mike Inouye
New paper: "Alcohol consumption and risk of cancer: a Mendelian randomization analysis of four biobanks and consortium data" out at BMC Medicine: link.springer.com/article/10.1.... Lots of interesting findings! Brief thread:
Alcohol consumption and risk of cancer: a Mendelian randomization analysis of four biobanks and consortium data - BMC Medicine
Background Alcohol consumption has been linked to cancer risk. Evidence is strongest for seven cancer types: breast, colorectum, oesophagus, liver, mouth, pharynx, and larynx. However, evidence suppor...
link.springer.com
December 16, 2025 at 9:55 AM
New paper: "Alcohol consumption and risk of cancer: a Mendelian randomization analysis of four biobanks and consortium data" out at BMC Medicine: link.springer.com/article/10.1.... Lots of interesting findings! Brief thread:
Reposted by Mike Inouye
🚨Wanted…emerging clinical academic leader in cardiology to join @vpd-hlri.bsky.social and @royalpapworth.bsky.social.
Get in touch if you’d like to discuss the role. We’d love to hear from you!
www.cam.ac.uk/jobs/assista...
Get in touch if you’d like to discuss the role. We’d love to hear from you!
www.cam.ac.uk/jobs/assista...
Assistant/Associate Professor in Cardiology (Honorary Consultant) (Fixed Term)
An exciting opportunity has arisen for a new University of Cambridge - Royal Papworth Hospital NHS Foundation Trust Assistant/Associate Professor in Cardiology. We are seeking expressions of interest
www.cam.ac.uk
December 16, 2025 at 10:55 PM
🚨Wanted…emerging clinical academic leader in cardiology to join @vpd-hlri.bsky.social and @royalpapworth.bsky.social.
Get in touch if you’d like to discuss the role. We’d love to hear from you!
www.cam.ac.uk/jobs/assista...
Get in touch if you’d like to discuss the role. We’d love to hear from you!
www.cam.ac.uk/jobs/assista...
Reposted by Mike Inouye
Are you an emerging clinical academic leader in respiratory medicine?
Come and join @vpd-hlri.bsky.social and @royalpapworth.bsky.social and build your career!
Get in touch if you’d like to discuss.
www.cam.ac.uk/jobs/assista...
Come and join @vpd-hlri.bsky.social and @royalpapworth.bsky.social and build your career!
Get in touch if you’d like to discuss.
www.cam.ac.uk/jobs/assista...
Assistant/Associate Professor in Respiratory Medicine (Honorary Consultant) (Fixed Term)
An exciting opportunity has arisen for a new University of Cambridge-Royal Papworth Hospital NHS Foundation Trust Assistant/Associate Professor in Respiratory Medicine. We are seeking applications
www.cam.ac.uk
December 16, 2025 at 10:53 PM
Are you an emerging clinical academic leader in respiratory medicine?
Come and join @vpd-hlri.bsky.social and @royalpapworth.bsky.social and build your career!
Get in touch if you’d like to discuss.
www.cam.ac.uk/jobs/assista...
Come and join @vpd-hlri.bsky.social and @royalpapworth.bsky.social and build your career!
Get in touch if you’d like to discuss.
www.cam.ac.uk/jobs/assista...
Reposted by Mike Inouye
Reposted by Mike Inouye
Researchers are devising creative ways to get together as Trump’s policies curb travel to US gatherings
go.nature.com/4adSEUq
go.nature.com/4adSEUq
Scientists skip key US meetings — and seize on smaller alternatives
Researchers are devising creative ways to get together as Trump’s policies curb travel to US gatherings.
go.nature.com
December 16, 2025 at 4:48 PM
Researchers are devising creative ways to get together as Trump’s policies curb travel to US gatherings
go.nature.com/4adSEUq
go.nature.com/4adSEUq
Reposted by Mike Inouye
Less than 48 hours after the deadly attack at Sydney's Bondi Beach that left more than a dozen dead, Australian authorities announced proposals for sweeping new gun laws. n.pr/48UTa7g
Australia announces strict new gun laws. Here's how it can act so swiftly
Less than 48 hours after the deadly attack at Sydney's Bondi Beach that left more than a dozen dead, Australian authorities announced proposals for sweeping new gun laws.
n.pr
December 15, 2025 at 9:41 PM
Less than 48 hours after the deadly attack at Sydney's Bondi Beach that left more than a dozen dead, Australian authorities announced proposals for sweeping new gun laws. n.pr/48UTa7g