Mike Inouye
@mikeinouye.bsky.social
Computational biologist. Geriatric Millennial. Professor, University of Cambridge. Director of Data Sciences, Baker Heart & Diabetes Institute. British | Australian | American.
www.inouyelab.org | Cambridge, UK
www.inouyelab.org | Cambridge, UK
Reposted by Mike Inouye
🧬 PRSs in practice (4/5): Lower-risk PRS results — false reassurance, or false assumption?
A common concern is that lower-risk PRS results cause false reassurance. But evidence & theory do not support this.
Read my paper with @mikeinouye.bsky.social here👉 rdcu.be/eNeKN
#Genomics #PolygenicScores
A common concern is that lower-risk PRS results cause false reassurance. But evidence & theory do not support this.
Read my paper with @mikeinouye.bsky.social here👉 rdcu.be/eNeKN
#Genomics #PolygenicScores
November 10, 2025 at 9:50 AM
🧬 PRSs in practice (4/5): Lower-risk PRS results — false reassurance, or false assumption?
A common concern is that lower-risk PRS results cause false reassurance. But evidence & theory do not support this.
Read my paper with @mikeinouye.bsky.social here👉 rdcu.be/eNeKN
#Genomics #PolygenicScores
A common concern is that lower-risk PRS results cause false reassurance. But evidence & theory do not support this.
Read my paper with @mikeinouye.bsky.social here👉 rdcu.be/eNeKN
#Genomics #PolygenicScores
Reposted by Mike Inouye
Agency scientists speak out about the irreplaceable facilities, institutional knowledge and training opportunities that the USA is losing
go.nature.com/49CE3Bt
go.nature.com/49CE3Bt
Dismantling of US federal agencies will ‘destroy science’
Nature - From NASA to the National Institutes of Health, federal agencies conduct research that universities cannot. Agency scientists speak out about the irreplaceable facilities, institutional...
go.nature.com
November 9, 2025 at 5:28 PM
Agency scientists speak out about the irreplaceable facilities, institutional knowledge and training opportunities that the USA is losing
go.nature.com/49CE3Bt
go.nature.com/49CE3Bt
Straight onto the reading list: Forensic genetics in the omics era www.nature.com/articles/s41...
Forensic genetics in the omics era - Nature Reviews Genetics
Recent advances in forensic genetics have improved the range, precision and reliability of forensic information obtainable from biological trace material. The author reviews how non-targeted and ...
www.nature.com
November 9, 2025 at 5:12 PM
Straight onto the reading list: Forensic genetics in the omics era www.nature.com/articles/s41...
Reposted by Mike Inouye
Get this: Coffee suppressed atrial fibrillation!
Unexpected results for recurrence from a randomized trial in participants after cardioversion from AF
#AHA25 @jama.com
jamanetwork.com/journals/jam...
Unexpected results for recurrence from a randomized trial in participants after cardioversion from AF
#AHA25 @jama.com
jamanetwork.com/journals/jam...
November 9, 2025 at 2:51 PM
Get this: Coffee suppressed atrial fibrillation!
Unexpected results for recurrence from a randomized trial in participants after cardioversion from AF
#AHA25 @jama.com
jamanetwork.com/journals/jam...
Unexpected results for recurrence from a randomized trial in participants after cardioversion from AF
#AHA25 @jama.com
jamanetwork.com/journals/jam...
Reposted by Mike Inouye
If you believe either that Franklin discovered the double helix, and / or Watson and Crick stole her data, ask yourself how you know this. Then take a read of this article.
If I see one more stupid Rosalind Franklin take I'm going to lose my mind. Thank god for @matthewcobb.bsky.social and @nccomfort.bsky.social. www.nature.com/articles/d41...
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
www.nature.com
November 8, 2025 at 7:32 AM
If you believe either that Franklin discovered the double helix, and / or Watson and Crick stole her data, ask yourself how you know this. Then take a read of this article.
Reposted by Mike Inouye
8 high level positions at NIH posted including 6 institute director positions (NIMH, NIGMS, NICHD, NIDCR, NHGRI, NLM).
Only open for 2 weeks (applications due November 21).
Application materials include a) CV b) vision statement c) a photocopy of doctoral degree.
hr.nih.gov/careers/open...
Only open for 2 weeks (applications due November 21).
Application materials include a) CV b) vision statement c) a photocopy of doctoral degree.
hr.nih.gov/careers/open...
hr.nih.gov
November 7, 2025 at 10:20 PM
8 high level positions at NIH posted including 6 institute director positions (NIMH, NIGMS, NICHD, NIDCR, NHGRI, NLM).
Only open for 2 weeks (applications due November 21).
Application materials include a) CV b) vision statement c) a photocopy of doctoral degree.
hr.nih.gov/careers/open...
Only open for 2 weeks (applications due November 21).
Application materials include a) CV b) vision statement c) a photocopy of doctoral degree.
hr.nih.gov/careers/open...
Reposted by Mike Inouye
NYT obituary of Jim Watson.
A long and fairly balanced view of a complicated man who participated in one of the greatest discoveries in biology.
[Gift Link]
www.nytimes.com/2025/11/07/s...
A long and fairly balanced view of a complicated man who participated in one of the greatest discoveries in biology.
[Gift Link]
www.nytimes.com/2025/11/07/s...
James Watson, Co-Discoverer of the Structure of DNA, Is Dead at 97
www.nytimes.com
November 7, 2025 at 7:59 PM
NYT obituary of Jim Watson.
A long and fairly balanced view of a complicated man who participated in one of the greatest discoveries in biology.
[Gift Link]
www.nytimes.com/2025/11/07/s...
A long and fairly balanced view of a complicated man who participated in one of the greatest discoveries in biology.
[Gift Link]
www.nytimes.com/2025/11/07/s...
Wow, a whole new way to 'see' our Milky Way! Radiowave light (top) as compared to visual light (bottom).
h\t Western Australia and ICRAR! www.icrar.org/gleam-x-gala...
h\t Western Australia and ICRAR! www.icrar.org/gleam-x-gala...
November 7, 2025 at 5:52 PM
Wow, a whole new way to 'see' our Milky Way! Radiowave light (top) as compared to visual light (bottom).
h\t Western Australia and ICRAR! www.icrar.org/gleam-x-gala...
h\t Western Australia and ICRAR! www.icrar.org/gleam-x-gala...
Well, this is an important role... hopefully someone who understands genomics is appointed
JOB POSTING: Director, National Human Genome Research Institute hr.nih.gov/careers/open...
hr.nih.gov
November 7, 2025 at 4:20 PM
Well, this is an important role... hopefully someone who understands genomics is appointed
The Green Algorithms Initiative is recruiting a Research Software Engineer! www.cam.ac.uk/jobs/researc...
Check out www.green-algorithms.org for more info about the initiative and/or contact @loiclnlg.bsky.social if interested
Check out www.green-algorithms.org for more info about the initiative and/or contact @loiclnlg.bsky.social if interested
Research Software Engineer (Sustainable computing, Green Algorithms Initiative)
An exciting opportunity has arisen for a Research Software Engineer to join our team and the Green Algorithms Initiative, one of the leading academic teams in the field of sustainable computing. The
www.cam.ac.uk
November 7, 2025 at 8:23 AM
The Green Algorithms Initiative is recruiting a Research Software Engineer! www.cam.ac.uk/jobs/researc...
Check out www.green-algorithms.org for more info about the initiative and/or contact @loiclnlg.bsky.social if interested
Check out www.green-algorithms.org for more info about the initiative and/or contact @loiclnlg.bsky.social if interested
Reposted by Mike Inouye
🧬 PRSs in practice (3/5): Higher-risk results = behaviour change?
A common concern is that higher-risk polygenic risk scores (PRSs) don’t motivate lifestyle behaviour change.
My @nathumbehav.nature.com paper with @mikeinouye.bsky.social addresses this 👉 rdcu.be/eNeKN
#Genomics #BehaviourChange
A common concern is that higher-risk polygenic risk scores (PRSs) don’t motivate lifestyle behaviour change.
My @nathumbehav.nature.com paper with @mikeinouye.bsky.social addresses this 👉 rdcu.be/eNeKN
#Genomics #BehaviourChange
November 6, 2025 at 2:27 PM
🧬 PRSs in practice (3/5): Higher-risk results = behaviour change?
A common concern is that higher-risk polygenic risk scores (PRSs) don’t motivate lifestyle behaviour change.
My @nathumbehav.nature.com paper with @mikeinouye.bsky.social addresses this 👉 rdcu.be/eNeKN
#Genomics #BehaviourChange
A common concern is that higher-risk polygenic risk scores (PRSs) don’t motivate lifestyle behaviour change.
My @nathumbehav.nature.com paper with @mikeinouye.bsky.social addresses this 👉 rdcu.be/eNeKN
#Genomics #BehaviourChange
Reposted by Mike Inouye
Denmark eyes new law to protect citizens from AI deepfakes
Denmark plans to give citizens copyright over their likeness to ban and force removal of nonconsensual deepfakes (images, video or voice), targeting rising AI-generated abuse and misinformation.
Denmark plans to give citizens copyright over their likeness to ban and force removal of nonconsensual deepfakes (images, video or voice), targeting rising AI-generated abuse and misinformation.
Denmark eyes new law to protect citizens from AI deepfakes
Denmark plans to give citizens copyright over their likeness to ban and force removal of nonconsensual deepfakes (images, video or voice), targeting rising AI-generated abuse and misinformation.
apnews.com
November 6, 2025 at 11:08 AM
Denmark eyes new law to protect citizens from AI deepfakes
Denmark plans to give citizens copyright over their likeness to ban and force removal of nonconsensual deepfakes (images, video or voice), targeting rising AI-generated abuse and misinformation.
Denmark plans to give citizens copyright over their likeness to ban and force removal of nonconsensual deepfakes (images, video or voice), targeting rising AI-generated abuse and misinformation.
Reposted by Mike Inouye
🧬 PRSs in practice (2/5): Do higher-risk polygenic risk score (PRS) results really cause distress?
Evidence so far doesn’t suggest substantial or lasting psychological harm — though research remains limited.
👉 rdcu.be/eNeKN
#Genomics #PolygenicRiskScores #Risk #MentalHealth #Depression #Anxiety
Evidence so far doesn’t suggest substantial or lasting psychological harm — though research remains limited.
👉 rdcu.be/eNeKN
#Genomics #PolygenicRiskScores #Risk #MentalHealth #Depression #Anxiety
November 5, 2025 at 10:05 AM
🧬 PRSs in practice (2/5): Do higher-risk polygenic risk score (PRS) results really cause distress?
Evidence so far doesn’t suggest substantial or lasting psychological harm — though research remains limited.
👉 rdcu.be/eNeKN
#Genomics #PolygenicRiskScores #Risk #MentalHealth #Depression #Anxiety
Evidence so far doesn’t suggest substantial or lasting psychological harm — though research remains limited.
👉 rdcu.be/eNeKN
#Genomics #PolygenicRiskScores #Risk #MentalHealth #Depression #Anxiety
It was wonderful to see all the exciting science going on at @kiroxford.bsky.social! It has nothing to do with me but check out this fantastic postdoc opening with @y-luo.bsky.social and their MRC CoRE www.kennedy.ox.ac.uk/jobs/postdoc...
If I was 15 years younger, would be jumping at the chance.
If I was 15 years younger, would be jumping at the chance.
November 4, 2025 at 8:22 PM
It was wonderful to see all the exciting science going on at @kiroxford.bsky.social! It has nothing to do with me but check out this fantastic postdoc opening with @y-luo.bsky.social and their MRC CoRE www.kennedy.ox.ac.uk/jobs/postdoc...
If I was 15 years younger, would be jumping at the chance.
If I was 15 years younger, would be jumping at the chance.
Reposted by Mike Inouye
Are you looking for a #tenuretrack or #openrank job in #biostatistics or #statistics? @fredhutch.org is hiring! Seattle is a wonderful place to grow your career; the bio/stat & science scene here is world-class; and you will work w/ amazing UW Biostat students. Apply!
apply.interfolio.com/176402
apply.interfolio.com/176402
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
November 4, 2025 at 6:57 PM
Are you looking for a #tenuretrack or #openrank job in #biostatistics or #statistics? @fredhutch.org is hiring! Seattle is a wonderful place to grow your career; the bio/stat & science scene here is world-class; and you will work w/ amazing UW Biostat students. Apply!
apply.interfolio.com/176402
apply.interfolio.com/176402
Reposted by Mike Inouye
🧬 I’ve started a series on polygenic risk scores (PRSs) in healthcare practice, from my new paper with @mikeinouye.bsky.social in @nathumbehav.nature.com.
Yesterday’s post was on public understanding.
Tomorrow: do higher-risk PRS results cause distress?
👉 rdcu.be/eNeKN
#Genomics #PolygenicScores
Yesterday’s post was on public understanding.
Tomorrow: do higher-risk PRS results cause distress?
👉 rdcu.be/eNeKN
#Genomics #PolygenicScores
Psychological and behavioural considerations for integrating polygenic risk scores for disease into clinical practice
Nature Human Behaviour - The application of polygenic risk scores (PRSs) in clinical practice has advanced but also received criticism. In this Perspective, major psychological and behavioural...
rdcu.be
November 4, 2025 at 11:03 AM
🧬 I’ve started a series on polygenic risk scores (PRSs) in healthcare practice, from my new paper with @mikeinouye.bsky.social in @nathumbehav.nature.com.
Yesterday’s post was on public understanding.
Tomorrow: do higher-risk PRS results cause distress?
👉 rdcu.be/eNeKN
#Genomics #PolygenicScores
Yesterday’s post was on public understanding.
Tomorrow: do higher-risk PRS results cause distress?
👉 rdcu.be/eNeKN
#Genomics #PolygenicScores
Reposted by Mike Inouye
Apart from the AI junk part… the notion that one should not offer a potential mechanistic explanation for an observation, without first spending years & (unavailable) $$ trying to test possibilities before sharing the observation with others (who may be better equipped to investigate the mechanism)…
Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
November 3, 2025 at 10:37 PM
Apart from the AI junk part… the notion that one should not offer a potential mechanistic explanation for an observation, without first spending years & (unavailable) $$ trying to test possibilities before sharing the observation with others (who may be better equipped to investigate the mechanism)…
New commentary from @katholt.bsky.social just dropped 😊
New online! Microbial genomics for antimicrobial resistance ecology and action
Microbial genomics for antimicrobial resistance ecology and action
Nature Reviews Genetics, Published online: 03 November 2025; doi:10.1038/s41576-025-00909-zMicrobial genomics can improve our understanding of antimicrobial resistance dynamics across ecosystems. In this Comment, Kathryn Holt emphasizes the interconnectedness of human, animal and environmental health and calls for greater integration of microbial genomic data through robust analytical frameworks to unravel the complexity of antimicrobial resistance dynamics.
www.nature.com
November 3, 2025 at 9:43 PM
New commentary from @katholt.bsky.social just dropped 😊
Succinct explainer from @saskiasanderson.bsky.social on our recent work assessing common arguments re the potential psych/behaviour risks of PRS
Rather than slowing implementation, the answer is education, engagement, and co-design — not avoidance.
Read the paper here 👉 rdcu.be/eNeKN
#PolygenicRiskScores #Genomics #RiskCommunication #PublicUnderstandingOfRisk #ScienceCommunication #PrecisionMedicine
Read the paper here 👉 rdcu.be/eNeKN
#PolygenicRiskScores #Genomics #RiskCommunication #PublicUnderstandingOfRisk #ScienceCommunication #PrecisionMedicine
Psychological and behavioural considerations for integrating polygenic risk scores for disease into clinical practice
Nature Human Behaviour - The application of polygenic risk scores (PRSs) in clinical practice has advanced but also received criticism. In this Perspective, major psychological and behavioural...
rdcu.be
November 3, 2025 at 9:51 AM
Succinct explainer from @saskiasanderson.bsky.social on our recent work assessing common arguments re the potential psych/behaviour risks of PRS
Reposted by Mike Inouye
🧬 PRSs in practice (1/5): Public understanding — are we underestimating the public?
A common claim: “The public won’t understand polygenic risk scores (PRSs)” — so using them in healthcare could be risky.
But is that really true? 🧵
A common claim: “The public won’t understand polygenic risk scores (PRSs)” — so using them in healthcare could be risky.
But is that really true? 🧵
November 3, 2025 at 9:40 AM
🧬 PRSs in practice (1/5): Public understanding — are we underestimating the public?
A common claim: “The public won’t understand polygenic risk scores (PRSs)” — so using them in healthcare could be risky.
But is that really true? 🧵
A common claim: “The public won’t understand polygenic risk scores (PRSs)” — so using them in healthcare could be risky.
But is that really true? 🧵
I’m in Oxford this Monday and Tuesday (morning). Looking forward to seeing many old friends and colleagues… and hopefully meet some new ones! talks.ox.ac.uk/talks/id/b6e...
Genetic prediction and multi-omics: Towards disease prevention
The last 10 years have seen the emergence of predictive models based on genetics which quantify an individual’s genetic predisposition for a specific trait or disease. In this talk, I will present our...
talks.ox.ac.uk
November 2, 2025 at 8:49 PM
I’m in Oxford this Monday and Tuesday (morning). Looking forward to seeing many old friends and colleagues… and hopefully meet some new ones! talks.ox.ac.uk/talks/id/b6e...
Reposted by Mike Inouye
We’ve put up summary statistics for over 3,000 traits in the All of Us resource, and a shiny new browser alongside it! Explore your favorite gene or phenotype here: allbyall.researchallofus.org #ASHG24
All by All
The All by All browser maps known and novel associations between genotypes and phenotypes using data contributed by All of Us Research Program participants as of July 1, 2022. All by All encompasses a...
allbyall.researchallofus.org
November 8, 2024 at 8:32 PM
We’ve put up summary statistics for over 3,000 traits in the All of Us resource, and a shiny new browser alongside it! Explore your favorite gene or phenotype here: allbyall.researchallofus.org #ASHG24
Reposted by Mike Inouye
I’ve spent many years explaining/defending biorxiv’s “no reviews” policy.
The logic was always that opening Word and opining is a far lower barrier than doing actual research, so noise’d be >> signal and we didn’t want to make subjective quality judgements.
LLMs mean it makes even more sense 1/2
The logic was always that opening Word and opining is a far lower barrier than doing actual research, so noise’d be >> signal and we didn’t want to make subjective quality judgements.
LLMs mean it makes even more sense 1/2
arXiv will no longer accept review articles and position papers unless they have been accepted at a journal or a conference and complete successful peer review.
This is due to being overwhelmed by a hundreds of AI generated papers a month.
Yet another open submission process killed by LLMs.
This is due to being overwhelmed by a hundreds of AI generated papers a month.
Yet another open submission process killed by LLMs.
Attention Authors: Updated Practice for Review Articles and Position Papers in arXiv CS Category – arXiv blog
blog.arxiv.org
November 2, 2025 at 5:33 PM
I’ve spent many years explaining/defending biorxiv’s “no reviews” policy.
The logic was always that opening Word and opining is a far lower barrier than doing actual research, so noise’d be >> signal and we didn’t want to make subjective quality judgements.
LLMs mean it makes even more sense 1/2
The logic was always that opening Word and opining is a far lower barrier than doing actual research, so noise’d be >> signal and we didn’t want to make subjective quality judgements.
LLMs mean it makes even more sense 1/2
Reposted by Mike Inouye
this is the Pope
his entire thing is going around waving to crowds and looking happy
he is also such a White Sox fan that this is the maddest - and most human - I have ever a pope look
his entire thing is going around waving to crowds and looking happy
he is also such a White Sox fan that this is the maddest - and most human - I have ever a pope look
Mar Awa III, patriarch of the Assyrian Church of the East, also born in Chicago, gave Pope Leo a Cubs jersey.
October 29, 2025 at 12:59 AM
this is the Pope
his entire thing is going around waving to crowds and looking happy
he is also such a White Sox fan that this is the maddest - and most human - I have ever a pope look
his entire thing is going around waving to crowds and looking happy
he is also such a White Sox fan that this is the maddest - and most human - I have ever a pope look
Well done @eliasallara.bsky.social! Burden of cardiovascular diseases in England (2020–24): a national cohort using electronic health records data. www.thelancet.com/journals/lan...
Burden of cardiovascular diseases in England (2020–24): a national cohort using electronic health records data
Our study offers new insights into recent cardiovascular disease patterns and reveals
important health inequalities at a whole-population scale for multiple cardiovascular
diseases, during and after t...
www.thelancet.com
October 28, 2025 at 4:46 PM
Well done @eliasallara.bsky.social! Burden of cardiovascular diseases in England (2020–24): a national cohort using electronic health records data. www.thelancet.com/journals/lan...