Eric Topol
@erictopol.bsky.social
physician-scientist, author, editor
https://www.scripps.edu/faculty/topol/
Ground Truths https://erictopol.substack.com
SUPER AGERS https://www.simonandschuster.com/books/Super-Agers/Eric-Topol/9781668067666
https://www.scripps.edu/faculty/topol/
Ground Truths https://erictopol.substack.com
SUPER AGERS https://www.simonandschuster.com/books/Super-Agers/Eric-Topol/9781668067666
Pinned
Eric Topol
@erictopol.bsky.social
· May 27
A new cover for SUPER AGERS after making the NYT bestseller list. Thanks to you for making it the #1 ranked new non-fiction book on Amazon.
amazon.com/gp/new-relea...
amazon.com/gp/new-relea...
A success story for a physician with Alzheimer's which, in spite of the obstacles outlined, is a precursor for our enhanced ability to prevent the disease in the future
gift link
www.wsj.com/opinion/i-ca...
gift link
www.wsj.com/opinion/i-ca...
February 4, 2026 at 2:06 PM
A success story for a physician with Alzheimer's which, in spite of the obstacles outlined, is a precursor for our enhanced ability to prevent the disease in the future
gift link
www.wsj.com/opinion/i-ca...
gift link
www.wsj.com/opinion/i-ca...
Our circadian clock and cancer chronotherapy, a terrific
@scripps.edu review, open-access, related to below!
jci.org/articles/vie...
@scripps.edu review, open-access, related to below!
jci.org/articles/vie...
February 3, 2026 at 9:27 PM
Our circadian clock and cancer chronotherapy, a terrific
@scripps.edu review, open-access, related to below!
jci.org/articles/vie...
@scripps.edu review, open-access, related to below!
jci.org/articles/vie...
An exposé of the so-called "body protection compound" peptide (BPC-157) heavily promoted by paid influencers, without data on safety or efficacy, and now its proponents are pressuring FDA
www.statnews.com/2026/02/03/b...
www.statnews.com/2026/02/03/b...
From Croatia to MAHA: How an unapproved drug became the next hot peptide
BPC-157 hasn't been approved by the FDA. But that hasn't stopped this buzzy drug from gaining traction – and attention from MAHA.
www.statnews.com
February 3, 2026 at 4:21 PM
An exposé of the so-called "body protection compound" peptide (BPC-157) heavily promoted by paid influencers, without data on safety or efficacy, and now its proponents are pressuring FDA
www.statnews.com/2026/02/03/b...
www.statnews.com/2026/02/03/b...
The skinny on intermittent fasting
"the better the study , the less it finds"
gift link www.nytimes.com/2026/01/26/w...
"the better the study , the less it finds"
gift link www.nytimes.com/2026/01/26/w...
February 3, 2026 at 3:54 PM
The skinny on intermittent fasting
"the better the study , the less it finds"
gift link www.nytimes.com/2026/01/26/w...
"the better the study , the less it finds"
gift link www.nytimes.com/2026/01/26/w...
The US isn't Denmark when it comes to vaccines, written by a scientist from Denmark @annalsofim.bsky.social
www.acpjournals.org/doi/10.7326/...
www.acpjournals.org/doi/10.7326/...
February 2, 2026 at 10:18 PM
The US isn't Denmark when it comes to vaccines, written by a scientist from Denmark @annalsofim.bsky.social
www.acpjournals.org/doi/10.7326/...
www.acpjournals.org/doi/10.7326/...
The time of day for cancer immunotherapy is associated with major outcomes. Early is better. Results from a randomized trial of lung cancer, backs up the importance of our circadian rhythm and immune system
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 2, 2026 at 4:10 PM
The time of day for cancer immunotherapy is associated with major outcomes. Early is better. Results from a randomized trial of lung cancer, backs up the importance of our circadian rhythm and immune system
www.nature.com/articles/s41...
www.nature.com/articles/s41...
no data or evidence for that (maybe worth testing in the future)
February 1, 2026 at 5:46 PM
no data or evidence for that (maybe worth testing in the future)
I asked Kevin about VNS use in POTS, Long Covid, what may be considered an ideal use case
This is part of his reponse. Then there's the ear access.....
This is part of his reponse. Then there's the ear access.....
February 1, 2026 at 5:45 PM
I asked Kevin about VNS use in POTS, Long Covid, what may be considered an ideal use case
This is part of his reponse. Then there's the ear access.....
This is part of his reponse. Then there's the ear access.....
1 minute of vagus nerve stimulation per day was recently FDA approved as a treatment for rheumatoid arthritis. A new Ground Truths podcast with Kevin J. Tracey who pioneered this field
erictopol.substack.com/p/vagus-nerv...
erictopol.substack.com/p/vagus-nerv...
Vagus Nerve Stimulation and the Immune System
Kevin Tracey, the pioneering neurosurgeon who discovered the connection, talks about the recent FDA approval for rheumatoid arthritis and where this is headed
erictopol.substack.com
February 1, 2026 at 5:30 PM
1 minute of vagus nerve stimulation per day was recently FDA approved as a treatment for rheumatoid arthritis. A new Ground Truths podcast with Kevin J. Tracey who pioneered this field
erictopol.substack.com/p/vagus-nerv...
erictopol.substack.com/p/vagus-nerv...
"Our study highlights the presence of widespread neuroinflammation in the brain and increased levels of inflammatory cytokines in the plasma of individuals with post–COVID-19 active temporal lobe epilepsy.".
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Neuroimmune activation in temporal lobe epilepsy patients with worsening seizure following the COVID-19 pandemic: A [18F]DPA-714 PET/MR study
TSPO PET and inflammatory markers reveal spread neuroinflammation in temporal lobe epilepsy with seizure worsening after COVID-19.
www.science.org
January 30, 2026 at 7:39 PM
"Our study highlights the presence of widespread neuroinflammation in the brain and increased levels of inflammatory cytokines in the plasma of individuals with post–COVID-19 active temporal lobe epilepsy.".
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
What drives immunosenescence—the degradation of function our immune system with aging that increases the risk of age-related diseases?
Today's report: B cells are identified as the bad actors because they induce T cell (CD4) dysfunction and inflammaging
science.org/doi/10.1126/...
Today's report: B cells are identified as the bad actors because they induce T cell (CD4) dysfunction and inflammaging
science.org/doi/10.1126/...
B cells drive CD4 T cell immunosenescence and age-associated health decline
B cells promote CD4 T cell aging and decline in health-span parameters through intercellular communication and nutrient sensing.
science.org
January 30, 2026 at 7:34 PM
What drives immunosenescence—the degradation of function our immune system with aging that increases the risk of age-related diseases?
Today's report: B cells are identified as the bad actors because they induce T cell (CD4) dysfunction and inflammaging
science.org/doi/10.1126/...
Today's report: B cells are identified as the bad actors because they induce T cell (CD4) dysfunction and inflammaging
science.org/doi/10.1126/...
"We are bearing witness to what fear can do to the health of a community"
A poignant piece @NEJM about the Minneapolis devastation
"We care for our patients because they are human beings. Our patients are being harmed. People are dying unnecessarily."
www.nejm.org/doi/full/10....
A poignant piece @NEJM about the Minneapolis devastation
"We care for our patients because they are human beings. Our patients are being harmed. People are dying unnecessarily."
www.nejm.org/doi/full/10....
January 30, 2026 at 12:21 AM
"We are bearing witness to what fear can do to the health of a community"
A poignant piece @NEJM about the Minneapolis devastation
"We care for our patients because they are human beings. Our patients are being harmed. People are dying unnecessarily."
www.nejm.org/doi/full/10....
A poignant piece @NEJM about the Minneapolis devastation
"We care for our patients because they are human beings. Our patients are being harmed. People are dying unnecessarily."
www.nejm.org/doi/full/10....
The largest randomized trial of medical A.I.
—Over 100,000 women in Sweden
—radiologist + AI vs 2 radiologists, in follow-up
—AI added led to 29% more cancer detected, 44% reduced workload, and
—Less cancer dx in subsequent 2 years, and, when found, less aggressive
thelancet.com/journals/lan...
—Over 100,000 women in Sweden
—radiologist + AI vs 2 radiologists, in follow-up
—AI added led to 29% more cancer detected, 44% reduced workload, and
—Less cancer dx in subsequent 2 years, and, when found, less aggressive
thelancet.com/journals/lan...
January 29, 2026 at 11:47 PM
The largest randomized trial of medical A.I.
—Over 100,000 women in Sweden
—radiologist + AI vs 2 radiologists, in follow-up
—AI added led to 29% more cancer detected, 44% reduced workload, and
—Less cancer dx in subsequent 2 years, and, when found, less aggressive
thelancet.com/journals/lan...
—Over 100,000 women in Sweden
—radiologist + AI vs 2 radiologists, in follow-up
—AI added led to 29% more cancer detected, 44% reduced workload, and
—Less cancer dx in subsequent 2 years, and, when found, less aggressive
thelancet.com/journals/lan...
Discovery of an entirely new potential approach to atherosclerotic heart disease: targeted immunotherapy!
Studies in human coronary arteries to reduce plaque and the mouse experimental model. Another win for spatial multiomics @science.org
www.science.org/doi/10.1126/...
Studies in human coronary arteries to reduce plaque and the mouse experimental model. Another win for spatial multiomics @science.org
www.science.org/doi/10.1126/...
Targeting modulated vascular smooth muscle cells in atherosclerosis via FAP-directed immunotherapy
Vascular smooth muscle cell (VSMC) diversification drives atherosclerotic coronary artery disease (CAD). Mechanisms governing these cell state transitions remain unclear. We applied multiomic single-c...
www.science.org
January 29, 2026 at 7:12 PM
Discovery of an entirely new potential approach to atherosclerotic heart disease: targeted immunotherapy!
Studies in human coronary arteries to reduce plaque and the mouse experimental model. Another win for spatial multiomics @science.org
www.science.org/doi/10.1126/...
Studies in human coronary arteries to reduce plaque and the mouse experimental model. Another win for spatial multiomics @science.org
www.science.org/doi/10.1126/...
🆕 @science.org
Revising the heritability of lifespan, from 25% to ~50%, by correcting for extrinsic factors
science.org/doi/10.1126/...
Revising the heritability of lifespan, from 25% to ~50%, by correcting for extrinsic factors
science.org/doi/10.1126/...
January 29, 2026 at 7:04 PM
🆕 @science.org
Revising the heritability of lifespan, from 25% to ~50%, by correcting for extrinsic factors
science.org/doi/10.1126/...
Revising the heritability of lifespan, from 25% to ~50%, by correcting for extrinsic factors
science.org/doi/10.1126/...
More on this under-appreciated evidence of risk
erictopol.substack.com/p/the-lowdow...
erictopol.substack.com/p/the-lowdow...
The Lowdown on Low-Dose Aspirin for Primary Prevention
Pivotal Randomized Trials and Guidelines
erictopol.substack.com
January 29, 2026 at 4:37 PM
More on this under-appreciated evidence of risk
erictopol.substack.com/p/the-lowdow...
erictopol.substack.com/p/the-lowdow...
In follow-up of a randomized trial of low-dose aspirin in >19,000 older adults, cancer was not prevented and mortality related to cancer was increased
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
January 29, 2026 at 4:16 PM
In follow-up of a randomized trial of low-dose aspirin in >19,000 older adults, cancer was not prevented and mortality related to cancer was increased
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
How much exercise is needed? Any is a step forward for promoting health
www.nature.com/articles/d41...
www.nature.com/articles/d41...
January 28, 2026 at 4:23 PM
How much exercise is needed? Any is a step forward for promoting health
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Today @nature.com, it's #AlphaGenome, to decipher and determine functionality of the regulatory (very challenging) variants in our genome.
Another big step of AI for advancing life science
nature.com/articles/s41...
Another big step of AI for advancing life science
nature.com/articles/s41...
January 28, 2026 at 4:19 PM
Today @nature.com, it's #AlphaGenome, to decipher and determine functionality of the regulatory (very challenging) variants in our genome.
Another big step of AI for advancing life science
nature.com/articles/s41...
Another big step of AI for advancing life science
nature.com/articles/s41...
24 one-liners for promoting health www.nytimes.com/interactive/...
24 Tips for Better Health and Wellness (Gift Article)
We asked doctors, therapists and other experts to sum up their best advice in a few memorable words.
www.nytimes.com
January 28, 2026 at 3:55 PM
24 one-liners for promoting health www.nytimes.com/interactive/...
First evidence that healthy donor fecal microbiota transplant, added to immunotherapy, can enhance efficacy vs cancer
3 clinical trial reports (renal, small cell lung, melanoma)
nature.com/articles/s41...
nature.com/articles/s41...
nature.com/articles/s41...
Holy 💩!
3 clinical trial reports (renal, small cell lung, melanoma)
nature.com/articles/s41...
nature.com/articles/s41...
nature.com/articles/s41...
Holy 💩!
Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial - Nature Medicine
In a phase 2 trial evaluating healthy donor fecal microbial transplantation plus either anti-PD-1 in patients with non-small cell lung cancer or anti-PD-1 and anti-CTLA-4 in patients with melanoma, en...
nature.com
January 28, 2026 at 3:31 PM
First evidence that healthy donor fecal microbiota transplant, added to immunotherapy, can enhance efficacy vs cancer
3 clinical trial reports (renal, small cell lung, melanoma)
nature.com/articles/s41...
nature.com/articles/s41...
nature.com/articles/s41...
Holy 💩!
3 clinical trial reports (renal, small cell lung, melanoma)
nature.com/articles/s41...
nature.com/articles/s41...
nature.com/articles/s41...
Holy 💩!
Facts on peptides
erictopol.substack.com/p/the-peptid...
erictopol.substack.com/p/the-peptid...
The Peptide Craze
The Surge in Use of Off-Label and Non-FDA Approved Peptides
erictopol.substack.com
January 27, 2026 at 5:22 PM
Facts on peptides
erictopol.substack.com/p/the-peptid...
erictopol.substack.com/p/the-peptid...