James Pirruccello 🌉
@jamespirruccello.com
AI slop (except one) enjoyer
Interesting paper using genomic language models to assist with discovery. But not immediately obvious from a statistical standpoint that this should do much beyond a standard GWAS (barring close-proximity epistasis)—or that the gene-level analysis (stage 3) would beat MAGMA (not compared).
February 11, 2026 at 6:53 AM
Interesting paper using genomic language models to assist with discovery. But not immediately obvious from a statistical standpoint that this should do much beyond a standard GWAS (barring close-proximity epistasis)—or that the gene-level analysis (stage 3) would beat MAGMA (not compared).
RIP to MGH’s John D Goodson. He was the platonic ideal of a PCP and a shining example to those of us who trained there.
February 10, 2026 at 4:04 PM
RIP to MGH’s John D Goodson. He was the platonic ideal of a PCP and a shining example to those of us who trained there.
All of my banger Olympic tweets are currently in limbo while I seek out the express written consent of the International Olympic Committee.
February 10, 2026 at 3:59 AM
All of my banger Olympic tweets are currently in limbo while I seek out the express written consent of the International Olympic Committee.
Bad Bunny got a bunch of post-graduate educated people talking about the legal status of Puerto Rico and I think that is magnificent.
February 9, 2026 at 6:13 AM
Bad Bunny got a bunch of post-graduate educated people talking about the legal status of Puerto Rico and I think that is magnificent.
Is the NFL blaring fog horns or are those real fog horns because of all the fog that I see rolling in all around me?
February 9, 2026 at 12:41 AM
Is the NFL blaring fog horns or are those real fog horns because of all the fog that I see rolling in all around me?
About to turn on the air conditioning in San Francisco.
February 8, 2026 at 9:34 PM
About to turn on the air conditioning in San Francisco.
Cooking up one spaghetto
February 8, 2026 at 12:07 AM
Cooking up one spaghetto
Reposted by James Pirruccello 🌉
For both #RareDisease month and #MarfanSyndrome awareness month, I thought I'd share this article I wrote for the @ahajournals.bsky.social about being a patient-scientist working on developing genetic therapies for my condition and related conditions.
February 7, 2026 at 8:26 PM
For both #RareDisease month and #MarfanSyndrome awareness month, I thought I'd share this article I wrote for the @ahajournals.bsky.social about being a patient-scientist working on developing genetic therapies for my condition and related conditions.
My ride to work this morning
February 7, 2026 at 5:19 AM
My ride to work this morning
Can we discuss how the "opera" in Tenet was very clearly an orchestral concert, not an opera?
February 7, 2026 at 4:08 AM
Can we discuss how the "opera" in Tenet was very clearly an orchestral concert, not an opera?
Inside of you there are two wolves:
February 7, 2026 at 2:56 AM
Inside of you there are two wolves:
Reposted by James Pirruccello 🌉
Publication in Circulation. #UCSFCardiology Drs. Javid Moslehi and Amir Munir generated a new preclinical model of Immune Checkpoint Inhibitor myocarditis and identified cardiac CXCR6+ T-cells as a key pathogenic mediator of the disease.
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
CXCR6+ T Cells Drive Immune Checkpoint Inhibitor Myocarditis | Circulation
BACKGROUND: Myocarditis is a severe complication of immune checkpoint inhibitors (ICIs). The major
risk factor for ICI myocarditis is the use of combination ICI treatment, especially
when relatlimab, ...
www.ahajournals.org
February 5, 2026 at 8:08 PM
Publication in Circulation. #UCSFCardiology Drs. Javid Moslehi and Amir Munir generated a new preclinical model of Immune Checkpoint Inhibitor myocarditis and identified cardiac CXCR6+ T-cells as a key pathogenic mediator of the disease.
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
Constitutional amendment to ban political fundraising text messages. Who is working on this?
February 4, 2026 at 5:31 PM
Constitutional amendment to ban political fundraising text messages. Who is working on this?
Sunset from Twin Peaks today. Nice Super Bowl weather.
February 4, 2026 at 2:35 AM
Sunset from Twin Peaks today. Nice Super Bowl weather.
OK the nuclear helicopter thing flies incredibly low above the rooftops, TIL.
February 3, 2026 at 10:36 PM
OK the nuclear helicopter thing flies incredibly low above the rooftops, TIL.
What just blew up
February 3, 2026 at 8:29 AM
What just blew up
Congrats to a great Californian.
February 2, 2026 at 1:25 AM
Congrats to a great Californian.
Market Street. San Francisco, CA. January 30, 2026.
January 31, 2026 at 3:48 AM
Market Street. San Francisco, CA. January 30, 2026.
Some guy on Market Street just shouted "I'm walkin' here" and I had to check my GPS to make sure I was still in SF.
January 30, 2026 at 4:17 AM
Some guy on Market Street just shouted "I'm walkin' here" and I had to check my GPS to make sure I was still in SF.
Say what you will about the 'no free lunch' theorem, but at least it implies lunch.
January 29, 2026 at 8:10 AM
Say what you will about the 'no free lunch' theorem, but at least it implies lunch.
You may have abandoned the gold standard, but the gold standard hasn't abandoned you.
January 29, 2026 at 7:41 AM
You may have abandoned the gold standard, but the gold standard hasn't abandoned you.