James Pirruccello 🌉
@jamespirruccello.com
AI slop (except one) enjoyer
Soft launching a new conspiracy theory that PG&E's outages have all secretly been on purpose, because their execs read too much Yudkowsky.
Yeesh, much earlier and bigger than the scope of the upcoming planned outage:
December 29, 2025 at 4:30 AM
Soft launching a new conspiracy theory that PG&E's outages have all secretly been on purpose, because their execs read too much Yudkowsky.
Elder rich horror
December 27, 2025 at 5:08 AM
Elder rich horror
Mr. Worldwide? You mean Santa Claus?
December 25, 2025 at 6:52 AM
Mr. Worldwide? You mean Santa Claus?
Nice little Yuletide fire in the CVRI lobby today
December 23, 2025 at 3:26 AM
Nice little Yuletide fire in the CVRI lobby today
Power is back!
December 21, 2025 at 4:39 AM
Power is back!
TIL that 125k people out of 825k people is 2.2%, not the 15% that I mistakenly had believed. Thank you, PG&E.
December 20, 2025 at 11:24 PM
TIL that 125k people out of 825k people is 2.2%, not the 15% that I mistakenly had believed. Thank you, PG&E.
Marked safe ✅ from even perceiving the earthquake.
December 20, 2025 at 3:55 AM
Marked safe ✅ from even perceiving the earthquake.
We did a deep dive into aortic stenosis genetics, and took first steps to understand the genetics behind normal human variation in flow across the aortic valve.
We’re excited to share our new Nature Genetics paper examining the genetic architecture of aortic valve function and aortic stenosis. We used deep learning of cardiac MRI and MTAG to study disease biology long before clinical diagnosis.
nature.com/articles/s41...
1/10
nature.com/articles/s41...
1/10
December 19, 2025 at 11:11 PM
We did a deep dive into aortic stenosis genetics, and took first steps to understand the genetics behind normal human variation in flow across the aortic valve.
Reposted by James Pirruccello 🌉
Please also check out the excellent AS GWAS from @broadinstitute.org friends and colleagues @aeronsmall.bsky.social and @pnatarajanmd.bsky.social, published concurrently in Nature Genetics. Their work provides impressive insights into the genetic architecture of AS
nature.com/articles/s41...
10/10
nature.com/articles/s41...
10/10
Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction - Nature Genetics
Multi-ancestry genome-wide and transcriptome-wide association studies of aortic stenosis identify more than 200 independent risk loci and provide insights into its genetic architecture.
nature.com
December 19, 2025 at 7:51 PM
Please also check out the excellent AS GWAS from @broadinstitute.org friends and colleagues @aeronsmall.bsky.social and @pnatarajanmd.bsky.social, published concurrently in Nature Genetics. Their work provides impressive insights into the genetic architecture of AS
nature.com/articles/s41...
10/10
nature.com/articles/s41...
10/10
Reposted by James Pirruccello 🌉
We’re excited to share our new Nature Genetics paper examining the genetic architecture of aortic valve function and aortic stenosis. We used deep learning of cardiac MRI and MTAG to study disease biology long before clinical diagnosis.
nature.com/articles/s41...
1/10
nature.com/articles/s41...
1/10
December 19, 2025 at 7:51 PM
We’re excited to share our new Nature Genetics paper examining the genetic architecture of aortic valve function and aortic stenosis. We used deep learning of cardiac MRI and MTAG to study disease biology long before clinical diagnosis.
nature.com/articles/s41...
1/10
nature.com/articles/s41...
1/10
glad cow disease
December 19, 2025 at 1:23 AM
glad cow disease
It’s always nice to see the markets green and having a good time.
December 18, 2025 at 4:48 AM
It’s always nice to see the markets green and having a good time.
Reposted by James Pirruccello 🌉
california is the america of america, you might even say
December 16, 2025 at 6:15 PM
california is the america of america, you might even say
Fire near Dolores Park
December 16, 2025 at 12:37 AM
Fire near Dolores Park
People who don’t create useful commit messages: why?
December 14, 2025 at 7:05 PM
People who don’t create useful commit messages: why?
Reposted by James Pirruccello 🌉
We explore a bunch of alternative models in the paper, but our main conclusion is that nearly all recessive genes have small (quantitative) effects in heterozygotes, and this is actually the main target of selection.
December 13, 2025 at 4:45 PM
We explore a bunch of alternative models in the paper, but our main conclusion is that nearly all recessive genes have small (quantitative) effects in heterozygotes, and this is actually the main target of selection.
What goes on here?
December 13, 2025 at 3:40 AM
What goes on here?
New AWS outage explainer: your zone was unexpectedly deorbited.
The heat dispersal part is so funny. They think space means free cooling.
December 11, 2025 at 7:14 PM
New AWS outage explainer: your zone was unexpectedly deorbited.
Every single academic who has preprinted anything in the past year got this email from UChicago. I was so skeptical that I actually contacted the University of Chicago IRB, which indeed confirmed that they had (to paraphrase) approved spamming every academic.
1/2 I was asked to review an AI summary of a paper I'd published. It was part of a research project into the application of AI to research. The summary was not particularly good summary of the introduction and abstract. I was then asked to review 5 hypotheses generated by AI.
#AIscience
#AIscience
December 11, 2025 at 5:30 PM
Every single academic who has preprinted anything in the past year got this email from UChicago. I was so skeptical that I actually contacted the University of Chicago IRB, which indeed confirmed that they had (to paraphrase) approved spamming every academic.
SHapley Additive Reasoning Traces
December 10, 2025 at 7:59 PM
SHapley Additive Reasoning Traces