Raquel Fueyo
@fueyoraquel.bsky.social
Group Leader at Max Planck Institute of Molecular Genetics
https://www.molgen.mpg.de/fueyo-lab
Gene regulation | Transposons | Human embryo development
https://www.molgen.mpg.de/fueyo-lab
Gene regulation | Transposons | Human embryo development
Pinned
Raquel Fueyo
@fueyoraquel.bsky.social
· Oct 1
A human-specific regulatory mechanism revealed in a pre-implantation model
Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.
rdcu.be
Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Reposted by Raquel Fueyo
Ever notice that when one gene is disrupted, its orthologs get upregulated? This phenomenon, known as transcriptional adaptation, has been controversial and mysterious - glad to see that we are starting to learn how it works.
Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation
Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...
www.science.org
February 13, 2026 at 9:42 PM
Ever notice that when one gene is disrupted, its orthologs get upregulated? This phenomenon, known as transcriptional adaptation, has been controversial and mysterious - glad to see that we are starting to learn how it works.
Reposted by Raquel Fueyo
New Year, New Paper!🎊
Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
www.biorxiv.org/content/10.6...
Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!🧵
Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
www.biorxiv.org/content/10.6...
Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!🧵
Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
Transposable elements (TEs) make up about half of the human and mouse genomes and play important regulatory roles in immune responses. However, the cis -regulatory contribution of TEs to immune cell d...
www.biorxiv.org
January 7, 2026 at 7:45 PM
New Year, New Paper!🎊
Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
www.biorxiv.org/content/10.6...
Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!🧵
Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
www.biorxiv.org/content/10.6...
Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!🧵
Reposted by Raquel Fueyo
🚨New paper from our team on our favorite sex locus ANTSR! 🚨New collaboration with @hugodarras.bsky.social , led by our talented @chuanxinyu.bsky.social, we show that ants, bees and stinging wasps share an ancient sex locus, a suspicion we had when we first found the locus in the Argentine ants!
New work from @miyapan.bsky.social and our team, bringing ant, bee, and wasp labs together. @chuanxinyu.bsky.social shows that the ANTSR locus we discovered in ants has determined sex for 150+ My across bees and stinging wasps 🐜🐝, despite virtually no sequence conservation 😮 doi.org/10.1073/pnas...
January 6, 2026 at 5:18 AM
🚨New paper from our team on our favorite sex locus ANTSR! 🚨New collaboration with @hugodarras.bsky.social , led by our talented @chuanxinyu.bsky.social, we show that ants, bees and stinging wasps share an ancient sex locus, a suspicion we had when we first found the locus in the Argentine ants!
Reposted by Raquel Fueyo
Happy to begin the year with the publication of a Journal Club article - Programmed ‘DNA splicing’ removes transposons from genes.
rdcu.be/eXBym
rdcu.be/eXBym
Programmed ‘DNA splicing’ removes transposons from genes
Nature Reviews Molecular Cell Biology - A study that showed that programmed DNA elimination in somatic genomes of ciliates involves excision of intrusive, transposon-derived sequences from genes.
rdcu.be
January 5, 2026 at 2:07 PM
Happy to begin the year with the publication of a Journal Club article - Programmed ‘DNA splicing’ removes transposons from genes.
rdcu.be/eXBym
rdcu.be/eXBym
Don't miss this great opportunity!
📢 LAST CALL! Celebrate the New Year by applying for one of our #PhD projects & #IMPRS-BAC #gradschool until Jan 7th, 2026!
👉 www.molgen.mpg.de/IMPRS/applic...
👉 www.molgen.mpg.de/IMPRS/applic...
January 3, 2026 at 4:25 PM
Don't miss this great opportunity!
Reposted by Raquel Fueyo
🧠Si eres Investigador/a Postdoctoral y quieres incorporarte a nuestro lab #Parkinson #Metabolism #Mitochondria
- 5 años desde la lectura de tesis.
- 1 año de estancia internacional.
⚠️Contrato postdoctoral de 3 años con estabilización.
Contáctame: pgonzalez4@us.es
📍IBiS, Sevilla
- 5 años desde la lectura de tesis.
- 1 año de estancia internacional.
⚠️Contrato postdoctoral de 3 años con estabilización.
Contáctame: pgonzalez4@us.es
📍IBiS, Sevilla
January 3, 2026 at 2:05 PM
🧠Si eres Investigador/a Postdoctoral y quieres incorporarte a nuestro lab #Parkinson #Metabolism #Mitochondria
- 5 años desde la lectura de tesis.
- 1 año de estancia internacional.
⚠️Contrato postdoctoral de 3 años con estabilización.
Contáctame: pgonzalez4@us.es
📍IBiS, Sevilla
- 5 años desde la lectura de tesis.
- 1 año de estancia internacional.
⚠️Contrato postdoctoral de 3 años con estabilización.
Contáctame: pgonzalez4@us.es
📍IBiS, Sevilla
Reposted by Raquel Fueyo
Open Senior Bioinformatician position at
@sangerinstitute.bsky.social
Tree of Life, to work on the Biodiversity Cell Atlas initiative with @marakat.bsky.social and me.
📅 Apply by January 18
🔗 sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Please share with anyone who might be interested!
@sangerinstitute.bsky.social
Tree of Life, to work on the Biodiversity Cell Atlas initiative with @marakat.bsky.social and me.
📅 Apply by January 18
🔗 sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Please share with anyone who might be interested!
Senior Bioinformatician - Biodiversity Cell Atlas
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
sanger.wd103.myworkdayjobs.com
January 2, 2026 at 1:12 PM
Open Senior Bioinformatician position at
@sangerinstitute.bsky.social
Tree of Life, to work on the Biodiversity Cell Atlas initiative with @marakat.bsky.social and me.
📅 Apply by January 18
🔗 sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Please share with anyone who might be interested!
@sangerinstitute.bsky.social
Tree of Life, to work on the Biodiversity Cell Atlas initiative with @marakat.bsky.social and me.
📅 Apply by January 18
🔗 sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Please share with anyone who might be interested!
Reposted by Raquel Fueyo
I’m so excited to share that I’ve accepted an assistant professor position at the University of Colorado Anschutz, BMG department and Barbara Davis Diabetes center! I’m so grateful to many who have helped me get here, especially mentors at Joslin, @hmsbpa.bsky.social @leadingedgeprogram.bsky.social
December 19, 2025 at 11:08 PM
I’m so excited to share that I’ve accepted an assistant professor position at the University of Colorado Anschutz, BMG department and Barbara Davis Diabetes center! I’m so grateful to many who have helped me get here, especially mentors at Joslin, @hmsbpa.bsky.social @leadingedgeprogram.bsky.social
Reposted by Raquel Fueyo
🚨 Postdoc opportunity!
If you’re interested in applying for a postdoctoral contract in #Neuroscience, #BrainEnergyMetabolism & #ParkinsonsDisease, email me: pgonzalez4@us.es
🔗 lajunta.es/6697y
If you’re interested in applying for a postdoctoral contract in #Neuroscience, #BrainEnergyMetabolism & #ParkinsonsDisease, email me: pgonzalez4@us.es
🔗 lajunta.es/6697y
La Junta convoca ayudas por valor de 9,01M€ para contratar a 65 investigadores doctores
- Esta línea de incentivos incluye el compromiso de las universidades de crear una plaza con el mismo perfil de la ayuda concedida
lajunta.es
December 24, 2025 at 12:19 AM
🚨 Postdoc opportunity!
If you’re interested in applying for a postdoctoral contract in #Neuroscience, #BrainEnergyMetabolism & #ParkinsonsDisease, email me: pgonzalez4@us.es
🔗 lajunta.es/6697y
If you’re interested in applying for a postdoctoral contract in #Neuroscience, #BrainEnergyMetabolism & #ParkinsonsDisease, email me: pgonzalez4@us.es
🔗 lajunta.es/6697y
Reposted by Raquel Fueyo
🧬 Are you interested in synthetic biology, CRISPR-Cas9 genome editing and cutting-edge genomics? Apply by 07.01.2026 to join Stefan Mundlos’ lab @stemundi.bsky.social at the MPIMG. #IMPRS-BAC #gradschool! @nataliabenetti.bsky.social
👉 www.molgen.mpg.de/5124667/Mund...
👉 www.molgen.mpg.de/5124667/Mund...
December 11, 2025 at 2:07 PM
🧬 Are you interested in synthetic biology, CRISPR-Cas9 genome editing and cutting-edge genomics? Apply by 07.01.2026 to join Stefan Mundlos’ lab @stemundi.bsky.social at the MPIMG. #IMPRS-BAC #gradschool! @nataliabenetti.bsky.social
👉 www.molgen.mpg.de/5124667/Mund...
👉 www.molgen.mpg.de/5124667/Mund...
Reposted by Raquel Fueyo
Very happy that this part of my postdoc work is now out as a preprint!! Our findings reveal a new mechanism by which retroviral pandemics may have shaped primate brain evolution 🧬🐒🧠 This was a true team effort! w/ @ofeliakarlsson.bsky.social @raquelgarza.bsky.social @jakobssonlab.bsky.social #TEsky
New preprint from our lab: ‘Retroviral insertions contributed to the divergence of human and chimpanzee brains’. Very proud of this piece which took almost a decade to finish.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Retroviral insertions contributed to the divergence of human and chimpanzee brains
Over the past 5 to 7 million years, humans and chimpanzees have diverged in brain size, structural complexity, and cognitive abilities despite high conservation of protein-coding genes. Notably, the e...
www.biorxiv.org
December 14, 2025 at 10:10 PM
Very happy that this part of my postdoc work is now out as a preprint!! Our findings reveal a new mechanism by which retroviral pandemics may have shaped primate brain evolution 🧬🐒🧠 This was a true team effort! w/ @ofeliakarlsson.bsky.social @raquelgarza.bsky.social @jakobssonlab.bsky.social #TEsky
Reposted by Raquel Fueyo
Excited to co-organize with @weieli.bsky.social a symposium at SMBE 2026 on how synthetic & systems biology can illuminate the molecular mechanisms of evolution. Honored to have @christianlandry.bsky.social as invited speaker! Join us!
SMBE2026 Symposium 6 | Synthetic and systems biology approaches to dissecting the molecular mechanisms of evolution
📨 Abstract submission
smbe2026.org/abstracts
📋 Programme details
smbe2026.org/programme
#SMBE2026
📨 Abstract submission
smbe2026.org/abstracts
📋 Programme details
smbe2026.org/programme
#SMBE2026
December 5, 2025 at 11:16 PM
Excited to co-organize with @weieli.bsky.social a symposium at SMBE 2026 on how synthetic & systems biology can illuminate the molecular mechanisms of evolution. Honored to have @christianlandry.bsky.social as invited speaker! Join us!
Reposted by Raquel Fueyo
We are excited to share our new preprint:
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
December 3, 2025 at 6:53 PM
We are excited to share our new preprint:
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
Reposted by Raquel Fueyo
Tomorrow (Thursday) at the Systems Virology Journal Club, Noor Youssef will present her work with Debbie Marks on developing an AI model that predicts how viruses evolve to evade the immune response.
Paper: pubmed.ncbi.nlm.nih.gov/40345199/
Paper: pubmed.ncbi.nlm.nih.gov/40345199/
🚨 Systems Virology Journal Club – 8th Series! 🚨
#BillSchneider and I are delighted to announce another round of cutting-edge talks in #SystemsVirology! 🦠💡
Join us and an outstanding lineup of speakers, starting Oct 30.
Free registration: shiraweingartengabbay.com/systems-viro... 🔬✨
#BillSchneider and I are delighted to announce another round of cutting-edge talks in #SystemsVirology! 🦠💡
Join us and an outstanding lineup of speakers, starting Oct 30.
Free registration: shiraweingartengabbay.com/systems-viro... 🔬✨
December 4, 2025 at 2:18 AM
Tomorrow (Thursday) at the Systems Virology Journal Club, Noor Youssef will present her work with Debbie Marks on developing an AI model that predicts how viruses evolve to evade the immune response.
Paper: pubmed.ncbi.nlm.nih.gov/40345199/
Paper: pubmed.ncbi.nlm.nih.gov/40345199/
Reposted by Raquel Fueyo
The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.
November 30, 2025 at 2:36 PM
The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.
The IMPRS-BAC is an outstanding PhD program in Europe. And the endogenous retroviruses in development... what can I say? So much exciting biology to uncover! 🦠🧬#TEsky #StemCells
Read the instructions and apply! ⬇️⬇️⬇️
Read the instructions and apply! ⬇️⬇️⬇️
Want to analyze the role of endogenous retroviruses in early human development or investigate their regulation in pluripotency and early development for your PhD?
Join the lab of @fueyoraquel.bsky.social via the IMPRS-BAC #gradschool!
👉 www.molgen.mpg.de/5094682/Fuey...
Join the lab of @fueyoraquel.bsky.social via the IMPRS-BAC #gradschool!
👉 www.molgen.mpg.de/5094682/Fuey...
November 28, 2025 at 10:00 AM
The IMPRS-BAC is an outstanding PhD program in Europe. And the endogenous retroviruses in development... what can I say? So much exciting biology to uncover! 🦠🧬#TEsky #StemCells
Read the instructions and apply! ⬇️⬇️⬇️
Read the instructions and apply! ⬇️⬇️⬇️
Reposted by Raquel Fueyo
🔬 Hot #PhD topic: Single-molecule fluorescence and super-resolution microscopy! Use quantitative nanoscale imaging to map nuclear organization. Apply by Jan 7 to join Johannes Stein’s Lab @jmstein.bsky.social & #IMPRS-BAC #gradschool!
👉 www.molgen.mpg.de/5098010/stei...
👉 www.molgen.mpg.de/5098010/stei...
November 25, 2025 at 2:18 PM
🔬 Hot #PhD topic: Single-molecule fluorescence and super-resolution microscopy! Use quantitative nanoscale imaging to map nuclear organization. Apply by Jan 7 to join Johannes Stein’s Lab @jmstein.bsky.social & #IMPRS-BAC #gradschool!
👉 www.molgen.mpg.de/5098010/stei...
👉 www.molgen.mpg.de/5098010/stei...
Reposted by Raquel Fueyo
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
November 24, 2025 at 1:03 PM
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
Reposted by Raquel Fueyo
We are excited to participate this year again in the VBC summer school! If you want to work with me and my amazing student Maria, apply!
The Vienna BioCenter Summer School 2026 call is now open for talented undergrads, it's a great opportunity for students who are interested in graduate study in the life sciences. Christa Buecker from Max Perutz Labs Vienna is recruiting! Please share
https://training.vbc.ac.at/summer-school/
https://training.vbc.ac.at/summer-school/
November 21, 2025 at 3:36 PM
We are excited to participate this year again in the VBC summer school! If you want to work with me and my amazing student Maria, apply!
Reposted by Raquel Fueyo
It's always special when you find your own paper in the table of contents of the journal 😍
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
November 18, 2025 at 4:11 PM
It's always special when you find your own paper in the table of contents of the journal 😍
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
Reposted by Raquel Fueyo
IMPRS-BAC #gradschool: Our new groupleader @sedonamurphy.bsky.social has an open PhD project in her lab. Topic: Spatial feedback between epigenetic regulation and chromatin regulation. Apply by Jan 7, 2026!
👉 www.molgen.mpg.de/5091778/Murp...
👉 www.molgen.mpg.de/5091778/Murp...
November 18, 2025 at 4:05 PM
IMPRS-BAC #gradschool: Our new groupleader @sedonamurphy.bsky.social has an open PhD project in her lab. Topic: Spatial feedback between epigenetic regulation and chromatin regulation. Apply by Jan 7, 2026!
👉 www.molgen.mpg.de/5091778/Murp...
👉 www.molgen.mpg.de/5091778/Murp...
Reposted by Raquel Fueyo
Thrilled to share our new review in Current Opinion in Genetics & Development on TE driven innovation in gene regulation🤘. I am honored to be part of this with two major TE aficionados @cedricfeschotte.bsky.social and @trono-lab.bsky.social
#TEsky #TEworldwide
authors.elsevier.com/c/1m6MC,LqAZ...
#TEsky #TEworldwide
authors.elsevier.com/c/1m6MC,LqAZ...
November 15, 2025 at 5:23 PM
Thrilled to share our new review in Current Opinion in Genetics & Development on TE driven innovation in gene regulation🤘. I am honored to be part of this with two major TE aficionados @cedricfeschotte.bsky.social and @trono-lab.bsky.social
#TEsky #TEworldwide
authors.elsevier.com/c/1m6MC,LqAZ...
#TEsky #TEworldwide
authors.elsevier.com/c/1m6MC,LqAZ...
Reposted by Raquel Fueyo
📣 SAVE THE DATE
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
November 17, 2025 at 11:39 AM
📣 SAVE THE DATE
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
Reposted by Raquel Fueyo
Happy to share our paper now out in @cp-cellreports.bsky.social - and check out our thread about the findings at bsky.app/profile/vale...
In vivo differentiation of embryonic cells devoid of key reprogramming factors
In vivo differentiation of embryonic cells devoid of key reprogramming factors
Youlten, Miao et al. use zebrafish transplantation to understand the fate of cells lacking pluripotency factors Nanog, Pou5f3, and Sox19b (NPS) in developmental reprogramming and cell identity establishment. They found that NPS are required for proper cell identity for most, but not all, lineages, likely through nuclear and cytoplasmic reprogramming.
dlvr.it
November 13, 2025 at 12:34 AM
Happy to share our paper now out in @cp-cellreports.bsky.social - and check out our thread about the findings at bsky.app/profile/vale...