Olga Rosspopoff, PhD
@orpsf.bsky.social
postdoc @trono-lab.bsky.social at EPFL🇨🇭// Future PI at @igbmc.bsky.social 🇫🇷 // Fascinated in transposons 🤘 and embryogenesis 👶
Future Lab: https://orspf.github.io/Rosspopoff.Lab.io/
Future Lab: https://orspf.github.io/Rosspopoff.Lab.io/
Pinned
Olga Rosspopoff, PhD
@orpsf.bsky.social
· Nov 15
Thrilled to share our new review in Current Opinion in Genetics & Development on TE driven innovation in gene regulation🤘. I am honored to be part of this with two major TE aficionados @cedricfeschotte.bsky.social and @trono-lab.bsky.social
#TEsky #TEworldwide
authors.elsevier.com/c/1m6MC,LqAZ...
#TEsky #TEworldwide
authors.elsevier.com/c/1m6MC,LqAZ...
Reposted by Olga Rosspopoff, PhD
This is the equivalent of Jesus on a toast for developmental biologists 🧪
September 16, 2025 at 3:00 PM
This is the equivalent of Jesus on a toast for developmental biologists 🧪
Reposted by Olga Rosspopoff, PhD
Christmas has come early. Fantastic to see this beautiful study from Peter Rugg-Gunn's lab at The Babraham Institute published today. Congratulations to Matteo Mole, Sarah Elderkin, Irene Zorzan and all other authors!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Modeling human embryo implantation in vitro
Building an in vitro model of receptive endometrium allows investigation of human
embryo implantation and early post-implantation development and recapitulates the
earliest stages in establishing the ...
www.cell.com
December 23, 2025 at 3:55 PM
Christmas has come early. Fantastic to see this beautiful study from Peter Rugg-Gunn's lab at The Babraham Institute published today. Congratulations to Matteo Mole, Sarah Elderkin, Irene Zorzan and all other authors!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Olga Rosspopoff, PhD
🚨Our story is published! Same bones but + dissection of MERVL’s role integrating signals from #ZGA factors, & + about pathological DUX4 activation of NOXA #TEsky. Thanks to all revs for their helpful comments improving the ms. Even #rev3 - until they ghosted us 😜
www.science.org/doi/epdf/10....
www.science.org/doi/epdf/10....
December 22, 2025 at 12:32 PM
🚨Our story is published! Same bones but + dissection of MERVL’s role integrating signals from #ZGA factors, & + about pathological DUX4 activation of NOXA #TEsky. Thanks to all revs for their helpful comments improving the ms. Even #rev3 - until they ghosted us 😜
www.science.org/doi/epdf/10....
www.science.org/doi/epdf/10....
Reposted by Olga Rosspopoff, PhD
🚨 New paper out!
A human epiblast model reveals how dynamic TGF‑β signalling controls epithelial identity in early mammalian development
Here is the full paper: rdcu.be/eSWEs
🧵 A twittorial:
THREAD
A human epiblast model reveals how dynamic TGF‑β signalling controls epithelial identity in early mammalian development
Here is the full paper: rdcu.be/eSWEs
🧵 A twittorial:
THREAD
A human epiblast model reveals dynamic TGFβ-mediated control of epithelial identity during mammalian epiblast development
Nature Cell Biology - The authors optimize an in vitro human epiblast model, which they utilize to show that early TGFβ family inhibition prevents epithelial identity, whereas it is...
rdcu.be
December 11, 2025 at 1:32 PM
🚨 New paper out!
A human epiblast model reveals how dynamic TGF‑β signalling controls epithelial identity in early mammalian development
Here is the full paper: rdcu.be/eSWEs
🧵 A twittorial:
THREAD
A human epiblast model reveals how dynamic TGF‑β signalling controls epithelial identity in early mammalian development
Here is the full paper: rdcu.be/eSWEs
🧵 A twittorial:
THREAD
Reposted by Olga Rosspopoff, PhD
Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
Escape from X inactivation is directly modulated by Xist noncoding RNA
Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...
rdcu.be
December 15, 2025 at 4:22 PM
Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
Reposted by Olga Rosspopoff, PhD
Join us for the 2026 Glycolipid & Sphingolipid Biology Gordon Research Conference (GRC).
📍 Renaissance Tuscany Il Ciocco (Italy)
🗓️ March 22 - 27, 2026
Theme: "Molecular Codes of Cell Identity and Recognition"
#LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime
📍 Renaissance Tuscany Il Ciocco (Italy)
🗓️ March 22 - 27, 2026
Theme: "Molecular Codes of Cell Identity and Recognition"
#LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime
December 19, 2025 at 9:09 AM
Join us for the 2026 Glycolipid & Sphingolipid Biology Gordon Research Conference (GRC).
📍 Renaissance Tuscany Il Ciocco (Italy)
🗓️ March 22 - 27, 2026
Theme: "Molecular Codes of Cell Identity and Recognition"
#LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime
📍 Renaissance Tuscany Il Ciocco (Italy)
🗓️ March 22 - 27, 2026
Theme: "Molecular Codes of Cell Identity and Recognition"
#LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime
Reposted by Olga Rosspopoff, PhD
Attending #EMBOevoChromo25 next week? Our Reviews Editor @ingridtsang.bsky.social will be attending - feel free to talk to her about the journal or @biologists.bsky.social activities!
Learn about #chromatin and #evolution at EMBO Workshop "EvoChromo: Evolutionary approaches to research in chromatin" in Sant Feliu de Guixols, Spain, 9–12 December 2025
Deadline: 10 September 2025
meetings.embo.org/event/24-evo...
#EMBOevoChromo25 #EMBOevents 🧪
Deadline: 10 September 2025
meetings.embo.org/event/24-evo...
#EMBOevoChromo25 #EMBOevents 🧪
EvoChromo: Evolutionary approaches to research in chromatin
Chromatin is the complex of DNA, RNA and protein that is found making up the chromosomes in eukaryotic cells. Chromatin is essential for proper genome function and is involved in chromosome segregati…
meetings.embo.org
December 3, 2025 at 6:23 PM
Attending #EMBOevoChromo25 next week? Our Reviews Editor @ingridtsang.bsky.social will be attending - feel free to talk to her about the journal or @biologists.bsky.social activities!
Reposted by Olga Rosspopoff, PhD
The new issue @cp-devcell.bsky.social brings the final form of our opossum heterochrony work www.cell.com/developmenta... And it also brings two great papers from @oliveringe.bsky.social @santoslab.bsky.social and @tobyandrews.bsky.social @rashmi-priya.bsky.social 🙌 great #DevBio from @crick.ac.uk
December 2, 2025 at 11:06 AM
The new issue @cp-devcell.bsky.social brings the final form of our opossum heterochrony work www.cell.com/developmenta... And it also brings two great papers from @oliveringe.bsky.social @santoslab.bsky.social and @tobyandrews.bsky.social @rashmi-priya.bsky.social 🙌 great #DevBio from @crick.ac.uk
Reposted by Olga Rosspopoff, PhD
Happy to present TOGA2, developed by Yury Malovichko @ymalovichko.bsky.social, the faster, memory-efficient & more accurate TOGA1 successor (github.com/hillerlab/TO...). And annotations, orthologs & gene loss/dup data generated with 4 references for 883 placental mammal and with 5 refs for 676 ...
November 23, 2025 at 9:49 PM
Happy to present TOGA2, developed by Yury Malovichko @ymalovichko.bsky.social, the faster, memory-efficient & more accurate TOGA1 successor (github.com/hillerlab/TO...). And annotations, orthologs & gene loss/dup data generated with 4 references for 883 placental mammal and with 5 refs for 676 ...
Reposted by Olga Rosspopoff, PhD
Check out our latest issue where we interview Cassandra Extavour, who studies the evolution of the genetic mechanisms employed during early animal embryogenesis to specify cell fate, development, and differentiation at Harvard University. www.cell.com/current-biol...
Q & A
Interview with Cassandra Extavour, who studies the evolution of the genetic mechanisms
employed during early animal embryogenesis to specify cell fate, development, and
differentiation at Harvard Univ...
www.cell.com
November 20, 2025 at 10:34 AM
Check out our latest issue where we interview Cassandra Extavour, who studies the evolution of the genetic mechanisms employed during early animal embryogenesis to specify cell fate, development, and differentiation at Harvard University. www.cell.com/current-biol...
Reposted by Olga Rosspopoff, PhD
TE x ZFP = Evolution!
Writing this with Olga @orpsf.bsky.social & Didier @trono-lab.bsky.social was a major highlight of my 🇨🇭sabbatical. Such a treat! 🍫Hope you enjoy it as much as we enjoy piecing it together.
Writing this with Olga @orpsf.bsky.social & Didier @trono-lab.bsky.social was a major highlight of my 🇨🇭sabbatical. Such a treat! 🍫Hope you enjoy it as much as we enjoy piecing it together.
November 18, 2025 at 3:16 PM
TE x ZFP = Evolution!
Writing this with Olga @orpsf.bsky.social & Didier @trono-lab.bsky.social was a major highlight of my 🇨🇭sabbatical. Such a treat! 🍫Hope you enjoy it as much as we enjoy piecing it together.
Writing this with Olga @orpsf.bsky.social & Didier @trono-lab.bsky.social was a major highlight of my 🇨🇭sabbatical. Such a treat! 🍫Hope you enjoy it as much as we enjoy piecing it together.
Thrilled to share our new review in Current Opinion in Genetics & Development on TE driven innovation in gene regulation🤘. I am honored to be part of this with two major TE aficionados @cedricfeschotte.bsky.social and @trono-lab.bsky.social
#TEsky #TEworldwide
authors.elsevier.com/c/1m6MC,LqAZ...
#TEsky #TEworldwide
authors.elsevier.com/c/1m6MC,LqAZ...
November 15, 2025 at 5:23 PM
Thrilled to share our new review in Current Opinion in Genetics & Development on TE driven innovation in gene regulation🤘. I am honored to be part of this with two major TE aficionados @cedricfeschotte.bsky.social and @trono-lab.bsky.social
#TEsky #TEworldwide
authors.elsevier.com/c/1m6MC,LqAZ...
#TEsky #TEworldwide
authors.elsevier.com/c/1m6MC,LqAZ...
Reposted by Olga Rosspopoff, PhD
Welcome to Day 3 of #EMBOMobileGenome 🙌🏼
While this morning's session is already underway, here's a few snaps from yesterday's 🔸last minute breakthrough talk 🔸
➡️ 'Transposable element co-option drives transcription factor neofunctionalization' presented by Olga Rosspopoff (EPFL, Switzerland)
While this morning's session is already underway, here's a few snaps from yesterday's 🔸last minute breakthrough talk 🔸
➡️ 'Transposable element co-option drives transcription factor neofunctionalization' presented by Olga Rosspopoff (EPFL, Switzerland)
November 6, 2025 at 9:48 AM
Welcome to Day 3 of #EMBOMobileGenome 🙌🏼
While this morning's session is already underway, here's a few snaps from yesterday's 🔸last minute breakthrough talk 🔸
➡️ 'Transposable element co-option drives transcription factor neofunctionalization' presented by Olga Rosspopoff (EPFL, Switzerland)
While this morning's session is already underway, here's a few snaps from yesterday's 🔸last minute breakthrough talk 🔸
➡️ 'Transposable element co-option drives transcription factor neofunctionalization' presented by Olga Rosspopoff (EPFL, Switzerland)
Had an absolute blast presenting my “Last Minute Breakthrough talk” at #EMBOmobilegenome today! 🔥 What an incredible crowd, the energy in the room was unreal. Huge thanks to the organizers for selecting me and to everyone who came, asked questions, and made it such a fun session! 🙌
November 5, 2025 at 6:58 PM
Had an absolute blast presenting my “Last Minute Breakthrough talk” at #EMBOmobilegenome today! 🔥 What an incredible crowd, the energy in the room was unreal. Huge thanks to the organizers for selecting me and to everyone who came, asked questions, and made it such a fun session! 🙌
Reposted by Olga Rosspopoff, PhD
An iPSC-derived heart muscle cell assembling sarcomeres videoed through a spinning disk confocal microscope by Burnette Lab graduate student, Emma Koory. Alpha-actinin-2 is shown. Colors denote Z slices (red-bottom; green-middle; blue-top). Movie length- 40 hours.
November 4, 2025 at 6:50 PM
An iPSC-derived heart muscle cell assembling sarcomeres videoed through a spinning disk confocal microscope by Burnette Lab graduate student, Emma Koory. Alpha-actinin-2 is shown. Colors denote Z slices (red-bottom; green-middle; blue-top). Movie length- 40 hours.
Reposted by Olga Rosspopoff, PhD
Welcome to Day 1 of 'The mobile genome: genetic and physiological impacts of transposable elements'! 🧬
The opening remarks by Julius Brennecke accompanied by his fellow scientific organisers:
🔹Déborah Bourc'his
🔹Josefa González
🔹Joseph Peters
#EMBOMobileGenome
The opening remarks by Julius Brennecke accompanied by his fellow scientific organisers:
🔹Déborah Bourc'his
🔹Josefa González
🔹Joseph Peters
#EMBOMobileGenome
November 4, 2025 at 1:31 PM
Welcome to Day 1 of 'The mobile genome: genetic and physiological impacts of transposable elements'! 🧬
The opening remarks by Julius Brennecke accompanied by his fellow scientific organisers:
🔹Déborah Bourc'his
🔹Josefa González
🔹Joseph Peters
#EMBOMobileGenome
The opening remarks by Julius Brennecke accompanied by his fellow scientific organisers:
🔹Déborah Bourc'his
🔹Josefa González
🔹Joseph Peters
#EMBOMobileGenome
Reposted by Olga Rosspopoff, PhD
“The bad review will come from your list of suggested reviewers”
October 31, 2025 at 7:39 AM
“The bad review will come from your list of suggested reviewers”
Reposted by Olga Rosspopoff, PhD
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
October 28, 2025 at 8:25 AM
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
Reposted by Olga Rosspopoff, PhD
📣 New preprint! Stoked to share a fantastic collaboration with @campaslab.bsky.social!
We discover a unique mammalian mechanism for body axis elongation using mouse and human gastruloids, and confirm central findings in mouse embryos.
Check out the 🧵 👇
@mpi-cbg.de @poldresden.bsky.social
We discover a unique mammalian mechanism for body axis elongation using mouse and human gastruloids, and confirm central findings in mouse embryos.
Check out the 🧵 👇
@mpi-cbg.de @poldresden.bsky.social
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
October 28, 2025 at 3:34 PM
📣 New preprint! Stoked to share a fantastic collaboration with @campaslab.bsky.social!
We discover a unique mammalian mechanism for body axis elongation using mouse and human gastruloids, and confirm central findings in mouse embryos.
Check out the 🧵 👇
@mpi-cbg.de @poldresden.bsky.social
We discover a unique mammalian mechanism for body axis elongation using mouse and human gastruloids, and confirm central findings in mouse embryos.
Check out the 🧵 👇
@mpi-cbg.de @poldresden.bsky.social
Reposted by Olga Rosspopoff, PhD
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Olga Rosspopoff, PhD
How do embryos develop robustly despite variability in gene expression, cell properties, and tissue growth? In our new review, we explore how optimal selection of coupled parameters can contribute to robustness in development. Have a look at the article:
doi.org/10.1016/j.tc...
doi.org/10.1016/j.tc...
Redirecting
doi.org
October 10, 2025 at 8:18 AM
How do embryos develop robustly despite variability in gene expression, cell properties, and tissue growth? In our new review, we explore how optimal selection of coupled parameters can contribute to robustness in development. Have a look at the article:
doi.org/10.1016/j.tc...
doi.org/10.1016/j.tc...
Reposted by Olga Rosspopoff, PhD
🚨 New paper alert on telomeres! 🚨
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
October 9, 2025 at 5:33 AM
🚨 New paper alert on telomeres! 🚨
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
Reposted by Olga Rosspopoff, PhD
We lost another Gem of a scientist:
www.cam.ac.uk/research/new...
His work inspired so many of us, such a brilliant mind and a kind human
Apart from rewriting our fundamental understanding of cell identity, his love for science is equally legendary
www.cam.ac.uk/research/new...
His work inspired so many of us, such a brilliant mind and a kind human
Apart from rewriting our fundamental understanding of cell identity, his love for science is equally legendary
"I was the worst out of 250." John Gurdon, Nobel Prize in Physiology or Medicine 2012
YouTube video by Nobel Prize
www.youtube.com
October 8, 2025 at 5:04 PM
We lost another Gem of a scientist:
www.cam.ac.uk/research/new...
His work inspired so many of us, such a brilliant mind and a kind human
Apart from rewriting our fundamental understanding of cell identity, his love for science is equally legendary
www.cam.ac.uk/research/new...
His work inspired so many of us, such a brilliant mind and a kind human
Apart from rewriting our fundamental understanding of cell identity, his love for science is equally legendary
Reposted by Olga Rosspopoff, PhD
New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
1/
doi.org/10.1101/2025...
1/
doi.org/10.1101/2025...
October 8, 2025 at 1:05 PM
New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
1/
doi.org/10.1101/2025...
1/
doi.org/10.1101/2025...
Reposted by Olga Rosspopoff, PhD
🔬For the 2025 Fête de la Science, Institut Curie opens its doors to the public! Follow the steps of Marie Curie’s research in Paris and explore the fascinating world of biology.
⏩https://www.fetedelascience.fr/la-fete-de-la-science-2025-l-institut-curie
⏩https://www.fetedelascience.fr/la-fete-de-la-science-2025-l-institut-curie
October 1, 2025 at 1:38 PM
🔬For the 2025 Fête de la Science, Institut Curie opens its doors to the public! Follow the steps of Marie Curie’s research in Paris and explore the fascinating world of biology.
⏩https://www.fetedelascience.fr/la-fete-de-la-science-2025-l-institut-curie
⏩https://www.fetedelascience.fr/la-fete-de-la-science-2025-l-institut-curie