Guillaume Bourque
@guilbourque.bsky.social
Prof in Human Genetics at McGill, Director of Bioinformatics at the McGill Genome Center and Director of @C3Genomics
https://computationalgenomics.ca/BourqueLab/
https://computationalgenomics.ca/BourqueLab/
Exciting! Glad to see the Gold Cohort starting to get used for new discoveries!
🧬 🌐 Uncovering cancer’s hidden driver mutations through the power of the Gold Cohort 🧬 🌐
A research team led by Dr. Ian Watson will harness the power of MOHCCN's Gold Cohort to identify new mutations that may be responsible for driving cancer.
tinyurl.com/5n7c6ub8
A research team led by Dr. Ian Watson will harness the power of MOHCCN's Gold Cohort to identify new mutations that may be responsible for driving cancer.
tinyurl.com/5n7c6ub8
November 7, 2025 at 5:38 PM
Exciting! Glad to see the Gold Cohort starting to get used for new discoveries!
Reposted by Guillaume Bourque
Excited to share our preprint on the “Integrated Metabolic Complex Genetic Interaction Network of Chromosome 4p Loss in Basal Breast Cancer” led by @lynnkaram.bsky.social! www.biorxiv.org/content/10.1...
October 17, 2025 at 5:55 PM
Excited to share our preprint on the “Integrated Metabolic Complex Genetic Interaction Network of Chromosome 4p Loss in Basal Breast Cancer” led by @lynnkaram.bsky.social! www.biorxiv.org/content/10.1...
Such a great @ga4gh.org meeting in Uppsala this past week. Genomics, with the help of GA4GH standards and policies, is really moving into the Age of Implementation globally!
October 11, 2025 at 4:26 AM
Such a great @ga4gh.org meeting in Uppsala this past week. Genomics, with the help of GA4GH standards and policies, is really moving into the Age of Implementation globally!
If you’re planning to be at ASHG, you should go see the poster ⬇️
Thanks for sharing our work, @guilbourque.bsky.social!
This work will also be presented at the #ASHG2025 conference on Wednesday, October 15th, in Boston!!
My poster can be found at Board 1100W at the Thomas M. Menino Convention Center. Come and talk to me 🧬!!
This work will also be presented at the #ASHG2025 conference on Wednesday, October 15th, in Boston!!
My poster can be found at Board 1100W at the Thomas M. Menino Convention Center. Come and talk to me 🧬!!
🚨 New paper alert on telomeres! 🚨
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
October 10, 2025 at 10:33 AM
If you’re planning to be at ASHG, you should go see the poster ⬇️
Wow, great summary!
Some thoughts on the blossoming of genomic medicine stimulated by the excellent @ga4gh.org meeting in lovely Uppsala Sweden. www.linkedin.com/pulse/though...
Thoughts from Uppsala - Genomic Medicine blossoming
I have had a wonderful three days in Uppsala Sweden, at the Global Alliance for Genomics and Health plenary hosted locally by the generous SciLifeLab . It was a meeting of course focused on the standa...
www.linkedin.com
October 10, 2025 at 7:33 AM
Wow, great summary!
Reposted by Guillaume Bourque
Thanks for sharing our work, @guilbourque.bsky.social!
This work will also be presented at the #ASHG2025 conference on Wednesday, October 15th, in Boston!!
My poster can be found at Board 1100W at the Thomas M. Menino Convention Center. Come and talk to me 🧬!!
This work will also be presented at the #ASHG2025 conference on Wednesday, October 15th, in Boston!!
My poster can be found at Board 1100W at the Thomas M. Menino Convention Center. Come and talk to me 🧬!!
🚨 New paper alert on telomeres! 🚨
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
October 9, 2025 at 5:30 PM
Thanks for sharing our work, @guilbourque.bsky.social!
This work will also be presented at the #ASHG2025 conference on Wednesday, October 15th, in Boston!!
My poster can be found at Board 1100W at the Thomas M. Menino Convention Center. Come and talk to me 🧬!!
This work will also be presented at the #ASHG2025 conference on Wednesday, October 15th, in Boston!!
My poster can be found at Board 1100W at the Thomas M. Menino Convention Center. Come and talk to me 🧬!!
🚨 New paper alert on telomeres! 🚨
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
October 9, 2025 at 5:33 AM
🚨 New paper alert on telomeres! 🚨
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
So inspiring to run with Darryl Fox to support Terry’s dream and the @marathonofhope.bsky.social
September 27, 2025 at 12:52 PM
So inspiring to run with Darryl Fox to support Terry’s dream and the @marathonofhope.bsky.social
Reposted by Guillaume Bourque
Excited for the start of the Croucher Retrotransposons meeting organized by Danny Leung in Hong Kong. First speaker, the King of Krabs!
projects.croucher.org.hk/advanced-stu...
projects.croucher.org.hk/advanced-stu...
August 11, 2025 at 2:19 AM
Excited for the start of the Croucher Retrotransposons meeting organized by Danny Leung in Hong Kong. First speaker, the King of Krabs!
projects.croucher.org.hk/advanced-stu...
projects.croucher.org.hk/advanced-stu...
The issue that jumped at us in the current annotation of young LTR subfamilies in human, is that there was lot of variability in divergence rate (sometimes bimodal). That's what we tried to improve.
July 30, 2025 at 5:26 PM
The issue that jumped at us in the current annotation of young LTR subfamilies in human, is that there was lot of variability in divergence rate (sometimes bimodal). That's what we tried to improve.
Is the annotation of viruses in the human genome accurate? We think not. Take a look at our new paper and let us know if you agree! www.science.org/doi/10.1126/...
A phylogenetic approach uncovers cryptic endogenous retrovirus subfamilies in the primate lineage
A phylogenetic approach reveals cryptic LTR subfamilies and functional insights at nucleotide resolution in primates.
www.science.org
July 21, 2025 at 1:51 PM
Is the annotation of viruses in the human genome accurate? We think not. Take a look at our new paper and let us know if you agree! www.science.org/doi/10.1126/...
Reposted by Guillaume Bourque
Lentivirus massively parallel reporter assays integrate & enrich for specific sequences in the genome. We utilize this to test their epigenetic modifications & open chromatin alongside their regulatory activity. Amazing work by Zicong Zhang, Fumitaka Inoue & others.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Simultaneous epigenomic profiling and regulatory activity measurement using e2MPRA
Cis-regulatory elements (CREs) have a major effect on phenotypes including disease. They are identified in a genome-wide manner by analyzing the binding of transcription factors (TFs), various co-fact...
www.biorxiv.org
July 1, 2025 at 3:13 PM
Lentivirus massively parallel reporter assays integrate & enrich for specific sequences in the genome. We utilize this to test their epigenetic modifications & open chromatin alongside their regulatory activity. Amazing work by Zicong Zhang, Fumitaka Inoue & others.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Guillaume Bourque
The human pangenome continues to grow and improve! Release 2 is here! Click through for the details, but this is a pretty amazing dataset including not just the phased assemblies, but PacBio HiFi, ONT Ultralong, Dovetail/Illumina Hi-C, PacBio Kinnex, and Illumina WGS for all samples
📢 HPRC Release 2 is here!
Now with phased genomes from 200+ individuals, a 5x increase from Release 1.
Explore sequencing data, assemblies, annotations & alignments in our interactive data explorer ⬇️:
humanpangenome.org/hprc-data-re...
Now with phased genomes from 200+ individuals, a 5x increase from Release 1.
Explore sequencing data, assemblies, annotations & alignments in our interactive data explorer ⬇️:
humanpangenome.org/hprc-data-re...
May 12, 2025 at 1:52 PM
The human pangenome continues to grow and improve! Release 2 is here! Click through for the details, but this is a pretty amazing dataset including not just the phased assemblies, but PacBio HiFi, ONT Ultralong, Dovetail/Illumina Hi-C, PacBio Kinnex, and Illumina WGS for all samples
Reposted by Guillaume Bourque
Canada’s genomics community is rising to the challenge.
➡️ We’re sequencing 100K human genomes in 4 years to give researchers and innovators the data they need to transform health care.
Learn how the diversity of the dataset we build will set Canada apart as a global leader in #PrecisionHealth.
➡️ We’re sequencing 100K human genomes in 4 years to give researchers and innovators the data they need to transform health care.
Learn how the diversity of the dataset we build will set Canada apart as a global leader in #PrecisionHealth.
A golden era for personalized medicine is approaching, but are we ready?
A golden era for personalized medicine is approaching, but are we ready?
By understanding a patient’s unique genetic profile, biomarker readings and lifestyle information, doctors could tailor the most effective and safest treatments for that individual.
theconversation.com
April 25, 2025 at 1:14 AM
Canada’s genomics community is rising to the challenge.
➡️ We’re sequencing 100K human genomes in 4 years to give researchers and innovators the data they need to transform health care.
Learn how the diversity of the dataset we build will set Canada apart as a global leader in #PrecisionHealth.
➡️ We’re sequencing 100K human genomes in 4 years to give researchers and innovators the data they need to transform health care.
Learn how the diversity of the dataset we build will set Canada apart as a global leader in #PrecisionHealth.
Reposted by Guillaume Bourque
Excellent opportunity for PI positions at the Genome Institute of Singapore! Outstanding facilities, latest genomic technologies, strong and stable science funding. Junior candidates and established scientists are welcome to apply
Are you passionate about advancing scientific research?🧬🔬 🧪
We are #hiring Principal Investigators who are ready to make a difference in the world of genomic research in AI, Computational biology to develop novel high throughput technologies for unveiling new insights into the biology of DNA or RNA!
We are #hiring Principal Investigators who are ready to make a difference in the world of genomic research in AI, Computational biology to develop novel high throughput technologies for unveiling new insights into the biology of DNA or RNA!
A*STAR - Agency for Science, Technology and Research hiring Principal Investigators (GIS) in Singapore, Singapore | LinkedIn
Posted 11:59:37 AM. The Genome Institute of Singapore (GIS) is Singapore"s flagship institute for the genomic sciences.…See this and similar jobs on LinkedIn.
www.linkedin.com
April 14, 2025 at 6:25 AM
Excellent opportunity for PI positions at the Genome Institute of Singapore! Outstanding facilities, latest genomic technologies, strong and stable science funding. Junior candidates and established scientists are welcome to apply
Bye bye magical Kyoto, see you next time!
April 10, 2025 at 7:04 AM
Bye bye magical Kyoto, see you next time!
Check out the new STR tool from @davidlougheed.bsky.social in the group! Works with both PacBio and Nanopore!
April 1, 2025 at 7:15 AM
Check out the new STR tool from @davidlougheed.bsky.social in the group! Works with both PacBio and Nanopore!
Reposted by Guillaume Bourque
On January 6th, 1995, my (now ex) wife and I boarded a flight from Heathrow to JFK on a one way ticket. We had two suitcases and about $900 in cash - this was everything we owned and we were moving to the US. We thought it was maybe for 2-3 years. I had visited the US once, for a conference, and
February 15, 2025 at 5:48 AM
On January 6th, 1995, my (now ex) wife and I boarded a flight from Heathrow to JFK on a one way ticket. We had two suitcases and about $900 in cash - this was everything we owned and we were moving to the US. We thought it was maybe for 2-3 years. I had visited the US once, for a conference, and
Reposted by Guillaume Bourque
We are recruiting! We have an open position for a postdoctoral fellow to join our team at the Genome Institute of Singapore to work with long read RNA-Seq data. It’s a beautiful city state and outstanding research environment! More details here: jglab.org/postdoc-posi...
February 13, 2025 at 9:38 AM
We are recruiting! We have an open position for a postdoctoral fellow to join our team at the Genome Institute of Singapore to work with long read RNA-Seq data. It’s a beautiful city state and outstanding research environment! More details here: jglab.org/postdoc-posi...
Amazing! So moving. Such an important cause.
Two remarkable and iconic Canadians who brought Canada together, #TerryFox and #GordDownie of the #TragicallyHip. An anthem of our time. Cancer: Finish It.
February 5, 2025 at 4:35 PM
Amazing! So moving. Such an important cause.
Thanks for sharing this very nice story of collaboration!
I wanted to write briefly about a very pleasant experience we recently had coordinating and collaborating closely on competing publications with 2 other teams. 1/
January 27, 2025 at 11:16 AM
Thanks for sharing this very nice story of collaboration!