Human Pangenome Reference Consortium
@humanpangenome.bsky.social
Diverse Human References Drive Genomic Discoveries for Everyone
IGGSy 2026 is coming!
July 5 - 9, join researchers from around the world to explore genome graphs, pangenomics, and metagenomics, including a dedicated Human Pangenome Project session with keynotes from HPRC members.
Registration open now!
iggsy.org
July 5 - 9, join researchers from around the world to explore genome graphs, pangenomics, and metagenomics, including a dedicated Human Pangenome Project session with keynotes from HPRC members.
Registration open now!
iggsy.org
February 10, 2026 at 6:24 PM
IGGSy 2026 is coming!
July 5 - 9, join researchers from around the world to explore genome graphs, pangenomics, and metagenomics, including a dedicated Human Pangenome Project session with keynotes from HPRC members.
Registration open now!
iggsy.org
July 5 - 9, join researchers from around the world to explore genome graphs, pangenomics, and metagenomics, including a dedicated Human Pangenome Project session with keynotes from HPRC members.
Registration open now!
iggsy.org
What does “broad data sharing” really mean in genomics?
A recent Nature Genetics Perspective clarifies the term and provides a framework for ethical sharing going forward.
Uncover the research behind it:
www.nature.com/articles/s41...
A recent Nature Genetics Perspective clarifies the term and provides a framework for ethical sharing going forward.
Uncover the research behind it:
www.nature.com/articles/s41...
Overcoming challenges associated with broad sharing of human genomic data - Nature Genetics
This Perspective discusses the definitions of ‘broad’ that have been used in the context of sharing of human genomic data and proposes a clarified and reformed terminology for describing genomic data ...
www.nature.com
February 6, 2026 at 4:56 PM
What does “broad data sharing” really mean in genomics?
A recent Nature Genetics Perspective clarifies the term and provides a framework for ethical sharing going forward.
Uncover the research behind it:
www.nature.com/articles/s41...
A recent Nature Genetics Perspective clarifies the term and provides a framework for ethical sharing going forward.
Uncover the research behind it:
www.nature.com/articles/s41...
Clinical genetics is powerful, but much of the human genome remains poorly understood.
In this Q&A, Andrew Stergachis, PhD, shares how HPRC research is helping uncover genetic variation, improve diagnosis, and open new paths toward treatment.
▶️: youtu.be/ghCJWp5jPdg
In this Q&A, Andrew Stergachis, PhD, shares how HPRC research is helping uncover genetic variation, improve diagnosis, and open new paths toward treatment.
▶️: youtu.be/ghCJWp5jPdg
How will HPRC research advance our understanding of human health and disease?
YouTube video by Human Pangenome Reference Consortium
youtu.be
February 4, 2026 at 7:53 PM
Clinical genetics is powerful, but much of the human genome remains poorly understood.
In this Q&A, Andrew Stergachis, PhD, shares how HPRC research is helping uncover genetic variation, improve diagnosis, and open new paths toward treatment.
▶️: youtu.be/ghCJWp5jPdg
In this Q&A, Andrew Stergachis, PhD, shares how HPRC research is helping uncover genetic variation, improve diagnosis, and open new paths toward treatment.
▶️: youtu.be/ghCJWp5jPdg
A recent preprint introduces the LungMAP Portal Ecosystem, a centralized, FAIR resource integrating single-cell, imaging, and multi-omic lung data across species, development, and disease.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
January 30, 2026 at 6:27 PM
A recent preprint introduces the LungMAP Portal Ecosystem, a centralized, FAIR resource integrating single-cell, imaging, and multi-omic lung data across species, development, and disease.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
HPRC champions collaboration across the globe. 🌎
Our progress is driven by the people, partnerships, and shared commitment behind the Human Pangenome Reference Consortium.
Learn more and explore our collaborations: humanpangenome.org
Our progress is driven by the people, partnerships, and shared commitment behind the Human Pangenome Reference Consortium.
Learn more and explore our collaborations: humanpangenome.org
Human Pangenome Reference Consortium
Human Pangenome Reference Consortium
humanpangenome.org
January 29, 2026 at 6:57 PM
HPRC champions collaboration across the globe. 🌎
Our progress is driven by the people, partnerships, and shared commitment behind the Human Pangenome Reference Consortium.
Learn more and explore our collaborations: humanpangenome.org
Our progress is driven by the people, partnerships, and shared commitment behind the Human Pangenome Reference Consortium.
Learn more and explore our collaborations: humanpangenome.org
A scalable, lossless indexing method enables haplotype-aware querying of pangenome graphs.
Tested on HPRC graphs, it scales efficiently while preserving accurate mapping.
Uncover the research behind it: www.biorxiv.org/content/10.1...
Tested on HPRC graphs, it scales efficiently while preserving accurate mapping.
Uncover the research behind it: www.biorxiv.org/content/10.1...
www.biorxiv.org
January 23, 2026 at 7:25 PM
A scalable, lossless indexing method enables haplotype-aware querying of pangenome graphs.
Tested on HPRC graphs, it scales efficiently while preserving accurate mapping.
Uncover the research behind it: www.biorxiv.org/content/10.1...
Tested on HPRC graphs, it scales efficiently while preserving accurate mapping.
Uncover the research behind it: www.biorxiv.org/content/10.1...
HPRC is more than data and tools; it’s a collaborative experience that shapes careers.
Listen to Prajna Hebbar and other HPRC members reflect on what it means to be part of the consortium.
▶️ youtu.be/bJ7wkbwd5oU
Listen to Prajna Hebbar and other HPRC members reflect on what it means to be part of the consortium.
▶️ youtu.be/bJ7wkbwd5oU
January 21, 2026 at 4:33 PM
HPRC is more than data and tools; it’s a collaborative experience that shapes careers.
Listen to Prajna Hebbar and other HPRC members reflect on what it means to be part of the consortium.
▶️ youtu.be/bJ7wkbwd5oU
Listen to Prajna Hebbar and other HPRC members reflect on what it means to be part of the consortium.
▶️ youtu.be/bJ7wkbwd5oU
Even with HiFi sequencing, long-read metagenome assemblies can miss abundant species.
A recent study introduces reference-free methods to measure completeness and recover missing genomes, improving microbial community representation.
pmc.ncbi.nlm.nih.gov/articles/PMC...
A recent study introduces reference-free methods to measure completeness and recover missing genomes, improving microbial community representation.
pmc.ncbi.nlm.nih.gov/articles/PMC...
Evaluating and improving the representation of bacterial contents in long-read metagenome assemblies
In the metagenomic assembly of a microbial community, abundant species are often thought to assemble well given their deeper sequencing coverage. This conjuncture is rarely tested or evaluated in practice. We often do not know how many abundant ...
pmc.ncbi.nlm.nih.gov
January 13, 2026 at 3:10 PM
Even with HiFi sequencing, long-read metagenome assemblies can miss abundant species.
A recent study introduces reference-free methods to measure completeness and recover missing genomes, improving microbial community representation.
pmc.ncbi.nlm.nih.gov/articles/PMC...
A recent study introduces reference-free methods to measure completeness and recover missing genomes, improving microbial community representation.
pmc.ncbi.nlm.nih.gov/articles/PMC...
“And the goal of the HPRC project is just to build this common reference and release it to the world.”
Uncover why a globally representative pangenome matters and how it helps make genomics work for everyone.
Hear from HPRC member, Faith Okamoto:
youtu.be/qZrPM8KI-Js
Uncover why a globally representative pangenome matters and how it helps make genomics work for everyone.
Hear from HPRC member, Faith Okamoto:
youtu.be/qZrPM8KI-Js
Why Is It important To Build A Pangenome That Reflects Global Human Genetic Variation?
YouTube video by Human Pangenome Reference Consortium
youtu.be
December 19, 2025 at 7:35 PM
“And the goal of the HPRC project is just to build this common reference and release it to the world.”
Uncover why a globally representative pangenome matters and how it helps make genomics work for everyone.
Hear from HPRC member, Faith Okamoto:
youtu.be/qZrPM8KI-Js
Uncover why a globally representative pangenome matters and how it helps make genomics work for everyone.
Hear from HPRC member, Faith Okamoto:
youtu.be/qZrPM8KI-Js
Recent work brings forth MaxFuse, a modality-agnostic method for integrating cross-modal, single-cell, and spatial data.
MaxFuse improves integration accuracy and enables joint spatial analysis of proteomic, transcriptomic, and epigenomic data.
pmc.ncbi.nlm.nih.gov/articles/PMC...
MaxFuse improves integration accuracy and enables joint spatial analysis of proteomic, transcriptomic, and epigenomic data.
pmc.ncbi.nlm.nih.gov/articles/PMC...
Integration of spatial and single-cell data across modalities with weakly linked features
Although single-cell and spatial sequencing methods enable simultaneous measurement of more than one biological modality, no technology can capture all modalities within the same cell. For current data integration methods, the feasibility of ...
pmc.ncbi.nlm.nih.gov
December 16, 2025 at 7:08 PM
Recent work brings forth MaxFuse, a modality-agnostic method for integrating cross-modal, single-cell, and spatial data.
MaxFuse improves integration accuracy and enables joint spatial analysis of proteomic, transcriptomic, and epigenomic data.
pmc.ncbi.nlm.nih.gov/articles/PMC...
MaxFuse improves integration accuracy and enables joint spatial analysis of proteomic, transcriptomic, and epigenomic data.
pmc.ncbi.nlm.nih.gov/articles/PMC...
[We’re] building the computational infrastructure for pangenomics, not just for us, but for everyone.”
In our new Q&A, HPRC members share what motivates their work and how a more comprehensive pangenome will transform genomics.
Tune in:
youtu.be/bJ7wkbwd5oU?...
In our new Q&A, HPRC members share what motivates their work and how a more comprehensive pangenome will transform genomics.
Tune in:
youtu.be/bJ7wkbwd5oU?...
December 10, 2025 at 6:46 PM
[We’re] building the computational infrastructure for pangenomics, not just for us, but for everyone.”
In our new Q&A, HPRC members share what motivates their work and how a more comprehensive pangenome will transform genomics.
Tune in:
youtu.be/bJ7wkbwd5oU?...
In our new Q&A, HPRC members share what motivates their work and how a more comprehensive pangenome will transform genomics.
Tune in:
youtu.be/bJ7wkbwd5oU?...
A new era of genomics: gapless genomes and pangenomes are boosting accuracy and representation in human genetics research.
Uncover the science behind it: pubmed.ncbi.nlm.nih.gov/38663087/
Uncover the science behind it: pubmed.ncbi.nlm.nih.gov/38663087/
Beyond the Human Genome Project: The Age of Complete Human Genome Sequences and Pangenome References - PubMed
The Human Genome Project was an enormous accomplishment, providing a foundation for countless explorations into the genetics and genomics of the human species. Yet for many years, the human genome reference sequence remained incomplete and lacked representation of human genetic diversity. Recently, …
pubmed.ncbi.nlm.nih.gov
December 5, 2025 at 6:17 PM
A new era of genomics: gapless genomes and pangenomes are boosting accuracy and representation in human genetics research.
Uncover the science behind it: pubmed.ncbi.nlm.nih.gov/38663087/
Uncover the science behind it: pubmed.ncbi.nlm.nih.gov/38663087/
This season, we’re grateful for the chance to share the work, voices, and perspectives of the HPRC community.
Our new Q&A video features members from across the consortium reflecting on the technologies, collaborations, and insights shaping the human pangenome.
Watch here: youtu.be/bJ7wkbwd5oU?...
Our new Q&A video features members from across the consortium reflecting on the technologies, collaborations, and insights shaping the human pangenome.
Watch here: youtu.be/bJ7wkbwd5oU?...
The Human Pangenome Reference Consortium (HPRC) Q&A
YouTube video by Human Pangenome Reference Consortium
youtu.be
November 24, 2025 at 4:25 PM
This season, we’re grateful for the chance to share the work, voices, and perspectives of the HPRC community.
Our new Q&A video features members from across the consortium reflecting on the technologies, collaborations, and insights shaping the human pangenome.
Watch here: youtu.be/bJ7wkbwd5oU?...
Our new Q&A video features members from across the consortium reflecting on the technologies, collaborations, and insights shaping the human pangenome.
Watch here: youtu.be/bJ7wkbwd5oU?...
💡 Novel work supported by HPRC members highlights Locityper, a tool bringing accurate genotyping to some of the most challenging regions of the human genome.
Fast and precise, it outperforms current pipelines and scales to biobank-sized cohorts.
More at:
www.nature.com/articles/s41...
Fast and precise, it outperforms current pipelines and scales to biobank-sized cohorts.
More at:
www.nature.com/articles/s41...
Locityper enables targeted genotyping of complex polymorphic genes - Nature Genetics
Locityper is a general-purpose genotyper that can efficiently genotype and analyze a diverse set of genes, such as hyperpolymorphic HLA genes, using both short-read and long-read whole-genome sequenci...
www.nature.com
November 19, 2025 at 9:36 PM
💡 Novel work supported by HPRC members highlights Locityper, a tool bringing accurate genotyping to some of the most challenging regions of the human genome.
Fast and precise, it outperforms current pipelines and scales to biobank-sized cohorts.
More at:
www.nature.com/articles/s41...
Fast and precise, it outperforms current pipelines and scales to biobank-sized cohorts.
More at:
www.nature.com/articles/s41...
A new method using the Shasta assembler and GFAse tool improves the phasing of Oxford Nanopore Technologies (ONT) sequence data, enabling chromosome-scale phasing with higher accuracy and reduced complexity.
Learn more: pmc.ncbi.nlm.nih.gov/articles/PMC...
Learn more: pmc.ncbi.nlm.nih.gov/articles/PMC...
Phased nanopore assembly with Shasta and modular graph phasing with GFAse
Reference-free genome phasing is vital for understanding allele inheritance and the impact of single-molecule DNA variation on phenotypes. To achieve thorough phasing across homozygous or repetitive regions of the genome, long-read sequencing ...
pmc.ncbi.nlm.nih.gov
November 13, 2025 at 7:24 PM
A new method using the Shasta assembler and GFAse tool improves the phasing of Oxford Nanopore Technologies (ONT) sequence data, enabling chromosome-scale phasing with higher accuracy and reduced complexity.
Learn more: pmc.ncbi.nlm.nih.gov/articles/PMC...
Learn more: pmc.ncbi.nlm.nih.gov/articles/PMC...
Curious about the work behind the Human Pangenome Reference Consortium?
Discover how researchers worldwide are working together to build a more complete reference of human genetic variation.
Learn more at humanpangenome.org
Discover how researchers worldwide are working together to build a more complete reference of human genetic variation.
Learn more at humanpangenome.org
Human Pangenome Reference Consortium
Human Pangenome Reference Consortium
humanpangenome.org
November 5, 2025 at 8:12 PM
Curious about the work behind the Human Pangenome Reference Consortium?
Discover how researchers worldwide are working together to build a more complete reference of human genetic variation.
Learn more at humanpangenome.org
Discover how researchers worldwide are working together to build a more complete reference of human genetic variation.
Learn more at humanpangenome.org
Wishing everyone a spook-tacular Halloween! 👻
Whether you’re celebrating or just enjoying a well-earned weekend, we hope it’s a wickedly wonderful one!
Whether you’re celebrating or just enjoying a well-earned weekend, we hope it’s a wickedly wonderful one!
October 31, 2025 at 4:13 PM
Wishing everyone a spook-tacular Halloween! 👻
Whether you’re celebrating or just enjoying a well-earned weekend, we hope it’s a wickedly wonderful one!
Whether you’re celebrating or just enjoying a well-earned weekend, we hope it’s a wickedly wonderful one!
Transposable elements (TEs) do more than regulate genes; they help shape and preserve 3D genome structure across species.
Uncover the science behind it: pmc.ncbi.nlm.nih.gov/articles/PMC...
Uncover the science behind it: pmc.ncbi.nlm.nih.gov/articles/PMC...
Co-opted transposons help perpetuate conserved higher-order chromosomal structures
Transposable elements (TEs) make up half of mammalian genomes and shape genome regulation by harboring binding sites for regulatory factors. These include binding sites for architectural proteins, such as CTCF, RAD21, and SMC3, that are involved in ...
pmc.ncbi.nlm.nih.gov
October 29, 2025 at 7:31 PM
Transposable elements (TEs) do more than regulate genes; they help shape and preserve 3D genome structure across species.
Uncover the science behind it: pmc.ncbi.nlm.nih.gov/articles/PMC...
Uncover the science behind it: pmc.ncbi.nlm.nih.gov/articles/PMC...
Next week, we're headed to #ASHG2025!
HPRC members will be sharing their latest research and insights throughout the week.
See who's presenting ⬇️
HPRC members will be sharing their latest research and insights throughout the week.
See who's presenting ⬇️
October 8, 2025 at 7:02 PM
Next week, we're headed to #ASHG2025!
HPRC members will be sharing their latest research and insights throughout the week.
See who's presenting ⬇️
HPRC members will be sharing their latest research and insights throughout the week.
See who's presenting ⬇️
🌍 Researchers from around the world are joining forces through the Human Pangenome Reference Consortium to develop a more comprehensive and dynamic pangenome resource.
Learn more about our mission: humanpangenome.org
Learn more about our mission: humanpangenome.org
Human Pangenome Reference Consortium
Human Pangenome Reference Consortium
humanpangenome.org
October 2, 2025 at 4:20 PM
🌍 Researchers from around the world are joining forces through the Human Pangenome Reference Consortium to develop a more comprehensive and dynamic pangenome resource.
Learn more about our mission: humanpangenome.org
Learn more about our mission: humanpangenome.org
A complete telomere-to-telomere genome sequence reveals 213 human-specific gene families, including candidates shaping brain evolution.
Functional studies highlight roles for GPR89B and FRMPD2B in brain expansion and synapse signaling.
Read more in Cell:
www.cell.com/cell/abstrac...
Functional studies highlight roles for GPR89B and FRMPD2B in brain expansion and synapse signaling.
Read more in Cell:
www.cell.com/cell/abstrac...
Human-specific gene expansions contribute to brain evolution
A complete human genome and functional modeling in zebrafish pinpoint gene expansions
that may underlie the evolutionary innovations of the human brain.
www.cell.com
September 26, 2025 at 8:26 PM
A complete telomere-to-telomere genome sequence reveals 213 human-specific gene families, including candidates shaping brain evolution.
Functional studies highlight roles for GPR89B and FRMPD2B in brain expansion and synapse signaling.
Read more in Cell:
www.cell.com/cell/abstrac...
Functional studies highlight roles for GPR89B and FRMPD2B in brain expansion and synapse signaling.
Read more in Cell:
www.cell.com/cell/abstrac...
HPRC will see you at #ASHG!
Join our workshop, The Human Pangenome: Data, Tools, and Workflows, on Oct 14 (10–12 pm) + look out for HPRC member presentations throughout the meeting.
Check out the presentations highlighted below, with more to come!
Join our workshop, The Human Pangenome: Data, Tools, and Workflows, on Oct 14 (10–12 pm) + look out for HPRC member presentations throughout the meeting.
Check out the presentations highlighted below, with more to come!
September 25, 2025 at 8:15 PM
HPRC will see you at #ASHG!
Join our workshop, The Human Pangenome: Data, Tools, and Workflows, on Oct 14 (10–12 pm) + look out for HPRC member presentations throughout the meeting.
Check out the presentations highlighted below, with more to come!
Join our workshop, The Human Pangenome: Data, Tools, and Workflows, on Oct 14 (10–12 pm) + look out for HPRC member presentations throughout the meeting.
Check out the presentations highlighted below, with more to come!
👣 A big step forward for pangenome research.
New tool ropebwt3 makes large-scale BWT indexing feasible, scaling to hundreds of human genomes & terabases of bacterial assemblies.
Uncover the science behind it: pmc.ncbi.nlm.nih.gov/articles/PMC...
New tool ropebwt3 makes large-scale BWT indexing feasible, scaling to hundreds of human genomes & terabases of bacterial assemblies.
Uncover the science behind it: pmc.ncbi.nlm.nih.gov/articles/PMC...
BWT construction and search at the terabase scale
Burrows–Wheeler Transform (BWT) is a common component in full-text indices. Initially developed for data compression, it is particularly powerful for encoding redundant sequences such as pangenome dat...
pmc.ncbi.nlm.nih.gov
September 19, 2025 at 6:41 PM
👣 A big step forward for pangenome research.
New tool ropebwt3 makes large-scale BWT indexing feasible, scaling to hundreds of human genomes & terabases of bacterial assemblies.
Uncover the science behind it: pmc.ncbi.nlm.nih.gov/articles/PMC...
New tool ropebwt3 makes large-scale BWT indexing feasible, scaling to hundreds of human genomes & terabases of bacterial assemblies.
Uncover the science behind it: pmc.ncbi.nlm.nih.gov/articles/PMC...
The Human Pangenome Reference Consortium is building a more complete and inclusive reference for human genetics, one that better reflects human variation and drives new discoveries.
Our story: humanpangenome.org
Our story: humanpangenome.org
September 17, 2025 at 7:09 PM
The Human Pangenome Reference Consortium is building a more complete and inclusive reference for human genetics, one that better reflects human variation and drives new discoveries.
Our story: humanpangenome.org
Our story: humanpangenome.org
~25% of human candidate cis-regulatory elements (cCREs) are derived from transposable elements, further shaping gene regulation, TF binding, and GWAS variant enrichment.
Uncover the science behind it: www.biorxiv.org/content/10.1...
Uncover the science behind it: www.biorxiv.org/content/10.1...
Regulatory Transposable Elements in the Encyclopedia of DNA Elements
Transposable elements (TEs) make up about half of the human genome and many have the biochemical hallmarks of tissue- or cell type-specific cis -regulatory elements. While some TEs have been rigorousl...
www.biorxiv.org
September 12, 2025 at 4:43 PM
~25% of human candidate cis-regulatory elements (cCREs) are derived from transposable elements, further shaping gene regulation, TF binding, and GWAS variant enrichment.
Uncover the science behind it: www.biorxiv.org/content/10.1...
Uncover the science behind it: www.biorxiv.org/content/10.1...