Manvendra Singh
@manusingh.bsky.social
#NewPI #CNRS #CPJ #Recruiting
at Necker Institute and Institut Imagine, Paris.
Systems Biology of Mobile DNA (mostly Human Endogenous Retroviruses) and Genome Regulation
Alum: Feschotte lab (post-doc), Izsvak Lab (PhD) and Max-Planck Institute.
at Necker Institute and Institut Imagine, Paris.
Systems Biology of Mobile DNA (mostly Human Endogenous Retroviruses) and Genome Regulation
Alum: Feschotte lab (post-doc), Izsvak Lab (PhD) and Max-Planck Institute.
Pinned
🔥🎉 🧠 SuperThrilled to share our paper (preprint) - Human erythropoietin (rhEPO) reshapes the adult hippocampal chromatin landscape, around transposons to promote neurogenesis. 🧵1/8
Massive kudos to #UmutCakir who drove multi-omics through dark roads of the genome.
www.biorxiv.org/content/10.1...
Massive kudos to #UmutCakir who drove multi-omics through dark roads of the genome.
www.biorxiv.org/content/10.1...
#TESKY 🎉 Phenomenal work! After the humans, the variety of mouse immune cell systems also co-opts transposon-derived enhancers/promoters. Big Kudos to Jason, Andrew Grimson, and @cedricfeschotte.bsky.social
New Year, New Paper!🎊
Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
www.biorxiv.org/content/10.6...
Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!🧵
Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
www.biorxiv.org/content/10.6...
Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!🧵
Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
Transposable elements (TEs) make up about half of the human and mouse genomes and play important regulatory roles in immune responses. However, the cis -regulatory contribution of TEs to immune cell d...
www.biorxiv.org
January 7, 2026 at 8:01 PM
#TESKY 🎉 Phenomenal work! After the humans, the variety of mouse immune cell systems also co-opts transposon-derived enhancers/promoters. Big Kudos to Jason, Andrew Grimson, and @cedricfeschotte.bsky.social
Reposted by Manvendra Singh
Does a neuron’s "address" define its function? 🧠
Featured in @lefigaro.fr, new nature neuroscience research from Denis Jabaudon & colleagues shows that misplaced neurons can work perfectly & process senses. Brain structure ≠ function!
For more information: www.linkedin.com/posts/instit...
Featured in @lefigaro.fr, new nature neuroscience research from Denis Jabaudon & colleagues shows that misplaced neurons can work perfectly & process senses. Brain structure ≠ function!
For more information: www.linkedin.com/posts/instit...
#neuroscience #brainresearch #institutimagine #natureneuroscience #neurodevelopment #genetics | Institut Imagine
Does a neuron’s "address" define its function? 🧠
We are thrilled to share a new study published in Nature Neuroscience—also featured in Le Figaro—that challenges long-standing assumptions about how t...
www.linkedin.com
January 6, 2026 at 1:31 PM
Does a neuron’s "address" define its function? 🧠
Featured in @lefigaro.fr, new nature neuroscience research from Denis Jabaudon & colleagues shows that misplaced neurons can work perfectly & process senses. Brain structure ≠ function!
For more information: www.linkedin.com/posts/instit...
Featured in @lefigaro.fr, new nature neuroscience research from Denis Jabaudon & colleagues shows that misplaced neurons can work perfectly & process senses. Brain structure ≠ function!
For more information: www.linkedin.com/posts/instit...
🔥🎉 🧠 SuperThrilled to share our paper (preprint) - Human erythropoietin (rhEPO) reshapes the adult hippocampal chromatin landscape, around transposons to promote neurogenesis. 🧵1/8
Massive kudos to #UmutCakir who drove multi-omics through dark roads of the genome.
www.biorxiv.org/content/10.1...
Massive kudos to #UmutCakir who drove multi-omics through dark roads of the genome.
www.biorxiv.org/content/10.1...
January 5, 2026 at 11:49 AM
🔥🎉 🧠 SuperThrilled to share our paper (preprint) - Human erythropoietin (rhEPO) reshapes the adult hippocampal chromatin landscape, around transposons to promote neurogenesis. 🧵1/8
Massive kudos to #UmutCakir who drove multi-omics through dark roads of the genome.
www.biorxiv.org/content/10.1...
Massive kudos to #UmutCakir who drove multi-omics through dark roads of the genome.
www.biorxiv.org/content/10.1...
Happy new year and 3 more days to apply for Computational biology post doc position in my lab #Paris #transpoosns @inem-necker.bsky.social @institutimagine.bsky.social
January 2, 2026 at 2:41 PM
Happy new year and 3 more days to apply for Computational biology post doc position in my lab #Paris #transpoosns @inem-necker.bsky.social @institutimagine.bsky.social
This is the view where we shall have our regular lab meetings. Maybe this persuades you to join our team. #hiring #postdoc #computationalBiology #multiomics #deeplearning
December 20, 2025 at 9:58 AM
This is the view where we shall have our regular lab meetings. Maybe this persuades you to join our team. #hiring #postdoc #computationalBiology #multiomics #deeplearning
#hiring #postdoc #bioinformatics
We’re opening a Computational/Bioinformatics postdoc position in my new lab at INEM in Paris, connected with Imagine and Institut Pasteur.
The big theme:
👉 How do endogenous retroviruses and other mobile DNA rewire human immune regulation and genome control? 👇⬇️🧵
We’re opening a Computational/Bioinformatics postdoc position in my new lab at INEM in Paris, connected with Imagine and Institut Pasteur.
The big theme:
👉 How do endogenous retroviruses and other mobile DNA rewire human immune regulation and genome control? 👇⬇️🧵
December 10, 2025 at 9:56 AM
#hiring #postdoc #bioinformatics
We’re opening a Computational/Bioinformatics postdoc position in my new lab at INEM in Paris, connected with Imagine and Institut Pasteur.
The big theme:
👉 How do endogenous retroviruses and other mobile DNA rewire human immune regulation and genome control? 👇⬇️🧵
We’re opening a Computational/Bioinformatics postdoc position in my new lab at INEM in Paris, connected with Imagine and Institut Pasteur.
The big theme:
👉 How do endogenous retroviruses and other mobile DNA rewire human immune regulation and genome control? 👇⬇️🧵
Reposted by Manvendra Singh
Congrats Manvendra, well deserved!
#NewPI #Neuroscience #Immunology #Transposons #SciComm #HERVs
Stay tuned, a few postdoctoral, both molecular and computational biology positions are gonna be advertised soon.
Stay tuned, a few postdoctoral, both molecular and computational biology positions are gonna be advertised soon.
December 4, 2025 at 1:00 PM
Congrats Manvendra, well deserved!
Reposted by Manvendra Singh
Great news for the scientific community in France (especially TE aficionados :))!!
#NewPI #Neuroscience #Immunology #Transposons #SciComm #HERVs
Stay tuned, a few postdoctoral, both molecular and computational biology positions are gonna be advertised soon.
Stay tuned, a few postdoctoral, both molecular and computational biology positions are gonna be advertised soon.
December 4, 2025 at 2:11 PM
Great news for the scientific community in France (especially TE aficionados :))!!
It’s debatable, there exists arguments from both sides. I bet the quality of science will be diminished. When experts review the paper or grants, they get an idea of which citations hold how much water. AI doesn’t unless we first train it. So, I think it’s too soon to implement for grant review
UKRI exploring use of AI in grant review - this will prompt debate but interested to know if people think it’d encourage novelty or the opposite? www.chemistryworld.com/news/ukri-op...
UKRI opens up grant proposal data to explore using AI to smooth peer review
Surging applications has led the UK's main funder to look at ways to reduce the burden on reviewers
www.chemistryworld.com
December 4, 2025 at 1:32 PM
It’s debatable, there exists arguments from both sides. I bet the quality of science will be diminished. When experts review the paper or grants, they get an idea of which citations hold how much water. AI doesn’t unless we first train it. So, I think it’s too soon to implement for grant review
#NewPI #Neuroscience #Immunology #Transposons #SciComm #HERVs
Stay tuned, a few postdoctoral, both molecular and computational biology positions are gonna be advertised soon.
Stay tuned, a few postdoctoral, both molecular and computational biology positions are gonna be advertised soon.
December 4, 2025 at 11:50 AM
#NewPI #Neuroscience #Immunology #Transposons #SciComm #HERVs
Stay tuned, a few postdoctoral, both molecular and computational biology positions are gonna be advertised soon.
Stay tuned, a few postdoctoral, both molecular and computational biology positions are gonna be advertised soon.
Reposted by Manvendra Singh
Benchmarking cell type and gene set annotation by large language models with AnnDictionary www.nature.com/articles/s41... 🧬🖥️🧪 github.com/ggit12/anndi...
December 3, 2025 at 5:05 PM
Benchmarking cell type and gene set annotation by large language models with AnnDictionary www.nature.com/articles/s41... 🧬🖥️🧪 github.com/ggit12/anndi...
🎉 Thrilled to Announce a New Chapter!
🧵
I’m honoured to share that I’ve been appointed as CNRS Chaire de Professeur Junior (CPJ) at Université Paris Cité from 1st Jan.
My independent lab is hosted at the Necker Institute (INEM), with co-affiliations at the Imagine Institute and Pasteur Institute. ⬇️
🧵
I’m honoured to share that I’ve been appointed as CNRS Chaire de Professeur Junior (CPJ) at Université Paris Cité from 1st Jan.
My independent lab is hosted at the Necker Institute (INEM), with co-affiliations at the Imagine Institute and Pasteur Institute. ⬇️
December 3, 2025 at 10:30 AM
🎉 Thrilled to Announce a New Chapter!
🧵
I’m honoured to share that I’ve been appointed as CNRS Chaire de Professeur Junior (CPJ) at Université Paris Cité from 1st Jan.
My independent lab is hosted at the Necker Institute (INEM), with co-affiliations at the Imagine Institute and Pasteur Institute. ⬇️
🧵
I’m honoured to share that I’ve been appointed as CNRS Chaire de Professeur Junior (CPJ) at Université Paris Cité from 1st Jan.
My independent lab is hosted at the Necker Institute (INEM), with co-affiliations at the Imagine Institute and Pasteur Institute. ⬇️
Reposted by Manvendra Singh
"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)
October 2, 2025 at 1:47 PM
"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)
Reposted by Manvendra Singh
Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 24, 2025 at 3:12 PM
Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Manvendra Singh
Paper accepted!!!!
Congratultions to @lizebonaaugust.bsky.social Blanca del Rosal and Leslie Yeo it was a pleasure to work together on this amazing project! 🎊🎊🎊🎊
Congratultions to @lizebonaaugust.bsky.social Blanca del Rosal and Leslie Yeo it was a pleasure to work together on this amazing project! 🎊🎊🎊🎊
September 23, 2025 at 10:04 PM
Paper accepted!!!!
Congratultions to @lizebonaaugust.bsky.social Blanca del Rosal and Leslie Yeo it was a pleasure to work together on this amazing project! 🎊🎊🎊🎊
Congratultions to @lizebonaaugust.bsky.social Blanca del Rosal and Leslie Yeo it was a pleasure to work together on this amazing project! 🎊🎊🎊🎊
Reposted by Manvendra Singh
One of my all-time faves
Evolution is more like a tinkerer than an engineer. New things happen not by perfect engineering but by working with what's already available and repurposing existing objects through recombinations and modifications. This is a classic lesson for any kind of innovation, including that of new ideas..
August 13, 2025 at 2:37 AM
One of my all-time faves
Reposted by Manvendra Singh
📣 Our department is hiring an Assistant Professor in Evolutionary Cell and Molecular Biology to join the @weillinstitute.bsky.social PLS spread the word!
academicjobsonline.org/ajo/jobs/30607
academicjobsonline.org/ajo/jobs/30607
Cornell University, Molecular Biology & Genetics
Job #AJO30607, WDR-00055221 Assistant Professor, Molecular Biology & Genetics, Cornell University, Ithaca, New York, US
academicjobsonline.org
September 23, 2025 at 12:50 PM
📣 Our department is hiring an Assistant Professor in Evolutionary Cell and Molecular Biology to join the @weillinstitute.bsky.social PLS spread the word!
academicjobsonline.org/ajo/jobs/30607
academicjobsonline.org/ajo/jobs/30607
I'd be leaving soon for the new challenges
Before I go, here are a few brain’s stories on the table:
1 out in Nat Comm,
1 in press at Mol Psy,
and 🤞 for the third.
Preprints here:
www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...;
Onwards. 🖤
Before I go, here are a few brain’s stories on the table:
1 out in Nat Comm,
1 in press at Mol Psy,
and 🤞 for the third.
Preprints here:
www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...;
Onwards. 🖤
September 23, 2025 at 10:14 AM
I'd be leaving soon for the new challenges
Before I go, here are a few brain’s stories on the table:
1 out in Nat Comm,
1 in press at Mol Psy,
and 🤞 for the third.
Preprints here:
www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...;
Onwards. 🖤
Before I go, here are a few brain’s stories on the table:
1 out in Nat Comm,
1 in press at Mol Psy,
and 🤞 for the third.
Preprints here:
www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...;
Onwards. 🖤
Reposted by Manvendra Singh
www.cell.com/cell/abstrac...
A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis
A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis
A host organelle integrates stolen chloroplasts for animal photosynthesis
Sea slugs steal foreign chloroplasts and store them in specialized organelles that
facilitate photosynthesis and eventual digestion to mediate starvation resistance.
www.cell.com
September 17, 2025 at 5:04 PM
www.cell.com/cell/abstrac...
A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis
A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis
Reposted by Manvendra Singh
A study published in Genome Biology explores the role of transposable elements in antiviral resistance to HIV. The findings open new avenues for understanding the molecular mechanisms of viral control and developing targeted interventions for HIV-1 treatment.
#Epigenetics
#Epigenetics
Transposable elements may enhance antiviral resistance in HIV-1 elite controllers
Genome Biology
bit.ly
September 15, 2025 at 5:30 PM
A study published in Genome Biology explores the role of transposable elements in antiviral resistance to HIV. The findings open new avenues for understanding the molecular mechanisms of viral control and developing targeted interventions for HIV-1 treatment.
#Epigenetics
#Epigenetics
Reposted by Manvendra Singh
New ERC Starting Grant for Juliane Glaser to study role of epigenetic mechanisms, specifically the control of transposable elements, in mammalian embryonic development.
Read all details here: www.ie-freiburg.mpg.de/6057908/2025...
Congratulations @julianeg.bsky.social
@erc.europa.eu #ERCStG
Read all details here: www.ie-freiburg.mpg.de/6057908/2025...
Congratulations @julianeg.bsky.social
@erc.europa.eu #ERCStG
September 4, 2025 at 10:43 AM
New ERC Starting Grant for Juliane Glaser to study role of epigenetic mechanisms, specifically the control of transposable elements, in mammalian embryonic development.
Read all details here: www.ie-freiburg.mpg.de/6057908/2025...
Congratulations @julianeg.bsky.social
@erc.europa.eu #ERCStG
Read all details here: www.ie-freiburg.mpg.de/6057908/2025...
Congratulations @julianeg.bsky.social
@erc.europa.eu #ERCStG
Reposted by Manvendra Singh
17 ERC Starting Grants for Max Planck scientists! This puts the Max Planck Society at the top of the European ranking. mpg.de/25324951/erc... Congratulations to all grantees 🎉👏 #ERCStG @erc.europa.eu
17 ERC Starting Grants for Max Planck
In 2025, the Max Planck Society received 17 Starting Grants from the ERC. This puts the MPG at the top of the European ranking.
mpg.de
September 5, 2025 at 2:11 PM
17 ERC Starting Grants for Max Planck scientists! This puts the Max Planck Society at the top of the European ranking. mpg.de/25324951/erc... Congratulations to all grantees 🎉👏 #ERCStG @erc.europa.eu
Not sure if they tested cooperative bindings of TFs, which might have been the key player for determining their activator/repressive roles. Also, it might not be feasible to test in Yeast system for all TFs. Great study, anyways.
The "Low overlap of transcription factor DNA binding and regulatory targets" paper shows our dual futility conjecture identified in humans applies in yeast too—for many transcription factors, most of their locations do not match the transcription factor motif. 🖥️🧬 www.nature.com/articles/s41...
September 3, 2025 at 9:36 PM
Not sure if they tested cooperative bindings of TFs, which might have been the key player for determining their activator/repressive roles. Also, it might not be feasible to test in Yeast system for all TFs. Great study, anyways.
Reposted by Manvendra Singh
August 14, 2025 at 6:05 PM
Reposted by Manvendra Singh
lh3/longdust: Identify long STRs, VNTRs, satellite DNA and other low-complexity regions in a genome github.com/lh3/longdust 🧬🖥️🧪
GitHub - lh3/longdust: Identify long STRs, VNTRs, satellite DNA and other low-complexity regions in a genome
Identify long STRs, VNTRs, satellite DNA and other low-complexity regions in a genome - lh3/longdust
github.com
August 1, 2025 at 3:30 PM
lh3/longdust: Identify long STRs, VNTRs, satellite DNA and other low-complexity regions in a genome github.com/lh3/longdust 🧬🖥️🧪