Manvendra Singh
@manusingh.bsky.social
#NewPI #CNRS #CPJ #Recruiting
at Necker Institute and Institut Imagine, Paris.
Systems Biology of Mobile DNA (mostly Human Endogenous Retroviruses) and Genome Regulation
Alum: Feschotte lab (post-doc), Izsvak Lab (PhD) and Max-Planck Institute.
at Necker Institute and Institut Imagine, Paris.
Systems Biology of Mobile DNA (mostly Human Endogenous Retroviruses) and Genome Regulation
Alum: Feschotte lab (post-doc), Izsvak Lab (PhD) and Max-Planck Institute.
Pinned
π₯π π§ SuperThrilled to share our paper (preprint) - Human erythropoietin (rhEPO) reshapes the adult hippocampal chromatin landscape, around transposons to promote neurogenesis. π§΅1/8
Massive kudos to #UmutCakir who drove multi-omics through dark roads of the genome.
www.biorxiv.org/content/10.1...
Massive kudos to #UmutCakir who drove multi-omics through dark roads of the genome.
www.biorxiv.org/content/10.1...
Of course! I remember Jasonβs valiant effort digging into mouse TEs. Super happy to see it out finally ππ½ππ½
January 7, 2026 at 8:59 PM
Of course! I remember Jasonβs valiant effort digging into mouse TEs. Super happy to see it out finally ππ½ππ½
#TESKY π Phenomenal work! After the humans, the variety of mouse immune cell systems also co-opts transposon-derived enhancers/promoters. Big Kudos to Jason, Andrew Grimson, and @cedricfeschotte.bsky.social
New Year, New Paper!π
Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
www.biorxiv.org/content/10.6...
Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!π§΅
Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
www.biorxiv.org/content/10.6...
Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!π§΅
Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
Transposable elements (TEs) make up about half of the human and mouse genomes and play important regulatory roles in immune responses. However, the cis -regulatory contribution of TEs to immune cell d...
www.biorxiv.org
January 7, 2026 at 8:01 PM
#TESKY π Phenomenal work! After the humans, the variety of mouse immune cell systems also co-opts transposon-derived enhancers/promoters. Big Kudos to Jason, Andrew Grimson, and @cedricfeschotte.bsky.social
Reposted by Manvendra Singh
Does a neuronβs "address" define its function? π§
Featured in @lefigaro.fr, new nature neuroscience research from Denis Jabaudon & colleagues shows that misplaced neurons can work perfectly & process senses. Brain structure β function!
For more information: www.linkedin.com/posts/instit...
Featured in @lefigaro.fr, new nature neuroscience research from Denis Jabaudon & colleagues shows that misplaced neurons can work perfectly & process senses. Brain structure β function!
For more information: www.linkedin.com/posts/instit...
#neuroscience #brainresearch #institutimagine #natureneuroscience #neurodevelopment #genetics | Institut Imagine
Does a neuronβs "address" define its function? π§
We are thrilled to share a new study published inΒ Nature Neuroscienceβalso featured inΒ Le Figaroβthat challenges long-standing assumptions about how t...
www.linkedin.com
January 6, 2026 at 1:31 PM
Does a neuronβs "address" define its function? π§
Featured in @lefigaro.fr, new nature neuroscience research from Denis Jabaudon & colleagues shows that misplaced neurons can work perfectly & process senses. Brain structure β function!
For more information: www.linkedin.com/posts/instit...
Featured in @lefigaro.fr, new nature neuroscience research from Denis Jabaudon & colleagues shows that misplaced neurons can work perfectly & process senses. Brain structure β function!
For more information: www.linkedin.com/posts/instit...
Btw! #Umut has joined bluesky with ID @cakirumut.bsky.social
January 5, 2026 at 2:55 PM
Btw! #Umut has joined bluesky with ID @cakirumut.bsky.social
Finally, to cross-validate - Independent TF ChIP-seq shows neurogenic TFs (FOXG1, NEUROD1/2, NEUROG2, ASCL1) selectively bind TE-derived sequences, thus supporting a model where EPO engages a transposon-based regulatory reservoir to drive adult neurogenesis.π§΅8/8
January 5, 2026 at 11:49 AM
Finally, to cross-validate - Independent TF ChIP-seq shows neurogenic TFs (FOXG1, NEUROD1/2, NEUROG2, ASCL1) selectively bind TE-derived sequences, thus supporting a model where EPO engages a transposon-based regulatory reservoir to drive adult neurogenesis.π§΅8/8
Hereβs the twist weβre most excited about:
A sizeable fraction of EPO-responsive regulatory elements overlaps ancient transposable elements (LINEs/SINEs). These arenβt βgenomic fossilsβ but they behave like reusable regulatory modules the brain can recruit during plasticity. π§΅7/8
A sizeable fraction of EPO-responsive regulatory elements overlaps ancient transposable elements (LINEs/SINEs). These arenβt βgenomic fossilsβ but they behave like reusable regulatory modules the brain can recruit during plasticity. π§΅7/8
January 5, 2026 at 11:49 AM
Hereβs the twist weβre most excited about:
A sizeable fraction of EPO-responsive regulatory elements overlaps ancient transposable elements (LINEs/SINEs). These arenβt βgenomic fossilsβ but they behave like reusable regulatory modules the brain can recruit during plasticity. π§΅7/8
A sizeable fraction of EPO-responsive regulatory elements overlaps ancient transposable elements (LINEs/SINEs). These arenβt βgenomic fossilsβ but they behave like reusable regulatory modules the brain can recruit during plasticity. π§΅7/8
The most striking effect sits in newly formed / immature pyramidal neurons.
EPO preferentially boosts accessibility and gene programs that look like a neurogenic push plus synaptic integration
π§΅6/8
EPO preferentially boosts accessibility and gene programs that look like a neurogenic push plus synaptic integration
π§΅6/8
January 5, 2026 at 11:49 AM
The most striking effect sits in newly formed / immature pyramidal neurons.
EPO preferentially boosts accessibility and gene programs that look like a neurogenic push plus synaptic integration
π§΅6/8
EPO preferentially boosts accessibility and gene programs that look like a neurogenic push plus synaptic integration
π§΅6/8
The strongest remodeling concentrates in excitatory neuronal lineages in dentate gyrus, with distinct responses across glia and neuroimmune compartments. This is why bulk approaches miss the story π§΅5/8
January 5, 2026 at 11:49 AM
The strongest remodeling concentrates in excitatory neuronal lineages in dentate gyrus, with distinct responses across glia and neuroimmune compartments. This is why bulk approaches miss the story π§΅5/8
We see broad, lineage-resolved chromatin opening (differential accessibility) that aligns with transcriptional activation of programs linked to neuronal differentiation, synaptogenesis, and plasticity. And a major portion of accessibility changes occurred around Transposons near these genes. π§΅4/8
January 5, 2026 at 11:49 AM
We see broad, lineage-resolved chromatin opening (differential accessibility) that aligns with transcriptional activation of programs linked to neuronal differentiation, synaptogenesis, and plasticity. And a major portion of accessibility changes occurred around Transposons near these genes. π§΅4/8
Our atlas resolves diverse lineages and their cell-type-specific regulatory βgrammarβ (motifs/TF programs) through specific regulatory codes. π§΅3/8
January 5, 2026 at 11:49 AM
Our atlas resolves diverse lineages and their cell-type-specific regulatory βgrammarβ (motifs/TF programs) through specific regulatory codes. π§΅3/8
We built a matched snRNA-seq + snATAC-seq atlas after rhEPO vs placebo to see which regulatory switches flip. π§ β¨
π§΅2/8
π§΅2/8
January 5, 2026 at 11:49 AM
We built a matched snRNA-seq + snATAC-seq atlas after rhEPO vs placebo to see which regulatory switches flip. π§ β¨
π§΅2/8
π§΅2/8
π₯π π§ SuperThrilled to share our paper (preprint) - Human erythropoietin (rhEPO) reshapes the adult hippocampal chromatin landscape, around transposons to promote neurogenesis. π§΅1/8
Massive kudos to #UmutCakir who drove multi-omics through dark roads of the genome.
www.biorxiv.org/content/10.1...
Massive kudos to #UmutCakir who drove multi-omics through dark roads of the genome.
www.biorxiv.org/content/10.1...
January 5, 2026 at 11:49 AM
π₯π π§ SuperThrilled to share our paper (preprint) - Human erythropoietin (rhEPO) reshapes the adult hippocampal chromatin landscape, around transposons to promote neurogenesis. π§΅1/8
Massive kudos to #UmutCakir who drove multi-omics through dark roads of the genome.
www.biorxiv.org/content/10.1...
Massive kudos to #UmutCakir who drove multi-omics through dark roads of the genome.
www.biorxiv.org/content/10.1...
ππ½ππ½ thanks Sarah, looking forward to get to know more about our cluster of Pasteur, Necker and Imagine ππ½
January 4, 2026 at 12:18 PM
ππ½ππ½ thanks Sarah, looking forward to get to know more about our cluster of Pasteur, Necker and Imagine ππ½
Happy new year and 3 more days to apply for Computational biology post doc position in my lab #Paris #transpoosns @inem-necker.bsky.social @institutimagine.bsky.social
January 2, 2026 at 2:41 PM
Happy new year and 3 more days to apply for Computational biology post doc position in my lab #Paris #transpoosns @inem-necker.bsky.social @institutimagine.bsky.social
I'd love to be on this list. How to join?, Happy holidays!!
December 28, 2025 at 12:38 PM
I'd love to be on this list. How to join?, Happy holidays!!
This is the view where we shall have our regular lab meetings. Maybe this persuades you to join our team. #hiring #postdoc #computationalBiology #multiomics #deeplearning
December 20, 2025 at 9:58 AM
This is the view where we shall have our regular lab meetings. Maybe this persuades you to join our team. #hiring #postdoc #computationalBiology #multiomics #deeplearning
Wow! Thanks a lot for sharing this.
My lab is starting from 1st Jan, first thing on my to do list is to join this consortium ππ½ππ½
My lab is starting from 1st Jan, first thing on my to do list is to join this consortium ππ½ππ½
December 10, 2025 at 11:30 AM
Wow! Thanks a lot for sharing this.
My lab is starting from 1st Jan, first thing on my to do list is to join this consortium ππ½ππ½
My lab is starting from 1st Jan, first thing on my to do list is to join this consortium ππ½ππ½
Thatβs great, congratulations!
We should have a Paris TE consortium to exchange ideas and also to co-opt our individual focus into inter-disciplines ππ½
We should have a Paris TE consortium to exchange ideas and also to co-opt our individual focus into inter-disciplines ππ½
December 10, 2025 at 11:19 AM
Thatβs great, congratulations!
We should have a Paris TE consortium to exchange ideas and also to co-opt our individual focus into inter-disciplines ππ½
We should have a Paris TE consortium to exchange ideas and also to co-opt our individual focus into inter-disciplines ππ½
I wish I'd known that you were in Berlin; I would have loved to have an opportunity to see/host you for lunch or even a coffee.π
December 10, 2025 at 10:01 AM
I wish I'd known that you were in Berlin; I would have loved to have an opportunity to see/host you for lunch or even a coffee.π
To apply:
Send to mnujnu@gmail.com
with #RETROVERSE_V1 in the subject:
A cover letter explaining how your interests connect to the lab, plus some of your own ideas (written candidly, without AI tools)
Your CV (with links to code if available)
Please share with people who might be interested.
Send to mnujnu@gmail.com
with #RETROVERSE_V1 in the subject:
A cover letter explaining how your interests connect to the lab, plus some of your own ideas (written candidly, without AI tools)
Your CV (with links to code if available)
Please share with people who might be interested.
December 10, 2025 at 9:56 AM
To apply:
Send to mnujnu@gmail.com
with #RETROVERSE_V1 in the subject:
A cover letter explaining how your interests connect to the lab, plus some of your own ideas (written candidly, without AI tools)
Your CV (with links to code if available)
Please share with people who might be interested.
Send to mnujnu@gmail.com
with #RETROVERSE_V1 in the subject:
A cover letter explaining how your interests connect to the lab, plus some of your own ideas (written candidly, without AI tools)
Your CV (with links to code if available)
Please share with people who might be interested.
#hiring #postdoc #bioinformatics
Weβre opening a Computational/Bioinformatics postdoc position in my new lab at INEM in Paris, connected with Imagine and Institut Pasteur.
The big theme:
π How do endogenous retroviruses and other mobile DNA rewire human immune regulation and genome control? πβ¬οΈπ§΅
Weβre opening a Computational/Bioinformatics postdoc position in my new lab at INEM in Paris, connected with Imagine and Institut Pasteur.
The big theme:
π How do endogenous retroviruses and other mobile DNA rewire human immune regulation and genome control? πβ¬οΈπ§΅
December 10, 2025 at 9:56 AM
#hiring #postdoc #bioinformatics
Weβre opening a Computational/Bioinformatics postdoc position in my new lab at INEM in Paris, connected with Imagine and Institut Pasteur.
The big theme:
π How do endogenous retroviruses and other mobile DNA rewire human immune regulation and genome control? πβ¬οΈπ§΅
Weβre opening a Computational/Bioinformatics postdoc position in my new lab at INEM in Paris, connected with Imagine and Institut Pasteur.
The big theme:
π How do endogenous retroviruses and other mobile DNA rewire human immune regulation and genome control? πβ¬οΈπ§΅
To apply:
Send to mnujnu@gmail.com
with #RETROVERSE_V1 in the subject:
A cover letter explaining how your interests connect to the lab, plus some of your own ideas (written candidly, without AI tools)
Your CV (with links to code if available)
Please share with people who might be interested.
Send to mnujnu@gmail.com
with #RETROVERSE_V1 in the subject:
A cover letter explaining how your interests connect to the lab, plus some of your own ideas (written candidly, without AI tools)
Your CV (with links to code if available)
Please share with people who might be interested.
December 10, 2025 at 9:53 AM
To apply:
Send to mnujnu@gmail.com
with #RETROVERSE_V1 in the subject:
A cover letter explaining how your interests connect to the lab, plus some of your own ideas (written candidly, without AI tools)
Your CV (with links to code if available)
Please share with people who might be interested.
Send to mnujnu@gmail.com
with #RETROVERSE_V1 in the subject:
A cover letter explaining how your interests connect to the lab, plus some of your own ideas (written candidly, without AI tools)
Your CV (with links to code if available)
Please share with people who might be interested.
ππ½ππ½
December 4, 2025 at 4:08 PM
ππ½ππ½