Arnau Sebé-Pedrós
@arnausebe.bsky.social
Group leader CRG; Associate Faculty ToL Sanger Institute.
Genome regulation, chromatin, cell types, and evolution. https://www.sebepedroslab.org
Genome regulation, chromatin, cell types, and evolution. https://www.sebepedroslab.org
Reposted by Arnau Sebé-Pedrós
The day is finally here!! On behalf of all the co-organizers the Comparative Genomics of Unicellular Eukaryotes website is open.
comparativegenomics2026.com
Invited speakers will be added to the website in the coming weeks. Watch this (well, that^) space!
comparativegenomics2026.com
Invited speakers will be added to the website in the coming weeks. Watch this (well, that^) space!
CGUE 2026 – Comparative Genomics of Unicellular Eukaryotes 2026. San Feliu, Spain. 5-10 October
comparativegenomics2026.com
January 30, 2026 at 4:20 PM
The day is finally here!! On behalf of all the co-organizers the Comparative Genomics of Unicellular Eukaryotes website is open.
comparativegenomics2026.com
Invited speakers will be added to the website in the coming weeks. Watch this (well, that^) space!
comparativegenomics2026.com
Invited speakers will be added to the website in the coming weeks. Watch this (well, that^) space!
Reposted by Arnau Sebé-Pedrós
Please share🙏:
Our lab opens 2 PhD positions to investigate fungi's evolution: #Barcelona
Wet lab in Biochemistry/Structural Biology of cryo-tolerant fungi
www.upf.edu/documents/d/...
Computational in Physical Chemistry of cellular processes under extrem environments
www.upf.edu/documents/d/...
Our lab opens 2 PhD positions to investigate fungi's evolution: #Barcelona
Wet lab in Biochemistry/Structural Biology of cryo-tolerant fungi
www.upf.edu/documents/d/...
Computational in Physical Chemistry of cellular processes under extrem environments
www.upf.edu/documents/d/...
www.upf.edu
January 26, 2026 at 11:53 AM
Please share🙏:
Our lab opens 2 PhD positions to investigate fungi's evolution: #Barcelona
Wet lab in Biochemistry/Structural Biology of cryo-tolerant fungi
www.upf.edu/documents/d/...
Computational in Physical Chemistry of cellular processes under extrem environments
www.upf.edu/documents/d/...
Our lab opens 2 PhD positions to investigate fungi's evolution: #Barcelona
Wet lab in Biochemistry/Structural Biology of cryo-tolerant fungi
www.upf.edu/documents/d/...
Computational in Physical Chemistry of cellular processes under extrem environments
www.upf.edu/documents/d/...
Reposted by Arnau Sebé-Pedrós
📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere.
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
January 23, 2026 at 6:41 AM
📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere.
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
Reposted by Arnau Sebé-Pedrós
Need a bit of escapism? Not exactly Lord of the Rings, but in similar vein:
doi.org/10.1038/s443...
doi.org/10.1038/s443...
Epimutations: raw material for evolution? - The EMBO Journal
Epigenetics is fundamental to cell differentiation as it enables cells with identical genomes to adopt distinct fates. Some epigenetic information can also be transmitted between generations, in a pro...
link.springer.com
January 6, 2026 at 6:33 PM
Need a bit of escapism? Not exactly Lord of the Rings, but in similar vein:
doi.org/10.1038/s443...
doi.org/10.1038/s443...
Reposted by Arnau Sebé-Pedrós
TF-MINDI is out! A new method to learn cis-regulatory codes through rich embeddings of TF binding sites. TF-MINDI decomposes motif neighbourhoods, and works downstream of any sequence-to-function deep learning model. We deeply study the enhancer code in human neural development, check out the thread
January 15, 2026 at 12:32 PM
TF-MINDI is out! A new method to learn cis-regulatory codes through rich embeddings of TF binding sites. TF-MINDI decomposes motif neighbourhoods, and works downstream of any sequence-to-function deep learning model. We deeply study the enhancer code in human neural development, check out the thread
Reposted by Arnau Sebé-Pedrós
Thrilled to share that I’ve been awarded a FIS-3 Advanced Grant (ERC-inspired) to study the evolution of neurogenic GRNs.
Recruiting soon: 4 postdocs + 3 PhDs
Press release in Italian — to decolonise scientific language 😄
magazine.unibo.it/it/articoli/...
Email me if interested in joining the lab
Recruiting soon: 4 postdocs + 3 PhDs
Press release in Italian — to decolonise scientific language 😄
magazine.unibo.it/it/articoli/...
Email me if interested in joining the lab
Un viaggio all’origine dei sistemi nervosi
Il nuovo progetto GRNevo, finanziato con un grant FIS-3 Advanced da 1,9 milioni di euro, studierà come si formano i neuroni durante lo sviluppo in specie animali molto distanti tra loro: dal moscerino...
magazine.unibo.it
January 13, 2026 at 11:14 AM
Thrilled to share that I’ve been awarded a FIS-3 Advanced Grant (ERC-inspired) to study the evolution of neurogenic GRNs.
Recruiting soon: 4 postdocs + 3 PhDs
Press release in Italian — to decolonise scientific language 😄
magazine.unibo.it/it/articoli/...
Email me if interested in joining the lab
Recruiting soon: 4 postdocs + 3 PhDs
Press release in Italian — to decolonise scientific language 😄
magazine.unibo.it/it/articoli/...
Email me if interested in joining the lab
Bravo Roberto! what a great way to start your new lab back in Italy.
January 14, 2026 at 8:59 AM
Bravo Roberto! what a great way to start your new lab back in Italy.
Reposted by Arnau Sebé-Pedrós
Our latest: Independent origins of spicules reconcile paleontological and molecular evidence of sponge evolutionary history, led by @meleonora-rossi.bsky.social with help from friends @bristolpalaeo.bsky.social including @anariesgo.bsky.social @evopalaeo.bsky.social Davide Pisani and many others
Independent origins of spicules reconcile paleontological and molecular evidence of sponge evolutionary history
Sponges have a cryptic Ediacaran history because ancestral sponges were soft-bodied and had low fossilization potential.
www.science.org
January 8, 2026 at 7:39 AM
Our latest: Independent origins of spicules reconcile paleontological and molecular evidence of sponge evolutionary history, led by @meleonora-rossi.bsky.social with help from friends @bristolpalaeo.bsky.social including @anariesgo.bsky.social @evopalaeo.bsky.social Davide Pisani and many others
Looks super interesting. Congrats Nikos and team!
January 10, 2026 at 12:02 PM
Looks super interesting. Congrats Nikos and team!
Reposted by Arnau Sebé-Pedrós
I am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!
Evolutionary dynamics of temporal transcription factor series in the insect optic lobe https://www.biorxiv.org/content/10.64898/2026.01.08.698497v1
January 10, 2026 at 9:43 AM
I am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!
Reposted by Arnau Sebé-Pedrós
Our eLetter github.com/caseywdunn/s... responding to a recent Science paper was just posted. The paper found more genes with consistent support for sponge-sister than ctenophore-sister. We found several technical issues that, when corrected, reverse the conclusions and recover ctenophore-sister.
January 9, 2026 at 11:44 AM
Our eLetter github.com/caseywdunn/s... responding to a recent Science paper was just posted. The paper found more genes with consistent support for sponge-sister than ctenophore-sister. We found several technical issues that, when corrected, reverse the conclusions and recover ctenophore-sister.
Reposted by Arnau Sebé-Pedrós
Our work on the evolution of the regulatory genome of echinoderms is now out in @natecoevo.nature.com. Led by my former PhD Marta Magri, Danila Voronov & Saoirse Foley. Great collaboration of Arnone, Hinman & Maeso labs, started long time ago with our missed José Luis Gomez-Skarmeta: rdcu.be/eXX8l
Deep conservation of cis-regulatory elements and chromatin organization in echinoderms uncover ancestral regulatory features of animal genomes
Nature Ecology & Evolution - Analysis of the 3D chromatin architecture and cis-regulatory elements in a sea urchin and a sea star reveals mechanisms of 3D chromatin organization in echinoderms...
rdcu.be
January 7, 2026 at 7:33 PM
Our work on the evolution of the regulatory genome of echinoderms is now out in @natecoevo.nature.com. Led by my former PhD Marta Magri, Danila Voronov & Saoirse Foley. Great collaboration of Arnone, Hinman & Maeso labs, started long time ago with our missed José Luis Gomez-Skarmeta: rdcu.be/eXX8l
Open Senior Bioinformatician position at
@sangerinstitute.bsky.social
Tree of Life, to work on the Biodiversity Cell Atlas initiative with @marakat.bsky.social and me.
📅 Apply by January 18
🔗 sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Please share with anyone who might be interested!
@sangerinstitute.bsky.social
Tree of Life, to work on the Biodiversity Cell Atlas initiative with @marakat.bsky.social and me.
📅 Apply by January 18
🔗 sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Please share with anyone who might be interested!
Senior Bioinformatician - Biodiversity Cell Atlas
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
sanger.wd103.myworkdayjobs.com
January 2, 2026 at 1:12 PM
Open Senior Bioinformatician position at
@sangerinstitute.bsky.social
Tree of Life, to work on the Biodiversity Cell Atlas initiative with @marakat.bsky.social and me.
📅 Apply by January 18
🔗 sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Please share with anyone who might be interested!
@sangerinstitute.bsky.social
Tree of Life, to work on the Biodiversity Cell Atlas initiative with @marakat.bsky.social and me.
📅 Apply by January 18
🔗 sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Please share with anyone who might be interested!
Reposted by Arnau Sebé-Pedrós
Looking to start your lab in generative biology / AI?
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
pls RT
tinyurl.com/GenGenFaculty
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
pls RT
tinyurl.com/GenGenFaculty
Group Leader - Generative Biology and AI
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
tinyurl.com
January 1, 2026 at 12:08 PM
Looking to start your lab in generative biology / AI?
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
pls RT
tinyurl.com/GenGenFaculty
Come join us at the @sangerinstitute.bsky.social
Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways!
pls RT
tinyurl.com/GenGenFaculty
Reposted by Arnau Sebé-Pedrós
🚨🚨🚨
We're looking for a research tech to work on alt splicing, pancreatic islets and diabetes. The goal is to set a high-throughput platform to investigate the role of alternative exons in beta cell biology!
Interested in joining our lab at @melisupf.bsky.social? 👇
www.upf.edu/documents/d/...
We're looking for a research tech to work on alt splicing, pancreatic islets and diabetes. The goal is to set a high-throughput platform to investigate the role of alternative exons in beta cell biology!
Interested in joining our lab at @melisupf.bsky.social? 👇
www.upf.edu/documents/d/...
www.upf.edu
December 23, 2025 at 12:36 PM
🚨🚨🚨
We're looking for a research tech to work on alt splicing, pancreatic islets and diabetes. The goal is to set a high-throughput platform to investigate the role of alternative exons in beta cell biology!
Interested in joining our lab at @melisupf.bsky.social? 👇
www.upf.edu/documents/d/...
We're looking for a research tech to work on alt splicing, pancreatic islets and diabetes. The goal is to set a high-throughput platform to investigate the role of alternative exons in beta cell biology!
Interested in joining our lab at @melisupf.bsky.social? 👇
www.upf.edu/documents/d/...
The exciting next question is what these regulatory sequences can tell us about the evolution of cell types across species. We’ll be working on this in the coming years.
December 22, 2025 at 10:22 AM
The exciting next question is what these regulatory sequences can tell us about the evolution of cell types across species. We’ll be working on this in the coming years.
This is similar to what @tschopplab.bsky.social recently reported for skeletogenic cells in vertebrates. These approaches can be particularly useful to study cell type ontogenetic relationships in non-genetically tractable species and without access to dev stages.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 22, 2025 at 10:22 AM
This is similar to what @tschopplab.bsky.social recently reported for skeletogenic cells in vertebrates. These approaches can be particularly useful to study cell type ontogenetic relationships in non-genetically tractable species and without access to dev stages.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
We observed that while gene activity groups cell type functionally, whereas CREs and regulatory seqs group them ontogenetically. E.g. mesenteric and tentacle retractor muscles, a dev convergence described by @alisongcole.bsky.social and @ulrichtechnau.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 22, 2025 at 10:17 AM
We observed that while gene activity groups cell type functionally, whereas CREs and regulatory seqs group them ontogenetically. E.g. mesenteric and tentacle retractor muscles, a dev convergence described by @alisongcole.bsky.social and @ulrichtechnau.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
With this TF-motif collection, we defined important TF in every cell type (expressed and with high motif accessibility) and we predicted TF-CRE regulatory links. In the example, the predicted cnidocyte GRN.
December 22, 2025 at 10:16 AM
With this TF-motif collection, we defined important TF in every cell type (expressed and with high motif accessibility) and we predicted TF-CRE regulatory links. In the example, the predicted cnidocyte GRN.
A major challenge was inferring TF binding motifs. We first derived multispecies motif archetypes from known and de novo motifs, then assigned archetypes to TFs by combining phylogenetic analysis (@zolotarg.bsky.social) with correlations between TF expression and motif accessibility.
December 22, 2025 at 10:15 AM
A major challenge was inferring TF binding motifs. We first derived multispecies motif archetypes from known and de novo motifs, then assigned archetypes to TFs by combining phylogenetic analysis (@zolotarg.bsky.social) with correlations between TF expression and motif accessibility.
Then, we used different sequence models to predict CRE activty. With the crucial help of @steinaerts.bsky.social and @lukasmahieu.bsky.social, who introduced us to the world of DL sequence models. In this example, top motif grammars defining cnidocyte CREs:
December 22, 2025 at 10:14 AM
Then, we used different sequence models to predict CRE activty. With the crucial help of @steinaerts.bsky.social and @lukasmahieu.bsky.social, who introduced us to the world of DL sequence models. In this example, top motif grammars defining cnidocyte CREs:
We map cell type-specific accessible regulatory landscapes in adult and gastrula stages, identifying over 112,000 candidate cis-regulatory elements (CREs), representing different types of promoters and non-promoter elements.
December 22, 2025 at 10:13 AM
We map cell type-specific accessible regulatory landscapes in adult and gastrula stages, identifying over 112,000 candidate cis-regulatory elements (CREs), representing different types of promoters and non-promoter elements.
Excited to share the final version of our study on Nematostella cell type regulatory programs. Part of our @erc.europa.eu StG project, this was a challenging 5-year effort extraodinarily led by @aelek.bsky.social and @martaig.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Decoding cnidarian cell type gene regulation - Nature Ecology & Evolution
This study reconstructs the gene regulatory networks that define cell types in the sea anemone Nematostella vectensis, providing a valuable resource for comparative regulatory genomics and the evoluti...
www.nature.com
December 22, 2025 at 10:12 AM
Excited to share the final version of our study on Nematostella cell type regulatory programs. Part of our @erc.europa.eu StG project, this was a challenging 5-year effort extraodinarily led by @aelek.bsky.social and @martaig.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Arnau Sebé-Pedrós
Thanks @jcellsci.bsky.social for this opportunity to contribute to your centenary collection with our take on the state of the field - 10 years after its modern reincarnation 🧪🌍
W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social
journals.biologists.com/jcs/article/...
W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social
journals.biologists.com/jcs/article/...
Evolutionary cell biology comes of age
Summary: This Perspective discusses how the discipline of evolutionary cell biology, by integrating evolutionary theory, comparative physiology and modern molecular approaches, works to understand how...
journals.biologists.com
December 19, 2025 at 4:13 PM
Thanks @jcellsci.bsky.social for this opportunity to contribute to your centenary collection with our take on the state of the field - 10 years after its modern reincarnation 🧪🌍
W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social
journals.biologists.com/jcs/article/...
W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social
journals.biologists.com/jcs/article/...
Reposted by Arnau Sebé-Pedrós
@science.org Multistep genomics on single cells and live cultures in subnanoliter capsules | Science www.science.org/doi/10.1126/...
Multistep genomics on single cells and live cultures in subnanoliter capsules
Single-cell sequencing methods uncover natural and induced variation between cells. Many functional genomic methods, however, require multiple steps that cannot yet be scaled to high throughput, inclu...
www.science.org
December 19, 2025 at 10:32 PM
@science.org Multistep genomics on single cells and live cultures in subnanoliter capsules | Science www.science.org/doi/10.1126/...