Ivano Legnini
@ilegnini.bsky.social
Group Leader @humantechnopole.bsky.social
Molecular and Systems Biology. RNA enthusiast
Molecular and Systems Biology. RNA enthusiast
1/6 We are hiring!!! 🐣🐣🐣
Fully funded postdoc position in my group!
humantechnopole.it/en/research-...
Fully funded postdoc position in my group!
humantechnopole.it/en/research-...
Legnini Group - Human Technopole
Laboratory for Molecular and Systems Biology of RNA The Legnini Group at Human Technopole combines molecular and systems biology approaches to study gene regulation. We use synthetic biology and opt...
humantechnopole.it
November 6, 2025 at 5:43 PM
1/6 We are hiring!!! 🐣🐣🐣
Fully funded postdoc position in my group!
humantechnopole.it/en/research-...
Fully funded postdoc position in my group!
humantechnopole.it/en/research-...
Looking for a master student to help with a superexciting EU-funded project on mRNA metabolism. It'll involve cutting-edge sequencing and imaging techniques as well as computational workflows and modelling - great training opportunity! Get in touch if interested
humantechnopole.it/en/research-...
humantechnopole.it/en/research-...
Legnini Group - Human Technopole
Laboratory for Molecular and Systems Biology of RNA The Legnini Group at Human Technopole combines molecular and systems biology approaches to study gene regulation. We use synthetic biology and opt...
humantechnopole.it
September 10, 2025 at 7:51 AM
Looking for a master student to help with a superexciting EU-funded project on mRNA metabolism. It'll involve cutting-edge sequencing and imaging techniques as well as computational workflows and modelling - great training opportunity! Get in touch if interested
humantechnopole.it/en/research-...
humantechnopole.it/en/research-...
Reposted by Ivano Legnini
Immune responses need to be fast ⏱️ mRNA metabolism adapts rapidly via alternative splicing, polyadenylation & decay. Find out more: febs.onlinelibrary.wiley.com/doi/10.1002/...
#Immunology #RNA #mRNAmetabolism @ilegnini.bsky.social
#Immunology #RNA #mRNAmetabolism @ilegnini.bsky.social
August 26, 2025 at 12:53 PM
Immune responses need to be fast ⏱️ mRNA metabolism adapts rapidly via alternative splicing, polyadenylation & decay. Find out more: febs.onlinelibrary.wiley.com/doi/10.1002/...
#Immunology #RNA #mRNAmetabolism @ilegnini.bsky.social
#Immunology #RNA #mRNAmetabolism @ilegnini.bsky.social
Reposted by Ivano Legnini
Great opportunity! Up to 4 Group Leader positions at the NOVA Institute for Medical Systems Biology (NIMSB) in Computational & Experimental Medical Systems Biology
📍 Lisbon
⏳ Apply by Oct 8
🔗 nimsb.unl.pt/wp-content/u...
#Job #SciencePositions #JobOffer #GroupLeaders #Innovation #systemsbiology
📍 Lisbon
⏳ Apply by Oct 8
🔗 nimsb.unl.pt/wp-content/u...
#Job #SciencePositions #JobOffer #GroupLeaders #Innovation #systemsbiology
August 7, 2025 at 8:05 AM
Great opportunity! Up to 4 Group Leader positions at the NOVA Institute for Medical Systems Biology (NIMSB) in Computational & Experimental Medical Systems Biology
📍 Lisbon
⏳ Apply by Oct 8
🔗 nimsb.unl.pt/wp-content/u...
#Job #SciencePositions #JobOffer #GroupLeaders #Innovation #systemsbiology
📍 Lisbon
⏳ Apply by Oct 8
🔗 nimsb.unl.pt/wp-content/u...
#Job #SciencePositions #JobOffer #GroupLeaders #Innovation #systemsbiology
Reposted by Ivano Legnini
🎉 A stellar wrap-up for the Milan #RNA Salon! On 18 July, 120+ scientists gathered at HT for the final event of the season.
🔬 Matthias Hentze @embl.org opened with a keynote on Riboregulation, followed by research talks from Laura Carpen (HT) and @mchiaragrieco.bsky.social @ceredalab.bsky.social
🔬 Matthias Hentze @embl.org opened with a keynote on Riboregulation, followed by research talks from Laura Carpen (HT) and @mchiaragrieco.bsky.social @ceredalab.bsky.social
July 25, 2025 at 8:06 AM
🎉 A stellar wrap-up for the Milan #RNA Salon! On 18 July, 120+ scientists gathered at HT for the final event of the season.
🔬 Matthias Hentze @embl.org opened with a keynote on Riboregulation, followed by research talks from Laura Carpen (HT) and @mchiaragrieco.bsky.social @ceredalab.bsky.social
🔬 Matthias Hentze @embl.org opened with a keynote on Riboregulation, followed by research talks from Laura Carpen (HT) and @mchiaragrieco.bsky.social @ceredalab.bsky.social
Reposted by Ivano Legnini
This job involve spending 1-2 years in Berlin and 1-2 years in Barcelona, a truly unique opportunity! 🌍
As the lead scientist, you will apply single-cell long-read sequencing, CRISPR interference, and small molecule modulation to dissect the molecular pathways underlying islet development.
As the lead scientist, you will apply single-cell long-read sequencing, CRISPR interference, and small molecule modulation to dissect the molecular pathways underlying islet development.
July 23, 2025 at 2:28 PM
This job involve spending 1-2 years in Berlin and 1-2 years in Barcelona, a truly unique opportunity! 🌍
As the lead scientist, you will apply single-cell long-read sequencing, CRISPR interference, and small molecule modulation to dissect the molecular pathways underlying islet development.
As the lead scientist, you will apply single-cell long-read sequencing, CRISPR interference, and small molecule modulation to dissect the molecular pathways underlying islet development.
Reposted by Ivano Legnini
🚨🚨🚨
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
www.upf.edu
July 23, 2025 at 2:28 PM
🚨🚨🚨
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Reposted by Ivano Legnini
We’re happy to share our new preprint form
@N_Rajewsky, with @tmpentimalli.bsky.social i.bsky.social @Ilan Theurillat
lab! 🎉
🧬 Spatiotemporal atlas of tumor–stroma crosstalk in a new TNBC model. Spatial transcriptomics (Open-ST), snRNA-seq, and functional validation.
🔗 biorxiv.org/content/10.1...
@N_Rajewsky, with @tmpentimalli.bsky.social i.bsky.social @Ilan Theurillat
lab! 🎉
🧬 Spatiotemporal atlas of tumor–stroma crosstalk in a new TNBC model. Spatial transcriptomics (Open-ST), snRNA-seq, and functional validation.
🔗 biorxiv.org/content/10.1...
Spatiotemporal dynamics of tumor microenvironment remodeling
During tumorigenesis, interactions between tumor and stromal cells progressively remodel the tumor microenvironment (TME) towards pro-tumoral functions. Understanding early TME remodeling dynamics is ...
biorxiv.org
July 22, 2025 at 9:48 AM
We’re happy to share our new preprint form
@N_Rajewsky, with @tmpentimalli.bsky.social i.bsky.social @Ilan Theurillat
lab! 🎉
🧬 Spatiotemporal atlas of tumor–stroma crosstalk in a new TNBC model. Spatial transcriptomics (Open-ST), snRNA-seq, and functional validation.
🔗 biorxiv.org/content/10.1...
@N_Rajewsky, with @tmpentimalli.bsky.social i.bsky.social @Ilan Theurillat
lab! 🎉
🧬 Spatiotemporal atlas of tumor–stroma crosstalk in a new TNBC model. Spatial transcriptomics (Open-ST), snRNA-seq, and functional validation.
🔗 biorxiv.org/content/10.1...
Reposted by Ivano Legnini
🚨 New preprint alert 🚨
We systematically benchmarked @nanoporetech.com 's modification-aware basecalling models released for RNA on sets of in vitro and in vivo sequences and made some curious observations 🧬🔍.
bit.ly/4lXqNul
Follow along for a little recap (1/12)
We systematically benchmarked @nanoporetech.com 's modification-aware basecalling models released for RNA on sets of in vitro and in vivo sequences and made some curious observations 🧬🔍.
bit.ly/4lXqNul
Follow along for a little recap (1/12)
Systematic benchmarking of basecalling models for RNA modification detection with highly multiplexed nanopore sequencing
Nanopore direct RNA sequencing (DRS) holds promise for advancing our understanding of the epitranscriptome by detecting RNA modifications in native RNA molecules. Recently, Oxford Nanopore Technologie...
bit.ly
July 14, 2025 at 4:00 PM
🚨 New preprint alert 🚨
We systematically benchmarked @nanoporetech.com 's modification-aware basecalling models released for RNA on sets of in vitro and in vivo sequences and made some curious observations 🧬🔍.
bit.ly/4lXqNul
Follow along for a little recap (1/12)
We systematically benchmarked @nanoporetech.com 's modification-aware basecalling models released for RNA on sets of in vitro and in vivo sequences and made some curious observations 🧬🔍.
bit.ly/4lXqNul
Follow along for a little recap (1/12)
Reposted by Ivano Legnini
‼️ Don't forget to submit your abstract for #EMBLSpatialBiology! The new deadline is 15 July 👉 https://s.embl.org/spb25-01-bl
📅 14–17 Oct
📍EMBL Heidelberg and Virtual
✨ ESSB will provide a fee subsidy for the top accepted abstracts. More info ➡️ https://s.embl.org/SPB25-01-practical-information
📅 14–17 Oct
📍EMBL Heidelberg and Virtual
✨ ESSB will provide a fee subsidy for the top accepted abstracts. More info ➡️ https://s.embl.org/SPB25-01-practical-information
July 9, 2025 at 11:00 AM
‼️ Don't forget to submit your abstract for #EMBLSpatialBiology! The new deadline is 15 July 👉 https://s.embl.org/spb25-01-bl
📅 14–17 Oct
📍EMBL Heidelberg and Virtual
✨ ESSB will provide a fee subsidy for the top accepted abstracts. More info ➡️ https://s.embl.org/SPB25-01-practical-information
📅 14–17 Oct
📍EMBL Heidelberg and Virtual
✨ ESSB will provide a fee subsidy for the top accepted abstracts. More info ➡️ https://s.embl.org/SPB25-01-practical-information
Reposted by Ivano Legnini
Scientists 3-D printed objects inside of living cells for the first time. Naturally, they chose to print an elephant.
Scientists 3-D printed a tiny elephant inside a cell
The first structures ever 3-D printed inside living cells point to applications for biology research.
buff.ly
July 12, 2025 at 1:10 PM
Scientists 3-D printed objects inside of living cells for the first time. Naturally, they chose to print an elephant.
Reposted by Ivano Legnini
📢 Announcing the MOPITAS Autumn School on Spatial Transcriptomics Data Analysis – taking place November 12–14, in Munich. Don't miss this excellent opportunity to deepen your expertise in data science and multi-OMICS analysis - especially as a PhD student in the data science community.
July 4, 2025 at 7:20 PM
📢 Announcing the MOPITAS Autumn School on Spatial Transcriptomics Data Analysis – taking place November 12–14, in Munich. Don't miss this excellent opportunity to deepen your expertise in data science and multi-OMICS analysis - especially as a PhD student in the data science community.
🧡
Science, Nature,Friends….the Legnini Lab retreat was an amazing experience! @ilegnini.bsky.social @lindamasante.bsky.social @fmarcuccio.bsky.social ❤️
June 26, 2025 at 7:03 PM
🧡
Reposted by Ivano Legnini
🚨We are looking for post-doctoral candidates to apply for a MSCA fellowship.
Projects on gene regulation in neural development or neurdegenerative diseases using single-cell omics.
Computational & wet-lab candidates are welcomed! #postdoc #MSCA #Barcelona #singlecell.
Projects on gene regulation in neural development or neurdegenerative diseases using single-cell omics.
Computational & wet-lab candidates are welcomed! #postdoc #MSCA #Barcelona #singlecell.
Postdoctoral Fellowships
The information provided on this page is a summary of the main rules and requirements for Postdoctoral Fellowships (PFs) and who can apply for them.
marie-sklodowska-curie-actions.ec.europa.eu
June 25, 2025 at 8:23 AM
🚨We are looking for post-doctoral candidates to apply for a MSCA fellowship.
Projects on gene regulation in neural development or neurdegenerative diseases using single-cell omics.
Computational & wet-lab candidates are welcomed! #postdoc #MSCA #Barcelona #singlecell.
Projects on gene regulation in neural development or neurdegenerative diseases using single-cell omics.
Computational & wet-lab candidates are welcomed! #postdoc #MSCA #Barcelona #singlecell.
Reposted by Ivano Legnini
#RNA Framework 2.9.3 is out! Lots of improvements! Check it out: github.com/dincarnato/R... & see the CHANGELOG (raw.githubusercontent.com/dincarnato/R...) for the details!
June 19, 2025 at 12:21 PM
#RNA Framework 2.9.3 is out! Lots of improvements! Check it out: github.com/dincarnato/R... & see the CHANGELOG (raw.githubusercontent.com/dincarnato/R...) for the details!
Reposted by Ivano Legnini
In Science, researchers present a new method to safely and preferentially generate CAR T cells directly inside the body using targeted lipid nanoparticles that deliver mRNA directly to T cells.
Learn more: scim.ag/4jVfcuk
#SciencePerspective: scim.ag/3STvdWC
Learn more: scim.ag/4jVfcuk
#SciencePerspective: scim.ag/3STvdWC
June 19, 2025 at 7:56 PM
In Science, researchers present a new method to safely and preferentially generate CAR T cells directly inside the body using targeted lipid nanoparticles that deliver mRNA directly to T cells.
Learn more: scim.ag/4jVfcuk
#SciencePerspective: scim.ag/3STvdWC
Learn more: scim.ag/4jVfcuk
#SciencePerspective: scim.ag/3STvdWC
Reposted by Ivano Legnini
🧬 Ageing, immunity & chronic diseases: HT wins €2.5M @erc.europa.eu Advanced Grant for a 5-year project led by @nicolesoranzo.bsky.social. Using AI & big data, the group will decode how our immune system weakens over time. A huge step for precision medicine!
humantechnopole.it/en/news/agei...
humantechnopole.it/en/news/agei...
Ageing and Chronic Diseases: Europe Rewards Human Technopole’s Research - Human Technopole
The ERC has awarded HT a €2.5 million grant for a study investigating how lifestyle, biology and environmental exposures weaken the immune system over the course of life and increase vulnerability to ...
humantechnopole.it
June 17, 2025 at 10:08 AM
🧬 Ageing, immunity & chronic diseases: HT wins €2.5M @erc.europa.eu Advanced Grant for a 5-year project led by @nicolesoranzo.bsky.social. Using AI & big data, the group will decode how our immune system weakens over time. A huge step for precision medicine!
humantechnopole.it/en/news/agei...
humantechnopole.it/en/news/agei...
Reposted by Ivano Legnini
But this is happening to people around us: foreign professors, teachers, students, postdocs, neighbors. And sometimes much worse. Please don’t assume this can’t happen where you live. And if you witness it, say something. Silence is complicity.
June 9, 2025 at 5:25 PM
But this is happening to people around us: foreign professors, teachers, students, postdocs, neighbors. And sometimes much worse. Please don’t assume this can’t happen where you live. And if you witness it, say something. Silence is complicity.
Reposted by Ivano Legnini
Thrilled to share our latest preprint describing an optimized spatial tissue proteomics workflow for the preparation and analysis of >100 proteomes / day at high spatial resolution.
Kudos to @melissaklingeberg.bsky.social 🥳 and big thanks to all our collaborators! bit.ly/3SCARw4
Kudos to @melissaklingeberg.bsky.social 🥳 and big thanks to all our collaborators! bit.ly/3SCARw4
An ultrasensitive spatial tissue proteomics workflow exceeding 100 proteomes per day
Achieving high-resolution spatial tissue proteomes requires careful balancing and integration of optimized sample processing, chromatography, and MS acquisition. Here, we present an advanced cellenONE...
bit.ly
June 5, 2025 at 5:57 PM
Thrilled to share our latest preprint describing an optimized spatial tissue proteomics workflow for the preparation and analysis of >100 proteomes / day at high spatial resolution.
Kudos to @melissaklingeberg.bsky.social 🥳 and big thanks to all our collaborators! bit.ly/3SCARw4
Kudos to @melissaklingeberg.bsky.social 🥳 and big thanks to all our collaborators! bit.ly/3SCARw4
Reposted by Ivano Legnini
🚨 We’re looking for a curious mind to join our lab at the NIH!
Passionate about #RNA biology, #MachineLearning, and the #genomics of #aging?
Interested in a postdoc or a PhD research visit at NIH? Let’s connect.
📩 DM or email for details!
#Bioinformatics #AI #ComputationalBiology
Passionate about #RNA biology, #MachineLearning, and the #genomics of #aging?
Interested in a postdoc or a PhD research visit at NIH? Let’s connect.
📩 DM or email for details!
#Bioinformatics #AI #ComputationalBiology
June 4, 2025 at 5:30 PM
🚨 We’re looking for a curious mind to join our lab at the NIH!
Passionate about #RNA biology, #MachineLearning, and the #genomics of #aging?
Interested in a postdoc or a PhD research visit at NIH? Let’s connect.
📩 DM or email for details!
#Bioinformatics #AI #ComputationalBiology
Passionate about #RNA biology, #MachineLearning, and the #genomics of #aging?
Interested in a postdoc or a PhD research visit at NIH? Let’s connect.
📩 DM or email for details!
#Bioinformatics #AI #ComputationalBiology
Reposted by Ivano Legnini
Organoids are becoming a valid alternative, but they can’t fully replace animal research – yet. At the #mdcBerlin, we’re working on better models and transparent communication. That's what @eara.eu's #BOARD25 is all about!
More on our organoid research:
🔗 www.mdc-berlin.de/themen/organ...
More on our organoid research:
🔗 www.mdc-berlin.de/themen/organ...
June 3, 2025 at 3:30 PM
Organoids are becoming a valid alternative, but they can’t fully replace animal research – yet. At the #mdcBerlin, we’re working on better models and transparent communication. That's what @eara.eu's #BOARD25 is all about!
More on our organoid research:
🔗 www.mdc-berlin.de/themen/organ...
More on our organoid research:
🔗 www.mdc-berlin.de/themen/organ...
Reposted by Ivano Legnini
KODAMA goes spatial.
doi.org/10.1101/2025...
#spatialtranscriptomics #visium #visiumhd #seurat #giotto
doi.org/10.1101/2025...
#spatialtranscriptomics #visium #visiumhd #seurat #giotto
June 2, 2025 at 8:22 PM
KODAMA goes spatial.
doi.org/10.1101/2025...
#spatialtranscriptomics #visium #visiumhd #seurat #giotto
doi.org/10.1101/2025...
#spatialtranscriptomics #visium #visiumhd #seurat #giotto
Reposted by Ivano Legnini
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
My lab studies bacterial infections. We spend a lot of time looking at (or for) species-specific genetic and genomic databases for hosts and microbes. FlyBase is the best of all—there is literally no comparison. Its existence is under threat. Please donate.
www.philanthropy.cam.ac.uk/give-to-camb...
www.philanthropy.cam.ac.uk/give-to-camb...
Drosophila Genetic Database
The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...
www.philanthropy.cam.ac.uk
June 3, 2025 at 5:20 PM
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
Reposted by Ivano Legnini
Check out our latest work on the evolution of animal genome regulation out today in @nature.com. Nicely summarized below by @ianakim.bsky.social.
www.nature.com/articles/s41...
This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu
www.nature.com/articles/s41...
This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu
May 7, 2025 at 3:32 PM
Check out our latest work on the evolution of animal genome regulation out today in @nature.com. Nicely summarized below by @ianakim.bsky.social.
www.nature.com/articles/s41...
This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu
www.nature.com/articles/s41...
This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu
Reposted by Ivano Legnini
Monday is the big day! Very much looking forward to welcoming all participants and speakers of the Neurogenomics Conference to @humantechnopole.bsky.social in Milan. It promises to be an exciting few days filled with amazing science.
May 17, 2025 at 11:06 AM
Monday is the big day! Very much looking forward to welcoming all participants and speakers of the Neurogenomics Conference to @humantechnopole.bsky.social in Milan. It promises to be an exciting few days filled with amazing science.