FEBS Letters
@febsletters.bsky.social
Publishing cutting-edge reports in Biochemistry, Structural Biology, Molecular Cell Biology, Biophysics, Systems Biology, Microbiology and more. Part of @febspress.bsky.social. febsletters.org
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Our final issue of 2025 is online now!🎉
We close 2025 with:
- A guide to creating excellent graphical abstracts 🎨
- A tribute to Jaroslav Cinatl
- Reviews on synthetic cells, lipidated proteins, & endothelial cells
- Research on DNA damage & more!
Read the issue here ▶️https://tinyurl.com/yswns5aa
We close 2025 with:
- A guide to creating excellent graphical abstracts 🎨
- A tribute to Jaroslav Cinatl
- Reviews on synthetic cells, lipidated proteins, & endothelial cells
- Research on DNA damage & more!
Read the issue here ▶️https://tinyurl.com/yswns5aa
In #diabetes, #endothelial cells are sensitive to changes in blood glucose. Bushell et al. show DHLA supplementation enhances H2S production via 3-MST & improves endothelial function under high glucose conditions, with implications for diabetes treatment.
➡️ doi.org/10.1002/1873-3468.70239
➡️ doi.org/10.1002/1873-3468.70239
January 9, 2026 at 12:01 PM
In #diabetes, #endothelial cells are sensitive to changes in blood glucose. Bushell et al. show DHLA supplementation enhances H2S production via 3-MST & improves endothelial function under high glucose conditions, with implications for diabetes treatment.
➡️ doi.org/10.1002/1873-3468.70239
➡️ doi.org/10.1002/1873-3468.70239
⌛ Increases in human life expectancy are not matched by increased health in old age. In a new review in FEBS Letters, @jetteleng.bsky.social et al. explore research on #hematopoieticstemcell rejuvenation in #ageing.
➡️ doi.org/10.1002/1873-3468.70215
➡️ doi.org/10.1002/1873-3468.70215
January 8, 2026 at 12:01 PM
⌛ Increases in human life expectancy are not matched by increased health in old age. In a new review in FEBS Letters, @jetteleng.bsky.social et al. explore research on #hematopoieticstemcell rejuvenation in #ageing.
➡️ doi.org/10.1002/1873-3468.70215
➡️ doi.org/10.1002/1873-3468.70215
🧪 New method alert! Hannes Mutschler et al. describe FLARE, a new single-tube, real-time assay for monitoring of ribonucleotide reductase activity. Read the OA article for free here:
➡️ doi.org/10.1002/1873-3468.70237
#RAR #ribonucleotidereductase #methods #DNA #ribonucleotide
➡️ doi.org/10.1002/1873-3468.70237
#RAR #ribonucleotidereductase #methods #DNA #ribonucleotide
January 7, 2026 at 12:01 PM
🧪 New method alert! Hannes Mutschler et al. describe FLARE, a new single-tube, real-time assay for monitoring of ribonucleotide reductase activity. Read the OA article for free here:
➡️ doi.org/10.1002/1873-3468.70237
#RAR #ribonucleotidereductase #methods #DNA #ribonucleotide
➡️ doi.org/10.1002/1873-3468.70237
#RAR #ribonucleotidereductase #methods #DNA #ribonucleotide
🫧 #Phosphoinositides play an essential role in #membrane biology, influencing stress response, membrane remodelling, endosomal trafficking, and more. Read about the latest advances in a new review by Carla Alemany and Etienne Morel:
➡️ doi.org/10.1002/1873-3468.70213
@membramics-lab.bsky.social
➡️ doi.org/10.1002/1873-3468.70213
@membramics-lab.bsky.social
January 6, 2026 at 12:01 PM
🫧 #Phosphoinositides play an essential role in #membrane biology, influencing stress response, membrane remodelling, endosomal trafficking, and more. Read about the latest advances in a new review by Carla Alemany and Etienne Morel:
➡️ doi.org/10.1002/1873-3468.70213
@membramics-lab.bsky.social
➡️ doi.org/10.1002/1873-3468.70213
@membramics-lab.bsky.social
🔔 FEBS Letters' final issue of 2025 features:
🖊️ Reviews covering circulating endothelial cells, synthetic #CellMembranes, & lipidated cargo trafficking
👩🔬 Scientists' Forum articles including a deep-dive on the #GraphicalAbstract
🧬 Research on #DNA damage & more...
➡️ bit.ly/4jpcfUf
🖊️ Reviews covering circulating endothelial cells, synthetic #CellMembranes, & lipidated cargo trafficking
👩🔬 Scientists' Forum articles including a deep-dive on the #GraphicalAbstract
🧬 Research on #DNA damage & more...
➡️ bit.ly/4jpcfUf
January 5, 2026 at 12:00 PM
🔔 FEBS Letters' final issue of 2025 features:
🖊️ Reviews covering circulating endothelial cells, synthetic #CellMembranes, & lipidated cargo trafficking
👩🔬 Scientists' Forum articles including a deep-dive on the #GraphicalAbstract
🧬 Research on #DNA damage & more...
➡️ bit.ly/4jpcfUf
🖊️ Reviews covering circulating endothelial cells, synthetic #CellMembranes, & lipidated cargo trafficking
👩🔬 Scientists' Forum articles including a deep-dive on the #GraphicalAbstract
🧬 Research on #DNA damage & more...
➡️ bit.ly/4jpcfUf
🎊 The FEBS Letters team thanks all our authors, reviewers, editors, and readers for our success in 2025! 🎊
We look forward to bringing you more fast publishing for curious scientists in the new year!
We look forward to bringing you more fast publishing for curious scientists in the new year!
December 31, 2025 at 12:03 PM
🎊 The FEBS Letters team thanks all our authors, reviewers, editors, and readers for our success in 2025! 🎊
We look forward to bringing you more fast publishing for curious scientists in the new year!
We look forward to bringing you more fast publishing for curious scientists in the new year!
The #DPPIV family #proteases were thought to function just as dipeptidyl #peptidases, cleaving only after proline or alanine. Here, Trivedi and Gudipati report that C. elegans DPF-3 and human DPP4 possess previously unrecognized tripeptidyl peptidase activity.
➡️ doi.org/10.1002/1873-3468.70219
➡️ doi.org/10.1002/1873-3468.70219
December 30, 2025 at 12:02 PM
The #DPPIV family #proteases were thought to function just as dipeptidyl #peptidases, cleaving only after proline or alanine. Here, Trivedi and Gudipati report that C. elegans DPF-3 and human DPP4 possess previously unrecognized tripeptidyl peptidase activity.
➡️ doi.org/10.1002/1873-3468.70219
➡️ doi.org/10.1002/1873-3468.70219
🧑🏫 Postdocs often supervise students, and even though it helps them build #LeadershipSkills needed for future roles, many find this task a burden. This article offers tips to align expectations, build trust, and turn #Mentorship to a driver for better science.
➡️ doi.org/10.1002/1873-3468.70214
➡️ doi.org/10.1002/1873-3468.70214
December 29, 2025 at 12:01 PM
🧑🏫 Postdocs often supervise students, and even though it helps them build #LeadershipSkills needed for future roles, many find this task a burden. This article offers tips to align expectations, build trust, and turn #Mentorship to a driver for better science.
➡️ doi.org/10.1002/1873-3468.70214
➡️ doi.org/10.1002/1873-3468.70214
☃️ Happy holidays and happy new year from the editorial office of FEBS Letters!
December 24, 2025 at 12:02 PM
☃️ Happy holidays and happy new year from the editorial office of FEBS Letters!
Tracking phosphoinositides is challenging—they’re dynamic & compartment-specific. This review summarizes how pairing #LiveCell imaging with advanced #MassSpectrometry enables precise, isomer-resolved quantification, offering insights into these molecules' dynamics.
➡️ doi.org/10.1002/1873-3468.70200
➡️ doi.org/10.1002/1873-3468.70200
December 23, 2025 at 12:02 PM
Tracking phosphoinositides is challenging—they’re dynamic & compartment-specific. This review summarizes how pairing #LiveCell imaging with advanced #MassSpectrometry enables precise, isomer-resolved quantification, offering insights into these molecules' dynamics.
➡️ doi.org/10.1002/1873-3468.70200
➡️ doi.org/10.1002/1873-3468.70200
🏅🎉We congratulate🌟Huda Amilina🌟 (The University of Tokyo, Japan), on winning the FEBS Letters poster prize at the EMBO/EMBL Symposium #EESNucleus, held in Heidelberg, Germany! 👏👏👏🎉🎉🎊
@events.embl.org
@events.embl.org
December 23, 2025 at 9:41 AM
🏅🎉We congratulate🌟Huda Amilina🌟 (The University of Tokyo, Japan), on winning the FEBS Letters poster prize at the EMBO/EMBL Symposium #EESNucleus, held in Heidelberg, Germany! 👏👏👏🎉🎉🎊
@events.embl.org
@events.embl.org
Our final issue of 2025 is online now!🎉
We close 2025 with:
- A guide to creating excellent graphical abstracts 🎨
- A tribute to Jaroslav Cinatl
- Reviews on synthetic cells, lipidated proteins, & endothelial cells
- Research on DNA damage & more!
Read the issue here ▶️https://tinyurl.com/yswns5aa
We close 2025 with:
- A guide to creating excellent graphical abstracts 🎨
- A tribute to Jaroslav Cinatl
- Reviews on synthetic cells, lipidated proteins, & endothelial cells
- Research on DNA damage & more!
Read the issue here ▶️https://tinyurl.com/yswns5aa
December 22, 2025 at 12:03 PM
Our final issue of 2025 is online now!🎉
We close 2025 with:
- A guide to creating excellent graphical abstracts 🎨
- A tribute to Jaroslav Cinatl
- Reviews on synthetic cells, lipidated proteins, & endothelial cells
- Research on DNA damage & more!
Read the issue here ▶️https://tinyurl.com/yswns5aa
We close 2025 with:
- A guide to creating excellent graphical abstracts 🎨
- A tribute to Jaroslav Cinatl
- Reviews on synthetic cells, lipidated proteins, & endothelial cells
- Research on DNA damage & more!
Read the issue here ▶️https://tinyurl.com/yswns5aa
Dysregulated FGF signaling can fuel tumor growth and therapy resistance—but how it rewires cancer metabolism is still unclear. This review shows how understanding these pathways and their role in #CancerMetabolism could reveal new #DrugTargets.
➡️ doi.org/10.1002/1873-3468.70199
➡️ doi.org/10.1002/1873-3468.70199
December 19, 2025 at 12:01 PM
Dysregulated FGF signaling can fuel tumor growth and therapy resistance—but how it rewires cancer metabolism is still unclear. This review shows how understanding these pathways and their role in #CancerMetabolism could reveal new #DrugTargets.
➡️ doi.org/10.1002/1873-3468.70199
➡️ doi.org/10.1002/1873-3468.70199
💡 The #LH2 complex is required for #lightharvesting in many bacteria. In a recently published study, Konstantin M. Boyko et al. reveal that a colorless #carotenoid fully substitutes for colored pigments while maintaining the octameric symmetry of the complex.
➡️ doi.org/10.1002/1873-3468.70242
➡️ doi.org/10.1002/1873-3468.70242
December 18, 2025 at 12:01 PM
💡 The #LH2 complex is required for #lightharvesting in many bacteria. In a recently published study, Konstantin M. Boyko et al. reveal that a colorless #carotenoid fully substitutes for colored pigments while maintaining the octameric symmetry of the complex.
➡️ doi.org/10.1002/1873-3468.70242
➡️ doi.org/10.1002/1873-3468.70242
⏰ Our body clock runs on a cycle of activation and repression. This review explains how phosphorylation helps switch off the CLOCK-BMAL1 complex, tuning daily rhythms and timing. A fresh look at #CircadianBiology, #PhosphorylationControl, and #MolecularTiming.
➡️ doi.org/10.1002/1873-3468.70194
➡️ doi.org/10.1002/1873-3468.70194
December 17, 2025 at 12:01 PM
⏰ Our body clock runs on a cycle of activation and repression. This review explains how phosphorylation helps switch off the CLOCK-BMAL1 complex, tuning daily rhythms and timing. A fresh look at #CircadianBiology, #PhosphorylationControl, and #MolecularTiming.
➡️ doi.org/10.1002/1873-3468.70194
➡️ doi.org/10.1002/1873-3468.70194
The AAA+ ATPase #Msp1 clears faulty proteins from the membrane for cell survival, but how its six subunits work together is incompletely understood. Here, Matthew Wohlever et al. reveal how Msp1 subunits cooperate to extract proteins from the #lipid bilayer.
➡️ doi.org/10.1002/1873-3468.70187
➡️ doi.org/10.1002/1873-3468.70187
December 16, 2025 at 12:00 PM
The AAA+ ATPase #Msp1 clears faulty proteins from the membrane for cell survival, but how its six subunits work together is incompletely understood. Here, Matthew Wohlever et al. reveal how Msp1 subunits cooperate to extract proteins from the #lipid bilayer.
➡️ doi.org/10.1002/1873-3468.70187
➡️ doi.org/10.1002/1873-3468.70187
Inositol pyrophosphates are powerful messengers that guide early development and shape health later in life. This review highlights how IP6K and PPIP5K enzymes control #CellSignals and why they’re promising #DrugTargets for future therapies.
➡️ doi.org/10.1002/1873-3468.70192
➡️ doi.org/10.1002/1873-3468.70192
December 15, 2025 at 12:02 PM
Inositol pyrophosphates are powerful messengers that guide early development and shape health later in life. This review highlights how IP6K and PPIP5K enzymes control #CellSignals and why they’re promising #DrugTargets for future therapies.
➡️ doi.org/10.1002/1873-3468.70192
➡️ doi.org/10.1002/1873-3468.70192
Reposted by FEBS Letters
New Review published from Dr. Rashna Bhandari's Lab in collaboration with Fiedler Lab on Protein pyrophosphorylation by inositol pyrophosphatases.
Read the review here: febs.onlinelibrary.wiley.com/doi/10.1002/...
@febsletters.bsky.social
#ptm #pyrophosphorylation
Read the review here: febs.onlinelibrary.wiley.com/doi/10.1002/...
@febsletters.bsky.social
#ptm #pyrophosphorylation
December 12, 2025 at 8:56 AM
New Review published from Dr. Rashna Bhandari's Lab in collaboration with Fiedler Lab on Protein pyrophosphorylation by inositol pyrophosphatases.
Read the review here: febs.onlinelibrary.wiley.com/doi/10.1002/...
@febsletters.bsky.social
#ptm #pyrophosphorylation
Read the review here: febs.onlinelibrary.wiley.com/doi/10.1002/...
@febsletters.bsky.social
#ptm #pyrophosphorylation
🚨 Some plants and algae can use far-red light in #photosynthesis thanks to red #chlorophyll forms, allowing them to thrive even in shade. This review explores their evolution and how we could use them to design crops to capture more light & grow more efficiently.
➡️ doi.org/10.1002/1873-3468.70191
➡️ doi.org/10.1002/1873-3468.70191
December 11, 2025 at 12:01 PM
🚨 Some plants and algae can use far-red light in #photosynthesis thanks to red #chlorophyll forms, allowing them to thrive even in shade. This review explores their evolution and how we could use them to design crops to capture more light & grow more efficiently.
➡️ doi.org/10.1002/1873-3468.70191
➡️ doi.org/10.1002/1873-3468.70191
Reposted by FEBS Letters
Our new review: Hematopoietic (stem) cells—The elixir of life? 🧐
Rejuvenation of the blood system might also improve the health of other organs! #FEBS Letters
Link to final video: lengefeldlab.com?page_id=203
Please RT. Happy reading 😃
febs.onlinelibrary.wiley.com/doi/10.1002/...
Rejuvenation of the blood system might also improve the health of other organs! #FEBS Letters
Link to final video: lengefeldlab.com?page_id=203
Please RT. Happy reading 😃
febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Press
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the hear....
febs.onlinelibrary.wiley.com
December 8, 2025 at 6:52 PM
Our new review: Hematopoietic (stem) cells—The elixir of life? 🧐
Rejuvenation of the blood system might also improve the health of other organs! #FEBS Letters
Link to final video: lengefeldlab.com?page_id=203
Please RT. Happy reading 😃
febs.onlinelibrary.wiley.com/doi/10.1002/...
Rejuvenation of the blood system might also improve the health of other organs! #FEBS Letters
Link to final video: lengefeldlab.com?page_id=203
Please RT. Happy reading 😃
febs.onlinelibrary.wiley.com/doi/10.1002/...
🔔 Our December issue is live! Dive in for:
🐟 Zebrafish & liver biology
🦠 Reviews on topics in #microbiology and #enzymology
🖼️ A new Graphical Review on aminoacyl-tRNA synthetases
👩🔬 Scientists' Forum articles from the #Marfan Europe Network & our #WomenInScience writing contest
➡️ bit.ly/4pSdiOo
🐟 Zebrafish & liver biology
🦠 Reviews on topics in #microbiology and #enzymology
🖼️ A new Graphical Review on aminoacyl-tRNA synthetases
👩🔬 Scientists' Forum articles from the #Marfan Europe Network & our #WomenInScience writing contest
➡️ bit.ly/4pSdiOo
December 10, 2025 at 10:00 AM
🔔 Our December issue is live! Dive in for:
🐟 Zebrafish & liver biology
🦠 Reviews on topics in #microbiology and #enzymology
🖼️ A new Graphical Review on aminoacyl-tRNA synthetases
👩🔬 Scientists' Forum articles from the #Marfan Europe Network & our #WomenInScience writing contest
➡️ bit.ly/4pSdiOo
🐟 Zebrafish & liver biology
🦠 Reviews on topics in #microbiology and #enzymology
🖼️ A new Graphical Review on aminoacyl-tRNA synthetases
👩🔬 Scientists' Forum articles from the #Marfan Europe Network & our #WomenInScience writing contest
➡️ bit.ly/4pSdiOo
👩🔬 In our latest issue, we share a runner-up from our #WomenInScience contest! Mahaiwon Shadang’s essay shows how peer support among women fosters nurturing academic communities—proving mentorship doesn’t have to be hierarchical.
➡️ doi.org/10.1002/1873-3468.70209
➡️ doi.org/10.1002/1873-3468.70209
December 9, 2025 at 12:01 PM
👩🔬 In our latest issue, we share a runner-up from our #WomenInScience contest! Mahaiwon Shadang’s essay shows how peer support among women fosters nurturing academic communities—proving mentorship doesn’t have to be hierarchical.
➡️ doi.org/10.1002/1873-3468.70209
➡️ doi.org/10.1002/1873-3468.70209
New review out now from our recently published Biology of B-cell Malignancies special issue!
📕 Goodbye flat lymphoma biology, highlights current 3D non-Hodgkin #lymphoma models, detailing their features, ➕s, and ➖s.
Read the open access review, here ➡️ febs.onlinelibrary.wiley.com/doi/10.1002/...
📕 Goodbye flat lymphoma biology, highlights current 3D non-Hodgkin #lymphoma models, detailing their features, ➕s, and ➖s.
Read the open access review, here ➡️ febs.onlinelibrary.wiley.com/doi/10.1002/...
December 8, 2025 at 11:12 AM
New review out now from our recently published Biology of B-cell Malignancies special issue!
📕 Goodbye flat lymphoma biology, highlights current 3D non-Hodgkin #lymphoma models, detailing their features, ➕s, and ➖s.
Read the open access review, here ➡️ febs.onlinelibrary.wiley.com/doi/10.1002/...
📕 Goodbye flat lymphoma biology, highlights current 3D non-Hodgkin #lymphoma models, detailing their features, ➕s, and ➖s.
Read the open access review, here ➡️ febs.onlinelibrary.wiley.com/doi/10.1002/...
💊 #Atovaquone (AV) is an #antiplasmodial drug. A recent study by Alejandro Miguel Katzin, Marcell Crispim et al. shows that 4-nitrobenzoate targets the 4-HPT enzyme and enhances in vitro antiplasmodial efficacy and selectivity of AV.
➡️ doi.org/10.1002/1873-3468.70186
#malaria
➡️ doi.org/10.1002/1873-3468.70186
#malaria
December 5, 2025 at 12:02 PM
💊 #Atovaquone (AV) is an #antiplasmodial drug. A recent study by Alejandro Miguel Katzin, Marcell Crispim et al. shows that 4-nitrobenzoate targets the 4-HPT enzyme and enhances in vitro antiplasmodial efficacy and selectivity of AV.
➡️ doi.org/10.1002/1873-3468.70186
#malaria
➡️ doi.org/10.1002/1873-3468.70186
#malaria
☀️ #Sunlight impacts #skin cells in surprising ways. While UVA harms metabolism, red light boosts it in keratinocytes. A new study by @aliciakowaltowski.bsky.social et al. shows activation of AMPK-dependent fatty acid oxidation, enhancing proliferation & energy use.
➡️ doi.org/10.1002/1873-3468.70195
➡️ doi.org/10.1002/1873-3468.70195
December 3, 2025 at 12:01 PM
☀️ #Sunlight impacts #skin cells in surprising ways. While UVA harms metabolism, red light boosts it in keratinocytes. A new study by @aliciakowaltowski.bsky.social et al. shows activation of AMPK-dependent fatty acid oxidation, enhancing proliferation & energy use.
➡️ doi.org/10.1002/1873-3468.70195
➡️ doi.org/10.1002/1873-3468.70195