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A biophysically principled sequence model IceQream characterises complex Transcription Factor-DNA interactions from chromosome accessibility analysis.
@Akhiad.bsky.social
#BiotechNatureComms
www.nature.com/articles/s41...
@Akhiad.bsky.social
#BiotechNatureComms
www.nature.com/articles/s41...
IceQream: Quantitative chromosome accessibility analysis using physical TF models - Nature Communications
Cis regulatory elements endow genomes with sequence-encoded logic to drive cellular differentiation. Here, the authors introduce a biophysically principled sequence model that characterises complex TF...
www.nature.com
October 14, 2025 at 5:52 PM
A biophysically principled sequence model IceQream characterises complex Transcription Factor-DNA interactions from chromosome accessibility analysis.
@Akhiad.bsky.social
#BiotechNatureComms
www.nature.com/articles/s41...
@Akhiad.bsky.social
#BiotechNatureComms
www.nature.com/articles/s41...
Do we need LLMs to predict epigenomes from DNA—or is biophysics enough? 🧬
IceQream (IQ) is a biophysics-based framework that predicts epigenomes with SOTA-level accuracy—and is fully explainable.
@NatureComms: www.nature.com/articles/s41...
Thread 🧵👇
1/
IceQream (IQ) is a biophysics-based framework that predicts epigenomes with SOTA-level accuracy—and is fully explainable.
@NatureComms: www.nature.com/articles/s41...
Thread 🧵👇
1/
October 17, 2025 at 8:31 AM
Do we need LLMs to predict epigenomes from DNA—or is biophysics enough? 🧬
IceQream (IQ) is a biophysics-based framework that predicts epigenomes with SOTA-level accuracy—and is fully explainable.
@NatureComms: www.nature.com/articles/s41...
Thread 🧵👇
1/
IceQream (IQ) is a biophysics-based framework that predicts epigenomes with SOTA-level accuracy—and is fully explainable.
@NatureComms: www.nature.com/articles/s41...
Thread 🧵👇
1/