Arnau Sebé-Pedrós
@arnausebe.bsky.social
Group leader CRG; Associate Faculty ToL Sanger Institute.
Genome regulation, chromatin, cell types, and evolution. https://www.sebepedroslab.org
Genome regulation, chromatin, cell types, and evolution. https://www.sebepedroslab.org
A thing of beauty. Congratulations @dudinlab.bsky.social @gautamdey.bsky.social and team!
October 31, 2025 at 3:55 PM
A thing of beauty. Congratulations @dudinlab.bsky.social @gautamdey.bsky.social and team!
Great to see this published. Congratulations @jgahan.bsky.social and team!
October 29, 2025 at 5:42 PM
Great to see this published. Congratulations @jgahan.bsky.social and team!
🤷♂️ what can you do? Thanks Ferdi!
October 17, 2025 at 9:46 AM
🤷♂️ what can you do? Thanks Ferdi!
Thank you Omaya!
October 16, 2025 at 7:52 AM
Thank you Omaya!
With the help and support of Tali Mass (sites.google.com/marsci.haifa...) and contributions from multiple lab members: @ianakim.bsky.social @sebasn1.bsky.social Ewa Ksiezopolska, @aelek.bsky.social Laia Montes and @seanamontgomery.bsky.social
October 15, 2025 at 9:02 PM
With the help and support of Tali Mass (sites.google.com/marsci.haifa...) and contributions from multiple lab members: @ianakim.bsky.social @sebasn1.bsky.social Ewa Ksiezopolska, @aelek.bsky.social Laia Montes and @seanamontgomery.bsky.social
Dive in for more: www.nature.com/articles/s41...
The evolution of facultative symbiosis in stony corals - Nature
Genomic sequencing of the thermotolerant coral species Oculina patagonica, single-cell transcriptomic analyses of symbiotic and non-symbiotic specimens and comparisons with obligate symbiotic coral sp...
www.nature.com
October 15, 2025 at 8:04 PM
Dive in for more: www.nature.com/articles/s41...
Finally, comparisons with other cnidarian atlases show specific adaptations in Oculina, pointing to an evolutionary shift toward increased capacity for heterotrophic feeding, a dual hetero/symbiotrophic feeding strategy that may underpin Oculina resilience to extreme conditions.
October 15, 2025 at 8:00 PM
Finally, comparisons with other cnidarian atlases show specific adaptations in Oculina, pointing to an evolutionary shift toward increased capacity for heterotrophic feeding, a dual hetero/symbiotrophic feeding strategy that may underpin Oculina resilience to extreme conditions.
We also reconstruct the evolution of the algal-hosting cell type gene expression program (see @xgrau.bsky.social's beautiful summary figure below!)
October 15, 2025 at 8:00 PM
We also reconstruct the evolution of the algal-hosting cell type gene expression program (see @xgrau.bsky.social's beautiful summary figure below!)
Comparing naturally aposymbiotic to symbiotic Oculina colonies showed an increase in (putative) phagocytic immune-like cells and a dowregulation of diverse metabolic pathways in the gastrodermis.
October 15, 2025 at 7:59 PM
Comparing naturally aposymbiotic to symbiotic Oculina colonies showed an increase in (putative) phagocytic immune-like cells and a dowregulation of diverse metabolic pathways in the gastrodermis.
Building on our 2021 Stylophora cell (www.sciencedirect.com/science/arti...), we now provide new atlases for Oculina and Acropora millepora
and reveal remarkable conservation of cell type programs across 250+ million years of stony coral evolution.
and reveal remarkable conservation of cell type programs across 250+ million years of stony coral evolution.
October 15, 2025 at 7:59 PM
Building on our 2021 Stylophora cell (www.sciencedirect.com/science/arti...), we now provide new atlases for Oculina and Acropora millepora
and reveal remarkable conservation of cell type programs across 250+ million years of stony coral evolution.
and reveal remarkable conservation of cell type programs across 250+ million years of stony coral evolution.
The Oculina genome shows high macrosyntenic conservation across corals. Remarkably high gene counts are explained by species-specific expansions driven by tandem duplications and, using single-cell data, we can explore the functional fate of these frequent duplicates:
October 15, 2025 at 7:58 PM
The Oculina genome shows high macrosyntenic conservation across corals. Remarkably high gene counts are explained by species-specific expansions driven by tandem duplications and, using single-cell data, we can explore the functional fate of these frequent duplicates: