Carmelo Ferrai
@carmeloferrai.bsky.social
RNAPII &Transcription Regulation -Chromatin Conformation & Nuclear Architecture - ESCs & Neuronal Differentiation - Nuclear Mechanotransduction - Cell Plasticity
UMG, Göttingen, Germany
UMG, Göttingen, Germany
Pinned
Tread -1- EpiSci - I am very proud to share with you our new study that you can access on @biorxivpreprint.bsky.social (see link below)
"The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A.
www.biorxiv.org/content/10.6...
"The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A.
www.biorxiv.org/content/10.6...
Reposted by Carmelo Ferrai
Open Postdoc position in our lab!
#actin #Huntingtin #cryoET #cellbio
If you enjoy working at the interface of cell biology, structural biology, and quantitative imaging, this could be an excellent fit.
ista.ac.at/en/job/postd...
Please share and feel free to reach out if there are questions!
#actin #Huntingtin #cryoET #cellbio
If you enjoy working at the interface of cell biology, structural biology, and quantitative imaging, this could be an excellent fit.
ista.ac.at/en/job/postd...
Please share and feel free to reach out if there are questions!
Postdoc Research Group Schur
The Schur lab at the Institute of Science and Technology Austria (ISTA) has an open postdoc position for a highly motivated candidate to be part of our ERC-funded project ActinID.
Our Group
...
ista.ac.at
February 13, 2026 at 3:50 PM
Open Postdoc position in our lab!
#actin #Huntingtin #cryoET #cellbio
If you enjoy working at the interface of cell biology, structural biology, and quantitative imaging, this could be an excellent fit.
ista.ac.at/en/job/postd...
Please share and feel free to reach out if there are questions!
#actin #Huntingtin #cryoET #cellbio
If you enjoy working at the interface of cell biology, structural biology, and quantitative imaging, this could be an excellent fit.
ista.ac.at/en/job/postd...
Please share and feel free to reach out if there are questions!
Tread -1- EpiSci - 🧬 - 🧪 I am very proud to share with you our new study that you can access on @biorxivpreprint.bsky.social (see link below)
"The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A.
www.biorxiv.org/content/10.6...
"The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A.
www.biorxiv.org/content/10.6...
February 14, 2026 at 12:01 PM
Tread -1- EpiSci - 🧬 - 🧪 I am very proud to share with you our new study that you can access on @biorxivpreprint.bsky.social (see link below)
"The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A.
www.biorxiv.org/content/10.6...
"The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A.
www.biorxiv.org/content/10.6...
Tread -1- EpiSci - I am very proud to share with you our new study that you can access on @biorxivpreprint.bsky.social (see link below)
"The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A.
www.biorxiv.org/content/10.6...
"The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A.
www.biorxiv.org/content/10.6...
February 14, 2026 at 10:00 AM
Tread -1- EpiSci - I am very proud to share with you our new study that you can access on @biorxivpreprint.bsky.social (see link below)
"The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A.
www.biorxiv.org/content/10.6...
"The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A.
www.biorxiv.org/content/10.6...
Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability
Marmolejo et al. uncover transcription condensate dynamics at histone locus bodies
across the cell cycle. These dynamics are governed by cell cycle (DDK and CDK1/2)
and checkpoint (ATR-CHK1) kinases t...
www.cell.com
February 5, 2026 at 6:49 AM
Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Comparative transcriptomic analysis of embryonic stem cells across mammalian species
x.com/martinperaja...
x.com/martinperaja...
Martin Pera on X: "Comparative transcriptomic analysis of embryonic stem cells across mam... https://t.co/yl1cJAXQSU" / X
Comparative transcriptomic analysis of embryonic stem cells across mam... https://t.co/yl1cJAXQSU
x.com
January 28, 2026 at 2:54 PM
Comparative transcriptomic analysis of embryonic stem cells across mammalian species
x.com/martinperaja...
x.com/martinperaja...
Reposted by Carmelo Ferrai
🥁 #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026!
📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
January 21, 2026 at 10:48 AM
🥁 #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026!
📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
Reposted by Carmelo Ferrai
Both positions are for 2+ years.
📍 Location: Turku, Finland 🇫🇮 📅 Deadline: Feb 23, 2026
Come work in a vibrant environment with the IMMENs consortium!
Learn more about IMMENs: www.helsinki.fi/en/researchg...
📍 Location: Turku, Finland 🇫🇮 📅 Deadline: Feb 23, 2026
Come work in a vibrant environment with the IMMENs consortium!
Learn more about IMMENs: www.helsinki.fi/en/researchg...
Centre of Excellence in Immune - Endothelial Interfaces (IMMENs) | University of Helsinki
The overarching aim of IMMENs, a Research Council of Finland funded Centre of Excellence, is to understand how local immune responses are regulated at the lymphatic endothelium-immune cell interface.
www.helsinki.fi
January 21, 2026 at 7:57 AM
Both positions are for 2+ years.
📍 Location: Turku, Finland 🇫🇮 📅 Deadline: Feb 23, 2026
Come work in a vibrant environment with the IMMENs consortium!
Learn more about IMMENs: www.helsinki.fi/en/researchg...
📍 Location: Turku, Finland 🇫🇮 📅 Deadline: Feb 23, 2026
Come work in a vibrant environment with the IMMENs consortium!
Learn more about IMMENs: www.helsinki.fi/en/researchg...
Reposted by Carmelo Ferrai
Job 2: Postdoc in Cell Biology 🧫🧬
Focus on cells interacts with the lymphatic endothelium.
We are looking for someone excited about vascular biology, microfluidics/organ-on-chip and microscopy.
Apply here: abo.rekrytointi.com/paikat/index...
Focus on cells interacts with the lymphatic endothelium.
We are looking for someone excited about vascular biology, microfluidics/organ-on-chip and microscopy.
Apply here: abo.rekrytointi.com/paikat/index...
Researcher (postdoctoral level) in Cell Biology, 1.4.2026–31.08.2028
abo.rekrytointi.com
January 21, 2026 at 7:57 AM
Job 2: Postdoc in Cell Biology 🧫🧬
Focus on cells interacts with the lymphatic endothelium.
We are looking for someone excited about vascular biology, microfluidics/organ-on-chip and microscopy.
Apply here: abo.rekrytointi.com/paikat/index...
Focus on cells interacts with the lymphatic endothelium.
We are looking for someone excited about vascular biology, microfluidics/organ-on-chip and microscopy.
Apply here: abo.rekrytointi.com/paikat/index...
Reposted by Carmelo Ferrai
🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
CELL MIGRATION LAB
We study cell migration in health and disease
cellmig.org
January 21, 2026 at 7:57 AM
🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
Reposted by Carmelo Ferrai
Would anyone out there be able to share some Mus Spretus DNA with us? 🐀🧬 Any tissue of origin, for PCR amplification of selected genomic regions. Many thanks in advance!
January 20, 2026 at 12:59 PM
Would anyone out there be able to share some Mus Spretus DNA with us? 🐀🧬 Any tissue of origin, for PCR amplification of selected genomic regions. Many thanks in advance!
Interplay between cohesin and RNA polymerase II in regulating chromatin interactions and gene transcription
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Interplay between cohesin and RNA polymerase II in regulating chromatin interactions and gene transcription - Nature Structural & Molecular Biology
Kim, Wang, Clow and colleagues show that long-range chromatin loops bringing distal enhancers or super-enhancers together with promoters are cohesin dependent and cell type specific, whereas most shor...
www.nature.com
January 16, 2026 at 9:04 AM
Interplay between cohesin and RNA polymerase II in regulating chromatin interactions and gene transcription
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Carmelo Ferrai
Fully-funded #PhD positions in #epigenetics, #biophysics & #metabolism, gene regulation, cell biology and more…
Are you already on track to start an exciting research career @maxplanck.de & @uni-freiburg.de?
This is your timeline. Apply by February 6th, 2026
www.ie-freiburg.mpg.de/apply-imprs-...
Are you already on track to start an exciting research career @maxplanck.de & @uni-freiburg.de?
This is your timeline. Apply by February 6th, 2026
www.ie-freiburg.mpg.de/apply-imprs-...
January 8, 2026 at 12:32 PM
Fully-funded #PhD positions in #epigenetics, #biophysics & #metabolism, gene regulation, cell biology and more…
Are you already on track to start an exciting research career @maxplanck.de & @uni-freiburg.de?
This is your timeline. Apply by February 6th, 2026
www.ie-freiburg.mpg.de/apply-imprs-...
Are you already on track to start an exciting research career @maxplanck.de & @uni-freiburg.de?
This is your timeline. Apply by February 6th, 2026
www.ie-freiburg.mpg.de/apply-imprs-...
Stress controls heterochromatin inheritance via histone H3 ubiquitylation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Stress controls heterochromatin inheritance via histone H3 ubiquitylation - Nature
A histone ubiquitin-dependent regulatory hub governs stimulus-dependent heterochromatin propagation, with important implications for understanding mechanisms governing rapid changes in the epigen...
www.nature.com
January 8, 2026 at 8:09 AM
Stress controls heterochromatin inheritance via histone H3 ubiquitylation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ending 2025 with a nice study from the labs of Laura Lettice & @wbickmor.bsky.social
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function
x.com/genesdev/sta...
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function
x.com/genesdev/sta...
x.com
December 25, 2025 at 2:56 PM
Ending 2025 with a nice study from the labs of Laura Lettice & @wbickmor.bsky.social
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function
x.com/genesdev/sta...
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function
x.com/genesdev/sta...
Also this year… tradition is renewed!
All the best to the all the friends worldwide!
All the best to the all the friends worldwide!
December 25, 2025 at 2:14 PM
Also this year… tradition is renewed!
All the best to the all the friends worldwide!
All the best to the all the friends worldwide!
Reposted by Carmelo Ferrai
If you want to map the spatial composition of a tissue or organ, 3D mapping is not an option.
It is absolutely necessary.
Due to its inherent undersampling, 2D omic mapping is almost always misleading.
See details here: www.sciencedirect.com/science/arti...
It is absolutely necessary.
Due to its inherent undersampling, 2D omic mapping is almost always misleading.
See details here: www.sciencedirect.com/science/arti...
December 24, 2025 at 10:32 AM
If you want to map the spatial composition of a tissue or organ, 3D mapping is not an option.
It is absolutely necessary.
Due to its inherent undersampling, 2D omic mapping is almost always misleading.
See details here: www.sciencedirect.com/science/arti...
It is absolutely necessary.
Due to its inherent undersampling, 2D omic mapping is almost always misleading.
See details here: www.sciencedirect.com/science/arti...
Lovely work from @grosselab.bsky.social Showing how: “Nuclear Myosin VI cooperates with actin to promote transcriptional cluster formation at androgen receptors”
www.jbc.org/article/S002...
www.jbc.org/article/S002...
Nuclear Myosin VI cooperates with actin to promote transcriptional cluster formation at androgen receptors
Steroid hormone receptors are ligand-binding transcription factors essential for mammalian
physiology. The androgen receptor (AR) binds testosterone mediating gene expression
for sexual, somatic, and ...
www.jbc.org
December 23, 2025 at 2:39 PM
Lovely work from @grosselab.bsky.social Showing how: “Nuclear Myosin VI cooperates with actin to promote transcriptional cluster formation at androgen receptors”
www.jbc.org/article/S002...
www.jbc.org/article/S002...
Reposted by Carmelo Ferrai
✨ Blinking #nanobodies that work for single-molecule localization 🔬
Our new preprint shows that the self-blinking dye JF635b restores robust, buffer-free blinking in #nanobodies, enabling reliable #dSTORM, #MINFLUX, and more, without chemical-switching buffers. Opening new possibilities for #ExM!
Our new preprint shows that the self-blinking dye JF635b restores robust, buffer-free blinking in #nanobodies, enabling reliable #dSTORM, #MINFLUX, and more, without chemical-switching buffers. Opening new possibilities for #ExM!
December 22, 2025 at 10:45 AM
✨ Blinking #nanobodies that work for single-molecule localization 🔬
Our new preprint shows that the self-blinking dye JF635b restores robust, buffer-free blinking in #nanobodies, enabling reliable #dSTORM, #MINFLUX, and more, without chemical-switching buffers. Opening new possibilities for #ExM!
Our new preprint shows that the self-blinking dye JF635b restores robust, buffer-free blinking in #nanobodies, enabling reliable #dSTORM, #MINFLUX, and more, without chemical-switching buffers. Opening new possibilities for #ExM!
Reposted by Carmelo Ferrai
Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm - Nature Cell Biology
Schooley et al. find that mitotically bookmarked loci drive a transient chromosome folding state during G1 entry that is subsequently modulated by factors inherited through the cytoplasm.
www.nature.com
December 22, 2025 at 11:45 AM
Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Fantastic talk today from @alex-stark.bsky.social
December 19, 2025 at 4:48 AM
Fantastic talk today from @alex-stark.bsky.social
Targeting RhoA nuclear mechanoactivity rejuvenates aged hematopoietic stem cells
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Targeting RhoA nuclear mechanoactivity rejuvenates aged hematopoietic stem cells - Nature Aging
Mejía-Ramírez, Iáñez Picazo, Walter et al. explore how nuclear biomechanical changes limit the regenerative capacity of aged hematopoietic stem cells and show that targeting RhoA rejuvenates aged hema...
www.nature.com
November 25, 2025 at 12:55 PM
Targeting RhoA nuclear mechanoactivity rejuvenates aged hematopoietic stem cells
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted by Carmelo Ferrai
I am very excited to be organizing a session for postdocs (with focus on those in the job market). Be on the lookout for info and registration! 🐟🧪
November 19, 2025 at 7:12 PM
I am very excited to be organizing a session for postdocs (with focus on those in the job market). Be on the lookout for info and registration! 🐟🧪
Street “heart”
(By Foddis A.)
(By Foddis A.)
November 18, 2025 at 8:30 AM
Street “heart”
(By Foddis A.)
(By Foddis A.)
Reposted by Carmelo Ferrai
In the most recent episode we talked with @andersshansen.bsky.social from MIT about his work on the impact of 3D genome structures on gene expression and techniques like Region Capture Micro-C for mapping genome organisation. #podcast #epigenetics
Listen here: activemotif.com/podcasts-and...
Listen here: activemotif.com/podcasts-and...
November 17, 2025 at 8:00 AM
In the most recent episode we talked with @andersshansen.bsky.social from MIT about his work on the impact of 3D genome structures on gene expression and techniques like Region Capture Micro-C for mapping genome organisation. #podcast #epigenetics
Listen here: activemotif.com/podcasts-and...
Listen here: activemotif.com/podcasts-and...
Great work from the lab of @jojdavies.bsky.social
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
Li et al. apply base-pair resolution Micro Capture-C ultra to map chromatin contacts
between individual motifs within cis-regulatory elements and reveal a unified model
of biophysically mediated enhan...
www.cell.com
November 17, 2025 at 6:55 AM
Great work from the lab of @jojdavies.bsky.social
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
www.cell.com/cell/fulltex...