Institut Imagine
@institutimagine.bsky.social
🔬 Premier centre européen dédié aux maladies génétiques.
📍 Campus Necker - Enfants Malades, Paris | #Recherche #Santé #Innovation
🌐 www.institutimagine.org
📍 Campus Necker - Enfants Malades, Paris | #Recherche #Santé #Innovation
🌐 www.institutimagine.org
Reposted by Institut Imagine
Complete and partial forms of X-linked MCTS1 deficiency in patients with mycobacterial disease. New study by Qinhua Zhou (Fudan University), Jacinta Bustamante @institutimagine.bsky.social, Jonathan Bohlen @jonathanbohlen.bsky.social @lmumuenchen.bsky.social & colleagues rupress.org/jhi/article/...
February 6, 2026 at 2:30 PM
Complete and partial forms of X-linked MCTS1 deficiency in patients with mycobacterial disease. New study by Qinhua Zhou (Fudan University), Jacinta Bustamante @institutimagine.bsky.social, Jonathan Bohlen @jonathanbohlen.bsky.social @lmumuenchen.bsky.social & colleagues rupress.org/jhi/article/...
Reposted by Institut Imagine
A study from @casanovalab.bsky.social shows that autoantibodies in a small subset of the population can allow weakened vaccine viruses to escape control, explaining some adverse events tied to one kind of Chikungunya vaccine, which is no longer available in the U.S.
The Rockefeller University » In rare cases, autoantibodies can cause severe reactions to a live-attenuated virus Chikungunya vaccine that has been discontinued in the U.S.
New insights could fine-tune this immunotherapy to avoid a common side effect without sacrificing efficacy.
www.rockefeller.edu
January 27, 2026 at 8:24 PM
A study from @casanovalab.bsky.social shows that autoantibodies in a small subset of the population can allow weakened vaccine viruses to escape control, explaining some adverse events tied to one kind of Chikungunya vaccine, which is no longer available in the U.S.
Reposted by Institut Imagine
Jensen, @casanovalab.bsky.social, Mogensen @au.dk and colleagues study type I interferon neutralizing autoAbs in people with #HIV, and find that the prevalence does not significantly differ from that in the general population. rupress.org/jhi/article/...
@esidsociety.bsky.social
@esidsociety.bsky.social
January 30, 2026 at 5:45 PM
Jensen, @casanovalab.bsky.social, Mogensen @au.dk and colleagues study type I interferon neutralizing autoAbs in people with #HIV, and find that the prevalence does not significantly differ from that in the general population. rupress.org/jhi/article/...
@esidsociety.bsky.social
@esidsociety.bsky.social
📢 Kicking off today’s MAGIC meeting: Jean-François Gautier (Lariboisière) is discussing the shift in how we view Type 2 Diabetes, not just as a metabolic disorder, but as a chronic inflammatory disease. 🧬
February 5, 2026 at 12:04 PM
📢 Kicking off today’s MAGIC meeting: Jean-François Gautier (Lariboisière) is discussing the shift in how we view Type 2 Diabetes, not just as a metabolic disorder, but as a chronic inflammatory disease. 🧬
🧬 Advancing Research in Paris with the Region's First AVITI24™ (Element Biosciences) !
We are thrilled to announce that Institut Imagine has officially acquired the first AVITI24 system in Paris.
We are thrilled to announce that Institut Imagine has officially acquired the first AVITI24 system in Paris.
February 2, 2026 at 4:30 PM
🧬 Advancing Research in Paris with the Region's First AVITI24™ (Element Biosciences) !
We are thrilled to announce that Institut Imagine has officially acquired the first AVITI24 system in Paris.
We are thrilled to announce that Institut Imagine has officially acquired the first AVITI24 system in Paris.
Live at our weekly seminar: Prof. Chantal Pichon (Univ. Orléans) on the design of imidazolium lipid-based LNPs for mRNA delivery. 🧬
These LNPs use pH-responsive headgroups to improve cytosolic release for cancer vaccines & immune cell engineering. The future of nanomedicine! 🧪🎯 #mRNA #LNP
These LNPs use pH-responsive headgroups to improve cytosolic release for cancer vaccines & immune cell engineering. The future of nanomedicine! 🧪🎯 #mRNA #LNP
February 2, 2026 at 12:36 PM
Reposted by Institut Imagine
X-linked MCTS1 deficiency causes susceptibility to mycobacterial disease. In @jhumimmunity.org, Zhou et al. show that report 4 new patients carrying 3 previously undescribed truncating or loss-of-expression variants, presenting w/ BCG disease or M. abscessus infection. rupress.org/jhi/article/...
January 30, 2026 at 6:00 PM
X-linked MCTS1 deficiency causes susceptibility to mycobacterial disease. In @jhumimmunity.org, Zhou et al. show that report 4 new patients carrying 3 previously undescribed truncating or loss-of-expression variants, presenting w/ BCG disease or M. abscessus infection. rupress.org/jhi/article/...
Reposted by Institut Imagine
X-linked MCTS1 deficiency causes susceptibility to mycobacterial disease. Zhou, Bustamante, Bohlen et al. show that report 4 new patients carrying 3 previously undescribed truncating or loss-of-expression variants, presenting w/ BCG disease or M. abscessus infection. rupress.org/jhi/article/...
January 30, 2026 at 5:00 PM
X-linked MCTS1 deficiency causes susceptibility to mycobacterial disease. Zhou, Bustamante, Bohlen et al. show that report 4 new patients carrying 3 previously undescribed truncating or loss-of-expression variants, presenting w/ BCG disease or M. abscessus infection. rupress.org/jhi/article/...
Reposted by Institut Imagine
1/ We are excited to share our new report in PNAS: all three cases of encephalitis triggered by the live-attenuated chikungunya (CHIKV) vaccine (IXCHIQ®) are due to pre-existing autoantibodies neutralizing type I IFN (AAN-I-IFN) (doi.org/10.1073/pnas...).
January 26, 2026 at 9:30 PM
1/ We are excited to share our new report in PNAS: all three cases of encephalitis triggered by the live-attenuated chikungunya (CHIKV) vaccine (IXCHIQ®) are due to pre-existing autoantibodies neutralizing type I IFN (AAN-I-IFN) (doi.org/10.1073/pnas...).
🔬 Que se passe-t-il vraiment derrière une découverte scientifique ?
Le vendredi 6 mars 2026, l’Institut Imagine vous invite à participer à une rencontre d'une demi-journée sur le thème : « Qu’est-ce que la Recherche à l’Institut Imagine ? »
📌 Inscriptions : yji1wvqwixz.typeform.com/to/spGbo2dC
Le vendredi 6 mars 2026, l’Institut Imagine vous invite à participer à une rencontre d'une demi-journée sur le thème : « Qu’est-ce que la Recherche à l’Institut Imagine ? »
📌 Inscriptions : yji1wvqwixz.typeform.com/to/spGbo2dC
January 27, 2026 at 8:19 AM
🔬 Que se passe-t-il vraiment derrière une découverte scientifique ?
Le vendredi 6 mars 2026, l’Institut Imagine vous invite à participer à une rencontre d'une demi-journée sur le thème : « Qu’est-ce que la Recherche à l’Institut Imagine ? »
📌 Inscriptions : yji1wvqwixz.typeform.com/to/spGbo2dC
Le vendredi 6 mars 2026, l’Institut Imagine vous invite à participer à une rencontre d'une demi-journée sur le thème : « Qu’est-ce que la Recherche à l’Institut Imagine ? »
📌 Inscriptions : yji1wvqwixz.typeform.com/to/spGbo2dC
Reposted by Institut Imagine
Yet another reason to screen people over 65 years of age for type I IFN autoantibodies:
Type I IFN autoantibodies underlie chikungunya live-attenuated vaccine encephalitis | PNAS www.pnas.org/doi/10.1073/...
Type I IFN autoantibodies underlie chikungunya live-attenuated vaccine encephalitis | PNAS www.pnas.org/doi/10.1073/...
Type I IFN autoantibodies underlie chikungunya live-attenuated vaccine encephalitis | PNAS
Human autoantibodies neutralizing type I interferons (IFNs) have emerged as strong,
common, and global determinants of a growing number of severe v...
www.pnas.org
January 22, 2026 at 7:09 PM
Yet another reason to screen people over 65 years of age for type I IFN autoantibodies:
Type I IFN autoantibodies underlie chikungunya live-attenuated vaccine encephalitis | PNAS www.pnas.org/doi/10.1073/...
Type I IFN autoantibodies underlie chikungunya live-attenuated vaccine encephalitis | PNAS www.pnas.org/doi/10.1073/...
We are live for our weekly scientific meeting! 🧪
First up, Pierre Isnard from @inem-necker.bsky.social is presenting on HNF1B.
He is discussing how this factor integrates signals that drive failed repair and the progression of kidney disease. Critical insights into renal pathophysiology. 🩺
First up, Pierre Isnard from @inem-necker.bsky.social is presenting on HNF1B.
He is discussing how this factor integrates signals that drive failed repair and the progression of kidney disease. Critical insights into renal pathophysiology. 🩺
January 22, 2026 at 12:15 PM
We are live for our weekly scientific meeting! 🧪
First up, Pierre Isnard from @inem-necker.bsky.social is presenting on HNF1B.
He is discussing how this factor integrates signals that drive failed repair and the progression of kidney disease. Critical insights into renal pathophysiology. 🩺
First up, Pierre Isnard from @inem-necker.bsky.social is presenting on HNF1B.
He is discussing how this factor integrates signals that drive failed repair and the progression of kidney disease. Critical insights into renal pathophysiology. 🩺
Reposted by Institut Imagine
.@elrig.org announces Drs Stephen Ward (Cell and Gene Therapy Catapult) & Annarita Miccio @institutimagine.bsky.social as keynote speakers for #ELRIGCGT2026 📆 9–10 Mar📍 #Cambridge UK
#pressrelease 🗞️ elrig.org/elrig-announ...
Free registration 👉 elrig.org/portfolio/ce... #ELRIG #messengersinscience
#pressrelease 🗞️ elrig.org/elrig-announ...
Free registration 👉 elrig.org/portfolio/ce... #ELRIG #messengersinscience
January 20, 2026 at 1:00 PM
.@elrig.org announces Drs Stephen Ward (Cell and Gene Therapy Catapult) & Annarita Miccio @institutimagine.bsky.social as keynote speakers for #ELRIGCGT2026 📆 9–10 Mar📍 #Cambridge UK
#pressrelease 🗞️ elrig.org/elrig-announ...
Free registration 👉 elrig.org/portfolio/ce... #ELRIG #messengersinscience
#pressrelease 🗞️ elrig.org/elrig-announ...
Free registration 👉 elrig.org/portfolio/ce... #ELRIG #messengersinscience
En 2026, continuons à faire avancer une recherche qui change des vies.
En ce début d’année, je vous adresse mes vœux les plus sincères. Merci à toutes celles et ceux qui nous soutiennent et nous font confiance.
Voir la vidéo : youtu.be/dVpBP92F2FI
En ce début d’année, je vous adresse mes vœux les plus sincères. Merci à toutes celles et ceux qui nous soutiennent et nous font confiance.
Voir la vidéo : youtu.be/dVpBP92F2FI
Voeux de la Pr Bana Jabri, Directrice générale de l'Institut Imagine
YouTube video by Institut Imagine
youtu.be
January 19, 2026 at 4:28 PM
En 2026, continuons à faire avancer une recherche qui change des vies.
En ce début d’année, je vous adresse mes vœux les plus sincères. Merci à toutes celles et ceux qui nous soutiennent et nous font confiance.
Voir la vidéo : youtu.be/dVpBP92F2FI
En ce début d’année, je vous adresse mes vœux les plus sincères. Merci à toutes celles et ceux qui nous soutiennent et nous font confiance.
Voir la vidéo : youtu.be/dVpBP92F2FI
Reposted by Institut Imagine
[SEMINAR]
📢 Paris Postdoc Seminar at INEM on Thursday January 22
Maria Lizarralde-Iragorri from @institutimagine.bsky.social will present the @parispostdocs.bsky.social seminar "Investigating Hematopoiesis and Erythropoiesis in Sickle Cell Disease"
More info ➡️ tinyurl.com/ykjnp873
📢 Paris Postdoc Seminar at INEM on Thursday January 22
Maria Lizarralde-Iragorri from @institutimagine.bsky.social will present the @parispostdocs.bsky.social seminar "Investigating Hematopoiesis and Erythropoiesis in Sickle Cell Disease"
More info ➡️ tinyurl.com/ykjnp873
January 15, 2026 at 3:59 PM
[SEMINAR]
📢 Paris Postdoc Seminar at INEM on Thursday January 22
Maria Lizarralde-Iragorri from @institutimagine.bsky.social will present the @parispostdocs.bsky.social seminar "Investigating Hematopoiesis and Erythropoiesis in Sickle Cell Disease"
More info ➡️ tinyurl.com/ykjnp873
📢 Paris Postdoc Seminar at INEM on Thursday January 22
Maria Lizarralde-Iragorri from @institutimagine.bsky.social will present the @parispostdocs.bsky.social seminar "Investigating Hematopoiesis and Erythropoiesis in Sickle Cell Disease"
More info ➡️ tinyurl.com/ykjnp873
Reposted by Institut Imagine
Monogenic disorders of immunity: Common variants are not so rare: Cell Genomics www.cell.com/cell-genomic...
Monogenic disorders of immunity: Common variants are not so rare
While monogenic disorders of immunity typically involve rare alleles, some arise from
alleles common in specific populations. Examples include IFNAR1/2 null alleles in
the Arctic/Pacific and PTCRA hyp...
www.cell.com
January 9, 2026 at 9:20 AM
Monogenic disorders of immunity: Common variants are not so rare: Cell Genomics www.cell.com/cell-genomic...
📢 We are live for our weekly scientific meeting! First up is Fabian Zanchetta (O. Hermine Lab) tackling "Unexplained Erythrocytosis." 🩸
Using the Dr. Warehouse clinical database, they are identifying new genetic drivers for patients with high red blood cell counts. 📉🔍
Using the Dr. Warehouse clinical database, they are identifying new genetic drivers for patients with high red blood cell counts. 📉🔍
January 15, 2026 at 12:09 PM
📢 We are live for our weekly scientific meeting! First up is Fabian Zanchetta (O. Hermine Lab) tackling "Unexplained Erythrocytosis." 🩸
Using the Dr. Warehouse clinical database, they are identifying new genetic drivers for patients with high red blood cell counts. 📉🔍
Using the Dr. Warehouse clinical database, they are identifying new genetic drivers for patients with high red blood cell counts. 📉🔍
Reposted by Institut Imagine
📣 this is tomorrow - seminar
@devstempasteur.bsky.social
🗓️ 2025 Tuesday Jan. 13th
🕣11am
📍Amphi Ullmann
Agnese Loda, Ph.D.
Institut Imagine, Paris, France
Understanding the sex-specific regulation and
function of X-linked gene dosage
Invited by Romain Levayer
@devstempasteur.bsky.social
🗓️ 2025 Tuesday Jan. 13th
🕣11am
📍Amphi Ullmann
Agnese Loda, Ph.D.
Institut Imagine, Paris, France
Understanding the sex-specific regulation and
function of X-linked gene dosage
Invited by Romain Levayer
January 12, 2026 at 5:03 PM
📣 this is tomorrow - seminar
@devstempasteur.bsky.social
🗓️ 2025 Tuesday Jan. 13th
🕣11am
📍Amphi Ullmann
Agnese Loda, Ph.D.
Institut Imagine, Paris, France
Understanding the sex-specific regulation and
function of X-linked gene dosage
Invited by Romain Levayer
@devstempasteur.bsky.social
🗓️ 2025 Tuesday Jan. 13th
🕣11am
📍Amphi Ullmann
Agnese Loda, Ph.D.
Institut Imagine, Paris, France
Understanding the sex-specific regulation and
function of X-linked gene dosage
Invited by Romain Levayer
Pour la Pr Bana Jabri, investir dans la science est un choix essentiel pour notre santé et notre économie.
📖 Retrouvez l'entretien complet dans Le Figaro : sante.lefigaro.fr/medecine/pr-...
📖 Retrouvez l'entretien complet dans Le Figaro : sante.lefigaro.fr/medecine/pr-...
January 13, 2026 at 3:23 PM
Pour la Pr Bana Jabri, investir dans la science est un choix essentiel pour notre santé et notre économie.
📖 Retrouvez l'entretien complet dans Le Figaro : sante.lefigaro.fr/medecine/pr-...
📖 Retrouvez l'entretien complet dans Le Figaro : sante.lefigaro.fr/medecine/pr-...
Can bacteria teach us about human immunity? 🦠➡️🐘
Today at Institut Imagine, Dr. Aude Bernheim from @institutpasteur.bsky.social discusses how ancient antiphage systems in bacteria can be ancestors to eukaryotic immune pathways.
A fascinating look at the evolutionary conservation of defense!
Today at Institut Imagine, Dr. Aude Bernheim from @institutpasteur.bsky.social discusses how ancient antiphage systems in bacteria can be ancestors to eukaryotic immune pathways.
A fascinating look at the evolutionary conservation of defense!
January 12, 2026 at 12:41 PM
Can bacteria teach us about human immunity? 🦠➡️🐘
Today at Institut Imagine, Dr. Aude Bernheim from @institutpasteur.bsky.social discusses how ancient antiphage systems in bacteria can be ancestors to eukaryotic immune pathways.
A fascinating look at the evolutionary conservation of defense!
Today at Institut Imagine, Dr. Aude Bernheim from @institutpasteur.bsky.social discusses how ancient antiphage systems in bacteria can be ancestors to eukaryotic immune pathways.
A fascinating look at the evolutionary conservation of defense!
🫁 New study by Hermine Lab at Institut Imagine finds Acute Chest Syndrome is driven by local lung complement activation.
Analyzing "golden sputum" paves the way for new anti-complement trials in #SickleCell. 🩸
Read more: onlinelibrary.wiley.com/doi/10.1002/...
Analyzing "golden sputum" paves the way for new anti-complement trials in #SickleCell. 🩸
Read more: onlinelibrary.wiley.com/doi/10.1002/...
Proteomic Analysis of Golden Sputum Reveals Pulmonary Complement Activation During Acute Chest Syndrome in Children With Sickle Cell Disease
Acute chest syndrome (ACS) is one of the most common severe complications of sickle cell disease (SCD). In recent years, a major role of inflammation and innate immunity has been evidenced, but ACS p...
onlinelibrary.wiley.com
January 9, 2026 at 1:10 PM
🫁 New study by Hermine Lab at Institut Imagine finds Acute Chest Syndrome is driven by local lung complement activation.
Analyzing "golden sputum" paves the way for new anti-complement trials in #SickleCell. 🩸
Read more: onlinelibrary.wiley.com/doi/10.1002/...
Analyzing "golden sputum" paves the way for new anti-complement trials in #SickleCell. 🩸
Read more: onlinelibrary.wiley.com/doi/10.1002/...
Fier de voir nos recherches en thérapie génique dans le Top 10 des percées 2026 de L'Express ! 🚀
Un immense bravo à la Pr Marina Cavazzana et nos équipes. Notre objectif : passer à la vitesse supérieure pour les familles touchées par des maladies rares.
À lire ici : www.lexpress.fr/sciences-san...
Un immense bravo à la Pr Marina Cavazzana et nos équipes. Notre objectif : passer à la vitesse supérieure pour les familles touchées par des maladies rares.
À lire ici : www.lexpress.fr/sciences-san...
January 9, 2026 at 9:18 AM
Fier de voir nos recherches en thérapie génique dans le Top 10 des percées 2026 de L'Express ! 🚀
Un immense bravo à la Pr Marina Cavazzana et nos équipes. Notre objectif : passer à la vitesse supérieure pour les familles touchées par des maladies rares.
À lire ici : www.lexpress.fr/sciences-san...
Un immense bravo à la Pr Marina Cavazzana et nos équipes. Notre objectif : passer à la vitesse supérieure pour les familles touchées par des maladies rares.
À lire ici : www.lexpress.fr/sciences-san...
Reposted by Institut Imagine
🔥🎉 🧠 SuperThrilled to share our paper (preprint) - Human erythropoietin (rhEPO) reshapes the adult hippocampal chromatin landscape, around transposons to promote neurogenesis. 🧵1/8
Massive kudos to #UmutCakir who drove multi-omics through dark roads of the genome.
www.biorxiv.org/content/10.1...
Massive kudos to #UmutCakir who drove multi-omics through dark roads of the genome.
www.biorxiv.org/content/10.1...
January 5, 2026 at 11:49 AM
🔥🎉 🧠 SuperThrilled to share our paper (preprint) - Human erythropoietin (rhEPO) reshapes the adult hippocampal chromatin landscape, around transposons to promote neurogenesis. 🧵1/8
Massive kudos to #UmutCakir who drove multi-omics through dark roads of the genome.
www.biorxiv.org/content/10.1...
Massive kudos to #UmutCakir who drove multi-omics through dark roads of the genome.
www.biorxiv.org/content/10.1...
We are live from our weekly MAGIC meeting! 🧬
First up, Annarita Miccio sets the stage! 🩸 She is introducing the session and discussing editing approaches for hemoglobinopathies. Her team’s work on Sickle Cell Disease is paving the way for next-gen therapies for blood.
#sicklecelldisease
First up, Annarita Miccio sets the stage! 🩸 She is introducing the session and discussing editing approaches for hemoglobinopathies. Her team’s work on Sickle Cell Disease is paving the way for next-gen therapies for blood.
#sicklecelldisease
January 8, 2026 at 12:06 PM
We are live from our weekly MAGIC meeting! 🧬
First up, Annarita Miccio sets the stage! 🩸 She is introducing the session and discussing editing approaches for hemoglobinopathies. Her team’s work on Sickle Cell Disease is paving the way for next-gen therapies for blood.
#sicklecelldisease
First up, Annarita Miccio sets the stage! 🩸 She is introducing the session and discussing editing approaches for hemoglobinopathies. Her team’s work on Sickle Cell Disease is paving the way for next-gen therapies for blood.
#sicklecelldisease
Reposted by Institut Imagine
Paris just got its first AVITI24™ 🇫🇷✨
Institut Imagine is now home to the first AVITI24 in Paris and the Île-de-France region, using it for both sequencing and cytoprofiling. Thanks to the amazing team for a great training and warm welcome!
#AVITI24 #Multiomics #Cytoprofiling
Institut Imagine is now home to the first AVITI24 in Paris and the Île-de-France region, using it for both sequencing and cytoprofiling. Thanks to the amazing team for a great training and warm welcome!
#AVITI24 #Multiomics #Cytoprofiling
January 6, 2026 at 7:00 AM
Paris just got its first AVITI24™ 🇫🇷✨
Institut Imagine is now home to the first AVITI24 in Paris and the Île-de-France region, using it for both sequencing and cytoprofiling. Thanks to the amazing team for a great training and warm welcome!
#AVITI24 #Multiomics #Cytoprofiling
Institut Imagine is now home to the first AVITI24 in Paris and the Île-de-France region, using it for both sequencing and cytoprofiling. Thanks to the amazing team for a great training and warm welcome!
#AVITI24 #Multiomics #Cytoprofiling