Rockefeller University Press
@rupress.org
We publish the scientific journals @jcb.org, @jem.org, @jgp.org, @jhumimmunity.org, and co-publish @lsajournal.org. Visit our journals at https://rupress.org
Reposted by Rockefeller University Press
As 2025 is drawing to a close, @jem.org would like to highlight all of the women who have contributed to the #WomenInSTEM #Viewpoint series over the last 3 years! Learn more about their scientific journeys on the path to independence here 👉 tinyurl.com/2wrxk4mk
December 24, 2025 at 3:47 PM
As 2025 is drawing to a close, @jem.org would like to highlight all of the women who have contributed to the #WomenInSTEM #Viewpoint series over the last 3 years! Learn more about their scientific journeys on the path to independence here 👉 tinyurl.com/2wrxk4mk
Reposted by Rockefeller University Press
Scientific publishing has a bias against negative results and that hurts science, says Tim Fessenden, editor of @lsajournal.org, a publication of @rupress.org. Here’s how journal editors can help.
The value of publishing negative data - News
Scientific journals love news-worthy results. Editors want to publish studies with novel data that scientists will eagerly read and cite in their own work. Because of this desire for novelty, studies ...
www.rockefeller.edu
December 23, 2025 at 2:30 PM
Scientific publishing has a bias against negative results and that hurts science, says Tim Fessenden, editor of @lsajournal.org, a publication of @rupress.org. Here’s how journal editors can help.
Why do negative data, or null results, matter? @lsajournal.org's Tim Fessenden (@timisstuck.bsky.social) shares his insider perspective on why and how the scientific community should actively encourage the publication of negative results. From @rockefeller.edu 👉 www.rockefeller.edu/news/38829-t...
The value of publishing negative data - News
Scientific journals love news-worthy results. Editors want to publish studies with novel data that scientists will eagerly read and cite in their own work. Because of this desire for novelty, studies…
www.rockefeller.edu
December 23, 2025 at 4:00 PM
Why do negative data, or null results, matter? @lsajournal.org's Tim Fessenden (@timisstuck.bsky.social) shares his insider perspective on why and how the scientific community should actively encourage the publication of negative results. From @rockefeller.edu 👉 www.rockefeller.edu/news/38829-t...
🔔 @jhumimmunity.org is pleased to share the abstracts from the Latin American Society for Immunodeficiencies Meeting 2025 @lasidofficial.bsky.social, which took place October 15–18, in Buenos Aires. Explore the latest advancements and insights in immunodeficiencies 👉 rupress.org/jhi/issue/1/...
December 23, 2025 at 3:15 PM
🔔 @jhumimmunity.org is pleased to share the abstracts from the Latin American Society for Immunodeficiencies Meeting 2025 @lasidofficial.bsky.social, which took place October 15–18, in Buenos Aires. Explore the latest advancements and insights in immunodeficiencies 👉 rupress.org/jhi/issue/1/...
In @jgp.org, Nguyen et al. show that Arg-92 in GIRK2 is essential for PIP2-dependent gating, with substitutions causing structural rearrangements that disrupt G protein & alcohol activation—likely a conserved mechanism among inward rectifier potassium channels rupress.org/jgp/article/...
December 19, 2025 at 6:01 PM
In @jgp.org, Nguyen et al. show that Arg-92 in GIRK2 is essential for PIP2-dependent gating, with substitutions causing structural rearrangements that disrupt G protein & alcohol activation—likely a conserved mechanism among inward rectifier potassium channels rupress.org/jgp/article/...
Spotlight @jcb.org: Jeff Hardin highlights recent work from @xsciteng.bsky.social et al. of the @jeffbush.bsky.social lab (rupress.org/jcb/article/...), studying the function of p120-catenin and #cadherin-mediated #adhesion in upper lip fusion in mammalian embryos. rupress.org/jcb/article/...
December 19, 2025 at 5:15 PM
Spotlight @jcb.org: Jeff Hardin highlights recent work from @xsciteng.bsky.social et al. of the @jeffbush.bsky.social lab (rupress.org/jcb/article/...), studying the function of p120-catenin and #cadherin-mediated #adhesion in upper lip fusion in mammalian embryos. rupress.org/jcb/article/...
New @jgp.org study from Lopez-Mateos, Narang, & @vyy-sf.bsky.social @ucd-physiology.bsky.social reveals potential of #DeepLearning methods to model multiple states of human voltage-gated sodium channels and their interactions with β-subunits and calmodulin. rupress.org/jgp/article/...
#IonChannels
#IonChannels
December 18, 2025 at 7:30 PM
New @jgp.org study from Lopez-Mateos, Narang, & @vyy-sf.bsky.social @ucd-physiology.bsky.social reveals potential of #DeepLearning methods to model multiple states of human voltage-gated sodium channels and their interactions with β-subunits and calmodulin. rupress.org/jgp/article/...
#IonChannels
#IonChannels
@jhumimmunity.org: Dalvi et al describe 50 Indian patients w Mendelian susceptibility to mycobacterial disease, highlighting its clinical diversity & genetic heterogeneity. Immunological assays, flow cytometry & genetic testing aid diagnosis & targeted clinical management rupress.org/jhi/article/...
December 18, 2025 at 6:45 PM
@jhumimmunity.org: Dalvi et al describe 50 Indian patients w Mendelian susceptibility to mycobacterial disease, highlighting its clinical diversity & genetic heterogeneity. Immunological assays, flow cytometry & genetic testing aid diagnosis & targeted clinical management rupress.org/jhi/article/...
In @jcb.org, Zhengyang Guo, Guangshuo Ou et al. @tsinghuauniversity.bsky.social introduce SynSeg, a method that eliminates manual annotation by training #DeepLearning models on synthetic data from abstracted “primitives” to robustly segment diverse subcellular structures rupress.org/jcb/article/...
December 18, 2025 at 6:15 PM
In @jcb.org, Zhengyang Guo, Guangshuo Ou et al. @tsinghuauniversity.bsky.social introduce SynSeg, a method that eliminates manual annotation by training #DeepLearning models on synthetic data from abstracted “primitives” to robustly segment diverse subcellular structures rupress.org/jcb/article/...
@jgp.org's latest Research News: JGP study (De Giorgis et al. rupress.org/jgp/article/...) reveals that the auxiliary Caᵥβ₃ subunit regulates the cardiac calcium channel Caᵥ1.2 by modulating the two-step activation of VSD II. rupress.org/jgp/article/...
#IonChannels
#IonChannels
December 18, 2025 at 5:30 PM
@jgp.org's latest Research News: JGP study (De Giorgis et al. rupress.org/jgp/article/...) reveals that the auxiliary Caᵥβ₃ subunit regulates the cardiac calcium channel Caᵥ1.2 by modulating the two-step activation of VSD II. rupress.org/jgp/article/...
#IonChannels
#IonChannels
New review in @jem.org by Cayatte, Picant, Vétizou, & @ericvivier.bsky.social explores the expanding roles of #NKcells beyond #cancer, highlighting their pivotal functions in viral #infections, #neurodegeneration, #autoimmune diseases, and #transplantation medicine rupress.org/jem/article/...
December 17, 2025 at 7:45 PM
New review in @jem.org by Cayatte, Picant, Vétizou, & @ericvivier.bsky.social explores the expanding roles of #NKcells beyond #cancer, highlighting their pivotal functions in viral #infections, #neurodegeneration, #autoimmune diseases, and #transplantation medicine rupress.org/jem/article/...
In @jhumimmunity.org, Brumm et al evaluated 69 subjects w/ #SCID to assess the neurodevelopmental outcomes following HCT. Compared w/ the normative population, our subjects performed in the average range. There was no impact of newborn screening, conditioning, or genotype rupress.org/jhi/article/...
December 17, 2025 at 7:00 PM
In @jhumimmunity.org, Brumm et al evaluated 69 subjects w/ #SCID to assess the neurodevelopmental outcomes following HCT. Compared w/ the normative population, our subjects performed in the average range. There was no impact of newborn screening, conditioning, or genotype rupress.org/jhi/article/...
In @jgp.org: Eduardo Rios reviews the relevance for physiology and pathophysiology of the synchronous gating of sarco-endoplasmic reticulum Ca²⁺ release channels, reported in bilayer reconstitution experiments. rupress.org/jgp/article/...
#Biophysics #CardiacMuscle #ComputationalBiology
#Biophysics #CardiacMuscle #ComputationalBiology
December 17, 2025 at 6:30 PM
In @jgp.org: Eduardo Rios reviews the relevance for physiology and pathophysiology of the synchronous gating of sarco-endoplasmic reticulum Ca²⁺ release channels, reported in bilayer reconstitution experiments. rupress.org/jgp/article/...
#Biophysics #CardiacMuscle #ComputationalBiology
#Biophysics #CardiacMuscle #ComputationalBiology
In @jem.org, Liling Xu et al. of the Batista lab @ragoninstitute.bsky.social show that FIP200, a sensor involved in #autophagy regulation, governs the differentiation of plasma B cells. B cells without FIP200 are dysfunctional in #mitophagy & #metabolism. rupress.org/jem/article/...
December 17, 2025 at 5:45 PM
In @jem.org, Liling Xu et al. of the Batista lab @ragoninstitute.bsky.social show that FIP200, a sensor involved in #autophagy regulation, governs the differentiation of plasma B cells. B cells without FIP200 are dysfunctional in #mitophagy & #metabolism. rupress.org/jem/article/...
Spotlight @jcb.org: Ivan Radin discusses new work from Ryken and colleagues (rupress.org/jcb/article/...) which shows how localization and function of autoinhibitory calcium ATPases maintains the strength of the tip-focus Ca2²⁺ gradient during polarized plant growth. rupress.org/jcb/article/...
December 17, 2025 at 5:15 PM
Spotlight @jcb.org: Ivan Radin discusses new work from Ryken and colleagues (rupress.org/jcb/article/...) which shows how localization and function of autoinhibitory calcium ATPases maintains the strength of the tip-focus Ca2²⁺ gradient during polarized plant growth. rupress.org/jcb/article/...
In @jcb.org, Ben-Hamo-Arad, Toledano et al. reveal that #Drosophila cyst cells exist in two functionally distinct subpopulations: transient escort cells derived from #StemCell divisions & long-lived steady cyst cells that persist at the testis apex & mediate phagoptosis rupress.org/jcb/article/...
December 16, 2025 at 7:45 PM
In @jcb.org, Ben-Hamo-Arad, Toledano et al. reveal that #Drosophila cyst cells exist in two functionally distinct subpopulations: transient escort cells derived from #StemCell divisions & long-lived steady cyst cells that persist at the testis apex & mediate phagoptosis rupress.org/jcb/article/...
In @jhumimmunity.org, Freeman, Thielen @thie0149.bsky.social and Pozos provide practical advice on prevention, diagnosis, and management of infections in #InbornErrorsOfImmunity as well as management of common complications such as bronchiectasis. rupress.org/jhi/article/...
#HowITreat
#HowITreat
December 16, 2025 at 7:15 PM
In @jhumimmunity.org, Freeman, Thielen @thie0149.bsky.social and Pozos provide practical advice on prevention, diagnosis, and management of infections in #InbornErrorsOfImmunity as well as management of common complications such as bronchiectasis. rupress.org/jhi/article/...
#HowITreat
#HowITreat
In @jem.org, LeBlanc, Sobel, Constantinides et al. @scripps.edu show that antibiotic treatment in early life can deplete riboflavin-synthesizing commensals & impair #MAIT cell development, rendering adult animals more susceptible to bacterial #pneumonia. rupress.org/jem/article/...
#Microbiome
#Microbiome
December 16, 2025 at 6:30 PM
In @jem.org, LeBlanc, Sobel, Constantinides et al. @scripps.edu show that antibiotic treatment in early life can deplete riboflavin-synthesizing commensals & impair #MAIT cell development, rendering adult animals more susceptible to bacterial #pneumonia. rupress.org/jem/article/...
#Microbiome
#Microbiome
@jcb.org: Jacqmin et al report that the loss of maspardin, which is deficient in spastic paraplegia 21, results in RAB7 hyperactivation due to mislocalization. This abnormal RAB7 localization leads to defects in lysosome trafficking & disruption of the mTOR–TFEB pathway rupress.org/jcb/article/...
December 16, 2025 at 6:15 PM
@jcb.org: Jacqmin et al report that the loss of maspardin, which is deficient in spastic paraplegia 21, results in RAB7 hyperactivation due to mislocalization. This abnormal RAB7 localization leads to defects in lysosome trafficking & disruption of the mTOR–TFEB pathway rupress.org/jcb/article/...
In new @jhumimmunity.org report, Wang, Freeman et al. summarize the clinical phenotypes, immunologic findings, treatment, and outcomes of 10 patients with Phosphoglucomutase-3 (PGM3) deficiency rupress.org/jhi/article/...
@clinimmsoc.bsky.social
@clinimmsoc.bsky.social
Extended clinical phenotypes and long-term outcomes of phosphoglucomutase-3 deficiency | Journal of Human Immunity | Rockefeller University Press
PGM3 deficiency is a multisystem disorder characterized by recurrent infections, chronic severe neutropenia, and virus-associated malignancies, often leadi
rupress.org
December 12, 2025 at 7:00 PM
In new @jhumimmunity.org report, Wang, Freeman et al. summarize the clinical phenotypes, immunologic findings, treatment, and outcomes of 10 patients with Phosphoglucomutase-3 (PGM3) deficiency rupress.org/jhi/article/...
@clinimmsoc.bsky.social
@clinimmsoc.bsky.social
In @jem.org, Yongkang Yang, Gregg Semenza et al. show that, in response to intratumoral #hypoxia, #BreastCancer cells co-opt an antiviral mechanism to promote #cancer #StemCell specification and immune evasion, which are essential properties that enable #metastasis. rupress.org/jem/article/...
December 12, 2025 at 6:30 PM
In @jem.org, Yongkang Yang, Gregg Semenza et al. show that, in response to intratumoral #hypoxia, #BreastCancer cells co-opt an antiviral mechanism to promote #cancer #StemCell specification and immune evasion, which are essential properties that enable #metastasis. rupress.org/jem/article/...
In @jgp.org, @khandeliagroup.bsky.social show that the potassium pump KdpFABC's inter-subunit tunnel is mainly water-filled & has a single stable K+ site, challenging the idea of a continuous ion-wire and highlighting a key barrier at the KdpA-KdpB interface. rupress.org/jgp/article/...
December 12, 2025 at 5:45 PM
In @jgp.org, @khandeliagroup.bsky.social show that the potassium pump KdpFABC's inter-subunit tunnel is mainly water-filled & has a single stable K+ site, challenging the idea of a continuous ion-wire and highlighting a key barrier at the KdpA-KdpB interface. rupress.org/jgp/article/...
In @jem.org, Aroca-Crevillén, Hidalgo @drusqui.bsky.social et al. identify a #circadian checkpoint in #neutrophils, mediated by the CXCL12–CXCR4 axis, that limits tissue injury by inhibiting their intrinsic circadian clock. rupress.org/jem/article/...
#CardiovascularBiology #InnateImmunity
#CardiovascularBiology #InnateImmunity
December 12, 2025 at 5:00 PM
In @jem.org, Aroca-Crevillén, Hidalgo @drusqui.bsky.social et al. identify a #circadian checkpoint in #neutrophils, mediated by the CXCL12–CXCR4 axis, that limits tissue injury by inhibiting their intrinsic circadian clock. rupress.org/jem/article/...
#CardiovascularBiology #InnateImmunity
#CardiovascularBiology #InnateImmunity
📰 Press Release: Researchers at @yaleschoolofmed.bsky.social have identified a way to suppress the daily fluctuations in the activity of key immune cells known as neutrophils. www.eurekalert.org/news-release...
See original @jem.org paper by @drusqui.bsky.social group: rupress.org/jem/article/...
See original @jem.org paper by @drusqui.bsky.social group: rupress.org/jem/article/...
December 12, 2025 at 4:30 PM
📰 Press Release: Researchers at @yaleschoolofmed.bsky.social have identified a way to suppress the daily fluctuations in the activity of key immune cells known as neutrophils. www.eurekalert.org/news-release...
See original @jem.org paper by @drusqui.bsky.social group: rupress.org/jem/article/...
See original @jem.org paper by @drusqui.bsky.social group: rupress.org/jem/article/...
In @jcb.org, Rashmi Budhathoki et al. @blankenshiplab.bsky.social show that nuclear dispersion relies on a transition from centrosomal to embedded nucleus-associated, non-centrosomal #microtubules during #Drosophila tissue extension rupress.org/jcb/article/...
#Cytoskeleton #Development #Organelles
#Cytoskeleton #Development #Organelles
December 11, 2025 at 8:40 PM
In @jcb.org, Rashmi Budhathoki et al. @blankenshiplab.bsky.social show that nuclear dispersion relies on a transition from centrosomal to embedded nucleus-associated, non-centrosomal #microtubules during #Drosophila tissue extension rupress.org/jcb/article/...
#Cytoskeleton #Development #Organelles
#Cytoskeleton #Development #Organelles