Rockefeller University Press
@rupress.org
We publish the scientific journals @jcb.org, @jem.org, @jgp.org, @jhumimmunity.org, and co-publish @lsajournal.org. Visit our journals at https://rupress.org
Insights @jem.org: Bosteels, Stainier, and @reisesousalab.bsky.social highlight work by Tam et al. (rupress.org/jem/article/...) revealing that GPR34, a lysophosphatidylserine receptor, promotes apoptotic cell uptake and cross-presentation by type 1 #DendriticCells. rupress.org/jem/article/...
November 13, 2025 at 5:45 PM
Insights @jem.org: Bosteels, Stainier, and @reisesousalab.bsky.social highlight work by Tam et al. (rupress.org/jem/article/...) revealing that GPR34, a lysophosphatidylserine receptor, promotes apoptotic cell uptake and cross-presentation by type 1 #DendriticCells. rupress.org/jem/article/...
In @jcb.org, @xsciteng.bsky.social, @jeffbush.bsky.social et al. @ctbatucsf.bsky.social reveal cellular mechanisms of tissue fusion in the developing face. They demonstrate that actomyosin-generated forces drive tissue fusion, necessitating an elevated cadherin threshold. rupress.org/jcb/article/...
November 13, 2025 at 5:15 PM
In @jcb.org, @xsciteng.bsky.social, @jeffbush.bsky.social et al. @ctbatucsf.bsky.social reveal cellular mechanisms of tissue fusion in the developing face. They demonstrate that actomyosin-generated forces drive tissue fusion, necessitating an elevated cadherin threshold. rupress.org/jcb/article/...
From the adaptive plasticity of sensory neurons to the influence of synaptic architecture on glutamate dynamics within rod photoreceptor synapses, explore new #Neuroscience research in @jgp.org to accompany #SfN25 @sfn.org! 👉 rupress.org/jgp/collecti...
November 13, 2025 at 3:15 PM
From the adaptive plasticity of sensory neurons to the influence of synaptic architecture on glutamate dynamics within rod photoreceptor synapses, explore new #Neuroscience research in @jgp.org to accompany #SfN25 @sfn.org! 👉 rupress.org/jgp/collecti...
Spotlight @jcb.org: @juanmartin-serrano.bsky.social highlights work from Dam, Moreno, Brownlow, @longchrom.bsky.social et al. (rupress.org/jcb/article/...), which reveals how Srs2/PARI act as a missegregated chromatin sensor for NoCut, delaying cytokinetic abscission. rupress.org/jcb/article/...
November 12, 2025 at 5:00 PM
Spotlight @jcb.org: @juanmartin-serrano.bsky.social highlights work from Dam, Moreno, Brownlow, @longchrom.bsky.social et al. (rupress.org/jcb/article/...), which reveals how Srs2/PARI act as a missegregated chromatin sensor for NoCut, delaying cytokinetic abscission. rupress.org/jcb/article/...
Explore new discoveries in cellular neurobiology to accompany #SfN25 @sfn.org! @jcb.org's new collection comprises novel findings regarding tau- & α-synuclein aggregation and explores mechanisms underlying dendrite branching, axonal regeneration, & survival: rupress.org/jcb/collecti...
#Neuroscience
#Neuroscience
November 12, 2025 at 3:45 PM
Explore new discoveries in cellular neurobiology to accompany #SfN25 @sfn.org! @jcb.org's new collection comprises novel findings regarding tau- & α-synuclein aggregation and explores mechanisms underlying dendrite branching, axonal regeneration, & survival: rupress.org/jcb/collecti...
#Neuroscience
#Neuroscience
In @jhumimmunity.org, Ünal, Dublanc, Bustamante, @jrosain.bsky.social et al. @hopitalnecker.bsky.social report two patients with Whipple’s disease caused by autosomal dominant IRF4 deficiency. rupress.org/jhi/article/...
#InbornErrorsOfImmunity
#InbornErrorsOfImmunity
November 11, 2025 at 6:45 PM
In @jhumimmunity.org, Ünal, Dublanc, Bustamante, @jrosain.bsky.social et al. @hopitalnecker.bsky.social report two patients with Whipple’s disease caused by autosomal dominant IRF4 deficiency. rupress.org/jhi/article/...
#InbornErrorsOfImmunity
#InbornErrorsOfImmunity
In @jgp.org, Jaque-Fernandez, Allard et al. @cnrs.fr show that depolarization of #zebrafish #SkeletalMuscle fibers evokes a Mn²⁺ quenching signal that does not result from store-operated Ca²⁺ entry but from a displacement of Mn²⁺ accumulated on intracellular Ca²⁺ buffers rupress.org/jgp/article/...
November 11, 2025 at 6:15 PM
In @jgp.org, Jaque-Fernandez, Allard et al. @cnrs.fr show that depolarization of #zebrafish #SkeletalMuscle fibers evokes a Mn²⁺ quenching signal that does not result from store-operated Ca²⁺ entry but from a displacement of Mn²⁺ accumulated on intracellular Ca²⁺ buffers rupress.org/jgp/article/...
In @jem.org, Skoda and Silvennoinen highlight new work from Zhou et al. (rupress.org/jem/article/...) describing the different effects of heterozygous and homozygous JAK2V617F mutations on hematopoietic progenitors rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
November 11, 2025 at 5:30 PM
In @jem.org, Skoda and Silvennoinen highlight new work from Zhou et al. (rupress.org/jem/article/...) describing the different effects of heterozygous and homozygous JAK2V617F mutations on hematopoietic progenitors rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
Viewpoint @jcb.org: @fredmast.bsky.social, Rachubinski, and Aitchison @seattlechildrens.org challenge the PPAR paradigm and show human #peroxisomes expand via hominid-specific pathways that link specialization to immunometabolic functions. rupress.org/jcb/article/...
#Organelles #Development
#Organelles #Development
November 11, 2025 at 5:00 PM
Viewpoint @jcb.org: @fredmast.bsky.social, Rachubinski, and Aitchison @seattlechildrens.org challenge the PPAR paradigm and show human #peroxisomes expand via hominid-specific pathways that link specialization to immunometabolic functions. rupress.org/jcb/article/...
#Organelles #Development
#Organelles #Development
🧠 Read @jem.org's #Neuroscience collection of research articles and reviews to accompany #SfN25 @sfn.org! Explore the latest discoveries in #neuroscience, including meningeal #lymphatics, #pain, #neurodegeneration, #tauopathy, and #MultipleSclerosis. 👉 rupress.org/jem/collecti...
November 11, 2025 at 3:15 PM
🧠 Read @jem.org's #Neuroscience collection of research articles and reviews to accompany #SfN25 @sfn.org! Explore the latest discoveries in #neuroscience, including meningeal #lymphatics, #pain, #neurodegeneration, #tauopathy, and #MultipleSclerosis. 👉 rupress.org/jem/collecti...
In @jhumimmunity.org, Jeganathan et al. report that standard newborn screening using T cell receptor excision circles (TRECs) failed to detect delayed-onset ADA deficiency in two cases. But retrospective MS/MS analysis showed diagnostic deoxyadenosine elevation at birth. rupress.org/jhi/article/...
Early identification of delayed-onset ADA deficiency: The case for expanded first-tier newborn screening | Journal of Human Immunity | Rockefeller University Press
Standard newborn screening using T cell receptor excision circles (TRECs) failed to detect delayed-onset ADA deficiency in two cases. Retrospective mass sp
rupress.org
November 10, 2025 at 6:30 PM
In @jhumimmunity.org, Jeganathan et al. report that standard newborn screening using T cell receptor excision circles (TRECs) failed to detect delayed-onset ADA deficiency in two cases. But retrospective MS/MS analysis showed diagnostic deoxyadenosine elevation at birth. rupress.org/jhi/article/...
In @jem.org, Tam, Cyster et al. identify GPR34 as a splenic cDC1 receptor that is required for efferocytosis and for the cross-presentation of apoptotic cell–associated antigen to CD8 T cells. rupress.org/jem/article/...
#InnateImmunity #inflammation
@hhmi.org
#InnateImmunity #inflammation
@hhmi.org
November 10, 2025 at 5:45 PM
In @jem.org, Tam, Cyster et al. identify GPR34 as a splenic cDC1 receptor that is required for efferocytosis and for the cross-presentation of apoptotic cell–associated antigen to CD8 T cells. rupress.org/jem/article/...
#InnateImmunity #inflammation
@hhmi.org
#InnateImmunity #inflammation
@hhmi.org
In @jcb.org, Yanyan Li, Hongchang Li al. reveal that Aurora A–mediated phosphorylation of Numb triggers its dissociation from the plasma membrane, thereby promoting #myosin I–dependent membrane-to-cortex adhesion required for mitotic cell rounding rupress.org/jcb/article/...
#Mitosis #Genetics
#Mitosis #Genetics
November 10, 2025 at 5:01 PM
In @jcb.org, Yanyan Li, Hongchang Li al. reveal that Aurora A–mediated phosphorylation of Numb triggers its dissociation from the plasma membrane, thereby promoting #myosin I–dependent membrane-to-cortex adhesion required for mitotic cell rounding rupress.org/jcb/article/...
#Mitosis #Genetics
#Mitosis #Genetics
Reposted by Rockefeller University Press
It’s exciting to finally talk about the new gig!
@jem.org is pleased to introduce Natalie Cain as the Executive Editor of the journal! Natalie will guide the collaborative editorial process at JEM. Follow her at 🦋 @nataliecain.bsky.social
Learn more about Natalie 👉 rupress.org/jem/pages/je...
Learn more about Natalie 👉 rupress.org/jem/pages/je...
November 6, 2025 at 9:04 PM
It’s exciting to finally talk about the new gig!
In @jem.org, Cinque et al. @leuccilrcb.bsky.social showed that the #lncRNA LISRR contributes to the emergence of #melanoma clones resistant to the immune attack by assembling #specializedribosomes at the ER. rupress.org/jem/article/...
🎥 See a short video summary: youtu.be/AKSuTne83jQ
#Ribosomes
🎥 See a short video summary: youtu.be/AKSuTne83jQ
#Ribosomes
November 7, 2025 at 5:45 PM
In @jem.org, Cinque et al. @leuccilrcb.bsky.social showed that the #lncRNA LISRR contributes to the emergence of #melanoma clones resistant to the immune attack by assembling #specializedribosomes at the ER. rupress.org/jem/article/...
🎥 See a short video summary: youtu.be/AKSuTne83jQ
#Ribosomes
🎥 See a short video summary: youtu.be/AKSuTne83jQ
#Ribosomes
In @jcb.org, Calvo, Patel, Alonso @uva-es.bsky.social et al. describe a new bioluminescent sensor for measuring luminal Ca²⁺ in a mildly acidic subcompartment of the endo-lysosomal system. rupress.org/jcb/article/...
#CellSignaling #Organelles #Physiology #Technology #Lysosomes #Endosomes
#CellSignaling #Organelles #Physiology #Technology #Lysosomes #Endosomes
November 7, 2025 at 5:00 PM
In @jcb.org, Calvo, Patel, Alonso @uva-es.bsky.social et al. describe a new bioluminescent sensor for measuring luminal Ca²⁺ in a mildly acidic subcompartment of the endo-lysosomal system. rupress.org/jcb/article/...
#CellSignaling #Organelles #Physiology #Technology #Lysosomes #Endosomes
#CellSignaling #Organelles #Physiology #Technology #Lysosomes #Endosomes
In @jcb.org, Okada, Bi et al. @upenn.edu show that Bni5 interacts with #septin filaments, septin-associated kinase, and #myosin-II to regulate septin hourglass architecture and remodeling, retrograde #actin flow, and #cytokinesis. rupress.org/jcb/article/...
#CellDivision #Cytoskeleton #Genetics
#CellDivision #Cytoskeleton #Genetics
November 6, 2025 at 6:30 PM
In @jcb.org, Okada, Bi et al. @upenn.edu show that Bni5 interacts with #septin filaments, septin-associated kinase, and #myosin-II to regulate septin hourglass architecture and remodeling, retrograde #actin flow, and #cytokinesis. rupress.org/jcb/article/...
#CellDivision #Cytoskeleton #Genetics
#CellDivision #Cytoskeleton #Genetics
In @jcb.org, Peiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/...
#ER_literature #Migration #Organelles
#ER_literature #Migration #Organelles
November 6, 2025 at 5:45 PM
In @jcb.org, Peiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/...
#ER_literature #Migration #Organelles
#ER_literature #Migration #Organelles
In @jem.org, Chen, Weichselbaum et al. discover that YTHDF2 in #DendriticCells negatively regulates antitumor immunity of #radiotherapy. The SPI1–YTHDF2–Notch signaling–MHC-I axis orchestrates the antigen cross-presentation function of dendritic cells. rupress.org/jem/article/...
November 6, 2025 at 5:00 PM
In @jem.org, Chen, Weichselbaum et al. discover that YTHDF2 in #DendriticCells negatively regulates antitumor immunity of #radiotherapy. The SPI1–YTHDF2–Notch signaling–MHC-I axis orchestrates the antigen cross-presentation function of dendritic cells. rupress.org/jem/article/...
@jem.org is pleased to introduce Natalie Cain as the Executive Editor of the journal! Natalie will guide the collaborative editorial process at JEM. Follow her at 🦋 @nataliecain.bsky.social
Learn more about Natalie 👉 rupress.org/jem/pages/je...
Learn more about Natalie 👉 rupress.org/jem/pages/je...
November 6, 2025 at 4:02 PM
@jem.org is pleased to introduce Natalie Cain as the Executive Editor of the journal! Natalie will guide the collaborative editorial process at JEM. Follow her at 🦋 @nataliecain.bsky.social
Learn more about Natalie 👉 rupress.org/jem/pages/je...
Learn more about Natalie 👉 rupress.org/jem/pages/je...
In @jgp.org, De Giorgis, Neely et al. show that the auxiliary β-subunit remodels only voltage sensor II and its allosteric contribution to CaV1.2 channel opening upon the translocation of two charges before reaching full activation. rupress.org/jgp/article/...
#IonChannels
#IonChannels
November 5, 2025 at 5:45 PM
In @jgp.org, De Giorgis, Neely et al. show that the auxiliary β-subunit remodels only voltage sensor II and its allosteric contribution to CaV1.2 channel opening upon the translocation of two charges before reaching full activation. rupress.org/jgp/article/...
#IonChannels
#IonChannels
Esther Obeng is an attending physician and associate professor at Emory University, where she leads a research group focused on myelodysplastic syndromes (MDS). @jem.org spoke with Esther about her career, how her patients inform her research, and more: rupress.org/jem/article/...
#WomenInSTEM
#WomenInSTEM
November 5, 2025 at 5:00 PM
Esther Obeng is an attending physician and associate professor at Emory University, where she leads a research group focused on myelodysplastic syndromes (MDS). @jem.org spoke with Esther about her career, how her patients inform her research, and more: rupress.org/jem/article/...
#WomenInSTEM
#WomenInSTEM
Congratulations to Cedars-Sinai Postdoc Katarzyna Chojnacka, winner of the @jem.org Early Career Travel Award to attend the #Cytokines2025 meeting in Seattle. Learn more here: rupress.org/jem/pages/ea...
November 4, 2025 at 10:13 PM
Congratulations to Cedars-Sinai Postdoc Katarzyna Chojnacka, winner of the @jem.org Early Career Travel Award to attend the #Cytokines2025 meeting in Seattle. Learn more here: rupress.org/jem/pages/ea...
In new study @jcb.org from Ryken, Bezanilla et al., analysis of PIIB-type calcium pump localization and function elucidates one of the molecular mechanisms that maintains the strength of the calcium gradient during polarized growth. rupress.org/jcb/article/...
#PlantBiology #Cytoskeleton
#PlantBiology #Cytoskeleton
November 4, 2025 at 7:45 PM
In new study @jcb.org from Ryken, Bezanilla et al., analysis of PIIB-type calcium pump localization and function elucidates one of the molecular mechanisms that maintains the strength of the calcium gradient during polarized growth. rupress.org/jcb/article/...
#PlantBiology #Cytoskeleton
#PlantBiology #Cytoskeleton
In @jcb.org, Xu Liu, Ya Huang et al. show that the transcriptional regulator RTF1 promotes #circadian rhythm by enhancing CLOCK occupancy and H3K4me3 deposition at pacemaker gene loci. rupress.org/jcb/article/...
#Chromatin #Epigenetics
#Chromatin #Epigenetics
November 4, 2025 at 7:15 PM
In @jcb.org, Xu Liu, Ya Huang et al. show that the transcriptional regulator RTF1 promotes #circadian rhythm by enhancing CLOCK occupancy and H3K4me3 deposition at pacemaker gene loci. rupress.org/jcb/article/...
#Chromatin #Epigenetics
#Chromatin #Epigenetics