Michael Hoffman
@michaelhoffman.bsky.social
Chair, Computational BIology and Medicine Program, Princess Margaret Cancer Centre, University Health Network.
Associate Professor, Medical Biophysics, University of Toronto.
Disclosures: https://github.com/michaelmhoffman/disclosure/
Associate Professor, Medical Biophysics, University of Toronto.
Disclosures: https://github.com/michaelmhoffman/disclosure/
Pinned
My people!
Everyone booed at Don Valley Station and chanted "Science Centre"
February 8, 2026 at 2:26 PM
My people!
Reposted by Michael Hoffman
the magic of the Muppets is that there are two fourth walls. they constantly break the one that reminds the audience they are performers. they NEVER break the one that reminds the audience they are puppets. this dynamic is the key to their entire comedy style
MY KIDS: so why are there muppets in the AUDIENCE
ME: THE CONCEIT!! IS THAT THEY'RE PUTTING ON A VARIETY SHOW!!! IN A WORLD WHERE MUPPET AND HUMAN COEXIST!!! YOU ARE WATCHING A DOCUMENTARY!! FILMED!! IN REAL TIME!!!
ME: THE CONCEIT!! IS THAT THEY'RE PUTTING ON A VARIETY SHOW!!! IN A WORLD WHERE MUPPET AND HUMAN COEXIST!!! YOU ARE WATCHING A DOCUMENTARY!! FILMED!! IN REAL TIME!!!
February 8, 2026 at 6:22 AM
the magic of the Muppets is that there are two fourth walls. they constantly break the one that reminds the audience they are performers. they NEVER break the one that reminds the audience they are puppets. this dynamic is the key to their entire comedy style
Reposted by Michael Hoffman
you're doomscrolling I'm plumposting we are not the same
February 6, 2026 at 10:27 PM
you're doomscrolling I'm plumposting we are not the same
Reposted by Michael Hoffman
You've got to understand how cooked US local TV news is to understand in turn how insane it is that Vichy Twitter is 26 points Trumpier than that. Pravda doesn't cover it.
Trump job approval rating by news platform
🟢 Twitter/X: +9
🔴 Facebook: -7
🔴 Cable TV: -10
🔴 Podcasts/YouTube: -14
🔴 Local TV: -17
🔴 Instagram: -21
🔴 Broadcast TV: -28
🔴 TikTok: -28
🔴 Newspapers/news sites: -33
🔴 Reddit: -40
www.theargumentmag.com/p/twitter-is...
🟢 Twitter/X: +9
🔴 Facebook: -7
🔴 Cable TV: -10
🔴 Podcasts/YouTube: -14
🔴 Local TV: -17
🔴 Instagram: -21
🔴 Broadcast TV: -28
🔴 TikTok: -28
🔴 Newspapers/news sites: -33
🔴 Reddit: -40
www.theargumentmag.com/p/twitter-is...
February 6, 2026 at 1:54 PM
You've got to understand how cooked US local TV news is to understand in turn how insane it is that Vichy Twitter is 26 points Trumpier than that. Pravda doesn't cover it.
Reposted by Michael Hoffman
Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine.
faculty-einstein.icims.com/jobs/17847/a...
faculty-einstein.icims.com/jobs/17847/a...
Albert Einstein College of Medicine | Medical Education | Biomedical Research
faculty-einstein.icims.com
February 5, 2026 at 10:14 PM
Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine.
faculty-einstein.icims.com/jobs/17847/a...
faculty-einstein.icims.com/jobs/17847/a...
Reposted by Michael Hoffman
Sometimes you have to say it out loud to appreciate how dire t all is:
The president just openly declared his plans to steal the midterm elections — in an interview with the former number two person at the FBI.
The president just openly declared his plans to steal the midterm elections — in an interview with the former number two person at the FBI.
Trump: "These people were brought to our country to vote, & they vote illegally. The Republicans should say, we should take over the voting in at least 15 places. The Republicans ought to nationalize the voting. We have states that I won that show I didn't win. You're gonna see something in Georgia"
February 2, 2026 at 10:05 PM
Sometimes you have to say it out loud to appreciate how dire t all is:
The president just openly declared his plans to steal the midterm elections — in an interview with the former number two person at the FBI.
The president just openly declared his plans to steal the midterm elections — in an interview with the former number two person at the FBI.
Reposted by Michael Hoffman
Trump to Harvard: 2 billion $
NYT: Harvard to pay 2B$
Harvard: no
Trump: 1B
Harvard: no
NYT: Negotiations intensify
Trump: 200 million
NYT: Harvard-Trump reach deal
Harvard: no
Trump: 0$
Harvard: ok
NYT: Harvard not paying! Trump loses.
Trump: How about 1B$
Harvard: no
NYT: Negotiations resume!
NYT: Harvard to pay 2B$
Harvard: no
Trump: 1B
Harvard: no
NYT: Negotiations intensify
Trump: 200 million
NYT: Harvard-Trump reach deal
Harvard: no
Trump: 0$
Harvard: ok
NYT: Harvard not paying! Trump loses.
Trump: How about 1B$
Harvard: no
NYT: Negotiations resume!
February 3, 2026 at 2:21 PM
Trump to Harvard: 2 billion $
NYT: Harvard to pay 2B$
Harvard: no
Trump: 1B
Harvard: no
NYT: Negotiations intensify
Trump: 200 million
NYT: Harvard-Trump reach deal
Harvard: no
Trump: 0$
Harvard: ok
NYT: Harvard not paying! Trump loses.
Trump: How about 1B$
Harvard: no
NYT: Negotiations resume!
NYT: Harvard to pay 2B$
Harvard: no
Trump: 1B
Harvard: no
NYT: Negotiations intensify
Trump: 200 million
NYT: Harvard-Trump reach deal
Harvard: no
Trump: 0$
Harvard: ok
NYT: Harvard not paying! Trump loses.
Trump: How about 1B$
Harvard: no
NYT: Negotiations resume!
Reposted by Michael Hoffman
"Maybe the city's full" says the man living in a 2.7 million dollar house on Palmerston, while sipping $170 scotch after defeating a multiplex proposal across the street.
www.pressreader.com/canada/toron...
www.pressreader.com/canada/toron...
February 2, 2026 at 5:59 PM
"Maybe the city's full" says the man living in a 2.7 million dollar house on Palmerston, while sipping $170 scotch after defeating a multiplex proposal across the street.
www.pressreader.com/canada/toron...
www.pressreader.com/canada/toron...
Reposted by Michael Hoffman
Impeachment is the only Constitutional check Congress has against a lawless president and talking about it would be a good start to reasserting Congressional power in the future. Assuming of course Congress wants to do that
Speaking out like this is all they can do now. Impeachment is a total and complete joke, and threatening to use it is akin to threatening to hit someone with a wet noodle. Impeachment is no longer a viable tool to use against Republican politicians.
February 2, 2026 at 2:37 PM
Impeachment is the only Constitutional check Congress has against a lawless president and talking about it would be a good start to reasserting Congressional power in the future. Assuming of course Congress wants to do that
Reposted by Michael Hoffman
Chapeau to these early patio people in Toronto. It’s minus six and snow is still deep on the ground
February 1, 2026 at 7:55 PM
Chapeau to these early patio people in Toronto. It’s minus six and snow is still deep on the ground
!!!
Liam is home now and we are grateful to @joaquincastrotx.bsky.social for traveling to Minneapolis with him and his dad.
Welcome home Liam ❤️❤️
Welcome home Liam ❤️❤️
February 1, 2026 at 6:26 PM
!!!
Drivers in Toronto observing the snow route no-parking restrictions about as well as you might expect.
February 1, 2026 at 6:24 PM
Drivers in Toronto observing the snow route no-parking restrictions about as well as you might expect.
Reposted by Michael Hoffman
Never knew Stalin was a big walkability and cycling guy
February 1, 2026 at 12:29 PM
Never knew Stalin was a big walkability and cycling guy
Reposted by Michael Hoffman
Justice Frank Murphy's vehement dissent, condemning the Court for upholding FDR's Exec Order 9066 in resembling "the abhorrent and despicable treatment of minority groups by the dictatorial tyrannies which this nation is now pledged to destroy" – is worth revisiting. 3/
#Korematsu Day
#Korematsu Day
January 30, 2026 at 10:35 PM
Justice Frank Murphy's vehement dissent, condemning the Court for upholding FDR's Exec Order 9066 in resembling "the abhorrent and despicable treatment of minority groups by the dictatorial tyrannies which this nation is now pledged to destroy" – is worth revisiting. 3/
#Korematsu Day
#Korematsu Day
Reposted by Michael Hoffman
It has been two weeks since the unexpected death of Peer Bork, and all of us in his research group are deeply missing him. His scientific vision brought us together as a team, and we are immensely grateful for the time we spent together. 🧵
EMBL is deeply saddened by the passing of our Interim Director General Peer Bork, a pioneering scientist who left an indelible imprint on life science research in Europe and beyond.
We extend our deepest condolences to his family, friends, and colleagues.
www.embl.org/news/people-...
We extend our deepest condolences to his family, friends, and colleagues.
www.embl.org/news/people-...
January 30, 2026 at 3:05 PM
It has been two weeks since the unexpected death of Peer Bork, and all of us in his research group are deeply missing him. His scientific vision brought us together as a team, and we are immensely grateful for the time we spent together. 🧵
Reposted by Michael Hoffman
"I was 13 years old when Donald J. Trump raped me. Ghislaine Maxwell was also present."
January 30, 2026 at 6:45 PM
"I was 13 years old when Donald J. Trump raped me. Ghislaine Maxwell was also present."
Reposted by Michael Hoffman
To summarize:
Most important
Max Perutz was NOT an example of someone with a great idea who went against the establishment wisdom to solve an important problem that he had uniquely identified.
He was part of an organized team working on this problem. He got lots of help.
11/14
Most important
Max Perutz was NOT an example of someone with a great idea who went against the establishment wisdom to solve an important problem that he had uniquely identified.
He was part of an organized team working on this problem. He got lots of help.
11/14
January 30, 2026 at 7:58 PM
To summarize:
Most important
Max Perutz was NOT an example of someone with a great idea who went against the establishment wisdom to solve an important problem that he had uniquely identified.
He was part of an organized team working on this problem. He got lots of help.
11/14
Most important
Max Perutz was NOT an example of someone with a great idea who went against the establishment wisdom to solve an important problem that he had uniquely identified.
He was part of an organized team working on this problem. He got lots of help.
11/14
Reposted by Michael Hoffman
If you answer “No” you get an invitation to Mar-a-Lago
January 30, 2026 at 7:32 PM
If you answer “No” you get an invitation to Mar-a-Lago
Reposted by Michael Hoffman
TO: World’s Biggest Pedophile
FROM: Elon Musk
SUBJECT: RE: Pedophile party on your pedophile island
Any other famous pedophiles going to be there? Looking forward to doing a bunch of pedophile stuff btw.
FROM: Elon Musk
SUBJECT: RE: Pedophile party on your pedophile island
Any other famous pedophiles going to be there? Looking forward to doing a bunch of pedophile stuff btw.
OK, so Musk was planning to go to Epstein's island, but it's not like he went there with the intent to go to a wild party or something, it was probably just some business. Excuse me, an email just came in.
*Reads:* "What day/night will be the wildest party on your island?"
*Reads:* "What day/night will be the wildest party on your island?"
January 30, 2026 at 7:44 PM
TO: World’s Biggest Pedophile
FROM: Elon Musk
SUBJECT: RE: Pedophile party on your pedophile island
Any other famous pedophiles going to be there? Looking forward to doing a bunch of pedophile stuff btw.
FROM: Elon Musk
SUBJECT: RE: Pedophile party on your pedophile island
Any other famous pedophiles going to be there? Looking forward to doing a bunch of pedophile stuff btw.
Reposted by Michael Hoffman
I'm at the Willard Hotel where I've been denied entry and kicked out of the Reclaiming Science event with NIH director Bhattacharya & other top agency leaders.
@jocelynkaiser.bsky.social and I registered for the event months ago yet were told capacity was full, even as they let in dozens of others.
@jocelynkaiser.bsky.social and I registered for the event months ago yet were told capacity was full, even as they let in dozens of others.
January 30, 2026 at 6:07 PM
I'm at the Willard Hotel where I've been denied entry and kicked out of the Reclaiming Science event with NIH director Bhattacharya & other top agency leaders.
@jocelynkaiser.bsky.social and I registered for the event months ago yet were told capacity was full, even as they let in dozens of others.
@jocelynkaiser.bsky.social and I registered for the event months ago yet were told capacity was full, even as they let in dozens of others.
Reposted by Michael Hoffman
I used to have these knee-jerk reactions to people who were trying to get the Democrats to be better, but right now we are in primary season.
I will absolutely be voting for a Democrat in the midterms. But I am not quite sure which one I'll be voting for yet.
I will absolutely be voting for a Democrat in the midterms. But I am not quite sure which one I'll be voting for yet.
You're arguing with a strawman.
I just want them to say it was a mistake to create these agencies. I want them to show me they understand what has gone wrong and why.
I just want them to say it was a mistake to create these agencies. I want them to show me they understand what has gone wrong and why.
January 27, 2026 at 3:57 PM
I used to have these knee-jerk reactions to people who were trying to get the Democrats to be better, but right now we are in primary season.
I will absolutely be voting for a Democrat in the midterms. But I am not quite sure which one I'll be voting for yet.
I will absolutely be voting for a Democrat in the midterms. But I am not quite sure which one I'll be voting for yet.
Reposted by Michael Hoffman
my increasingly curmudgeonly take is that we all, in fact, have responsibilities. politics isn't an arena for self-actualization. it's an arena for public service. this is as true of voters as it is of politicians.
Ps: a common refrain that you'll hear is that "you're saying the Dems can't be at fault, it's the voters, as if the voters owe something to politicians and not the other way around!"
Yes, actually, that's how the social contract of democracy works. Voters yet the government they work for. Or don't.
Yes, actually, that's how the social contract of democracy works. Voters yet the government they work for. Or don't.
January 29, 2026 at 5:10 PM
my increasingly curmudgeonly take is that we all, in fact, have responsibilities. politics isn't an arena for self-actualization. it's an arena for public service. this is as true of voters as it is of politicians.
Reposted by Michael Hoffman
Surprised (but also not that surprised) that the AlphaGenome paper didn't officially cite any of the primary data used for training their model (see Fig. 1, thousands of datasets made with tremendous time and effort over >15yrs). What's up with that @nature.com ?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Advancing regulatory variant effect prediction with AlphaGenome - Nature
AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...
www.nature.com
January 30, 2026 at 2:20 AM
Surprised (but also not that surprised) that the AlphaGenome paper didn't officially cite any of the primary data used for training their model (see Fig. 1, thousands of datasets made with tremendous time and effort over >15yrs). What's up with that @nature.com ?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Michael Hoffman
notice how after ilhan omar was attacked by a maga true believer parroting donald trump, the mainstream media didnt kick off a multi-day orgy about how trump and other republicans need to change their tone and "lower the temperature"?
that discourse only goes one way for the msm.
that discourse only goes one way for the msm.
January 29, 2026 at 2:55 PM
notice how after ilhan omar was attacked by a maga true believer parroting donald trump, the mainstream media didnt kick off a multi-day orgy about how trump and other republicans need to change their tone and "lower the temperature"?
that discourse only goes one way for the msm.
that discourse only goes one way for the msm.
Bluesky PROTIP: I have never regretted muting the names of pundits with consistently bad takes.
January 29, 2026 at 3:07 PM
Bluesky PROTIP: I have never regretted muting the names of pundits with consistently bad takes.