Michael Hoffman
@michaelhoffman.bsky.social
Chair, Computational BIology and Medicine Program, Princess Margaret Cancer Centre, University Health Network.
Associate Professor, Medical Biophysics, University of Toronto.
Disclosures: https://github.com/michaelmhoffman/disclosure/
Associate Professor, Medical Biophysics, University of Toronto.
Disclosures: https://github.com/michaelmhoffman/disclosure/
Pinned
Michael Hoffman
@michaelhoffman.bsky.social
Β· Nov 12
I'm at Princess Margaret Cancer Centre and University of Toronto. We have three major interests:
1/Computational methods and #ML for gene regulation data π§¬π₯οΈ
2/Liquid biopsy beyond simple genetic variants (epigenomic, immunogenomic)
3/Reproducibility and robustness of biomedical analysis (esp. #ML)
1/Computational methods and #ML for gene regulation data π§¬π₯οΈ
2/Liquid biopsy beyond simple genetic variants (epigenomic, immunogenomic)
3/Reproducibility and robustness of biomedical analysis (esp. #ML)
Sorry man π
February 10, 2026 at 3:17 PM
Sorry man π
My people!
Everyone booed at Don Valley Station and chanted "Science Centre"
February 8, 2026 at 2:26 PM
My people!
Reposted by Michael Hoffman
the magic of the Muppets is that there are two fourth walls. they constantly break the one that reminds the audience they are performers. they NEVER break the one that reminds the audience they are puppets. this dynamic is the key to their entire comedy style
MY KIDS: so why are there muppets in the AUDIENCE
ME: THE CONCEIT!! IS THAT THEY'RE PUTTING ON A VARIETY SHOW!!! IN A WORLD WHERE MUPPET AND HUMAN COEXIST!!! YOU ARE WATCHING A DOCUMENTARY!! FILMED!! IN REAL TIME!!!
ME: THE CONCEIT!! IS THAT THEY'RE PUTTING ON A VARIETY SHOW!!! IN A WORLD WHERE MUPPET AND HUMAN COEXIST!!! YOU ARE WATCHING A DOCUMENTARY!! FILMED!! IN REAL TIME!!!
February 8, 2026 at 6:22 AM
the magic of the Muppets is that there are two fourth walls. they constantly break the one that reminds the audience they are performers. they NEVER break the one that reminds the audience they are puppets. this dynamic is the key to their entire comedy style
Reposted by Michael Hoffman
you're doomscrolling I'm plumposting we are not the same
February 6, 2026 at 10:27 PM
you're doomscrolling I'm plumposting we are not the same
Reposted by Michael Hoffman
You've got to understand how cooked US local TV news is to understand in turn how insane it is that Vichy Twitter is 26 points Trumpier than that. Pravda doesn't cover it.
Trump job approval rating by news platform
π’ Twitter/X: +9
π΄ Facebook: -7
π΄ Cable TV: -10
π΄ Podcasts/YouTube: -14
π΄ Local TV: -17
π΄ Instagram: -21
π΄ Broadcast TV: -28
π΄ TikTok: -28
π΄ Newspapers/news sites: -33
π΄ Reddit: -40
www.theargumentmag.com/p/twitter-is...
π’ Twitter/X: +9
π΄ Facebook: -7
π΄ Cable TV: -10
π΄ Podcasts/YouTube: -14
π΄ Local TV: -17
π΄ Instagram: -21
π΄ Broadcast TV: -28
π΄ TikTok: -28
π΄ Newspapers/news sites: -33
π΄ Reddit: -40
www.theargumentmag.com/p/twitter-is...
February 6, 2026 at 1:54 PM
You've got to understand how cooked US local TV news is to understand in turn how insane it is that Vichy Twitter is 26 points Trumpier than that. Pravda doesn't cover it.
Reposted by Michael Hoffman
Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine.
faculty-einstein.icims.com/jobs/17847/a...
faculty-einstein.icims.com/jobs/17847/a...
Albert Einstein College of Medicine | Medical Education | Biomedical Research
faculty-einstein.icims.com
February 5, 2026 at 10:14 PM
Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine.
faculty-einstein.icims.com/jobs/17847/a...
faculty-einstein.icims.com/jobs/17847/a...
I'm still mad I won't be able to take my kid to the Ontario Science Centre on it.
February 4, 2026 at 7:02 PM
I'm still mad I won't be able to take my kid to the Ontario Science Centre on it.
If someone has a practice of ignoring all review comments I would like to know about it so I can avoid wasting the time reviewing their manuscript and writing comments.
February 3, 2026 at 7:54 PM
If someone has a practice of ignoring all review comments I would like to know about it so I can avoid wasting the time reviewing their manuscript and writing comments.
Reposted by Michael Hoffman
Sometimes you have to say it out loud to appreciate how dire t all is:
The president just openly declared his plans to steal the midterm elections β in an interview with the former number two person at the FBI.
The president just openly declared his plans to steal the midterm elections β in an interview with the former number two person at the FBI.
Trump: "These people were brought to our country to vote, & they vote illegally. The Republicans should say, we should take over the voting in at least 15 places. The Republicans ought to nationalize the voting. We have states that I won that show I didn't win. You're gonna see something in Georgia"
February 2, 2026 at 10:05 PM
Sometimes you have to say it out loud to appreciate how dire t all is:
The president just openly declared his plans to steal the midterm elections β in an interview with the former number two person at the FBI.
The president just openly declared his plans to steal the midterm elections β in an interview with the former number two person at the FBI.
Reposted by Michael Hoffman
Trump to Harvard: 2 billion $
NYT: Harvard to pay 2B$
Harvard: no
Trump: 1B
Harvard: no
NYT: Negotiations intensify
Trump: 200 million
NYT: Harvard-Trump reach deal
Harvard: no
Trump: 0$
Harvard: ok
NYT: Harvard not paying! Trump loses.
Trump: How about 1B$
Harvard: no
NYT: Negotiations resume!
NYT: Harvard to pay 2B$
Harvard: no
Trump: 1B
Harvard: no
NYT: Negotiations intensify
Trump: 200 million
NYT: Harvard-Trump reach deal
Harvard: no
Trump: 0$
Harvard: ok
NYT: Harvard not paying! Trump loses.
Trump: How about 1B$
Harvard: no
NYT: Negotiations resume!
February 3, 2026 at 2:21 PM
Trump to Harvard: 2 billion $
NYT: Harvard to pay 2B$
Harvard: no
Trump: 1B
Harvard: no
NYT: Negotiations intensify
Trump: 200 million
NYT: Harvard-Trump reach deal
Harvard: no
Trump: 0$
Harvard: ok
NYT: Harvard not paying! Trump loses.
Trump: How about 1B$
Harvard: no
NYT: Negotiations resume!
NYT: Harvard to pay 2B$
Harvard: no
Trump: 1B
Harvard: no
NYT: Negotiations intensify
Trump: 200 million
NYT: Harvard-Trump reach deal
Harvard: no
Trump: 0$
Harvard: ok
NYT: Harvard not paying! Trump loses.
Trump: How about 1B$
Harvard: no
NYT: Negotiations resume!
This isn't the Onion? Lol
February 2, 2026 at 10:59 PM
This isn't the Onion? Lol
The real luxury is living in a huge lot all by yourself in a place that could easily support multiple families.
February 2, 2026 at 8:24 PM
The real luxury is living in a huge lot all by yourself in a place that could easily support multiple families.
Mentioning things you're only aware of because of your participation in the peer review are out of bounds (e.g. stuff that was changed). But you don't have to hold your tongue on the publication as it's published just because you reviewed it earlier. You shouldn't even have to use different words.
February 2, 2026 at 8:21 PM
Mentioning things you're only aware of because of your participation in the peer review are out of bounds (e.g. stuff that was changed). But you don't have to hold your tongue on the publication as it's published just because you reviewed it earlier. You shouldn't even have to use different words.
Under ordinary circumstances, the peer review process should remain confidential. Nothing stops you from making the same exact comments on matters in a publicly available paper that were present in the draft manuscript.
February 2, 2026 at 8:20 PM
Under ordinary circumstances, the peer review process should remain confidential. Nothing stops you from making the same exact comments on matters in a publicly available paper that were present in the draft manuscript.
Unless they paid you, they don't own squat
February 2, 2026 at 7:39 PM
Unless they paid you, they don't own squat
Reposted by Michael Hoffman
"Maybe the city's full" says the man living in a 2.7 million dollar house on Palmerston, while sipping $170 scotch after defeating a multiplex proposal across the street.
www.pressreader.com/canada/toron...
www.pressreader.com/canada/toron...
February 2, 2026 at 5:59 PM
"Maybe the city's full" says the man living in a 2.7 million dollar house on Palmerston, while sipping $170 scotch after defeating a multiplex proposal across the street.
www.pressreader.com/canada/toron...
www.pressreader.com/canada/toron...
Reposted by Michael Hoffman
Impeachment is the only Constitutional check Congress has against a lawless president and talking about it would be a good start to reasserting Congressional power in the future. Assuming of course Congress wants to do that
Speaking out like this is all they can do now. Impeachment is a total and complete joke, and threatening to use it is akin to threatening to hit someone with a wet noodle. Impeachment is no longer a viable tool to use against Republican politicians.
February 2, 2026 at 2:37 PM
Impeachment is the only Constitutional check Congress has against a lawless president and talking about it would be a good start to reasserting Congressional power in the future. Assuming of course Congress wants to do that
How convenient
February 2, 2026 at 2:46 PM
How convenient
I think we got disconnected.
February 2, 2026 at 2:45 PM
I think we got disconnected.
Have been waiting for a while here. Starting to think Joanne won't get back to me.
February 2, 2026 at 2:02 PM
Have been waiting for a while here. Starting to think Joanne won't get back to me.
Here I am in front of a 2 meter pile of snow in the bike lane where my Bike Lane Winter Maintenance Required was "Completed"
February 2, 2026 at 2:01 PM
Here I am in front of a 2 meter pile of snow in the bike lane where my Bike Lane Winter Maintenance Required was "Completed"
I reported that to 311 on Friday morning. Yesterday afternoon they closed it as "completed". @cycletoronto.bsky.social
February 2, 2026 at 1:40 AM
I reported that to 311 on Friday morning. Yesterday afternoon they closed it as "completed". @cycletoronto.bsky.social
Reposted by Michael Hoffman
Chapeau to these early patio people in Toronto. Itβs minus six and snow is still deep on the ground
February 1, 2026 at 7:55 PM
Chapeau to these early patio people in Toronto. Itβs minus six and snow is still deep on the ground
I also think the major snow event declaration and snow route warning should be at the top of toronto.ca rather than one link later.
toronto.ca
February 1, 2026 at 7:08 PM
I also think the major snow event declaration and snow route warning should be at the top of toronto.ca rather than one link later.
It's ridiculous that they haven't done that yet, but I am so completely unsurprised.
February 1, 2026 at 7:06 PM
It's ridiculous that they haven't done that yet, but I am so completely unsurprised.