John Greally
@greally.bsky.social
Using genomic information to improve medicine
Pinned
John Greally
@greally.bsky.social
· Oct 10
Epigenetics: History, Molecules, and Diseases
Buy Epigenetics: History, Molecules, and Diseases on Amazon.com ✓ FREE SHIPPING on qualified orders
www.amazon.com
My book on Epigenetics: History, Molecules and Diseases
www.amazon.com/Epigenetics-...
#EpigeneticsBook #Epigenetics
www.amazon.com/Epigenetics-...
#EpigeneticsBook #Epigenetics
I finally got around to putting together a quick overview of what my book is all about.
youtu.be/xPt1xy4_i-o?...
#epigenetics #epigeneticsbook #epigenome
youtu.be/xPt1xy4_i-o?...
#epigenetics #epigeneticsbook #epigenome
Epigenetics: History, Molecules, and Diseases -- Book overview
YouTube video by John Greally
youtu.be
January 2, 2026 at 7:26 PM
I finally got around to putting together a quick overview of what my book is all about.
youtu.be/xPt1xy4_i-o?...
#epigenetics #epigeneticsbook #epigenome
youtu.be/xPt1xy4_i-o?...
#epigenetics #epigeneticsbook #epigenome
Reposted by John Greally
Ending 2025 w/ our new paper @natcomms.nature.com which shows that the immediate early gene Egr1 induces sex-dependent changes in ventral hippocampal (vHIP) structure and in anxiety- & depression-related behavior, via direct regulation of chromatin structure 🧵👇 1/
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Egr1 is a sex-dependent regulator of neuronal chromatin, structural plasticity, and behaviour - Nature Communications
Molecular drivers of sex-specific brain plasticity are unknown. Here, authors show estrogen-driven Egr1 controls chromatin accessibility sex-dependently, driving gene expression, structural plasticity...
www.nature.com
December 31, 2025 at 8:57 PM
Ending 2025 w/ our new paper @natcomms.nature.com which shows that the immediate early gene Egr1 induces sex-dependent changes in ventral hippocampal (vHIP) structure and in anxiety- & depression-related behavior, via direct regulation of chromatin structure 🧵👇 1/
www.nature.com/articles/s41...
www.nature.com/articles/s41...
In Galway this week. Shop Street and Quay Street looking festive.
Being home is good for the soul.
Being home is good for the soul.
December 18, 2025 at 8:29 PM
In Galway this week. Shop Street and Quay Street looking festive.
Being home is good for the soul.
Being home is good for the soul.
I couldn't resist using the very festive-looking cover art from my book as a holiday card (image attribution to follow).
December 18, 2025 at 3:01 PM
I couldn't resist using the very festive-looking cover art from my book as a holiday card (image attribution to follow).
Reposted by John Greally
Incredible piece on Oliver Sacks. If you were ever awed at his supposedly true stories (I remember being stunned by the account of the autistic twins who rattled off large prime numbers), read this. He told wonderful stories, but they were in large part fiction.
www.newyorker.com/magazine/202...
www.newyorker.com/magazine/202...
Oliver Sacks Put Himself Into His Case Studies. What Was the Cost?
The scientist was famous for linking healing with storytelling. Sometimes that meant reshaping patients’ reality.
www.newyorker.com
December 12, 2025 at 10:33 PM
Incredible piece on Oliver Sacks. If you were ever awed at his supposedly true stories (I remember being stunned by the account of the autistic twins who rattled off large prime numbers), read this. He told wonderful stories, but they were in large part fiction.
www.newyorker.com/magazine/202...
www.newyorker.com/magazine/202...
Make it stop
NEW: Five years of social media history is only a fraction of what the US Government will shortly demand of overseas visitors.
The full requirements will end tourism in the United States.
Below is the full, mind-blowing list.
🚨THEY. WANT. YOUR. DNA.🚨
1/
The full requirements will end tourism in the United States.
Below is the full, mind-blowing list.
🚨THEY. WANT. YOUR. DNA.🚨
1/
December 12, 2025 at 10:39 AM
Make it stop
Take a bad idea.
Add DNA methylation.
Price it for the wealthy.
Sell it to the gullible.
partners.lifedna.com/methylation-...
We can't offer basic health care in the US and yet this kind of nonsense is permitted for direct-to-consumer sales?
Something is rotten.
Add DNA methylation.
Price it for the wealthy.
Sell it to the gullible.
partners.lifedna.com/methylation-...
We can't offer basic health care in the US and yet this kind of nonsense is permitted for direct-to-consumer sales?
Something is rotten.
LifeDNA - Methylation Genes
partners.lifedna.com
December 11, 2025 at 1:44 PM
Take a bad idea.
Add DNA methylation.
Price it for the wealthy.
Sell it to the gullible.
partners.lifedna.com/methylation-...
We can't offer basic health care in the US and yet this kind of nonsense is permitted for direct-to-consumer sales?
Something is rotten.
Add DNA methylation.
Price it for the wealthy.
Sell it to the gullible.
partners.lifedna.com/methylation-...
We can't offer basic health care in the US and yet this kind of nonsense is permitted for direct-to-consumer sales?
Something is rotten.
Reposted by John Greally
📢 SIGN & SHARE THE PETITION! 📢
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
Sign the Petition
Support a New York State Biomedical Institute for a Healthier, More Affordable Future
c.org
November 24, 2025 at 3:53 PM
📢 SIGN & SHARE THE PETITION! 📢
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
If you want to read something completely nuts from the unregulated world of direct to consumer genomics, look no further.
And when I say completely nuts, I’m being restrained and polite. Criminal is another word that springs to mind.
And when I say completely nuts, I’m being restrained and polite. Criminal is another word that springs to mind.
"Concerns about the legitimacy and integrity of Nucleus Genomics", by X account @sichuan_mala
totalhealthoptimization.com/2025/11/21/c...
totalhealthoptimization.com/2025/11/21/c...
Concerns about the legitimacy and integrity of Nucleus Genomics – Total Health Optimization
totalhealthoptimization.com
November 25, 2025 at 2:13 AM
If you want to read something completely nuts from the unregulated world of direct to consumer genomics, look no further.
And when I say completely nuts, I’m being restrained and polite. Criminal is another word that springs to mind.
And when I say completely nuts, I’m being restrained and polite. Criminal is another word that springs to mind.
Reposted by John Greally
Hey Bluesky arts/music folks in Ireland! At New Music Dublin we are looking to fill a new role: part-time general manager, working closely with our festival director and producer (& board). Role to commence in Jan. Detailed info here: www.newmusicdublin.ie/job-opportun... #SpeirGorm
Job Opportunities | Ireland’s foremost contemporary music festival
New Music Dublin takes place in Spring each year within the National Concert Hall and other venues throughout Dublin.
www.newmusicdublin.ie
November 21, 2025 at 11:59 AM
Hey Bluesky arts/music folks in Ireland! At New Music Dublin we are looking to fill a new role: part-time general manager, working closely with our festival director and producer (& board). Role to commence in Jan. Detailed info here: www.newmusicdublin.ie/job-opportun... #SpeirGorm
This garbage is what we’re up against.
I have seen multiple families who have received ‘stem cell therapy’ for their child with autism and intellectual disability. Not well-off families, probably spending 5-figure sums.
These bottom-feeding influencer scum are preying on the desperate.
I have seen multiple families who have received ‘stem cell therapy’ for their child with autism and intellectual disability. Not well-off families, probably spending 5-figure sums.
These bottom-feeding influencer scum are preying on the desperate.
How stem cell treatments, without evidence of benefit but with risk of harm, are promoted at YouTube by celebrities and influencers
cell.com/stem-cell-re...
cell.com/stem-cell-re...
Stem cells in your YouTube feed: The complex landscape and unexpected mediators of online information
In this article, Grundtvig and Munsie provide a large-scale analysis, identifying
4,481 stem cell-related videos on YouTube across 1,734 channels and attracting 134
million views. The article explores...
cell.com
November 20, 2025 at 5:34 PM
This garbage is what we’re up against.
I have seen multiple families who have received ‘stem cell therapy’ for their child with autism and intellectual disability. Not well-off families, probably spending 5-figure sums.
These bottom-feeding influencer scum are preying on the desperate.
I have seen multiple families who have received ‘stem cell therapy’ for their child with autism and intellectual disability. Not well-off families, probably spending 5-figure sums.
These bottom-feeding influencer scum are preying on the desperate.
These kinds of publications may be the most valuable today.
Their impact in terms of guiding sensible grant funding investments, manuscript evaluations, and science communications.
Nice work @wiringthebrain.bsky.social and colleagues.
Their impact in terms of guiding sensible grant funding investments, manuscript evaluations, and science communications.
Nice work @wiringthebrain.bsky.social and colleagues.
New paper with @statsepi.bsky.social and @deevybee.bsky.social in which we show there's really no evidence for a link between the gut microbiome and autism www.cell.com/neuron/fullt...
Conceptual and methodological flaws undermine claims of a link between the gut microbiome and autism
Claims that the gut microbiome causally contributes to autism regularly appear in
the scientific literature and popular press. Mitchell et al. critically examine influential
studies underpinning these...
www.cell.com
November 14, 2025 at 4:55 PM
These kinds of publications may be the most valuable today.
Their impact in terms of guiding sensible grant funding investments, manuscript evaluations, and science communications.
Nice work @wiringthebrain.bsky.social and colleagues.
Their impact in terms of guiding sensible grant funding investments, manuscript evaluations, and science communications.
Nice work @wiringthebrain.bsky.social and colleagues.
Interesting, from @garvaninstitute.bsky.social.
"We identify putative common regulatory variants for 83% of all 21,404 genes tested and cumulative rare variant signals for 47% of genes...about half of the effects are observed only in one or a few cell types"
www.medrxiv.org/content/10.1...
"We identify putative common regulatory variants for 83% of all 21,404 genes tested and cumulative rare variant signals for 47% of genes...about half of the effects are observed only in one or a few cell types"
www.medrxiv.org/content/10.1...
Impact of Rare and Common Genetic Variation on Cell Type-Specific Gene Expression
Understanding the genetic basis of gene expression can shed light on the regulatory mechanisms underlying complex traits and diseases. Single cell-resolved measures of RNA levels and single-cell expre...
www.medrxiv.org
November 12, 2025 at 3:15 PM
Interesting, from @garvaninstitute.bsky.social.
"We identify putative common regulatory variants for 83% of all 21,404 genes tested and cumulative rare variant signals for 47% of genes...about half of the effects are observed only in one or a few cell types"
www.medrxiv.org/content/10.1...
"We identify putative common regulatory variants for 83% of all 21,404 genes tested and cumulative rare variant signals for 47% of genes...about half of the effects are observed only in one or a few cell types"
www.medrxiv.org/content/10.1...
Irish culture. No apologies.
I am calling upon the people of Ireland to immediately begin construction of a thread on this site about how you or someone you know was roasted for a fashion choice. We need it.
All roasts must have come from Irish people *only*. Please respect this important rule, it makes a difference.
Tanks
All roasts must have come from Irish people *only*. Please respect this important rule, it makes a difference.
Tanks
November 12, 2025 at 2:37 PM
Irish culture. No apologies.
When I read the history of Waddington, I realized that, in using the epigenetic landscape model, this geology dropout student may have been trolling the field of biology!
www.amazon.com/Epigenetics-...
www.amazon.com/Epigenetics-...
November 10, 2025 at 1:18 PM
When I read the history of Waddington, I realized that, in using the epigenetic landscape model, this geology dropout student may have been trolling the field of biology!
www.amazon.com/Epigenetics-...
www.amazon.com/Epigenetics-...
Relatable
November 9, 2025 at 6:49 PM
Relatable
Reposted by John Greally
On the event of James Watson's death, I highly recommend this 2023 commentary from @matthewcobb.bsky.social and Nathaniel Comfort with crucial new insights into the discovery of the double helix. (And also check out Cobb's brand new biography of Francis Crick) www.nature.com/articles/d41...
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
www.nature.com
November 7, 2025 at 9:25 PM
On the event of James Watson's death, I highly recommend this 2023 commentary from @matthewcobb.bsky.social and Nathaniel Comfort with crucial new insights into the discovery of the double helix. (And also check out Cobb's brand new biography of Francis Crick) www.nature.com/articles/d41...
He made a massive impact. Respect.
November 7, 2025 at 8:59 PM
He made a massive impact. Respect.
Hot take — could this be a possible clue as to why @zohrankmamdani.bsky.social did so well in the #NYC election yesterday?
November 7, 2025 at 12:09 AM
Hot take — could this be a possible clue as to why @zohrankmamdani.bsky.social did so well in the #NYC election yesterday?
Reposted by John Greally
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 2:49 PM
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
Reposted by John Greally
📣 I am hiring a postdoc! aial.ie/hiring/postd...
applications from suitable candidates that are passionate about investigating the use of genAI in public service operations with the aim of keeping governments transparent and accountable are welcome
pls share with your networks
applications from suitable candidates that are passionate about investigating the use of genAI in public service operations with the aim of keeping governments transparent and accountable are welcome
pls share with your networks
October 30, 2025 at 7:51 PM
📣 I am hiring a postdoc! aial.ie/hiring/postd...
applications from suitable candidates that are passionate about investigating the use of genAI in public service operations with the aim of keeping governments transparent and accountable are welcome
pls share with your networks
applications from suitable candidates that are passionate about investigating the use of genAI in public service operations with the aim of keeping governments transparent and accountable are welcome
pls share with your networks
‘Exododus’ is an exodus of dodos. Not going to happen for many reasons.
Happy Election Day, New Yorkers
Happy Election Day, New Yorkers
Imagine how much nicer New York would be if it contained a million fewer racists.
November 4, 2025 at 11:01 AM
‘Exododus’ is an exodus of dodos. Not going to happen for many reasons.
Happy Election Day, New Yorkers
Happy Election Day, New Yorkers
Really concerned for Jamaica, this looks like a really horrible situation, only a year after the Southwest of the island took the brunt of another damaging hurricane
www.nytimes.com/live/2025/10...
www.nytimes.com/live/2025/10...
Hurricane Melissa Nears Jamaica as ‘Catastrophic’ Storm
www.nytimes.com
October 27, 2025 at 3:05 PM
Really concerned for Jamaica, this looks like a really horrible situation, only a year after the Southwest of the island took the brunt of another damaging hurricane
www.nytimes.com/live/2025/10...
www.nytimes.com/live/2025/10...