John Greally
@greally.bsky.social
Using genomic information to improve medicine
Pinned
John Greally
@greally.bsky.social
· Oct 10
Epigenetics: History, Molecules, and Diseases
Buy Epigenetics: History, Molecules, and Diseases on Amazon.com ✓ FREE SHIPPING on qualified orders
www.amazon.com
My book on Epigenetics: History, Molecules and Diseases
www.amazon.com/Epigenetics-...
#EpigeneticsBook #Epigenetics
www.amazon.com/Epigenetics-...
#EpigeneticsBook #Epigenetics
When I read the history of Waddington, I realized that, in using the epigenetic landscape model, this geology dropout student may have been trolling the field of biology!
www.amazon.com/Epigenetics-...
www.amazon.com/Epigenetics-...
November 10, 2025 at 1:18 PM
When I read the history of Waddington, I realized that, in using the epigenetic landscape model, this geology dropout student may have been trolling the field of biology!
www.amazon.com/Epigenetics-...
www.amazon.com/Epigenetics-...
Relatable
November 9, 2025 at 6:49 PM
Relatable
Reposted by John Greally
On the event of James Watson's death, I highly recommend this 2023 commentary from @matthewcobb.bsky.social and Nathaniel Comfort with crucial new insights into the discovery of the double helix. (And also check out Cobb's brand new biography of Francis Crick) www.nature.com/articles/d41...
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
www.nature.com
November 7, 2025 at 9:25 PM
On the event of James Watson's death, I highly recommend this 2023 commentary from @matthewcobb.bsky.social and Nathaniel Comfort with crucial new insights into the discovery of the double helix. (And also check out Cobb's brand new biography of Francis Crick) www.nature.com/articles/d41...
He made a massive impact. Respect.
November 7, 2025 at 8:59 PM
He made a massive impact. Respect.
Hot take — could this be a possible clue as to why @zohrankmamdani.bsky.social did so well in the #NYC election yesterday?
November 7, 2025 at 12:09 AM
Hot take — could this be a possible clue as to why @zohrankmamdani.bsky.social did so well in the #NYC election yesterday?
Reposted by John Greally
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 2:49 PM
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
Reposted by John Greally
📣 I am hiring a postdoc! aial.ie/hiring/postd...
applications from suitable candidates that are passionate about investigating the use of genAI in public service operations with the aim of keeping governments transparent and accountable are welcome
pls share with your networks
applications from suitable candidates that are passionate about investigating the use of genAI in public service operations with the aim of keeping governments transparent and accountable are welcome
pls share with your networks
October 30, 2025 at 7:51 PM
📣 I am hiring a postdoc! aial.ie/hiring/postd...
applications from suitable candidates that are passionate about investigating the use of genAI in public service operations with the aim of keeping governments transparent and accountable are welcome
pls share with your networks
applications from suitable candidates that are passionate about investigating the use of genAI in public service operations with the aim of keeping governments transparent and accountable are welcome
pls share with your networks
‘Exododus’ is an exodus of dodos. Not going to happen for many reasons.
Happy Election Day, New Yorkers
Happy Election Day, New Yorkers
Imagine how much nicer New York would be if it contained a million fewer racists.
November 4, 2025 at 11:01 AM
‘Exododus’ is an exodus of dodos. Not going to happen for many reasons.
Happy Election Day, New Yorkers
Happy Election Day, New Yorkers
Really concerned for Jamaica, this looks like a really horrible situation, only a year after the Southwest of the island took the brunt of another damaging hurricane
www.nytimes.com/live/2025/10...
www.nytimes.com/live/2025/10...
Hurricane Melissa Nears Jamaica as ‘Catastrophic’ Storm
www.nytimes.com
October 27, 2025 at 3:05 PM
Really concerned for Jamaica, this looks like a really horrible situation, only a year after the Southwest of the island took the brunt of another damaging hurricane
www.nytimes.com/live/2025/10...
www.nytimes.com/live/2025/10...
The figures from this book are all freely available through
@figshare.com, hopefully helpful for presentations and teaching:
figshare.com/projects/Epi...
Please let me know if you find any inaccuracies and I'll fix them. I've already updated one of the figures.
#EpigeneticsBook
@figshare.com, hopefully helpful for presentations and teaching:
figshare.com/projects/Epi...
Please let me know if you find any inaccuracies and I'll fix them. I've already updated one of the figures.
#EpigeneticsBook
October 24, 2025 at 3:09 PM
The figures from this book are all freely available through
@figshare.com, hopefully helpful for presentations and teaching:
figshare.com/projects/Epi...
Please let me know if you find any inaccuracies and I'll fix them. I've already updated one of the figures.
#EpigeneticsBook
@figshare.com, hopefully helpful for presentations and teaching:
figshare.com/projects/Epi...
Please let me know if you find any inaccuracies and I'll fix them. I've already updated one of the figures.
#EpigeneticsBook
Amazing job opportunity at the @institutimagine.bsky.social, Head of the Genomics Platform.
I am adding an English translation of the opportunity, but fluency in French is a (reasonable) requirement for the position. Application link below.
www.welcometothejungle.com/fr/companies...
I am adding an English translation of the opportunity, but fluency in French is a (reasonable) requirement for the position. Application link below.
www.welcometothejungle.com/fr/companies...
October 23, 2025 at 7:14 PM
Amazing job opportunity at the @institutimagine.bsky.social, Head of the Genomics Platform.
I am adding an English translation of the opportunity, but fluency in French is a (reasonable) requirement for the position. Application link below.
www.welcometothejungle.com/fr/companies...
I am adding an English translation of the opportunity, but fluency in French is a (reasonable) requirement for the position. Application link below.
www.welcometothejungle.com/fr/companies...
It's publication day, and Cold Spring Harbor Laboratory Press is running a promotion bundling the hard cover and e-book, and other offers:
cshlpress.com/default.tpl?...
#EpigeneticsBook
cshlpress.com/default.tpl?...
#EpigeneticsBook
October 21, 2025 at 3:18 PM
It's publication day, and Cold Spring Harbor Laboratory Press is running a promotion bundling the hard cover and e-book, and other offers:
cshlpress.com/default.tpl?...
#EpigeneticsBook
cshlpress.com/default.tpl?...
#EpigeneticsBook
Watching @wiringthebrain.bsky.social and @aylwyn-scally.bsky.social go at it in this thread, staying polite and respectful but challenging each other, gives me the old #ScienceYwitter vibes.
Good on you lads.
Good on you lads.
Great review on The Genetics of Human Handedness: Microtubules and Beyond www.cell.com/trends/genet... - handedness is such an interesting phenotype!
Genetics of human handedness: microtubules and beyond
Handedness (i.e., the preference to use either the left or the right hand for fine
motor tasks) is a widely investigated trait. Handedness heritability is consistently
estimated to be 25%. After decad...
www.cell.com
October 18, 2025 at 1:04 PM
Watching @wiringthebrain.bsky.social and @aylwyn-scally.bsky.social go at it in this thread, staying polite and respectful but challenging each other, gives me the old #ScienceYwitter vibes.
Good on you lads.
Good on you lads.
October 16, 2025 at 9:09 AM
Reposted by John Greally
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
qedscience.com
October 15, 2025 at 12:22 PM
Apparently Maynard has never done this with a book before, according to his owner.
I feel honoured.
#EpigeneticsBook
@cshlpress.bsky.social
I feel honoured.
#EpigeneticsBook
@cshlpress.bsky.social
October 13, 2025 at 7:22 PM
Apparently Maynard has never done this with a book before, according to his owner.
I feel honoured.
#EpigeneticsBook
@cshlpress.bsky.social
I feel honoured.
#EpigeneticsBook
@cshlpress.bsky.social
Looks like @leandrosboukas.bsky.social has been busy doing useful stuff. DNV detection in duos, very valuable in communities in which families are less stable.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Identification of de novo variants from parent-proband duos via long-read sequencing
While de novo variants cause many Mendelian disorders, their detection currently requires sequencing of the proband and both biological parents. This is not feasible when only one parent is available,...
www.medrxiv.org
October 11, 2025 at 12:26 PM
Looks like @leandrosboukas.bsky.social has been busy doing useful stuff. DNV detection in duos, very valuable in communities in which families are less stable.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
My book on Epigenetics: History, Molecules and Diseases
www.amazon.com/Epigenetics-...
#EpigeneticsBook #Epigenetics
www.amazon.com/Epigenetics-...
#EpigeneticsBook #Epigenetics
Epigenetics: History, Molecules, and Diseases
Buy Epigenetics: History, Molecules, and Diseases on Amazon.com ✓ FREE SHIPPING on qualified orders
www.amazon.com
October 10, 2025 at 7:04 PM
My book on Epigenetics: History, Molecules and Diseases
www.amazon.com/Epigenetics-...
#EpigeneticsBook #Epigenetics
www.amazon.com/Epigenetics-...
#EpigeneticsBook #Epigenetics
What an amazing assay.
DAF-seq, the evolution of Fiber-seq from the Andrew Stergachis group, using the @pacbio.bsky.social platform:
www.biorxiv.org/content/10.1...
This will revolutionise our understanding of transcriptional regulation and functional non-coding variants.
DAF-seq, the evolution of Fiber-seq from the Andrew Stergachis group, using the @pacbio.bsky.social platform:
www.biorxiv.org/content/10.1...
This will revolutionise our understanding of transcriptional regulation and functional non-coding variants.
Deaminase-assisted single-molecule and single-cell chromatin fiber sequencing
Gene regulation is mediated by the co-occupancy of numerous proteins along individual chromatin fibers. However, our tools for deeply profiling how proteins co-occupy individual fibers, especially at ...
www.biorxiv.org
October 4, 2025 at 12:06 PM
What an amazing assay.
DAF-seq, the evolution of Fiber-seq from the Andrew Stergachis group, using the @pacbio.bsky.social platform:
www.biorxiv.org/content/10.1...
This will revolutionise our understanding of transcriptional regulation and functional non-coding variants.
DAF-seq, the evolution of Fiber-seq from the Andrew Stergachis group, using the @pacbio.bsky.social platform:
www.biorxiv.org/content/10.1...
This will revolutionise our understanding of transcriptional regulation and functional non-coding variants.
Reposted by John Greally
Decades of research have proven that acetaminophen is safe for children when taken correctly and under the guidance of a child’s pediatrician. Learn more.
www.aap.org/en/news-room...
www.aap.org/en/news-room...
September 26, 2025 at 9:02 PM
Decades of research have proven that acetaminophen is safe for children when taken correctly and under the guidance of a child’s pediatrician. Learn more.
www.aap.org/en/news-room...
www.aap.org/en/news-room...
Seven years.
Over 400 pages.
About 750 references.
Over 40 figures.
Finally I get to hold the finished book.
It’s a big day.
#EpigeneticsBook
@cshlpress.bsky.social
Over 400 pages.
About 750 references.
Over 40 figures.
Finally I get to hold the finished book.
It’s a big day.
#EpigeneticsBook
@cshlpress.bsky.social
September 25, 2025 at 5:23 PM
Seven years.
Over 400 pages.
About 750 references.
Over 40 figures.
Finally I get to hold the finished book.
It’s a big day.
#EpigeneticsBook
@cshlpress.bsky.social
Over 400 pages.
About 750 references.
Over 40 figures.
Finally I get to hold the finished book.
It’s a big day.
#EpigeneticsBook
@cshlpress.bsky.social
Public service announcement 1:
jamanetwork.com/journals/jam...?
jamanetwork.com/journals/jam...?
Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability
This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children’s risk of autism, ADHD, and intellectual disability.
jamanetwork.com
September 24, 2025 at 12:20 AM
Public service announcement 1:
jamanetwork.com/journals/jam...?
jamanetwork.com/journals/jam...?