Quaid Morris
@quaidmorris.bsky.social
Computational biology, machine learning, AI, RNA, cancer genomics. My views are my own. https://www.morrislab.ai
He/him/his
He/him/his
Reposted by Quaid Morris
Great collaboration with @gingraslab.bsky.social
& congrats to lead author Vesal.
Paper: www.nature.com/articles/s41...
Thanks to @sinaihealth.bsky.social
& congrats to lead author Vesal.
Paper: www.nature.com/articles/s41...
Thanks to @sinaihealth.bsky.social
October 23, 2025 at 1:40 PM
Great collaboration with @gingraslab.bsky.social
& congrats to lead author Vesal.
Paper: www.nature.com/articles/s41...
Thanks to @sinaihealth.bsky.social
& congrats to lead author Vesal.
Paper: www.nature.com/articles/s41...
Thanks to @sinaihealth.bsky.social
Reposted by Quaid Morris
new Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4
rdcu.be/eOc0q
rdcu.be/eOc0q
Human DICER1 hotspot mutation induces both loss and gain of miRNA function
Nature Structural & Molecular Biology - Jee et al. study a cancer hotspot allele of DICER1 that disrupts RNaseIIIb activity. Beyond ablating 5p hairpin cleavage, 3p passenger strands are...
rdcu.be
November 10, 2025 at 4:43 PM
new Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4
rdcu.be/eOc0q
rdcu.be/eOc0q
Reposted by Quaid Morris
Good morning to all the puppies not observing the time change
November 2, 2025 at 11:30 AM
Good morning to all the puppies not observing the time change
Reposted by Quaid Morris
Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...
SCIENTIST – Developmental, Stem Cell & Cancer Biology Program - Toronto (City), Ontario (CA) job with The Hospital for Sick Children - Developmental & Stem Cell Biology Program | 12848200
Discovery-based and/or translational research using model organism genetics and/or stem cell and organoid platforms to study paediatric cancer.
www.nature.com
October 28, 2025 at 10:06 PM
Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...
Reposted by Quaid Morris
My institution---the Sloan Kettering Institute, the basic science arm of the Memorial Sloan Kettering Cancer Center---is hiring new faculty this cycle! Applications close Nov 15.
www.mskcc.org/research/ski...
www.mskcc.org/research/ski...
Faculty Positions
The Sloan Kettering Institute is seeking innovative scientists to join our faculty.
www.mskcc.org
October 27, 2025 at 2:45 PM
My institution---the Sloan Kettering Institute, the basic science arm of the Memorial Sloan Kettering Cancer Center---is hiring new faculty this cycle! Applications close Nov 15.
www.mskcc.org/research/ski...
www.mskcc.org/research/ski...
Reposted by Quaid Morris
The most important paper in evolutionary biology I'd never heard of:
1/
www.sciencedirect.com/science/arti...
1/
www.sciencedirect.com/science/arti...
October 6, 2025 at 2:00 PM
The most important paper in evolutionary biology I'd never heard of:
1/
www.sciencedirect.com/science/arti...
1/
www.sciencedirect.com/science/arti...
Reposted by Quaid Morris
Finalized my 2025 book tour!
Coming through New York, DC, Chicago, Toronto, San Francisco, Los Angeles, London, Oxford and Cambridge. Click here for details:
timwu.net#booktour
Coming through New York, DC, Chicago, Toronto, San Francisco, Los Angeles, London, Oxford and Cambridge. Click here for details:
timwu.net#booktour
October 3, 2025 at 2:39 PM
Finalized my 2025 book tour!
Coming through New York, DC, Chicago, Toronto, San Francisco, Los Angeles, London, Oxford and Cambridge. Click here for details:
timwu.net#booktour
Coming through New York, DC, Chicago, Toronto, San Francisco, Los Angeles, London, Oxford and Cambridge. Click here for details:
timwu.net#booktour
Reposted by Quaid Morris
I'm very pleased to announce the official publication of our lab's paper "DNA mutagenesis driven by transcription factor competition with mismatch repair" in today's issue of Cell! www.cell.com/cell/abstrac...
DNA mutagenesis driven by transcription factor competition with mismatch repair
Competition between transcription factors and mismatch repair machinery drives localized
hypermutation at regulatory elements, with implications for cancer and genome evolution.
www.cell.com
October 2, 2025 at 11:37 PM
I'm very pleased to announce the official publication of our lab's paper "DNA mutagenesis driven by transcription factor competition with mismatch repair" in today's issue of Cell! www.cell.com/cell/abstrac...
Reposted by Quaid Morris
Staff members at the NIH seem to have done the impossible: spend the agency's $48 billion budget.
“Everyone has been rallying together to clean up the mess, but it’s a mess that did not need to be made,” an NIH program officer told me.
www.nature.com/articles/d41...
“Everyone has been rallying together to clean up the mess, but it’s a mess that did not need to be made,” an NIH program officer told me.
www.nature.com/articles/d41...
NIH races to spend its 2025 grant money — but fewer projects win funding
Despite political obstacles, officials are on track to disburse all of the research funds allocated to US biomedical behemoth.
www.nature.com
September 30, 2025 at 3:32 PM
Staff members at the NIH seem to have done the impossible: spend the agency's $48 billion budget.
“Everyone has been rallying together to clean up the mess, but it’s a mess that did not need to be made,” an NIH program officer told me.
www.nature.com/articles/d41...
“Everyone has been rallying together to clean up the mess, but it’s a mess that did not need to be made,” an NIH program officer told me.
www.nature.com/articles/d41...
Reposted by Quaid Morris
www.biorxiv.org/content/10.1...
Delighted to share the story of two germline RBPs - one with little (DND1) and one with no (NANOS3) intrinsic sequence-specificity - that together build a continuous RNA binding surface recognizing a 7-mer (AUGAAUU) in target mRNA 3’UTRs, leading to deadenylation.
Delighted to share the story of two germline RBPs - one with little (DND1) and one with no (NANOS3) intrinsic sequence-specificity - that together build a continuous RNA binding surface recognizing a 7-mer (AUGAAUU) in target mRNA 3’UTRs, leading to deadenylation.
The DND1-NANOS3 complex shapes the primordial germ cell transcriptome via a heptanucleotide sequence in mRNA 3'UTRs
The RNA-binding proteins DND1 and NANOS3 are essential for primordial germ cell survival. Their co-immunoprecipitation and overlapping loss-of-function phenotypes suggest joint function, yet how they ...
www.biorxiv.org
September 27, 2025 at 3:39 PM
www.biorxiv.org/content/10.1...
Delighted to share the story of two germline RBPs - one with little (DND1) and one with no (NANOS3) intrinsic sequence-specificity - that together build a continuous RNA binding surface recognizing a 7-mer (AUGAAUU) in target mRNA 3’UTRs, leading to deadenylation.
Delighted to share the story of two germline RBPs - one with little (DND1) and one with no (NANOS3) intrinsic sequence-specificity - that together build a continuous RNA binding surface recognizing a 7-mer (AUGAAUU) in target mRNA 3’UTRs, leading to deadenylation.
Reposted by Quaid Morris
This is a fascinating paper that particular types of RNA binding proteins with IDRs that target nuclear speckles also can recruit their own RNAs to nuclear speckles as a negative feedback mechanism for condensation the authors call "interstasis" www.nature.com/articles/s41...
Collective homeostasis of condensation-prone proteins via their mRNAs - Nature
The authors discover a homeostatic process termed interstasis, in which an increased concentration of proteins within RNA–protein condensates induces the sequestration of their own mRNAs.
www.nature.com
September 25, 2025 at 8:24 PM
This is a fascinating paper that particular types of RNA binding proteins with IDRs that target nuclear speckles also can recruit their own RNAs to nuclear speckles as a negative feedback mechanism for condensation the authors call "interstasis" www.nature.com/articles/s41...
Reposted by Quaid Morris
Hi @npr.org! We worked late tonight putting together this handy pocket guide!
It doesn't address road design issues, but if we're going to educate road users, we should include drivers.
It's the size of a folded business card. Print it, fold it, put it in your wallet!
It doesn't address road design issues, but if we're going to educate road users, we should include drivers.
It's the size of a folded business card. Print it, fold it, put it in your wallet!
September 26, 2025 at 5:21 AM
Hi @npr.org! We worked late tonight putting together this handy pocket guide!
It doesn't address road design issues, but if we're going to educate road users, we should include drivers.
It's the size of a folded business card. Print it, fold it, put it in your wallet!
It doesn't address road design issues, but if we're going to educate road users, we should include drivers.
It's the size of a folded business card. Print it, fold it, put it in your wallet!
Reposted by Quaid Morris
hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!
September 15, 2025 at 5:26 PM
hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!
Reposted by Quaid Morris
A huge shoutout to all the dedicated grants management specialists at the NIH who are working around the clock to push grants out before the Sep 30 deadline. And also to the POs responding to frantic emails.
Not an easy job under the best of circumstances and right now it's the pits.
Thank you!
Not an easy job under the best of circumstances and right now it's the pits.
Thank you!
September 15, 2025 at 8:17 PM
A huge shoutout to all the dedicated grants management specialists at the NIH who are working around the clock to push grants out before the Sep 30 deadline. And also to the POs responding to frantic emails.
Not an easy job under the best of circumstances and right now it's the pits.
Thank you!
Not an easy job under the best of circumstances and right now it's the pits.
Thank you!
Reposted by Quaid Morris
YouTube link for MLCB2025 is up! Starting in 30 min. www.youtube.com/live/19I7xTh...
Machine Learning in Computational Biology 2025
YouTube video by Machine Learning in Computational Biology
www.youtube.com
September 10, 2025 at 1:01 PM
YouTube link for MLCB2025 is up! Starting in 30 min. www.youtube.com/live/19I7xTh...
Reposted by Quaid Morris
2025 Machine Learning in Computational Biology (#MLCB) meeting starts TODAY (9/10) at 9:30a (EST) at the NY Genome Center in NYC!
We have a great lineup of keynotes, contributed talks, and posters today and tomorrow
Schedule: mlcb.org/schedule
Join for free via livestream: m.youtube.com/@mlcbconf
We have a great lineup of keynotes, contributed talks, and posters today and tomorrow
Schedule: mlcb.org/schedule
Join for free via livestream: m.youtube.com/@mlcbconf
MLCB - Schedule
The in-person component will be held at the New York Genome Center, 101 6th Ave, New York, NY 10013. All times below are Eastern Time.
mlcb.org
September 10, 2025 at 11:42 AM
2025 Machine Learning in Computational Biology (#MLCB) meeting starts TODAY (9/10) at 9:30a (EST) at the NY Genome Center in NYC!
We have a great lineup of keynotes, contributed talks, and posters today and tomorrow
Schedule: mlcb.org/schedule
Join for free via livestream: m.youtube.com/@mlcbconf
We have a great lineup of keynotes, contributed talks, and posters today and tomorrow
Schedule: mlcb.org/schedule
Join for free via livestream: m.youtube.com/@mlcbconf
FYI, if your code is written in MATLAB, your 2025 manuscript will not be read by me
September 3, 2025 at 6:24 PM
FYI, if your code is written in MATLAB, your 2025 manuscript will not be read by me
Reposted by Quaid Morris
If you like transcription regulation and its mechanisms, this WIP list is for you.
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB
August 28, 2025 at 12:48 PM
If you like transcription regulation and its mechanisms, this WIP list is for you.
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB
Reposted by Quaid Morris
RNA is far more than a messenger.
Its structures regulate, evolve, and catalyze — carrying out functions DNA alone cannot.
But predicting #RNA structure from sequence is still extremely difficult.
In our recently published paper in @narjournal.bsky.social we present a way forward.
🧵 ⤵️
Its structures regulate, evolve, and catalyze — carrying out functions DNA alone cannot.
But predicting #RNA structure from sequence is still extremely difficult.
In our recently published paper in @narjournal.bsky.social we present a way forward.
🧵 ⤵️
August 25, 2025 at 3:02 AM
RNA is far more than a messenger.
Its structures regulate, evolve, and catalyze — carrying out functions DNA alone cannot.
But predicting #RNA structure from sequence is still extremely difficult.
In our recently published paper in @narjournal.bsky.social we present a way forward.
🧵 ⤵️
Its structures regulate, evolve, and catalyze — carrying out functions DNA alone cannot.
But predicting #RNA structure from sequence is still extremely difficult.
In our recently published paper in @narjournal.bsky.social we present a way forward.
🧵 ⤵️
Reposted by Quaid Morris
Thrilled to see my postdoctoral work published in @cellpress.bsky.social
OncoGAN generates simulated genomes to train genomic analysis tools —without the confidentiality risks of real genomes.
News story: t.co/J9QJZInPOE
Paper: t.co/ygEjM5vuGZ
#Genomics #Cancer #AI #Bioinformatics
OncoGAN generates simulated genomes to train genomic analysis tools —without the confidentiality risks of real genomes.
News story: t.co/J9QJZInPOE
Paper: t.co/ygEjM5vuGZ
#Genomics #Cancer #AI #Bioinformatics
https://www.cell.com/cell-genomics/fulltext/S2666-979X(25)00225-3
t.co
August 21, 2025 at 7:53 PM
Thrilled to see my postdoctoral work published in @cellpress.bsky.social
OncoGAN generates simulated genomes to train genomic analysis tools —without the confidentiality risks of real genomes.
News story: t.co/J9QJZInPOE
Paper: t.co/ygEjM5vuGZ
#Genomics #Cancer #AI #Bioinformatics
OncoGAN generates simulated genomes to train genomic analysis tools —without the confidentiality risks of real genomes.
News story: t.co/J9QJZInPOE
Paper: t.co/ygEjM5vuGZ
#Genomics #Cancer #AI #Bioinformatics
Reposted by Quaid Morris
Interested in #RNA research in the Asia-Pacific region? Join us at the first Asia RNA Club Symposium 2025!
🗓️ Nov 3-5, 2025
📍Seoul National University, Seoul, 🇰🇷
Submit your abstract by Aug 22nd
Register by Oct 10th
More info: asiarnaclub.org
#AsiaRNA2025 #RNASky @rnasociety.bsky.social
🔄🙏🏽
🗓️ Nov 3-5, 2025
📍Seoul National University, Seoul, 🇰🇷
Submit your abstract by Aug 22nd
Register by Oct 10th
More info: asiarnaclub.org
#AsiaRNA2025 #RNASky @rnasociety.bsky.social
🔄🙏🏽
August 16, 2025 at 12:25 AM
Interested in #RNA research in the Asia-Pacific region? Join us at the first Asia RNA Club Symposium 2025!
🗓️ Nov 3-5, 2025
📍Seoul National University, Seoul, 🇰🇷
Submit your abstract by Aug 22nd
Register by Oct 10th
More info: asiarnaclub.org
#AsiaRNA2025 #RNASky @rnasociety.bsky.social
🔄🙏🏽
🗓️ Nov 3-5, 2025
📍Seoul National University, Seoul, 🇰🇷
Submit your abstract by Aug 22nd
Register by Oct 10th
More info: asiarnaclub.org
#AsiaRNA2025 #RNASky @rnasociety.bsky.social
🔄🙏🏽
Reposted by Quaid Morris
To all post-docs: The Genome Biology dept @embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Group Leader - Genome Biology Unit
Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...
embl.wd103.myworkdayjobs.com
July 30, 2025 at 1:41 PM
To all post-docs: The Genome Biology dept @embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by Quaid Morris
Meet Jernej Ule (@ulelab.bsky.social) and Ben Blencowe, who set up the Brain RNA Regulatory Networks satellite lab here at the Crick.
We spoke to Ben and Jernej about their research into RNA auto-gated vectors and their potential applications in gene therapy.
www.crick.ac.uk/news/2025-07...
We spoke to Ben and Jernej about their research into RNA auto-gated vectors and their potential applications in gene therapy.
www.crick.ac.uk/news/2025-07...
Introducing... Jernej Ule and Ben Blencowe
We spoke to Jernej Ule and Ben Blencowe, who recently set up the Brain RNA Regulatory Networks satellite lab here at the Crick.
www.crick.ac.uk
July 29, 2025 at 12:44 PM
Meet Jernej Ule (@ulelab.bsky.social) and Ben Blencowe, who set up the Brain RNA Regulatory Networks satellite lab here at the Crick.
We spoke to Ben and Jernej about their research into RNA auto-gated vectors and their potential applications in gene therapy.
www.crick.ac.uk/news/2025-07...
We spoke to Ben and Jernej about their research into RNA auto-gated vectors and their potential applications in gene therapy.
www.crick.ac.uk/news/2025-07...
Reposted by Quaid Morris
An excellent systematic analysis of RBPs by @quaidmorris.bsky.social and colleagues (with a tiny contribution from us) #RNAsky #RNAbiology
New in @natbiotech.nature.com: a team led by scientists at MSK and University of Toronto have developed a new platform to facilitate the study of RNA-biding proteins (RBPs) across hundreds of species of plants, insects, and animals.
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function - Nature Biotechnology
RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.
www.nature.com
July 29, 2025 at 1:41 AM
An excellent systematic analysis of RBPs by @quaidmorris.bsky.social and colleagues (with a tiny contribution from us) #RNAsky #RNAbiology
Reposted by Quaid Morris
New in @natbiotech.nature.com: a team led by scientists at MSK and University of Toronto have developed a new platform to facilitate the study of RNA-biding proteins (RBPs) across hundreds of species of plants, insects, and animals.
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function - Nature Biotechnology
RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.
www.nature.com
July 28, 2025 at 3:34 PM
New in @natbiotech.nature.com: a team led by scientists at MSK and University of Toronto have developed a new platform to facilitate the study of RNA-biding proteins (RBPs) across hundreds of species of plants, insects, and animals.