Reactome
@reactome.org
Reactome is an open source curated pathway database that provides pathway and network analysis tools for life science researchers.
🎉 As of V95, Reactome is excited to announce the beta release of our redesigned Pathway Browser.
💡 Read more about V95 here: reactome.org/about/news/2...
💡 Read more about V95 here: reactome.org/about/news/2...
V95 Released - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
reactome.org
December 11, 2025 at 3:08 PM
🎉 As of V95, Reactome is excited to announce the beta release of our redesigned Pathway Browser.
💡 Read more about V95 here: reactome.org/about/news/2...
💡 Read more about V95 here: reactome.org/about/news/2...
👏 Thank you to our contributors, authors who have provided expert content and guidance, and peer-reviewers who provide feedback and ensure that everything entering Reactome is accurate. If you are interested in contributing, please reach out to us at help@reactome.org
V95 Released - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
reactome.org
December 11, 2025 at 3:08 PM
👏 Thank you to our contributors, authors who have provided expert content and guidance, and peer-reviewers who provide feedback and ensure that everything entering Reactome is accurate. If you are interested in contributing, please reach out to us at help@reactome.org
Release News: V95 of #Reactome is live! 🎉
We have new and updated topics and pathways, including Disease pathways such as Dengue virus infection, Gene Expression, Immune System, Metabolism, and Vesicle-mediated transport.
We have new and updated topics and pathways, including Disease pathways such as Dengue virus infection, Gene Expression, Immune System, Metabolism, and Vesicle-mediated transport.
December 11, 2025 at 3:08 PM
Release News: V95 of #Reactome is live! 🎉
We have new and updated topics and pathways, including Disease pathways such as Dengue virus infection, Gene Expression, Immune System, Metabolism, and Vesicle-mediated transport.
We have new and updated topics and pathways, including Disease pathways such as Dengue virus infection, Gene Expression, Immune System, Metabolism, and Vesicle-mediated transport.
New Reactome paper in NAR 2026 Databases Issue: doi.org/10.1093/nar/...
Redesigned Angular interface
ReacFoam & entity-level visualizations
Multi-omics analysis tools
React-to-Me chatbot
FAIR-compliant, CoreTrustSeal certified, and ELIXIR-recognized
🖥️🧬
Redesigned Angular interface
ReacFoam & entity-level visualizations
Multi-omics analysis tools
React-to-Me chatbot
FAIR-compliant, CoreTrustSeal certified, and ELIXIR-recognized
🖥️🧬
The Reactome Knowledgebase 2026
Abstract. The Reactome Knowledgebase (https://reactome.org) is a freely accessible, expert-curated, open-source, and open-data resource that describes huma
doi.org
December 8, 2025 at 9:26 PM
New Reactome paper in NAR 2026 Databases Issue: doi.org/10.1093/nar/...
Redesigned Angular interface
ReacFoam & entity-level visualizations
Multi-omics analysis tools
React-to-Me chatbot
FAIR-compliant, CoreTrustSeal certified, and ELIXIR-recognized
🖥️🧬
Redesigned Angular interface
ReacFoam & entity-level visualizations
Multi-omics analysis tools
React-to-Me chatbot
FAIR-compliant, CoreTrustSeal certified, and ELIXIR-recognized
🖥️🧬
Advances like this underline how much early detection and mechanistic clarity matter in rare metabolic disease. For those examining the underlying biology of Hunter syndrome, Reactome’s pathway (reactome.org/content/deta...) provides a clear view of the disrupted iduronate-2-sulfatase process.
November 25, 2025 at 4:14 PM
Advances like this underline how much early detection and mechanistic clarity matter in rare metabolic disease. For those examining the underlying biology of Hunter syndrome, Reactome’s pathway (reactome.org/content/deta...) provides a clear view of the disrupted iduronate-2-sulfatase process.
Contribute to the Reactome Community:
reactome.org/community
Learn more about World AMR Awareness Week:
www.who.int/campaigns/wo...
reactome.org/community
Learn more about World AMR Awareness Week:
www.who.int/campaigns/wo...
November 20, 2025 at 3:20 PM
Contribute to the Reactome Community:
reactome.org/community
Learn more about World AMR Awareness Week:
www.who.int/campaigns/wo...
reactome.org/community
Learn more about World AMR Awareness Week:
www.who.int/campaigns/wo...
AMR remains one of the most serious global public health threats. Continued curation is essential for supporting surveillance, target prioritization, and therapeutic development.
Which AMR-relevant proteins, mechanisms, or resistance determinants should we prioritize for annotation?
Which AMR-relevant proteins, mechanisms, or resistance determinants should we prioritize for annotation?
November 20, 2025 at 3:20 PM
AMR remains one of the most serious global public health threats. Continued curation is essential for supporting surveillance, target prioritization, and therapeutic development.
Which AMR-relevant proteins, mechanisms, or resistance determinants should we prioritize for annotation?
Which AMR-relevant proteins, mechanisms, or resistance determinants should we prioritize for annotation?
This week marks World Antimicrobial Resistance (AMR) Awareness Week.
In 2024, Reactome expanded its coverage of AMR biology with new pathway annotations. Explore our current AMR pathway set here:
reactome.org/PathwayBrows...
In 2024, Reactome expanded its coverage of AMR biology with new pathway annotations. Explore our current AMR pathway set here:
reactome.org/PathwayBrows...
November 20, 2025 at 3:20 PM
This week marks World Antimicrobial Resistance (AMR) Awareness Week.
In 2024, Reactome expanded its coverage of AMR biology with new pathway annotations. Explore our current AMR pathway set here:
reactome.org/PathwayBrows...
In 2024, Reactome expanded its coverage of AMR biology with new pathway annotations. Explore our current AMR pathway set here:
reactome.org/PathwayBrows...
🧠 We love to learn about how #Reactome empowers your research. If you have one to share, please reach out to us (help@reactome.org) to submit your work for our monthly spotlight!
October 21, 2025 at 2:18 PM
🧠 We love to learn about how #Reactome empowers your research. If you have one to share, please reach out to us (help@reactome.org) to submit your work for our monthly spotlight!
Check out our selection for October's #ReactomeResearchSpotlight!
Ringquist et al's September 2025 @natureportfolio.nature.com Biomedical Engineering paper, "An immune-competent lung-on-a-chip for modelling the human severe influenza infection response"
Read more: 🔗 reactome.org/content/reac...
🖥️🧬
Ringquist et al's September 2025 @natureportfolio.nature.com Biomedical Engineering paper, "An immune-competent lung-on-a-chip for modelling the human severe influenza infection response"
Read more: 🔗 reactome.org/content/reac...
🖥️🧬
An immune-competent lung-on-a-chip for modelling the human severe influenza infection response - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
reactome.org
October 21, 2025 at 2:18 PM
Check out our selection for October's #ReactomeResearchSpotlight!
Ringquist et al's September 2025 @natureportfolio.nature.com Biomedical Engineering paper, "An immune-competent lung-on-a-chip for modelling the human severe influenza infection response"
Read more: 🔗 reactome.org/content/reac...
🖥️🧬
Ringquist et al's September 2025 @natureportfolio.nature.com Biomedical Engineering paper, "An immune-competent lung-on-a-chip for modelling the human severe influenza infection response"
Read more: 🔗 reactome.org/content/reac...
🖥️🧬
See you all next week!
Exciting news! Reactome is hosting an interactive workshop at #ASHG25 on Tuesday, October 14th. Advanced ticket purchase is required, so don't forget to sign up for our session "Pathway Analysis for All" when you register for the conference.
October 10, 2025 at 3:54 PM
See you all next week!
🚨 New Beta Release: Reactome Pathway Browser
Explore biology with a modernized interface:
🔗 reactome.org/beta/Pathway...
Feedback welcome → forms.gle/TPBxaWnnVLLZ...
🖥️🧬
Explore biology with a modernized interface:
🔗 reactome.org/beta/Pathway...
Feedback welcome → forms.gle/TPBxaWnnVLLZ...
🖥️🧬
October 10, 2025 at 3:53 PM
🚨 New Beta Release: Reactome Pathway Browser
Explore biology with a modernized interface:
🔗 reactome.org/beta/Pathway...
Feedback welcome → forms.gle/TPBxaWnnVLLZ...
🖥️🧬
Explore biology with a modernized interface:
🔗 reactome.org/beta/Pathway...
Feedback welcome → forms.gle/TPBxaWnnVLLZ...
🖥️🧬
🎉 We just launched the Reactome Figma Library!
You can now drop our professionally illustrated pathway icons straight into your Figma designs — great for teaching, presentations, or science communication. All under CC BY 4.0.
www.figma.com/community/fi...
Demo video: youtu.be/xl2LfczKhGY
🖥️🧬
You can now drop our professionally illustrated pathway icons straight into your Figma designs — great for teaching, presentations, or science communication. All under CC BY 4.0.
www.figma.com/community/fi...
Demo video: youtu.be/xl2LfczKhGY
🖥️🧬
Reactome Icon Library | Figma
A curated set of biological icons designed to support scientists and designers in creating clear, consistent figures and posters. Includes pathway components such as proteins, complexes, reactions, an...
www.figma.com
October 7, 2025 at 2:38 PM
🎉 We just launched the Reactome Figma Library!
You can now drop our professionally illustrated pathway icons straight into your Figma designs — great for teaching, presentations, or science communication. All under CC BY 4.0.
www.figma.com/community/fi...
Demo video: youtu.be/xl2LfczKhGY
🖥️🧬
You can now drop our professionally illustrated pathway icons straight into your Figma designs — great for teaching, presentations, or science communication. All under CC BY 4.0.
www.figma.com/community/fi...
Demo video: youtu.be/xl2LfczKhGY
🖥️🧬
🖍️ As of V94, our illustration library now includes 2,500 icons and over 200 high-level interactive pathway Illustrations: reactome.org/icon-lib
💡 Read more about V94 here: reactome.org/about/news
💡 Read more about V94 here: reactome.org/about/news
Reactome | Icon Library
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
reactome.org
September 18, 2025 at 2:18 PM
🖍️ As of V94, our illustration library now includes 2,500 icons and over 200 high-level interactive pathway Illustrations: reactome.org/icon-lib
💡 Read more about V94 here: reactome.org/about/news
💡 Read more about V94 here: reactome.org/about/news
👏 Thank you to our contributors, authors who have provided expert text and guidance, and peer-reviewers who provide feedback and ensure that everything entering Reactome is accurate. If you are interested in contributing, learn more about how to do so at this link: reactome.org/community
Community - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
reactome.org
September 18, 2025 at 2:18 PM
👏 Thank you to our contributors, authors who have provided expert text and guidance, and peer-reviewers who provide feedback and ensure that everything entering Reactome is accurate. If you are interested in contributing, learn more about how to do so at this link: reactome.org/community
Release News: V94 of #Reactome is live! 🎉
We have new and updated topics and pathways, including Cell Cycle, Developmental Biology, Disease, Immune System, Metabolism of proteins, and Transport of small molecules
🖥️🧬
We have new and updated topics and pathways, including Cell Cycle, Developmental Biology, Disease, Immune System, Metabolism of proteins, and Transport of small molecules
🖥️🧬
September 18, 2025 at 2:18 PM
Release News: V94 of #Reactome is live! 🎉
We have new and updated topics and pathways, including Cell Cycle, Developmental Biology, Disease, Immune System, Metabolism of proteins, and Transport of small molecules
🖥️🧬
We have new and updated topics and pathways, including Cell Cycle, Developmental Biology, Disease, Immune System, Metabolism of proteins, and Transport of small molecules
🖥️🧬
Reposted by Reactome
Reactome audits all curated refs against Retraction Watch. Of 40,000+ papers, just 70 were retracted — and all annotations reviewed or removed. A small number, but we take every one seriously. #FAIRdata #OpenScience #Reactome
🖥️🧬
Read more about it here: reactome.org/content/reac...
🖥️🧬
Read more about it here: reactome.org/content/reac...
Reactome Strengthens Accuracy by Monitoring for Retracted Publications - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
reactome.org
May 30, 2025 at 2:18 PM
Reactome audits all curated refs against Retraction Watch. Of 40,000+ papers, just 70 were retracted — and all annotations reviewed or removed. A small number, but we take every one seriously. #FAIRdata #OpenScience #Reactome
🖥️🧬
Read more about it here: reactome.org/content/reac...
🖥️🧬
Read more about it here: reactome.org/content/reac...
Reposted by Reactome
Exciting news! Reactome is hosting an interactive workshop at #ASHG25 on Tuesday, October 14th. Advanced ticket purchase is required, so don't forget to sign up for our session "Pathway Analysis for All" when you register for the conference.
August 27, 2025 at 2:21 PM
Exciting news! Reactome is hosting an interactive workshop at #ASHG25 on Tuesday, October 14th. Advanced ticket purchase is required, so don't forget to sign up for our session "Pathway Analysis for All" when you register for the conference.
We love to learn about how #Reactome empowers your research. If you have one to share, please reach out to us (help@reactome.org) to submit your work for our monthly spotlight!
September 4, 2025 at 5:11 PM
We love to learn about how #Reactome empowers your research. If you have one to share, please reach out to us (help@reactome.org) to submit your work for our monthly spotlight!
This work highlights how Reactome provides a robust framework for enhancing the interpretability of machine learning models in precision medicine.
reactome.org/content/reac...
reactome.org/content/reac...
Learning and actioning general principles of cancer cell drug sensitivity - Reactome Pathway Database
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
reactome.org
September 4, 2025 at 5:11 PM
This work highlights how Reactome provides a robust framework for enhancing the interpretability of machine learning models in precision medicine.
reactome.org/content/reac...
reactome.org/content/reac...
The model leveraged Reactome pathways in combination with large language models (LLMs) to provide a mechanistic foundation. It demonstrated strong performance and was applied to predict patient drug responses, with predictions supported by experimental validation.
September 4, 2025 at 5:11 PM
The model leveraged Reactome pathways in combination with large language models (LLMs) to provide a mechanistic foundation. It demonstrated strong performance and was applied to predict patient drug responses, with predictions supported by experimental validation.
Starting the new academic year with a Reactome Research Spotlight🖥️🧬
In the February2025 issue of Nature Communications, Carli et al. reported the development of a predictive model of cell line drug sensitivity from RNA-seq data using machine learning approaches pmc.ncbi.nlm.nih.gov/articles/PMC...
In the February2025 issue of Nature Communications, Carli et al. reported the development of a predictive model of cell line drug sensitivity from RNA-seq data using machine learning approaches pmc.ncbi.nlm.nih.gov/articles/PMC...
September 4, 2025 at 5:11 PM
Starting the new academic year with a Reactome Research Spotlight🖥️🧬
In the February2025 issue of Nature Communications, Carli et al. reported the development of a predictive model of cell line drug sensitivity from RNA-seq data using machine learning approaches pmc.ncbi.nlm.nih.gov/articles/PMC...
In the February2025 issue of Nature Communications, Carli et al. reported the development of a predictive model of cell line drug sensitivity from RNA-seq data using machine learning approaches pmc.ncbi.nlm.nih.gov/articles/PMC...
More information here: meetings.ashg.org/event/ASHG25...
August 27, 2025 at 2:21 PM
More information here: meetings.ashg.org/event/ASHG25...