Matthew Hahn
3rdreviewer.bsky.social
Matthew Hahn
@3rdreviewer.bsky.social
Population geneticist
Pinned
It's official--we're escaping for a year!

Happy to say that we'll be on leave at the Wissenschaftskolleg in Berlin from August 2025-July 2026.

Looking forward to beer, travel, and scholarly learning ;)
Reposted by Matthew Hahn
Cheating on my German beer gardens to taste some good Dutch stuff:
December 30, 2025 at 11:45 AM
My year in Christmas markets...

#1 Schloss Charlottenburg
December 26, 2025 at 2:22 PM
Biergarten nummer zehn
December 23, 2025 at 5:13 PM
Achievement unlocked: I cancelled a doctor's appointment (for my kid) over the phone **in German**!
December 18, 2025 at 9:35 AM
Have you ever wondered: just how strong *is* the evidence for Muller's ratchet on mtDNA?

Well, wonder no more!

(Project led by Yu Mo, with @smishra677.bsky.social and @yadirapga.bsky.social)

"No molecular evidence for Muller's ratchet in mitochondrial genomes"
www.biorxiv.org/content/10.6...
No molecular evidence for Muller's ratchet in mitochondrial genomes
Muller's ratchet predicts that non-recombining genomes can accumulate deleterious mutations, though molecular evidence for it is rare. Previous studies have tried to detect ratchet-like behavior in mi...
www.biorxiv.org
December 17, 2025 at 2:36 PM
Reposted by Matthew Hahn
No molecular evidence for Muller's ratchet in mitochondrial genomes https://www.biorxiv.org/content/10.64898/2025.12.16.694700v1
December 17, 2025 at 3:33 AM
Biergarten nummer neun
December 12, 2025 at 8:07 PM
Reposted by Matthew Hahn
Today the members of the Evolution, Ecology, and Behavior graduate program at Indiana University celebrated the upcoming retirement of Dr. Ellen Ketterson. Ellen was a bastion of civility and scientific excellence. The program would not be what it is without her presence over these past decades.
December 11, 2025 at 11:21 PM
Hoo- Hoo- Hoo-
Hoosiers!
The Dems voted 10–0 against the gerrymander, and the Republicans voted against it 21–19.

A majority of the Republican members of the Indiana State Senate just told Trump to go fuck himself.
The Indiana State Senate is 40 Republicans, 10 Democrats. This result is not even close to nothing.
December 11, 2025 at 10:06 PM
New paper on minimal NNs for phylogenetic inference, with former grad student, Ben Rosenzweig:

arxiv.org/abs/2512.02223
On the Approximation of Phylogenetic Distance Functions by Artificial Neural Networks
Inferring the phylogenetic relationships among a sample of organisms is a fundamental problem in modern biology. While distance-based hierarchical clustering algorithms achieved early success on this ...
arxiv.org
December 3, 2025 at 12:29 PM
Reposted by Matthew Hahn
How to keep in step when your (protein) partner speeds up…

Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.

Congrats to whole team!

www.science.org/doi/10.1126/...
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity
Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...
www.science.org
November 28, 2025 at 5:22 PM
Reposted by Matthew Hahn
Please pass along - We've extended the CAMBIUM fellowship deadline to December 15! Our NSF NRT supports new grad students to harness biodiversity big data to adapt to & mitigate climate change impacts. Great fit for evolutionary genomics, bioinformatics, ecology & more. cambium.arizona.edu 🧬🌐🌎
November 26, 2025 at 7:19 PM
Hertha Berlin!
November 21, 2025 at 6:13 PM
Reposted by Matthew Hahn
absolutely LOVE this preprint on tricking LLMs using poetry:
arxiv.org/abs/2511.15304
Like magic spells, you need to use the correct pentameter or the demon won't listen
Adversarial Poetry as a Universal Single-Turn Jailbreak Mechanism in Large Language Models
We present evidence that adversarial poetry functions as a universal single-turn jailbreak technique for Large Language Models (LLMs). Across 25 frontier proprietary and open-weight models, curated po...
arxiv.org
November 21, 2025 at 2:07 AM
Reposted by Matthew Hahn
Read this story in The Chaser Annual 2025, available now: chasershop.com/products/the...
November 13, 2025 at 7:28 AM
Look-up your software name before publishing it!
Wow, I never really noticed this 'fastp' software. I'm apparently the only one though.

They simply re-used an existing name already employed by popular and historically significant software. How is this kind of thing possible?

academic.oup.com/bioinformati...
fastp: an ultra-fast all-in-one FASTQ preprocessor
AbstractMotivation. Quality control and preprocessing of FASTQ files are essential to providing clean data for downstream analysis. Traditionally, a differ
academic.oup.com
November 17, 2025 at 7:07 PM
Reposted by Matthew Hahn
twin fox kits, grunewald berlin
November 16, 2025 at 8:36 PM
Kaffeehaus
November 15, 2025 at 8:55 AM
Reposted by Matthew Hahn
Gus absolutely ascended. Volume up.
GUS-SPLOSIUON
November 8, 2025 at 8:31 PM
Reposted by Matthew Hahn
November 7, 2025 at 2:31 PM
Reposted by Matthew Hahn
If you're looking for a #postdoc but aren't quite a fit for my lab, check out this exciting opportunity via IU's Common Themes in Reproductive Diversity group! 2-year NIH traineeship to work on one of the group's core themes. Details here! ctrd.indiana.edu/how-to-apply/
How to apply
Learn how to apply to the Common Themes in Reproductive Diversity graduate program at Indiana University with detailed steps, requirements, and deadlines.
ctrd.indiana.edu
November 5, 2025 at 5:10 PM
Reposted by Matthew Hahn
Now in Evolution: academic.oup.com/evolut/artic...

This paper started when @3rdreviewer.bsky.social, Mike, and I had a lunch at which there was a lot of, "What do you mean when you say X?" Fun to spend time thinking about when terms get too muddy, and great work by Drew to pull it all together!
November 4, 2025 at 6:06 PM
Low tide, Normandy
October 28, 2025 at 6:17 PM
Just now realizing that most of the French I know comes from “Three Feet High and Rising”…
October 25, 2025 at 3:46 PM
Reposted by Matthew Hahn
Great new postdoc fellowship for foundational plant research.
If you’re into genetics and genomics of plant reproductive evolution or adaptive convergence (incl in the cool and charismatic nightshades!) I’d be happy to talk about possible projects!
www.simonsfoundation.org/grant/simons...
Simons Postdoctoral Fellowships in Plant Biology
Simons Postdoctoral Fellowships in Plant Biology on Simons Foundation
www.simonsfoundation.org
October 14, 2025 at 3:47 PM