Molly Przeworski
@mollyprz.bsky.social
Population & Human Genetics
Pinned
Registration for the 2026 NY Area Population Genetics meeting is now open, at events.simonsfoundation.org/e0mEoL?rt=8k.... Registration is free but required; if you are submitting an abstract, note that the deadline is *January 30th*.
Reposted by Molly Przeworski
Heritability = a statistical description of sources of interindividual variation in a specific set of people under a specific set of environmental conditions. It doesn't index a fixed underlying feature of human biology. A few lines in this paper acknowledge that but its overall framing may mislead.
Heritability of intrinsic human life span is about 50% when confounding factors are addressed
How heritable is human life span? If genetic heritability is high, longevity genes can reveal aging mechanisms and inform medicine and public health. However, current estimates of heritability are low...
www.science.org
January 30, 2026 at 3:36 PM
Heritability = a statistical description of sources of interindividual variation in a specific set of people under a specific set of environmental conditions. It doesn't index a fixed underlying feature of human biology. A few lines in this paper acknowledge that but its overall framing may mislead.
Reposted by Molly Przeworski
Join us at the Evolutionary Biology Centre at Uppsala University. We’re searching for an Assistant Professor in Biology. www.uu.se/en/about-uu/...
January 28, 2026 at 8:28 PM
Join us at the Evolutionary Biology Centre at Uppsala University. We’re searching for an Assistant Professor in Biology. www.uu.se/en/about-uu/...
Reposted by Molly Przeworski
Registration for the 2026 NY Area Population Genetics meeting is now open, at events.simonsfoundation.org/e0mEoL?rt=8k.... Registration is free but required; if you are submitting an abstract, note that the deadline is *January 30th*.
January 14, 2026 at 9:37 PM
Registration for the 2026 NY Area Population Genetics meeting is now open, at events.simonsfoundation.org/e0mEoL?rt=8k.... Registration is free but required; if you are submitting an abstract, note that the deadline is *January 30th*.
Reposted by Molly Przeworski
The US government lost more than 10,000 STEM PhDs last year, according to an analysis by Science of newly released OPM data, with 11 departures for every hire. And many OPM calls "voluntary" separations were probably pushed. www.science.org/content/arti...
U.S. government has lost more than 10,000 STEM Ph.D.s since Trump took office
A Science analysis reveals how many were fired, retired, or quit across 14 agencies
www.science.org
January 27, 2026 at 1:28 AM
The US government lost more than 10,000 STEM PhDs last year, according to an analysis by Science of newly released OPM data, with 11 departures for every hire. And many OPM calls "voluntary" separations were probably pushed. www.science.org/content/arti...
Reposted by Molly Przeworski
Moderna have announced that they won't run new phase three trials now with massive impacts for new vaccine development- why- its because of RFK Jr and his anti-vaccine campaigns and cancelling mRNA vaccine research which affect the sales the company can then make 🧪🧵 #PublicHealth
Moderna Won’t Run Phase III Vaccine Trials as Skepticism Grows in US: Bloomberg
Growing opposition to vaccines in the U.S., driven by recent government policy changes, makes it difficult to see a return on investment in vaccine development, Moderna CEO Stéphane Bancel said this w...
www.biospace.com
January 27, 2026 at 8:50 AM
Moderna have announced that they won't run new phase three trials now with massive impacts for new vaccine development- why- its because of RFK Jr and his anti-vaccine campaigns and cancelling mRNA vaccine research which affect the sales the company can then make 🧪🧵 #PublicHealth
Reposted by Molly Przeworski
🚨 New from me: Grant review at more than half of NIH's institutes could be frozen by the end of the year.
That's because crucial NIH grant-review panels are slated to be empty at those institutes by Jan 2027.
A wonky bureaucratic problem with big implications.
A short 🧵
That's because crucial NIH grant-review panels are slated to be empty at those institutes by Jan 2027.
A wonky bureaucratic problem with big implications.
A short 🧵
Exclusive: key NIH review panels due to lose all members by the end of 2026
Thirteen of the agency’s advisory councils, which must review grant applications before funding is awarded, are on track to have no voting members.
www.nature.com
January 22, 2026 at 7:46 PM
🚨 New from me: Grant review at more than half of NIH's institutes could be frozen by the end of the year.
That's because crucial NIH grant-review panels are slated to be empty at those institutes by Jan 2027.
A wonky bureaucratic problem with big implications.
A short 🧵
That's because crucial NIH grant-review panels are slated to be empty at those institutes by Jan 2027.
A wonky bureaucratic problem with big implications.
A short 🧵
Reposted by Molly Przeworski
Pregnancy loss is common in humans, and chromosomal abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that maternal variation in meiosis genes influences recombination and aneuploidy risk.
First authors: @saracarioscia.bsky.social & @aabiddanda.github.io
First authors: @saracarioscia.bsky.social & @aabiddanda.github.io
Common variation in meiosis genes shapes human recombination and aneuploidy - Nature
Analysis of data from pre-implantation genetic testing sheds light on the genetic basis of meiotic-origin aneuploidy, the leading cause of human pregnancy loss, identifying common genetic variants ass...
www.nature.com
January 21, 2026 at 9:14 PM
Pregnancy loss is common in humans, and chromosomal abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that maternal variation in meiosis genes influences recombination and aneuploidy risk.
First authors: @saracarioscia.bsky.social & @aabiddanda.github.io
First authors: @saracarioscia.bsky.social & @aabiddanda.github.io
Reposted by Molly Przeworski
🔬 Call to create junior research groups at the Institut Pasteur
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research
The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...
research.pasteur.fr
December 8, 2025 at 8:53 AM
🔬 Call to create junior research groups at the Institut Pasteur
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Reposted by Molly Przeworski
Job alert! Assistant professor position in the Department of Molecular Genetics (University of Toronto). Amazing department and city. jobs.utoronto.ca/job/Toronto-... Please share.
Assistant Professor - Virology
Assistant Professor - Virology
jobs.utoronto.ca
January 15, 2026 at 8:04 PM
Job alert! Assistant professor position in the Department of Molecular Genetics (University of Toronto). Amazing department and city. jobs.utoronto.ca/job/Toronto-... Please share.
Registration for the 2026 NY Area Population Genetics meeting is now open, at events.simonsfoundation.org/e0mEoL?rt=8k.... Registration is free but required; if you are submitting an abstract, note that the deadline is *January 30th*.
January 14, 2026 at 9:37 PM
Registration for the 2026 NY Area Population Genetics meeting is now open, at events.simonsfoundation.org/e0mEoL?rt=8k.... Registration is free but required; if you are submitting an abstract, note that the deadline is *January 30th*.
Reposted by Molly Przeworski
I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!
HLi Lab - Vacancies
Openings
hlilab.github.io
January 14, 2026 at 3:44 PM
I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!
Reposted by Molly Przeworski
We're recruiting for an Associate Professor of Statistics in the Department of Statistics, University of Oxford, in association with Jesus College.
⏰ One week left to apply – applications close Monday 19 January 2026.
➡️ Details and application information: tinyurl.com/59tjt7m2
⏰ One week left to apply – applications close Monday 19 January 2026.
➡️ Details and application information: tinyurl.com/59tjt7m2
January 12, 2026 at 2:50 PM
We're recruiting for an Associate Professor of Statistics in the Department of Statistics, University of Oxford, in association with Jesus College.
⏰ One week left to apply – applications close Monday 19 January 2026.
➡️ Details and application information: tinyurl.com/59tjt7m2
⏰ One week left to apply – applications close Monday 19 January 2026.
➡️ Details and application information: tinyurl.com/59tjt7m2
Reposted by Molly Przeworski
HAPPENING NOW: Tens of thousands have filled 5th Avenue in Manhattan on Sunday (Jan 11) in a massive anti-ICE protest.
New York showed up!
👏👏
(🎥Hands Off NYC)
New York showed up!
👏👏
(🎥Hands Off NYC)
January 11, 2026 at 7:39 PM
HAPPENING NOW: Tens of thousands have filled 5th Avenue in Manhattan on Sunday (Jan 11) in a massive anti-ICE protest.
New York showed up!
👏👏
(🎥Hands Off NYC)
New York showed up!
👏👏
(🎥Hands Off NYC)
Reposted by Molly Przeworski
Want to study the genomics of repeated adaptation with data from hundreds of species? New funding for non-Canadians @ grad or postdoc level. Internal competition at UCalgary with very short deadline so please get in touch ASAP!!
sshrc-crsh.canada.ca/en/funding/o...
sshrc-crsh.canada.ca/en/funding/o...
January 9, 2026 at 6:41 PM
Want to study the genomics of repeated adaptation with data from hundreds of species? New funding for non-Canadians @ grad or postdoc level. Internal competition at UCalgary with very short deadline so please get in touch ASAP!!
sshrc-crsh.canada.ca/en/funding/o...
sshrc-crsh.canada.ca/en/funding/o...
Reposted by Molly Przeworski
Muller’s ratchet but for an entire society, in real time.
January 9, 2026 at 9:40 PM
Muller’s ratchet but for an entire society, in real time.
Reposted by Molly Przeworski
Job AD. Research Directions:
1. Selection in early development; Pop gen methods applied to new technologies, i.e. scDNA-seq with D. Shao
2. Study of hypermutability and selection using population cohorts with E. Koch
3. Evolution of Mutagenesis with M. Penenell & @jgschraiber.bsky.social
1. Selection in early development; Pop gen methods applied to new technologies, i.e. scDNA-seq with D. Shao
2. Study of hypermutability and selection using population cohorts with E. Koch
3. Evolution of Mutagenesis with M. Penenell & @jgschraiber.bsky.social
POSTDOCTORAL RESEARCHER - McDermott Center HG&D - Seplyarskiy Lab
Discover POSTDOCTORAL RESEARCHER - McDermott Center HG&D - Seplyarskiy Lab and other PostDoc jobs in Dallas, TX and apply online today!
jobs.utsouthwestern.edu
December 8, 2025 at 5:31 PM
Job AD. Research Directions:
1. Selection in early development; Pop gen methods applied to new technologies, i.e. scDNA-seq with D. Shao
2. Study of hypermutability and selection using population cohorts with E. Koch
3. Evolution of Mutagenesis with M. Penenell & @jgschraiber.bsky.social
1. Selection in early development; Pop gen methods applied to new technologies, i.e. scDNA-seq with D. Shao
2. Study of hypermutability and selection using population cohorts with E. Koch
3. Evolution of Mutagenesis with M. Penenell & @jgschraiber.bsky.social
Reposted by Molly Przeworski
From an email to one of our faculty members....
Not even Plato can escape censorship at Texas A&M!
Not even Plato can escape censorship at Texas A&M!
January 6, 2026 at 8:15 PM
From an email to one of our faculty members....
Not even Plato can escape censorship at Texas A&M!
Not even Plato can escape censorship at Texas A&M!
Reposted by Molly Przeworski
I’m very excited to share our new preprint with @arbelharpak.bsky.social! We meta-analyze male-female allele frequency divergences across studies (gnomAD, UKB, AoU) and ask what drives the observed differences. (1/12)
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 7, 2026 at 9:33 PM
I’m very excited to share our new preprint with @arbelharpak.bsky.social! We meta-analyze male-female allele frequency divergences across studies (gnomAD, UKB, AoU) and ask what drives the observed differences. (1/12)
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Molly Przeworski
New preprint alert: we use sign errors as a test of how well TWAS works.
Very worryingly we find that TWAS gets the sign wrong around 1/3 of the time (compared to 50% for pure guessing). You can read more about our analysis here, and what we think is going on 👇
Very worryingly we find that TWAS gets the sign wrong around 1/3 of the time (compared to 50% for pure guessing). You can read more about our analysis here, and what we think is going on 👇
How well does TWAS estimate a gene’s direction of effect on a trait? We think of this as an important stress-test for the accuracy of TWAS.
In a new pre-print, we find that TWAS gets the sign wrong around 20-30% of the time!
doi.org/10.64898/202...
1/n
In a new pre-print, we find that TWAS gets the sign wrong around 20-30% of the time!
doi.org/10.64898/202...
1/n
High false sign rates in transcriptome-wide association studies
Transcriptome-wide association studies (TWAS) are widely used to identify genes involved in complex traits and to infer the direction of gene effects on traits. However, despite their popularity, it r...
doi.org
January 6, 2026 at 2:48 AM
New preprint alert: we use sign errors as a test of how well TWAS works.
Very worryingly we find that TWAS gets the sign wrong around 1/3 of the time (compared to 50% for pure guessing). You can read more about our analysis here, and what we think is going on 👇
Very worryingly we find that TWAS gets the sign wrong around 1/3 of the time (compared to 50% for pure guessing). You can read more about our analysis here, and what we think is going on 👇
Reposted by Molly Przeworski
I'm just delighted to announce our new preprint on genome-scale perturb-seq in CD4+ T cells. We learned both general lessons about the power of perturb-seq, and specific lessons about T cell biology.
Led by amazing postdocs Emma Dann and Ronghui Zhu, with my wonderful collaborator Alex Marson.
Led by amazing postdocs Emma Dann and Ronghui Zhu, with my wonderful collaborator Alex Marson.
Together with @ronghuizhu.bsky.social, we are thrilled to present our new perturb-seq study of 22M primary CD4+ T cells, across donors and timepoints – the result of a decade-long collaboration between the Marson @marsonlab.bsky.social and Pritchard @jkpritch.bsky.social labs 🧵 tinyurl.com/gwt2025
Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits
Gene regulatory networks encode the fundamental logic of cellular functions, but systematic network mapping remains challenging, especially in cell states relevant to human biology and disease. Here, ...
tinyurl.com
January 5, 2026 at 7:27 PM
I'm just delighted to announce our new preprint on genome-scale perturb-seq in CD4+ T cells. We learned both general lessons about the power of perturb-seq, and specific lessons about T cell biology.
Led by amazing postdocs Emma Dann and Ronghui Zhu, with my wonderful collaborator Alex Marson.
Led by amazing postdocs Emma Dann and Ronghui Zhu, with my wonderful collaborator Alex Marson.
Reposted by Molly Przeworski
Come and join me and my colleagues at the Department of Biology, #LundUniversity in #sweden! We have am open position as Senior Lecturer/Associate Professor in Biodiversity.
Apply here no later than February 11 2026:
https://lu.varbi.com/en/what:job/jobID:848749/type:job/where:4/apply:1
Apply here no later than February 11 2026:
https://lu.varbi.com/en/what:job/jobID:848749/type:job/where:4/apply:1
Senior Lecturer/Associate Professor in Biodiversity
The Department of Biology was established in 2010 through the merger of the Departments of Ecology, Cell and Organism Biology, Biological Undergraduate Education, and the Biological Museums. The depar
lu.varbi.com
December 20, 2025 at 3:58 PM
Come and join me and my colleagues at the Department of Biology, #LundUniversity in #sweden! We have am open position as Senior Lecturer/Associate Professor in Biodiversity.
Apply here no later than February 11 2026:
https://lu.varbi.com/en/what:job/jobID:848749/type:job/where:4/apply:1
Apply here no later than February 11 2026:
https://lu.varbi.com/en/what:job/jobID:848749/type:job/where:4/apply:1
Reposted by Molly Przeworski
The registration deadline is fast approaching for probgen 2026! Abstracts due by January 15, registration by January 31
probgen2026.github.io
probgen2026.github.io
Home - ProbGen 2026
Your Site Description
probgen2026.github.io
December 18, 2025 at 5:09 PM
The registration deadline is fast approaching for probgen 2026! Abstracts due by January 15, registration by January 31
probgen2026.github.io
probgen2026.github.io
Reposted by Molly Przeworski
Why do I have to read an Irish paper for a feature about this?
‘It’s surreal’: US sanctions lock International Criminal Court judge out of daily life
Canadian judge Kimberly Prost is unable to use credit cards, transfer money or book everyday services in what she calls an attack on the independence of the judiciary
www.irishtimes.com
January 1, 2026 at 12:24 PM
Why do I have to read an Irish paper for a feature about this?
Reposted by Molly Przeworski
Delighted to have our work on 🧬 resilience to 🩸cancer led by @g-agarwal.bsky.social & amazing collaborators, including @kharaslab.bsky.social, published in @science.org: www.science.org/doi/10.1126/... 🧵
January 2, 2026 at 2:01 PM
Delighted to have our work on 🧬 resilience to 🩸cancer led by @g-agarwal.bsky.social & amazing collaborators, including @kharaslab.bsky.social, published in @science.org: www.science.org/doi/10.1126/... 🧵
Reposted by Molly Przeworski
Somatic and germline mutational processes across the tree of life https://www.biorxiv.org/content/10.64898/2025.12.28.691837v1
December 30, 2025 at 2:32 PM
Somatic and germline mutational processes across the tree of life https://www.biorxiv.org/content/10.64898/2025.12.28.691837v1