Teams from the Paris Public Hospital Network (AP-HP), Université Paris Cité, Université Sorbonne Paris Nord, Inserm, the Institut Pasteur and FHU Prem'IMPACT, coordinated by Professor Laurent Mandelbr...

Natural killer (NK) cells are part of the innate immune system, our first line of defense. We already know that they can develop immune memory after infection with Streptococcus pneumoniae. More recen...

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Pourquoi certains moustiques sont-ils plus susceptibles de transmettre la dengue que d’autres ?

Disruption of host cell barriers is a fundamental strategy enabling pathogens to establish a paracellular infection. Here, using dual RNA-Seq, we determine the in vivo host-pathogen transcriptomic landscape upon infection by the extracellular pathogen Leptospira interrogans and uncover a mechanism of cell–cell junction disruption. We demonstrate that, upon infection, an increase in intracellular calcium triggers tight junction destabilization, by activating the calmodulin and myosin light chain kinase signalization. We identify two bacterial effectors of the Virulence-Modifying (VM) proteins family, structurally related to toxin-like proteins, that promote modulation of calcium homeostasis and disruption of cell–cell junctions, thereby allowing Leptospira translocation across epithelium barriers, tissue colonization and pathogenicity. Furthermore, we demonstrate that at least one of these VM proteins is secreted and associates with host cells. Altogether, these findings reveal a unique strategy by which an extracellular pathogen secretes toxin-like proteins to exploit host calcium signaling for breaching epithelial barriers. Here, the authors use in vivo dual RNA sequencing to determine the host-pathogen transcriptomic landscape upon infection by Leptospira interrogans, revealing alterations in pathways associated with paracellular permeability, like cell–cell junctions.

Dans un article publié dans Nature Ecology & Evolution, des scientifiques proposent une relecture de l’origine et

Women’s health, Women in Health March 17th 2026 • Institut Pasteur, Paris, France Registration and Poster application Fill the form The Institut Pasteur is pleased to invite you to the symposium Women...

HORBEC are protein complexes involved in the regulation of redox balance and energy conservation. The authors develop a bioinformatic tool for HORBEC annotation in bacterial and archaeal genomes and r...

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For several months now, the current U.S. administration has consistently attacked and endeavored to weaken biomedical research and public health action in the United States and worldwide with unparall...

The Bikard lab at Institut Pasteur in Paris is seeking to hire postdoctoral researchers. We are investigating bacteria / bacteriophages interactions, and the genetic innovation that happens at this in...