Adlung Lab
@adlunglab.com
Data-driven & knowledge-based. Rooted in Hamburg, Germany.
Adipose and/or Systems Biology + Inflammation.
Account handled by π @LorenzAdlung.com
www.adlunglab.com
Adipose and/or Systems Biology + Inflammation.
Account handled by π @LorenzAdlung.com
www.adlunglab.com
Gene Yeo (@ucsdmedschool.bsky.social,@ucsdstemcells.bsky.social) with good advise in Molecular Cell on steering interdisciplinary projects. A take-away: Define roles early on and adapt as projects evolve. Abstain from determining author lists last minute! www.cell.com/molecul... 🧪
February 11, 2026 at 1:59 PM
Gene Yeo (@ucsdmedschool.bsky.social,@ucsdstemcells.bsky.social) with good advise in Molecular Cell on steering interdisciplinary projects. A take-away: Define roles early on and adapt as projects evolve. Abstain from determining author lists last minute! www.cell.com/molecul... 🧪
Regulation of IFN responses is really intriguing: Adams et al. show that pDCs acquire "anticipatory" chromatin features at the type I interferon locus via IRF8 and cohesin, enabling rapid simultaneous induction of all IFN genes Immunity doi.org/10.1016/j.im... 🧪
Chromatin-mediated anticipatory control of type I interferon production in plasmacytoid dendritic cells
Type I interferons (IFN-I), including IFN-β and multiple IFN-α subtypes, are key antiviral proteins encoded within a single large locus. Here, we stud…
doi.org
February 11, 2026 at 1:27 PM
Regulation of IFN responses is really intriguing: Adams et al. show that pDCs acquire "anticipatory" chromatin features at the type I interferon locus via IRF8 and cohesin, enabling rapid simultaneous induction of all IFN genes Immunity doi.org/10.1016/j.im... 🧪
Very informative title in Cell Metabolism
"Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism" www.cell.com/cell-me... 🧪
"Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism" www.cell.com/cell-me... 🧪
February 10, 2026 at 12:01 PM
Very informative title in Cell Metabolism
"Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism" www.cell.com/cell-me... 🧪
"Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism" www.cell.com/cell-me... 🧪
Higher BMI from menarche to age 40 protects against breast cancer, but this effect attenuates when controlling for prepubertal adiposity, write Power et al. from @uob-ieu.bsky.social in @science.org Advances www.science.org/doi/... 🧪
February 5, 2026 at 12:59 PM
Higher BMI from menarche to age 40 protects against breast cancer, but this effect attenuates when controlling for prepubertal adiposity, write Power et al. from @uob-ieu.bsky.social in @science.org Advances www.science.org/doi/... 🧪
Reposted by Adlung Lab
A recent @derspiegel article on “one of Germany’s most renowned AI researchers” got me thinking. The person was new to me, but I think highlights a somewhat recurring issue: media visibility is not the same as scientific contribution.
www.spiegel.de/wissenschaft...
www.spiegel.de/wissenschaft...
(S+) Joscha Bach: Wie ein deutscher Forscher mit Epsteins Hilfe Karriere machte
Joscha Bach ist einer der renommiertesten deutschen KI-Forscher, offenbar hat er mehr als eine Million Dollar von Jeffrey Epstein erhalten. SPIEGEL-Recherchen zeigen: Der Kontakt reichte weit ins…
www.spiegel.de
February 4, 2026 at 1:32 PM
A recent @derspiegel article on “one of Germany’s most renowned AI researchers” got me thinking. The person was new to me, but I think highlights a somewhat recurring issue: media visibility is not the same as scientific contribution.
www.spiegel.de/wissenschaft...
www.spiegel.de/wissenschaft...
Marton Olbei et al. from Imperial College London map cytokine networks in ulcerative colitis and identify TL1A as an upstream regulator of TNF and IL-23A, a potential therapeutic target. Out now in @science.org Signaling: science.org/doi/10.1... 🧪
February 4, 2026 at 1:33 PM
Marton Olbei et al. from Imperial College London map cytokine networks in ulcerative colitis and identify TL1A as an upstream regulator of TNF and IL-23A, a potential therapeutic target. Out now in @science.org Signaling: science.org/doi/10.1... 🧪
Chan et al. from The Tarling-Vallim Lab (University of California) show bile acids selectively regulate fatty acid absorption, preferentially solubilizing polyunsaturated fats for uptake, offering strategies for obesity prevention in Cell Metabolism doi.org/10.1016/j.cm... 🧪
February 4, 2026 at 1:00 PM
Chan et al. from The Tarling-Vallim Lab (University of California) show bile acids selectively regulate fatty acid absorption, preferentially solubilizing polyunsaturated fats for uptake, offering strategies for obesity prevention in Cell Metabolism doi.org/10.1016/j.cm... 🧪
In press: Giraud-Gatineau et al. from @pasteur.fr reveal how Leptospira secretes toxin-like Virulence-Modifying (VM) proteins that hijack host calcium signaling to disrupt epithelial barriers and enable tissue colonization. In @natcomms.nature.com doi.org/10.1038/s414... 🧪
In vivo dual RNA-Seq uncovers key effectors of epithelial barrier disruption by an extracellular pathogen | Nature Communications
Disruption of host cell barriers is a fundamental strategy enabling pathogens to establish a paracellular infection. Here, using dual RNA-Seq, we determine the in vivo host-pathogen transcriptomic landscape upon infection by the extracellular pathogen Leptospira interrogans and uncover a mechanism of cell–cell junction disruption. We demonstrate that, upon infection, an increase in intracellular calcium triggers tight junction destabilization, by activating the calmodulin and myosin light chain kinase signalization. We identify two bacterial effectors of the Virulence-Modifying (VM) proteins family, structurally related to toxin-like proteins, that promote modulation of calcium homeostasis and disruption of cell–cell junctions, thereby allowing Leptospira translocation across epithelium barriers, tissue colonization and pathogenicity. Furthermore, we demonstrate that at least one of these VM proteins is secreted and associates with host cells. Altogether, these findings reveal a unique strategy by which an extracellular pathogen secretes toxin-like proteins to exploit host calcium signaling for breaching epithelial barriers. Here, the authors use in vivo dual RNA sequencing to determine the host-pathogen transcriptomic landscape upon infection by Leptospira interrogans, revealing alterations in pathways associated with paracellular permeability, like cell–cell junctions.
doi.org
February 4, 2026 at 10:08 AM
In press: Giraud-Gatineau et al. from @pasteur.fr reveal how Leptospira secretes toxin-like Virulence-Modifying (VM) proteins that hijack host calcium signaling to disrupt epithelial barriers and enable tissue colonization. In @natcomms.nature.com doi.org/10.1038/s414... 🧪
🧬🖥️ Btw: Our snRNA-seq study of murine brown adipose tissue (BAT) is now fully documented on GitHub.
TL;DR: We identified 21 cell populations including lipogenic adipocytes regulated by ChREBP during cold adaptation. All code & data available for reproducibility!
github.com/AdlungLab... 🧪
TL;DR: We identified 21 cell populations including lipogenic adipocytes regulated by ChREBP during cold adaptation. All code & data available for reproducibility!
github.com/AdlungLab... 🧪
GitHub - AdlungLab/ChREBP: Single-nucleus RNA-sequencing of murine brown adipose tissue under cold challenges
Single-nucleus RNA-sequencing of murine brown adipose tissue under cold challenges - AdlungLab/ChREBP
github.com
February 3, 2026 at 12:38 PM
🧬🖥️ Btw: Our snRNA-seq study of murine brown adipose tissue (BAT) is now fully documented on GitHub.
TL;DR: We identified 21 cell populations including lipogenic adipocytes regulated by ChREBP during cold adaptation. All code & data available for reproducibility!
github.com/AdlungLab... 🧪
TL;DR: We identified 21 cell populations including lipogenic adipocytes regulated by ChREBP during cold adaptation. All code & data available for reproducibility!
github.com/AdlungLab... 🧪
Weiler and Fabian Theis present CellRank 2, a Python framework for scalable cell fate inference from single cell RNA sequencing. Top notch as always, out now in: Nature Protocols doi.org/10.1038/s415... 🧪
CellRank: consistent and data view agnostic fate mapping for single-cell genomics
Nature Protocols - CellRank enables cell fate mapping from single-cell RNA sequencing data in a consistent and scalable manner, relying on different views of the data such as pseudotime or stemness...
doi.org
February 3, 2026 at 12:09 PM
Weiler and Fabian Theis present CellRank 2, a Python framework for scalable cell fate inference from single cell RNA sequencing. Top notch as always, out now in: Nature Protocols doi.org/10.1038/s415... 🧪
Daniel, Ullrich et al. (Universität zu Köln) find detectable neutralizing antibodies against H5N1 A/Texas/37/2024 in naive(!) individuals and isolate mAbs that protect mice from lethal challenge. Just out in Immunity doi.org/10.1016/j.im... 🧪
Pre-existing neutralizing antibodies against cattle-transmitted influenza A virus H5N1 are detectable in unexposed individuals
The transmission of influenza A virus H5N1 clade 2.3.4.4b from cattle to humans highlights the risk of an H5N1 pandemic. Pre-existing immunity strongl…
doi.org
February 2, 2026 at 1:23 PM
Daniel, Ullrich et al. (Universität zu Köln) find detectable neutralizing antibodies against H5N1 A/Texas/37/2024 in naive(!) individuals and isolate mAbs that protect mice from lethal challenge. Just out in Immunity doi.org/10.1016/j.im... 🧪
Forgot to post this: Tibocha-Bonilla et al. from UC San Diego developed coralME to automate reconstruction of 495 ME-models for gut bacteria, revealing how diet and metabolic dysbiosis impact disease, out since last month in Cell Systems doi.org/10.1016/j.ce... 🧪
Metabolism and gene expression models for the microbiome reveal how diet and metabolic dysbiosis impact disease
The gut microbiome plays a critical role in human health, spurring extensive research using multi-omic technologies. Although these tools offer valuab…
doi.org
February 2, 2026 at 9:50 AM
Forgot to post this: Tibocha-Bonilla et al. from UC San Diego developed coralME to automate reconstruction of 495 ME-models for gut bacteria, revealing how diet and metabolic dysbiosis impact disease, out since last month in Cell Systems doi.org/10.1016/j.ce... 🧪
Great mechanistic paper by da Silva et al. showing that Enterococcus faecalis lactic acid suppresses macrophage NF-κB activation via MCT-1 and GPR81 signaling, promoting bacterial persistence and polymicrobial wound infections. Cell Host & Microbe doi.org/10.1016/j.ch... 🧪
January 29, 2026 at 12:33 PM
Great mechanistic paper by da Silva et al. showing that Enterococcus faecalis lactic acid suppresses macrophage NF-κB activation via MCT-1 and GPR81 signaling, promoting bacterial persistence and polymicrobial wound infections. Cell Host & Microbe doi.org/10.1016/j.ch... 🧪
Interesting preprint by Ruan et al. (American Aging Association), who identify Myl1+ progenitors as dominant source of brown adipocytes in adult mice, revealing an age-dependent progenitor switch that shapes metabolic (glycolytic) heterogeneity in brown fat during aging. 🧪
Age-dependent progenitor switching shapes adult brown adipose tissue heterogeneity | Research Square
The ontogeny of brown adipose tissue (BAT) begins during embryogenesis and continues into the postnatal period and throughout adulthood. Distinct populations of adipose progenitor cells (APCs) have been identified to support BAT development and thermogenesis; however, the division of labor and te...
doi.org
January 28, 2026 at 1:33 PM
Interesting preprint by Ruan et al. (American Aging Association), who identify Myl1+ progenitors as dominant source of brown adipocytes in adult mice, revealing an age-dependent progenitor switch that shapes metabolic (glycolytic) heterogeneity in brown fat during aging. 🧪
Young, Dohai et al. show 80% of gut Pseudomonadota have type III secretion systems with effectors that modulate immune pathways and link to inflammatory bowel disease (IBD) genetics. Pascal Falter-Braun @univ-amu.fr Nature Microbiology doi.org/10.1038/s415... 🧪
Effector–host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation
Nature Microbiology - Large-scale computational and in vitro analyses identify commensal type III secretion systems and substrates in the human gut microbiome that can interact with human proteins...
doi.org
January 27, 2026 at 11:19 AM
Young, Dohai et al. show 80% of gut Pseudomonadota have type III secretion systems with effectors that modulate immune pathways and link to inflammatory bowel disease (IBD) genetics. Pascal Falter-Braun @univ-amu.fr Nature Microbiology doi.org/10.1038/s415... 🧪
Have a guess: What's the global macroeconomic burden of diabetes mellitus from 2020 to 2050?
Including losses in effective labor supply due to mortality and morbidity, treatment-related resource diversion and informal caregiving costs...
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Including losses in effective labor supply due to mortality and morbidity, treatment-related resource diversion and informal caregiving costs...
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January 26, 2026 at 9:13 AM
Have a guess: What's the global macroeconomic burden of diabetes mellitus from 2020 to 2050?
Including losses in effective labor supply due to mortality and morbidity, treatment-related resource diversion and informal caregiving costs...
👇🏻
1/2
Including losses in effective labor supply due to mortality and morbidity, treatment-related resource diversion and informal caregiving costs...
👇🏻
1/2
Really, really cool paper from Chakaroun et al. They develop metBMI, a metabolite signature of obesity that (not surprisingly, but still pleasing to see) outperforms BMI in predicting cardiometabolic risk and links to gut microbiome composition. Nature Medicine
doi.org/10.1038/s415... 🧪
doi.org/10.1038/s415... 🧪
Multi-omic definition of metabolic obesity through adipose tissue–microbiome interactions
Nature Medicine - Metabolomics, metagenomics, proteins and genetics were combined with clinical data to define a metabolic signature of obesity.
doi.org
January 22, 2026 at 12:30 PM
Really, really cool paper from Chakaroun et al. They develop metBMI, a metabolite signature of obesity that (not surprisingly, but still pleasing to see) outperforms BMI in predicting cardiometabolic risk and links to gut microbiome composition. Nature Medicine
doi.org/10.1038/s415... 🧪
doi.org/10.1038/s415... 🧪
Super cool paper from Gretchen Diehl Lab in @science.org Immunology on intestinal stem cells sensing E. coli flagellin via TLR5 to recruit CCR2+ macrophages to the lamina propria: www.science.org/doi/... 🧪
January 21, 2026 at 7:13 AM
Super cool paper from Gretchen Diehl Lab in @science.org Immunology on intestinal stem cells sensing E. coli flagellin via TLR5 to recruit CCR2+ macrophages to the lamina propria: www.science.org/doi/... 🧪
Reffsin, Miller, Cherry & Raj et al. discover that intrinsic cell states determine which cells become infected with SARS-CoV-2. Using single-cell clone tracing, they identified a TIG1-high state marking highly susceptible cells. What makes these cells vulnerable? 👇🏻
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January 20, 2026 at 12:50 PM
Reffsin, Miller, Cherry & Raj et al. discover that intrinsic cell states determine which cells become infected with SARS-CoV-2. Using single-cell clone tracing, they identified a TIG1-high state marking highly susceptible cells. What makes these cells vulnerable? 👇🏻
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Kurochkin et al. develop REPROcode, a platform that screens 50 transcription factors (TFs) simultaneously to reprogram fibroblasts into immune cells. How does this wonderful example of synthetic immunology work? 👇🏻
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January 20, 2026 at 6:22 AM
Kurochkin et al. develop REPROcode, a platform that screens 50 transcription factors (TFs) simultaneously to reprogram fibroblasts into immune cells. How does this wonderful example of synthetic immunology work? 👇🏻
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Marteau, Jiménez-Sánchez & Trajanoski et al. build a massive colorectal cancer atlas with 4.27 million cells. They find that not all neutrophils promote tumors. What distinguishes the good neutrophils from the bad ones? ⬇️
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January 19, 2026 at 1:59 PM
Marteau, Jiménez-Sánchez & Trajanoski et al. build a massive colorectal cancer atlas with 4.27 million cells. They find that not all neutrophils promote tumors. What distinguishes the good neutrophils from the bad ones? ⬇️
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Li, Hou et al. discover a new organelle (without a membrane!) in fatty liver disease (MASH). Lipid metabolites trigger formation of "lipid-induced granules" (LIGs) in steatotic hepatocytes. These granules protect against liver fibrosis. What is the mechanism? ⬇️
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January 19, 2026 at 1:14 PM
Li, Hou et al. discover a new organelle (without a membrane!) in fatty liver disease (MASH). Lipid metabolites trigger formation of "lipid-induced granules" (LIGs) in steatotic hepatocytes. These granules protect against liver fibrosis. What is the mechanism? ⬇️
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It is devastating that Peer Bork is dead. We've lost a true giant, a role model and a scientific idol for me. May his memory be a blessing and his legacy live on.
via @mannlab.bsky.social
www.embl.org/news/embl-an...
via @mannlab.bsky.social
www.embl.org/news/embl-an...
In remembrance of Peer Bork | EMBL
EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.
www.embl.org
January 19, 2026 at 10:17 AM
It is devastating that Peer Bork is dead. We've lost a true giant, a role model and a scientific idol for me. May his memory be a blessing and his legacy live on.
via @mannlab.bsky.social
www.embl.org/news/embl-an...
via @mannlab.bsky.social
www.embl.org/news/embl-an...
Zhang, Gao et al. discover that colorectal cancer cells evade dual KRAS and EGFR inhibition by transitioning into a Paneth-like state. These secretory cells, normally found in the intestinal crypt, become enriched in residual tumors. What drives this transition? ⬇️
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January 16, 2026 at 11:51 AM
Zhang, Gao et al. discover that colorectal cancer cells evade dual KRAS and EGFR inhibition by transitioning into a Paneth-like state. These secretory cells, normally found in the intestinal crypt, become enriched in residual tumors. What drives this transition? ⬇️
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Reposted by Adlung Lab
Obesity rewires nucleotide metabolism in immune cells, making inflammatory responses via NLRP3 inflammasome much easier to trigger
www.science.org/doi/10.1126/... @science.org @zhenyuzhong.bsky.social @utswim.bsky.social
www.science.org/doi/10.1126/... @science.org @zhenyuzhong.bsky.social @utswim.bsky.social
January 16, 2026 at 3:41 AM
Obesity rewires nucleotide metabolism in immune cells, making inflammatory responses via NLRP3 inflammasome much easier to trigger
www.science.org/doi/10.1126/... @science.org @zhenyuzhong.bsky.social @utswim.bsky.social
www.science.org/doi/10.1126/... @science.org @zhenyuzhong.bsky.social @utswim.bsky.social