Lorenz Adlung Lab
@adlunglab.com
Data-driven & knowledge-based. Rooted in Hamburg, Germany.
Adipose and/or Systems Biology + Inflammation.
Account handled by π @LorenzAdlung.com
www.adlunglab.com
Adipose and/or Systems Biology + Inflammation.
Account handled by π @LorenzAdlung.com
www.adlunglab.com
Dural mast cells at the CSF–brain interface are gatekeepers of neuroinflammation; blocking or permitting immune cell entry in stroke and meningitis. Spotlight in @cp-trendsimmuno.bsky.social by our good friends from @aleksdelab.bsky.social
doi.org/10.1016/j.it... 🧪
doi.org/10.1016/j.it... 🧪
Keep your neutrophils close, but your mast cells closer
Immune activity at the cerebrospinal fluid (CSF)–dura–brain interface regulates key functions of brain physiology. In two back-to-back papers, Mamulad…
doi.org
November 12, 2025 at 10:28 AM
Dural mast cells at the CSF–brain interface are gatekeepers of neuroinflammation; blocking or permitting immune cell entry in stroke and meningitis. Spotlight in @cp-trendsimmuno.bsky.social by our good friends from @aleksdelab.bsky.social
doi.org/10.1016/j.it... 🧪
doi.org/10.1016/j.it... 🧪
Aging remodels tissue-resident macrophages; e.g., pro-inflammatory(!), lipid-associated macrophages expand in aged muscle, reflecting altered repair and inflammatory states. Terekhova et al. review human human immune aging in @cp-immunity.bsky.social
doi.org/10.1016/j.im... 🧪
doi.org/10.1016/j.im... 🧪
Human immune aging
Aging is an essential aspect of human life, and studying its mechanisms is crucial for extending lifespan and improving quality of life. The immune sy…
doi.org
November 11, 2025 at 6:21 AM
Aging remodels tissue-resident macrophages; e.g., pro-inflammatory(!), lipid-associated macrophages expand in aged muscle, reflecting altered repair and inflammatory states. Terekhova et al. review human human immune aging in @cp-immunity.bsky.social
doi.org/10.1016/j.im... 🧪
doi.org/10.1016/j.im... 🧪
Was really great to host a workshop / "hackathon" for mathematical modelling of single-cell data in Hamburg, I think the pictures speak for themselves:
November 7, 2025 at 11:21 AM
Was really great to host a workshop / "hackathon" for mathematical modelling of single-cell data in Hamburg, I think the pictures speak for themselves:
"Healthy obese" in UK biobank. 266 genetic variants linked to body fat distribution & metabolic health.
8 genetic subtypes of obesity; some linked to *better* lipid, blood pressure, and glucose profiles. Great read by Nathalie Chami et al. in @natmed.nature.com: doi.org/10.1038/s415... 🧪
8 genetic subtypes of obesity; some linked to *better* lipid, blood pressure, and glucose profiles. Great read by Nathalie Chami et al. in @natmed.nature.com: doi.org/10.1038/s415... 🧪
Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities
Nature Medicine - Genotype-phenotype data from over 450,000 individuals was analyzed to discover 205 genomic loci where an allele associated with increase adiposity was associated with a lower...
doi.org
October 17, 2025 at 12:24 PM
"Healthy obese" in UK biobank. 266 genetic variants linked to body fat distribution & metabolic health.
8 genetic subtypes of obesity; some linked to *better* lipid, blood pressure, and glucose profiles. Great read by Nathalie Chami et al. in @natmed.nature.com: doi.org/10.1038/s415... 🧪
8 genetic subtypes of obesity; some linked to *better* lipid, blood pressure, and glucose profiles. Great read by Nathalie Chami et al. in @natmed.nature.com: doi.org/10.1038/s415... 🧪
I‘m very happy that our recent publication was selected as Paper Of the Month by the dean’s office. Paid off that I insisted to submit an application even though we knew it’s gonna be a tough competition.
www.sciencedirect.com/science/arti... 🧪
www.sciencedirect.com/science/arti... 🧪
October 17, 2025 at 10:39 AM
I‘m very happy that our recent publication was selected as Paper Of the Month by the dean’s office. Paid off that I insisted to submit an application even though we knew it’s gonna be a tough competition.
www.sciencedirect.com/science/arti... 🧪
www.sciencedirect.com/science/arti... 🧪
Wow, @pascual-reguant.bsky.social, very impressive talk at #EMBLSpatialBiology! Presented preprint with @hoheyn.bsky.social: www.biorxiv.org/content/10.1...
You can also read more on the STAMP technology in @natrevgenet.nature.com: www.nature.com/articles/s41... 🧪
You can also read more on the STAMP technology in @natrevgenet.nature.com: www.nature.com/articles/s41... 🧪
Imaging-based multimodal profiling of single cells with STAMP - Nature Reviews Genetics
In this Tools of the Trade article, Kellie Wise and Anna Pascual-Reguant introduce STAMP (single-cell transcriptomics analysis and multimodal profiling), which harnesses imaging to measure RNA and/or ...
www.nature.com
October 17, 2025 at 9:21 AM
Wow, @pascual-reguant.bsky.social, very impressive talk at #EMBLSpatialBiology! Presented preprint with @hoheyn.bsky.social: www.biorxiv.org/content/10.1...
You can also read more on the STAMP technology in @natrevgenet.nature.com: www.nature.com/articles/s41... 🧪
You can also read more on the STAMP technology in @natrevgenet.nature.com: www.nature.com/articles/s41... 🧪
Very interesting talk by @orrlaboratory.bsky.social at #EMBLSpatialBiology. In preparation, I read their recent paper, and found some decent astrocyte signalling and proteinopathy in it 👇🏻👇🏻 www.sciencedirect.com/science/arti... 🧪
Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology
Alterations in transactivating response region DNA-binding protein 43 (TDP-43) are prevalent in amyotrophic lateral sclerosis (ALS), frontotemporal de…
www.sciencedirect.com
October 17, 2025 at 8:16 AM
Very interesting talk by @orrlaboratory.bsky.social at #EMBLSpatialBiology. In preparation, I read their recent paper, and found some decent astrocyte signalling and proteinopathy in it 👇🏻👇🏻 www.sciencedirect.com/science/arti... 🧪
Clostridium butyricum targets colorectal cancer via secD–GRP78. Suppression of IL-6 reactivates CD8⁺ T cells & boosts anti-PD-1. Validated in humanized mice and patient organoids in co-culture with tumor-infiltrating lymphocytes: doi.org/10.1016/j.cc... 🧪 @cp-cancercell.bsky.social
Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression
Most colorectal cancer (CRC) patients do not respond to immune checkpoint blockade (ICB) therapy. Here, we identify Clostridium butyricum as a probiot…
doi.org
October 16, 2025 at 6:00 AM
Clostridium butyricum targets colorectal cancer via secD–GRP78. Suppression of IL-6 reactivates CD8⁺ T cells & boosts anti-PD-1. Validated in humanized mice and patient organoids in co-culture with tumor-infiltrating lymphocytes: doi.org/10.1016/j.cc... 🧪 @cp-cancercell.bsky.social
Awesome talk by @halloulab.bsky.social at #EMBLSpatialBiology. May the force be with you in biophysical phenotypes of spatial transcriptomics; out now in @natmethods.nature.com: www.nature.com/articles/s41... 🧪
A computational pipeline for spatial mechano-transcriptomics - Nature Methods
The authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic and mechanical state.
www.nature.com
October 15, 2025 at 1:58 PM
Awesome talk by @halloulab.bsky.social at #EMBLSpatialBiology. May the force be with you in biophysical phenotypes of spatial transcriptomics; out now in @natmethods.nature.com: www.nature.com/articles/s41... 🧪
Stunning, what @sabrinalewis.bsky.social just showed at #EMBLSpatialBiology! LeGO depicts cell populations in lung metastases in 3D: www.researchsquare.com/article/rs-6... 🧪 Soon out in npj Imaging @natureportfolio.nature.com
LeGO-3D: 3D imaging of lung metastases and vascularisation using light sheet fluorescence microscopy
Cancer metastasis involves a complex cascade of events, where cancer cells migrate from their site of origin to secondary sites via the lymphatic and circulatory system. During this process, some canc...
www.researchsquare.com
October 15, 2025 at 12:33 PM
Stunning, what @sabrinalewis.bsky.social just showed at #EMBLSpatialBiology! LeGO depicts cell populations in lung metastases in 3D: www.researchsquare.com/article/rs-6... 🧪 Soon out in npj Imaging @natureportfolio.nature.com
🧬 miR-10a liposomes rewire macrophage mitochondrial metabolism (↑OXPHOS), boost H3 acetylation, inducing epigenetic M1→M2 shift. Liposome injection leads to shrinkage of plaques in ApoE−/− mice. Fei Fang et al. in @natcomms.nature.com: doi.org/10.1038/s414... 🧪
Reprogramming mitochondrial metabolism and epigenetics of macrophages via miR-10a liposomes for atherosclerosis therapy
Nature Communications - This study shows that restoring mitochondrial respiration in atherosclerotic macrophages reopens their chromatin, enabling phenotype reprogramming. Using targeted liposomes...
doi.org
October 15, 2025 at 10:27 AM
🧬 miR-10a liposomes rewire macrophage mitochondrial metabolism (↑OXPHOS), boost H3 acetylation, inducing epigenetic M1→M2 shift. Liposome injection leads to shrinkage of plaques in ApoE−/− mice. Fei Fang et al. in @natcomms.nature.com: doi.org/10.1038/s414... 🧪
Really cool talk (even though confidential) by @pathologop.bsky.social at #EMBLSpatialBiology!
So let's look at his tumour histopathology “glossary” for AI developers in @plos.org Comp Biol:
journals.plos.org/ploscompbiol... 🧪
So let's look at his tumour histopathology “glossary” for AI developers in @plos.org Comp Biol:
journals.plos.org/ploscompbiol... 🧪
The tumour histopathology “glossary” for AI developers
The applications of artificial intelligence (AI) and deep learning (DL) are leading to significant advances in cancer research, particularly in analysing histopathology images for prognostic and treat...
journals.plos.org
October 15, 2025 at 9:29 AM
Really cool talk (even though confidential) by @pathologop.bsky.social at #EMBLSpatialBiology!
So let's look at his tumour histopathology “glossary” for AI developers in @plos.org Comp Biol:
journals.plos.org/ploscompbiol... 🧪
So let's look at his tumour histopathology “glossary” for AI developers in @plos.org Comp Biol:
journals.plos.org/ploscompbiol... 🧪
Very cool talk by @aruthak.bsky.social at #EMBLSpatialBiology!
Spatial signatures predict immunotherapy outcome in non-small cell lung cancer, out in @natgenet.nature.com: www.nature.com/articles/s41... 🧪
Spatial signatures predict immunotherapy outcome in non-small cell lung cancer, out in @natgenet.nature.com: www.nature.com/articles/s41... 🧪
Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer - Nature Genetics
This study uses spatial proteomic and spatial compartment-based whole-transcriptome profiling to develop predictive models for immunotherapy outcomes in non-small cell lung cancer.
www.nature.com
October 15, 2025 at 7:28 AM
Very cool talk by @aruthak.bsky.social at #EMBLSpatialBiology!
Spatial signatures predict immunotherapy outcome in non-small cell lung cancer, out in @natgenet.nature.com: www.nature.com/articles/s41... 🧪
Spatial signatures predict immunotherapy outcome in non-small cell lung cancer, out in @natgenet.nature.com: www.nature.com/articles/s41... 🧪
Ressource of chronic sinus inflammation shows that M2-like macrophages attract eosinophils, mast and tuft (!) cells amplifying Th2 response. Airway stem cells drive tissue remodeling; effects are reduced by dupilumab. @cp-immunity.bsky.social by Guanrui Liao et al. doi.org/10.1016/j.im... 🧪
Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation
Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease of the sinonasal cavity affecting millions worldwide. Its complex pathophysiolog…
doi.org
October 15, 2025 at 7:27 AM
Ressource of chronic sinus inflammation shows that M2-like macrophages attract eosinophils, mast and tuft (!) cells amplifying Th2 response. Airway stem cells drive tissue remodeling; effects are reduced by dupilumab. @cp-immunity.bsky.social by Guanrui Liao et al. doi.org/10.1016/j.im... 🧪
The one-and-only @hoheyn.bsky.social showcases "the power of millions" using (sub-)STAMP Imaging at #EMBLSpatialBiology @cp-cell.bsky.social
www.cell.com/cell/fulltex... 🧪
www.cell.com/cell/fulltex... 🧪
STAMP: Single-cell transcriptomics analysis and multimodal profiling through imaging
Single-cell transcriptomics analysis and multimodal profiling (STAMP) by imaging enables
single-cell analysis of cells in suspension without the need for sequencing. The markedly
reduced costs and fle...
www.cell.com
October 14, 2025 at 12:39 PM
The one-and-only @hoheyn.bsky.social showcases "the power of millions" using (sub-)STAMP Imaging at #EMBLSpatialBiology @cp-cell.bsky.social
www.cell.com/cell/fulltex... 🧪
www.cell.com/cell/fulltex... 🧪
Too bad I couldn’t make it in person to beautiful Heidelberg, but virtual participation from home is definitely the second-best option! #EMBLSpatialBiology
October 14, 2025 at 11:33 AM
Too bad I couldn’t make it in person to beautiful Heidelberg, but virtual participation from home is definitely the second-best option! #EMBLSpatialBiology
I just gave an impulse presentation at our bAIome here 🤓
October 14, 2025 at 10:25 AM
I just gave an impulse presentation at our bAIome here 🤓
Adipose tissue (AT) macrophages in space and time: Nerve-associated macs (NAMs) in AT sustain metabolic balance and curb inflammaging. Loss of these impairs lipolysis and drives age-related inflammation.
From the lab of Vishwa Deep Dixit, out in @nataging.nature.com: doi.org/10.1038/s435... 🧪
From the lab of Vishwa Deep Dixit, out in @nataging.nature.com: doi.org/10.1038/s435... 🧪
Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation
Nature Aging - Gonzalez-Hurtado, Leveau and colleagues characterize adipose resident tissue macrophages across lifespan in mice, finding that nerve-associated macrophages, which mitigate...
doi.org
October 14, 2025 at 8:06 AM
Adipose tissue (AT) macrophages in space and time: Nerve-associated macs (NAMs) in AT sustain metabolic balance and curb inflammaging. Loss of these impairs lipolysis and drives age-related inflammation.
From the lab of Vishwa Deep Dixit, out in @nataging.nature.com: doi.org/10.1038/s435... 🧪
From the lab of Vishwa Deep Dixit, out in @nataging.nature.com: doi.org/10.1038/s435... 🧪
Eislmayr et al. find neutrophils are *not* key to clearing Shigella. Instead, macrophages trigger IL-12 → IFN-γ, restricting bacterial replication in intestinal epithelial cells. New innate immunity from the lab of Russell Vance in @cp-cellhostmicrobe.bsky.social
doi.org/10.1016/j.ch... 🧪
doi.org/10.1016/j.ch... 🧪
Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ
Bacteria of the genus Shigella replicate in intestinal epithelial cells and cause shigellosis, a severe diarrheal disease that resolves spontaneously …
doi.org
October 11, 2025 at 8:33 AM
Eislmayr et al. find neutrophils are *not* key to clearing Shigella. Instead, macrophages trigger IL-12 → IFN-γ, restricting bacterial replication in intestinal epithelial cells. New innate immunity from the lab of Russell Vance in @cp-cellhostmicrobe.bsky.social
doi.org/10.1016/j.ch... 🧪
doi.org/10.1016/j.ch... 🧪
Great reference to get up to speed on B cells in IBD from our good friend @ejvillablanca.bsky.social
TL;DR B cells aren’t just bystanders in IBD, they’re active players in both gut protection, pathology and mucosal healing.
doi.org/10.1016/j.im... 🧪
TL;DR B cells aren’t just bystanders in IBD, they’re active players in both gut protection, pathology and mucosal healing.
doi.org/10.1016/j.im... 🧪
B cells in inflammatory bowel disease
Inflammatory bowel diseases (IBD) have traditionally been considered T cell-driven disorders; however, accumulating evidence challenges this view and …
doi.org
October 10, 2025 at 7:22 AM
Great reference to get up to speed on B cells in IBD from our good friend @ejvillablanca.bsky.social
TL;DR B cells aren’t just bystanders in IBD, they’re active players in both gut protection, pathology and mucosal healing.
doi.org/10.1016/j.im... 🧪
TL;DR B cells aren’t just bystanders in IBD, they’re active players in both gut protection, pathology and mucosal healing.
doi.org/10.1016/j.im... 🧪
Late to the party, but: Host-oxidized phospholipids (oxPLs) form during infection & epigenetically silence IL-10 via AKT→EZH2→H3K27me3, driving lethal inflammation. Blocking oxPLs boosts IL-10 + survival. Kudos, @lozanzi.bsky.social; out in @cp-immunity.bsky.social:
doi.org/10.1016/j.im... 🧪
doi.org/10.1016/j.im... 🧪
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
Phagocytes initiate immunity to invading microorganisms by detecting pathogen-associated molecular patterns via pattern recognition receptors. Pathoge…
doi.org
October 9, 2025 at 6:21 AM
Late to the party, but: Host-oxidized phospholipids (oxPLs) form during infection & epigenetically silence IL-10 via AKT→EZH2→H3K27me3, driving lethal inflammation. Blocking oxPLs boosts IL-10 + survival. Kudos, @lozanzi.bsky.social; out in @cp-immunity.bsky.social:
doi.org/10.1016/j.im... 🧪
doi.org/10.1016/j.im... 🧪
And another LYVE1⁺ macrophages! Here at septa of white fat, which guide adipocyte stem cells toward "white" fate via TGFβ1. Depleting septal LYVE1⁺ macrophages boosts beiging and counteracts obesity.
From labs of Florent Ginhoux & Svetoslav Chakarov @science.org
doi.org/10.1126/scie... 🧪
From labs of Florent Ginhoux & Svetoslav Chakarov @science.org
doi.org/10.1126/scie... 🧪
Septal LYVE1+ macrophages control adipocyte stem cell adipogenic potential
Tissue macrophages reside in anatomically distinct subtissular niches that shape their identity and function. In white adipose tissue (WAT), we identified three macrophage populations with distinct localization, turnover, and phenotypes. Septal adipose ...
doi.org
October 8, 2025 at 11:40 AM
And another LYVE1⁺ macrophages! Here at septa of white fat, which guide adipocyte stem cells toward "white" fate via TGFβ1. Depleting septal LYVE1⁺ macrophages boosts beiging and counteracts obesity.
From labs of Florent Ginhoux & Svetoslav Chakarov @science.org
doi.org/10.1126/scie... 🧪
From labs of Florent Ginhoux & Svetoslav Chakarov @science.org
doi.org/10.1126/scie... 🧪
Oral HO-1 inhibitor KCL-HO-1i targets LYVE-1+ perivascular TAMs, turns “cold” tumors hot, and synergizes with gemcitabine/5-FU to boost CD8+ T cells in mice, with low toxicity. Science Translational Medicine paper from the labs of Khondaker Miraz Rahman & James N. Arnold: www.science.org/doi/... 🧪
An oral heme oxygenase inhibitor targets immunosuppressive perivascular macrophages in preclinical models of cancer
A small-molecule heme oxygenase inhibitor disrupts perivascular macrophage–mediated suppression of T cell responses in preclinical models of cancer.
www.science.org
October 8, 2025 at 7:11 AM
Oral HO-1 inhibitor KCL-HO-1i targets LYVE-1+ perivascular TAMs, turns “cold” tumors hot, and synergizes with gemcitabine/5-FU to boost CD8+ T cells in mice, with low toxicity. Science Translational Medicine paper from the labs of Khondaker Miraz Rahman & James N. Arnold: www.science.org/doi/... 🧪
Myeloid-specific CAMKK2 deficiency protects against diet-induced obesity and insulin resistance by rewiring metabolic gene expression and enhancing energy expenditure
www.sciencedirect.com/science/arti... 🧪
www.sciencedirect.com/science/arti... 🧪
Myeloid-specific CAMKK2 deficiency protects against diet-induced obesity and insulin resistance by rewiring metabolic gene expression and enhancing energy expenditure
Obesity is associated with chronic, low-grade inflammation in metabolic tissues such as liver, adipose tissue and skeletal muscle implicating insulin …
www.sciencedirect.com
October 8, 2025 at 5:59 AM
Myeloid-specific CAMKK2 deficiency protects against diet-induced obesity and insulin resistance by rewiring metabolic gene expression and enhancing energy expenditure
www.sciencedirect.com/science/arti... 🧪
www.sciencedirect.com/science/arti... 🧪
Clair Crewe et al. offer a roadmap for studying extracellular vesicles (EVs), emphasizing plasma preparation, lipoprotein clearance, accurate particle dosing, and uptake validation to ensure reproducible results. @natmetabolism.nature.com doi.org/10.1038/s422... 🧪
A brief guide to studying extracellular vesicle function in the context of metabolism
Nature Metabolism - Extracellular vesicles (EVs) are now recognized as powerful modulators of metabolism, and thus the new field of EV-mediated metabolic regulation is growing exponentially. Here,...
doi.org
October 7, 2025 at 6:16 AM
Clair Crewe et al. offer a roadmap for studying extracellular vesicles (EVs), emphasizing plasma preparation, lipoprotein clearance, accurate particle dosing, and uptake validation to ensure reproducible results. @natmetabolism.nature.com doi.org/10.1038/s422... 🧪