Guillaume Bourque
@guilbourque.bsky.social
Prof in Human Genetics at McGill, Director of Bioinformatics at the McGill Genome Center and Director of @C3Genomics
https://computationalgenomics.ca/BourqueLab/
https://computationalgenomics.ca/BourqueLab/
Such a great @ga4gh.org meeting in Uppsala this past week. Genomics, with the help of GA4GH standards and policies, is really moving into the Age of Implementation globally!
October 11, 2025 at 4:26 AM
Such a great @ga4gh.org meeting in Uppsala this past week. Genomics, with the help of GA4GH standards and policies, is really moving into the Age of Implementation globally!
The most interesting finding was that in the child, paternally transmitted alleles were significantly longer than age-matched maternal ones (Δmean = 409 bp), particularly when from older parents (Δmean = 698 bp, p = 8.9e-05).
October 9, 2025 at 5:33 AM
The most interesting finding was that in the child, paternally transmitted alleles were significantly longer than age-matched maternal ones (Δmean = 409 bp), particularly when from older parents (Δmean = 698 bp, p = 8.9e-05).
It got really interesting when we started to do allelic tracing since we had trio data. Amazing to be able to do it by eye in some cases and then @davidlougheed.bsky.social helped us build a tool called TeloScore to apply it to all the families we had.
October 9, 2025 at 5:33 AM
It got really interesting when we started to do allelic tracing since we had trio data. Amazing to be able to do it by eye in some cases and then @davidlougheed.bsky.social helped us build a tool called TeloScore to apply it to all the families we had.
We were able to confirm that different chromosome arms have different length distribution, consistent with what was reported in Karimian et al 2024. We also observed the expected age-related length decrease.
October 9, 2025 at 5:33 AM
We were able to confirm that different chromosome arms have different length distribution, consistent with what was reported in Karimian et al 2024. We also observed the expected age-related length decrease.
🚨 New paper alert on telomeres! 🚨
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
October 9, 2025 at 5:33 AM
🚨 New paper alert on telomeres! 🚨
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.
So inspiring to run with Darryl Fox to support Terry’s dream and the @marathonofhope.bsky.social
September 27, 2025 at 12:52 PM
So inspiring to run with Darryl Fox to support Terry’s dream and the @marathonofhope.bsky.social
Excited for the start of the Croucher Retrotransposons meeting organized by Danny Leung in Hong Kong. First speaker, the King of Krabs!
projects.croucher.org.hk/advanced-stu...
projects.croucher.org.hk/advanced-stu...
August 11, 2025 at 2:19 AM
Excited for the start of the Croucher Retrotransposons meeting organized by Danny Leung in Hong Kong. First speaker, the King of Krabs!
projects.croucher.org.hk/advanced-stu...
projects.croucher.org.hk/advanced-stu...
The issue that jumped at us in the current annotation of young LTR subfamilies in human, is that there was lot of variability in divergence rate (sometimes bimodal). That's what we tried to improve.
July 30, 2025 at 5:26 PM
The issue that jumped at us in the current annotation of young LTR subfamilies in human, is that there was lot of variability in divergence rate (sometimes bimodal). That's what we tried to improve.
Bye bye magical Kyoto, see you next time!
April 10, 2025 at 7:04 AM
Bye bye magical Kyoto, see you next time!
Check out the new STR tool from @davidlougheed.bsky.social in the group! Works with both PacBio and Nanopore!
April 1, 2025 at 7:15 AM
Check out the new STR tool from @davidlougheed.bsky.social in the group! Works with both PacBio and Nanopore!
Back in Barbados!
January 5, 2025 at 3:08 PM
Back in Barbados!
Two months ago, Jeffrey from lab also became Dr. Hyacinthe!
His thesis was: "An Atlas of Transposable Elements Associated
with the Epigenome Across Human Cell Types"
His thesis was: "An Atlas of Transposable Elements Associated
with the Epigenome Across Human Cell Types"
December 11, 2024 at 6:56 AM
Two months ago, Jeffrey from lab also became Dr. Hyacinthe!
His thesis was: "An Atlas of Transposable Elements Associated
with the Epigenome Across Human Cell Types"
His thesis was: "An Atlas of Transposable Elements Associated
with the Epigenome Across Human Cell Types"
Congratulations to the newly minted Dr. Zhuang! Well done!
His thesis was about: "Unveiling Sex-Biased Patterns in RNA
Expression and DNA Methylation in Mice Organs".
His thesis was about: "Unveiling Sex-Biased Patterns in RNA
Expression and DNA Methylation in Mice Organs".
December 11, 2024 at 6:45 AM
Congratulations to the newly minted Dr. Zhuang! Well done!
His thesis was about: "Unveiling Sex-Biased Patterns in RNA
Expression and DNA Methylation in Mice Organs".
His thesis was about: "Unveiling Sex-Biased Patterns in RNA
Expression and DNA Methylation in Mice Organs".
