Gioele La Manno
@gioelelamanno.bsky.social
Professor at #EPFL - #RNAVelocity inventor - Laboratory of Brain Development and Biological Data Science. Single-cell and spatial biologist studying brain development and lipids. #ERCStg investigator
Reposted by Gioele La Manno
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 7:09 AM
Reposted by Gioele La Manno
This is a massive undertaking by a courageous group of experimentalists and computational scientists. I am honored to have contributed to this. #lipidtime chenges time zone today
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 7:35 AM
This is a massive undertaking by a courageous group of experimentalists and computational scientists. I am honored to have contributed to this. #lipidtime chenges time zone today
Reposted by Gioele La Manno
We're very much looking forward to your talk!
I am boarding a plane headed to @vibai.bsky.social. Super excited to present the culmination of one of the most exciting projects of recent years, as well as introducing my new vision of an #AI-powered #Brain #Atlas
October 16, 2025 at 7:36 AM
We're very much looking forward to your talk!
Reposted by Gioele La Manno
Fantastic Gioele!
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 7:47 AM
Fantastic Gioele!
Reposted by Gioele La Manno
Wow!
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 9:29 AM
Wow!
Reposted by Gioele La Manno
This is truly great work -and will be a fantastic resource for the community!
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 9:41 AM
This is truly great work -and will be a fantastic resource for the community!
Reposted by Gioele La Manno
🎉🎉🎉🎉🎉
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 11:01 AM
🎉🎉🎉🎉🎉
Reposted by Gioele La Manno
Amazing work Gioele et al. Your talk about the lipid brain atlas and how it connects within a grand vision, this morning at VIB.ai, was truly spectacular. We were honoured to hear the story on the day of the preprint :)
October 16, 2025 at 11:18 AM
Amazing work Gioele et al. Your talk about the lipid brain atlas and how it connects within a grand vision, this morning at VIB.ai, was truly spectacular. We were honoured to hear the story on the day of the preprint :)
Reposted by Gioele La Manno
Happy to finally see The Lipid Brain Atlas out! Lipids are not boring at all so, check it out!
Amazing team effort between computational and experimental work, led by @lucafusarbassini.bsky.social with @gioelelamanno.bsky.social and @giodang.bsky.social labs. Proud to be part of it.
Lipids rule!
Amazing team effort between computational and experimental work, led by @lucafusarbassini.bsky.social with @gioelelamanno.bsky.social and @giodang.bsky.social labs. Proud to be part of it.
Lipids rule!
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 12:32 PM
Happy to finally see The Lipid Brain Atlas out! Lipids are not boring at all so, check it out!
Amazing team effort between computational and experimental work, led by @lucafusarbassini.bsky.social with @gioelelamanno.bsky.social and @giodang.bsky.social labs. Proud to be part of it.
Lipids rule!
Amazing team effort between computational and experimental work, led by @lucafusarbassini.bsky.social with @gioelelamanno.bsky.social and @giodang.bsky.social labs. Proud to be part of it.
Lipids rule!
Reposted by Gioele La Manno
Fantastic story! Congratulations to everyone involved!
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 3:49 PM
Fantastic story! Congratulations to everyone involved!
Reposted by Gioele La Manno
Such a treat to host @gioelelamanno.bsky.social (EPFL) today and be the first to hear more about his lab's latest work, posted just two days ago on bioRxiv.
Missed the talk?
Here's the preprint: https://www.biorxiv.org/content/10.1101/2025.10.13.682018v1
Missed the talk?
Here's the preprint: https://www.biorxiv.org/content/10.1101/2025.10.13.682018v1
October 16, 2025 at 3:52 PM
Such a treat to host @gioelelamanno.bsky.social (EPFL) today and be the first to hear more about his lab's latest work, posted just two days ago on bioRxiv.
Missed the talk?
Here's the preprint: https://www.biorxiv.org/content/10.1101/2025.10.13.682018v1
Missed the talk?
Here's the preprint: https://www.biorxiv.org/content/10.1101/2025.10.13.682018v1
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
I am boarding a plane headed to @vibai.bsky.social. Super excited to present the culmination of one of the most exciting projects of recent years, as well as introducing my new vision of an #AI-powered #Brain #Atlas
October 15, 2025 at 4:06 PM
I am boarding a plane headed to @vibai.bsky.social. Super excited to present the culmination of one of the most exciting projects of recent years, as well as introducing my new vision of an #AI-powered #Brain #Atlas
I am deeply honoured to have been recognized by the European Research Council with a #StartingGrant. @erc.europa.eu
With this support, my team and I will launch #MOVIOLA. Our goal is to understand how human neural progenitors decide their fate during brain development.
With this support, my team and I will launch #MOVIOLA. Our goal is to understand how human neural progenitors decide their fate during brain development.
Two life sciences ERC Starting Grants at EPFL
Milena Schuhmacher and Gioele La Manno at EPFL’s School of Life Sciences have received European Research Council (ERC) Starting Grants. Former EPFL researcher Can Aztekin (now at Max Planck), is also ...
actu.epfl.ch
September 4, 2025 at 2:38 PM
I am deeply honoured to have been recognized by the European Research Council with a #StartingGrant. @erc.europa.eu
With this support, my team and I will launch #MOVIOLA. Our goal is to understand how human neural progenitors decide their fate during brain development.
With this support, my team and I will launch #MOVIOLA. Our goal is to understand how human neural progenitors decide their fate during brain development.
Reposted by Gioele La Manno
uMAIA offers an analytical framework designed to enable construction of high-resolution metabolic atlases using mass spec imaging data. @gioelelamanno.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Unified mass imaging maps the lipidome of vertebrate development - Nature Methods
uMAIA is an analytical framework designed to enable the construction of metabolic atlases at high resolution using mass spectrometry imaging data.
www.nature.com
September 3, 2025 at 4:59 PM
uMAIA offers an analytical framework designed to enable construction of high-resolution metabolic atlases using mass spec imaging data. @gioelelamanno.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Excited to share #uMAIA, our method to create 4D lipidomic atlases, now published in @natmethods.nature.com
We demonstrate that with uMAIA, the field is ready for atlas-level analyses capable of uncovering histological metabolic heterogeneity in both space and time. [1/2]
We demonstrate that with uMAIA, the field is ready for atlas-level analyses capable of uncovering histological metabolic heterogeneity in both space and time. [1/2]
Unified mass imaging maps the lipidome of vertebrate development - Nature Methods
uMAIA is an analytical framework designed to enable the construction of metabolic atlases at high resolution using mass spectrometry imaging data.
www.nature.com
September 3, 2025 at 4:16 PM
Excited to share #uMAIA, our method to create 4D lipidomic atlases, now published in @natmethods.nature.com
We demonstrate that with uMAIA, the field is ready for atlas-level analyses capable of uncovering histological metabolic heterogeneity in both space and time. [1/2]
We demonstrate that with uMAIA, the field is ready for atlas-level analyses capable of uncovering histological metabolic heterogeneity in both space and time. [1/2]
Reposted by Gioele La Manno
And he made it again!...tour the force from JIa-Wei´s Wang lab using comparative sc-transcriptomes, and developing new analytical tools, to tackle evolutionary trajectories of plant cell types!. Amazing work as usual! www.cell.com/cell/abstrac...
A unified cell atlas of vascular plants reveals cell-type foundational genes and accelerates gene discovery
A cross-species single-cell atlas highlights a core subset of cell-type foundational
genes associated with major vascular plant cell types, enabling the identification
of hidden cell types and the dev...
www.cell.com
August 20, 2025 at 3:50 PM
And he made it again!...tour the force from JIa-Wei´s Wang lab using comparative sc-transcriptomes, and developing new analytical tools, to tackle evolutionary trajectories of plant cell types!. Amazing work as usual! www.cell.com/cell/abstrac...
Reposted by Gioele La Manno
A little over two weeks to the deadline! 20 positions, generous startup funding, a great community and fantastic infrastructure. Come join us!
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
🔗 All positions: ki.se/en/about-ki/...
August 15, 2025 at 9:23 PM
A little over two weeks to the deadline! 20 positions, generous startup funding, a great community and fantastic infrastructure. Come join us!
Reposted by Gioele La Manno
Join us at the FENS Single-Cell & Spatial Omics Winter School with:
@sarabiz86.bsky.social
@rongfan8.bsky.social
@gokcegroup.bsky.social
@gioelelamanno.bsky.social
@sj-marzi.bsky.social
@jplopez-atalaya.bsky.social
Ana Falcão
Florian Rosenberger
Gabriel Baró
Bosiljka Tasic
Barbara Treutlein
@sarabiz86.bsky.social
@rongfan8.bsky.social
@gokcegroup.bsky.social
@gioelelamanno.bsky.social
@sj-marzi.bsky.social
@jplopez-atalaya.bsky.social
Ana Falcão
Florian Rosenberger
Gabriel Baró
Bosiljka Tasic
Barbara Treutlein
🌟 Registration is now OPEN! 🌟
Join the 2025-2026 #FENS-Hertie #WinterSchool and explore this year's topic – Single-cell and Spatial Omics to Understand Brain Heterogeneity! 🔬
📍 Alicante, Spain
🗓️ 11-17 Jan 2026
🔗 https://loom.ly/RM55lFQ
Join the 2025-2026 #FENS-Hertie #WinterSchool and explore this year's topic – Single-cell and Spatial Omics to Understand Brain Heterogeneity! 🔬
📍 Alicante, Spain
🗓️ 11-17 Jan 2026
🔗 https://loom.ly/RM55lFQ
August 12, 2025 at 11:24 AM
Join us at the FENS Single-Cell & Spatial Omics Winter School with:
@sarabiz86.bsky.social
@rongfan8.bsky.social
@gokcegroup.bsky.social
@gioelelamanno.bsky.social
@sj-marzi.bsky.social
@jplopez-atalaya.bsky.social
Ana Falcão
Florian Rosenberger
Gabriel Baró
Bosiljka Tasic
Barbara Treutlein
@sarabiz86.bsky.social
@rongfan8.bsky.social
@gokcegroup.bsky.social
@gioelelamanno.bsky.social
@sj-marzi.bsky.social
@jplopez-atalaya.bsky.social
Ana Falcão
Florian Rosenberger
Gabriel Baró
Bosiljka Tasic
Barbara Treutlein
Reposted by Gioele La Manno
An analysis shows that current deep learning models do not beat linear baselines in predicting gene perturbation effects, thus emphasizing the importance of further method development and evaluation. @const-ae.bsky.social @wkhuber.bsky.social @s-anders.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines - Nature Methods
The analysis presented in this Brief Communication shows that, despite their complexity, current deep learning models do not outperform linear baselines in predicting gene perturbation effects, thus e...
www.nature.com
August 4, 2025 at 4:07 PM
An analysis shows that current deep learning models do not beat linear baselines in predicting gene perturbation effects, thus emphasizing the importance of further method development and evaluation. @const-ae.bsky.social @wkhuber.bsky.social @s-anders.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Gioele La Manno
Hey, it's out!
doi.org/10.1016/j.ce... Aligning Big Brains and Atlases, ABBA in short, is published in Cell Reports @cp-cellreports.bsky.social . @biancasilvalab.bsky.social's lab added an analysis pipeline on top of it (BraiAn) and did all the relevant biological work. What is it ? Short thread:
doi.org/10.1016/j.ce... Aligning Big Brains and Atlases, ABBA in short, is published in Cell Reports @cp-cellreports.bsky.social . @biancasilvalab.bsky.social's lab added an analysis pipeline on top of it (BraiAn) and did all the relevant biological work. What is it ? Short thread:
July 24, 2025 at 10:04 AM
Hey, it's out!
doi.org/10.1016/j.ce... Aligning Big Brains and Atlases, ABBA in short, is published in Cell Reports @cp-cellreports.bsky.social . @biancasilvalab.bsky.social's lab added an analysis pipeline on top of it (BraiAn) and did all the relevant biological work. What is it ? Short thread:
doi.org/10.1016/j.ce... Aligning Big Brains and Atlases, ABBA in short, is published in Cell Reports @cp-cellreports.bsky.social . @biancasilvalab.bsky.social's lab added an analysis pipeline on top of it (BraiAn) and did all the relevant biological work. What is it ? Short thread:
Reposted by Gioele La Manno
Wowee! Super-resolution stimulated X-ray Raman spectroscopy | Nature share.google/Mdn4Z0ddIy2t...
Super-resolution stimulated X-ray Raman spectroscopy - Nature
A high-resolution spectroscopic tool is demonstrated using the stochastically fluctuating intensity spikes in time and energy domains of a self-amplified spontaneous emission X-ray free-electron laser...
share.google
July 16, 2025 at 8:49 PM
Wowee! Super-resolution stimulated X-ray Raman spectroscopy | Nature share.google/Mdn4Z0ddIy2t...
Reposted by Gioele La Manno
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
www.biorxiv.org/content/10.1...
1/
July 15, 2025 at 8:11 AM
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
www.biorxiv.org/content/10.1...
1/
Reposted by Gioele La Manno
I love the idea of "micropublications" www.micropublication.org (preparing one now)
microPublication - Get Your Data Out, Be Cited
www.micropublication.org
July 14, 2025 at 8:29 AM
I love the idea of "micropublications" www.micropublication.org (preparing one now)
Reposted by Gioele La Manno
Super thrilled to give a full day #DeepLabCut Workshop in Okinawa today!
We had a packed house and everyone got models trained 🚀 - even then used #CEBRA 🦓 and/or #DLC2Action on the outputs!
Thank you #OIST for hosting us!! 🥳
We had a packed house and everyone got models trained 🚀 - even then used #CEBRA 🦓 and/or #DLC2Action on the outputs!
Thank you #OIST for hosting us!! 🥳
July 1, 2025 at 9:46 AM
Super thrilled to give a full day #DeepLabCut Workshop in Okinawa today!
We had a packed house and everyone got models trained 🚀 - even then used #CEBRA 🦓 and/or #DLC2Action on the outputs!
Thank you #OIST for hosting us!! 🥳
We had a packed house and everyone got models trained 🚀 - even then used #CEBRA 🦓 and/or #DLC2Action on the outputs!
Thank you #OIST for hosting us!! 🥳