Anton Goloborodko
@golobor.bsky.social
A bio-physicist turned phys-biologist,
building models and software in genome biology.
3D genome structure in mitosis | DNA repair | meiosis.
A group leader at @IMBA_Vienna.
Dad x2.
building models and software in genome biology.
3D genome structure in mitosis | DNA repair | meiosis.
A group leader at @IMBA_Vienna.
Dad x2.
Pinned
Anton Goloborodko
@golobor.bsky.social
· Jul 15
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
www.biorxiv.org/content/10.1...
1/
Reposted by Anton Goloborodko
Aarhus University is seeking a Tenure-Track Assistant/Associate Professor in Bioinformatics/Co… https://nat.au.dk/en/about-the-faculty/vacant-positions-and-career/job/tenure-track-assistant-professor-associate-professor-in-bioinformatics-and-or-computational-biology-at-aarhus-university-denmark #job
Tenure-Track Assistant Professor / Associate Professor in Bioinformatics and/or Computational Biology at Aarhus University, Denmark - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - BiRC - Bioinformatics Research Center, Aarhus University
nat.au.dk
February 7, 2026 at 11:11 PM
Aarhus University is seeking a Tenure-Track Assistant/Associate Professor in Bioinformatics/Co… https://nat.au.dk/en/about-the-faculty/vacant-positions-and-career/job/tenure-track-assistant-professor-associate-professor-in-bioinformatics-and-or-computational-biology-at-aarhus-university-denmark #job
Reposted by Anton Goloborodko
I’m very pleased to share our work looking at what controls condensin II cell-cycle dependant activity; a great collaboration with @eugenekimlab.bsky.social, @damlatetiker.bsky.social, Kyle Muir and Kumiko Samejima
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
February 4, 2026 at 3:57 PM
I’m very pleased to share our work looking at what controls condensin II cell-cycle dependant activity; a great collaboration with @eugenekimlab.bsky.social, @damlatetiker.bsky.social, Kyle Muir and Kumiko Samejima
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Anton Goloborodko
Terrific paper on a new chromosomal
compartment where extensive loop
extrusion isolates domains from
other such domains
compartment where extensive loop
extrusion isolates domains from
other such domains
How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Unique territorial and compartmental organization of chromosomes in the holocentric silkworm - The EMBO Journal
Hallmarks of multicellular eukaryotic genome organization are chromosome territories, compartments, and loop-extrusion-mediated structures, including TADs. However, these have mainly been observed in ...
link.springer.com
February 3, 2026 at 9:55 PM
Terrific paper on a new chromosomal
compartment where extensive loop
extrusion isolates domains from
other such domains
compartment where extensive loop
extrusion isolates domains from
other such domains
Reposted by Anton Goloborodko
Does targeting enzymes and substrates in a condensate lead to rate enhancement? No. Here, we investigate how the condensate environment can inhibit an enzyme reaction.
Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.
doi.org/10.64898/202...
Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.
doi.org/10.64898/202...
February 2, 2026 at 2:25 PM
Does targeting enzymes and substrates in a condensate lead to rate enhancement? No. Here, we investigate how the condensate environment can inhibit an enzyme reaction.
Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.
doi.org/10.64898/202...
Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.
doi.org/10.64898/202...
Nice!!! Congratulations!
February 3, 2026 at 6:27 AM
Nice!!! Congratulations!
Reposted by Anton Goloborodko
Still some time to register to this great meeting! Great science and great location for a very affordable registration cost!
Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you
International Symposium on Chromosome Dynamics from Structure to Cellular Function
www.fbs.osaka-u.ac.jp
January 28, 2026 at 1:10 PM
Still some time to register to this great meeting! Great science and great location for a very affordable registration cost!
Reposted by Anton Goloborodko
Seconded. If anything, it has never been a better time to be a biophysicist, a complex system physicists, etc…. And it is a bit sad that much of it now happens *outside* of physics departments (for good and bad reasons…)
At any rate, your usual reminder: when the science media, being less careful than Natalie, asks "Is physics in crisis?", they mean high-energy physics, done by a small proportion of physicists.
January 29, 2026 at 5:24 PM
Seconded. If anything, it has never been a better time to be a biophysicist, a complex system physicists, etc…. And it is a bit sad that much of it now happens *outside* of physics departments (for good and bad reasons…)
Yeah! This confuses me: "In 1992, under the direction of the FDA, Greek ophthalmologist Ioannis Pallikaris introduced LASIK to ten VISX centers." - that's a year before the accident?.. Again, i know literally nothing about the history of the process, but Wikipedia seems to mention many more names
January 29, 2026 at 9:20 AM
Yeah! This confuses me: "In 1992, under the direction of the FDA, Greek ophthalmologist Ioannis Pallikaris introduced LASIK to ten VISX centers." - that's a year before the accident?.. Again, i know literally nothing about the history of the process, but Wikipedia seems to mention many more names
Sounds cool, but wikipedia suggests that LASIK was invented by others (en.wikipedia.org/wiki/LASIK#H...), contradicting the header of the linked article. Could it be that Mourou's team came up with a modification of an already existing technique?.. (i know very little about any of this...)
January 29, 2026 at 8:31 AM
Sounds cool, but wikipedia suggests that LASIK was invented by others (en.wikipedia.org/wiki/LASIK#H...), contradicting the header of the linked article. Could it be that Mourou's team came up with a modification of an already existing technique?.. (i know very little about any of this...)
Reposted by Anton Goloborodko
Join us at the Evolutionary Biology Centre at Uppsala University. We’re searching for an Assistant Professor in Biology. www.uu.se/en/about-uu/...
January 28, 2026 at 8:28 PM
Join us at the Evolutionary Biology Centre at Uppsala University. We’re searching for an Assistant Professor in Biology. www.uu.se/en/about-uu/...
Reposted by Anton Goloborodko
You have a background in math/physics/computer science/ML and are looking for an interdisciplinary postdoc fellowship in life sciences with free choice of host groups? Then join us at the CSBD as an ELBE postdoc! The application deadline is the 13 of March
January 28, 2026 at 8:19 AM
You have a background in math/physics/computer science/ML and are looking for an interdisciplinary postdoc fellowship in life sciences with free choice of host groups? Then join us at the CSBD as an ELBE postdoc! The application deadline is the 13 of March
Reposted by Anton Goloborodko
Reposted by Anton Goloborodko
it is the same playbook everywhere. “vote for us! we will make you great again by punishing the people you hate! do not pay attention to the fact that we’re also shoveling your money into the pockets of the uber wealthy and building a giant boot to step on your face too (preferably forever)”
The UK version of “Project 2025” by the Reform party includes a British ICE, a concentration camp for 24,000 people, mass surveillance and withdrawing from refugee, anti-torture and anti-trafficking conventions.
It’s on their website. That’s how comfortable fascists are in the UK today.
It’s on their website. That’s how comfortable fascists are in the UK today.
January 28, 2026 at 12:23 AM
it is the same playbook everywhere. “vote for us! we will make you great again by punishing the people you hate! do not pay attention to the fact that we’re also shoveling your money into the pockets of the uber wealthy and building a giant boot to step on your face too (preferably forever)”
Reposted by Anton Goloborodko
www.wur.nl/en/vacancy/f...
Become our new colleague (and next door neighbor) and lead a chair/group/department of Biophysics at Wageningen University. Reach out to me for info and please spread!!!
Become our new colleague (and next door neighbor) and lead a chair/group/department of Biophysics at Wageningen University. Reach out to me for info and please spread!!!
Full Professor and Chair Laboratory of Biophysics
We are looking for a Full Professor in the Biophysics chair group, part of Wageningen University & Research (WUR)
www.wur.nl
January 28, 2026 at 5:20 AM
www.wur.nl/en/vacancy/f...
Become our new colleague (and next door neighbor) and lead a chair/group/department of Biophysics at Wageningen University. Reach out to me for info and please spread!!!
Become our new colleague (and next door neighbor) and lead a chair/group/department of Biophysics at Wageningen University. Reach out to me for info and please spread!!!
AI-pocalypse has come to academic publishing. The slop that we see on reddit or GitHub is now flooding journals. (See the whole thread).
I can't imagine that low-filter paper counting academic systems will survive this.
I can't imagine that low-filter paper counting academic systems will survive this.
We’re getting so many journal submissions from people who think ‘it kinda works’ is the standard to aim for.
1. The thing about science that these jokers don't understand is that science cannot be vibe-coded.
Whatever its flaws, the point with vibe coding is that you're trying to quickly make something that sorta works, where you can immediately sorta see if it sorta works and then sorta use it.
Whatever its flaws, the point with vibe coding is that you're trying to quickly make something that sorta works, where you can immediately sorta see if it sorta works and then sorta use it.
January 28, 2026 at 7:12 AM
AI-pocalypse has come to academic publishing. The slop that we see on reddit or GitHub is now flooding journals. (See the whole thread).
I can't imagine that low-filter paper counting academic systems will survive this.
I can't imagine that low-filter paper counting academic systems will survive this.
this is a **unique** opportunity - Daan de Groot, our new neighbor at @imbavienna.bsky.social , is hiring
Big news! At least for me. I'll start building my own research group at the amazing IMBA in Vienna. Starting from single-cell omics data, we will develop computational tools and theoretical models to understand how single cells make decisions, in particular during development. I think that IMBA is
January 27, 2026 at 2:56 PM
this is a **unique** opportunity - Daan de Groot, our new neighbor at @imbavienna.bsky.social , is hiring
Reposted by Anton Goloborodko
🚨 New preprint from the lab. Combining modeling and data analysis of SisterC data in yeast, we investigate cohesion of replicated chromosomes and show that sister chromatids are loosely and asymmetrically aligned in G2/M. Check the tweetorial below ⬇️ www.biorxiv.org/content/10.6...
www.biorxiv.org
January 26, 2026 at 4:38 PM
🚨 New preprint from the lab. Combining modeling and data analysis of SisterC data in yeast, we investigate cohesion of replicated chromosomes and show that sister chromatids are loosely and asymmetrically aligned in G2/M. Check the tweetorial below ⬇️ www.biorxiv.org/content/10.6...
stunning work by our neighbors at @fbzt.bsky.social lab
I’m happy to share the main result of my PhD, which you can find on bioRxiv www.biorxiv.org/content/10.6.... If you are interested in learning about a new way to perform DNA-PAINT multiplexing, which we call Combi-PAINT, or if you are interested in the study of mRNA conformation, keep reading! 1/10
January 26, 2026 at 12:15 PM
stunning work by our neighbors at @fbzt.bsky.social lab
Reposted by Anton Goloborodko
Have you wondered how the rules of chromatin folding have evolved? Well, this task is not easy to formalize. But here is our take on it: train species-specific DNA-to-chromatin encoder, apply to DNA of unseen species, and build chromatin rules-based tree of life. Have a look:
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
January 26, 2026 at 10:58 AM
Have you wondered how the rules of chromatin folding have evolved? Well, this task is not easy to formalize. But here is our take on it: train species-specific DNA-to-chromatin encoder, apply to DNA of unseen species, and build chromatin rules-based tree of life. Have a look:
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
Speedruning Ceaușescu
January 26, 2026 at 6:57 AM
Speedruning Ceaușescu
Reposted by Anton Goloborodko
As usual this time of year, started drafting the list of gene regulation conferences for 2026, enjoy! generegulation.org/conferences-...
Know of a relevant event that’s missing? Please reply below
Know of a relevant event that’s missing? Please reply below
Conferences & Schools – 2026 – Gene Regulation – Teif Lab
generegulation.org
December 29, 2025 at 3:29 PM
As usual this time of year, started drafting the list of gene regulation conferences for 2026, enjoy! generegulation.org/conferences-...
Know of a relevant event that’s missing? Please reply below
Know of a relevant event that’s missing? Please reply below
Reposted by Anton Goloborodko
Showing cross-racial solidarity is a potential death sentence. There are few things white supremacists hate more.
37 year old white male citizen with a lawful permit to carry a firearm, says the Minneapolis Police Department.
January 24, 2026 at 6:11 PM
Showing cross-racial solidarity is a potential death sentence. There are few things white supremacists hate more.
Reposted by Anton Goloborodko
Out now in @science.org Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development | Science www.science.org/doi/10.1126/...
Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development
Zygotic genome activation (ZGA) failure leads to developmental arrest and poses a clinical challenge to women’s fertility. We observed that human embryos arresting at the eight-cell ZGA stage exhibite...
www.science.org
January 22, 2026 at 10:46 PM
Out now in @science.org Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development | Science www.science.org/doi/10.1126/...
Can it be obtained commercially now (as opposed to when you looked into it)?
January 24, 2026 at 2:43 PM
Can it be obtained commercially now (as opposed to when you looked into it)?
Reposted by Anton Goloborodko
Honestly the best grocery store in the world, definitely the thing I miss most about Somerville
Legitimately hard to find the words to express my awe and admiration for the Somerville Market Basket…checkout line wrapped around to the butter section, probably 75 people in front me, and I was out of there in 15 minutes. Truly extraordinary vibes, unbelievable workers.
January 24, 2026 at 1:58 AM
Honestly the best grocery store in the world, definitely the thing I miss most about Somerville