Anton Goloborodko
@golobor.bsky.social
A bio-physicist turned phys-biologist,
building models and software in genome biology.
3D genome structure in mitosis | DNA repair | meiosis.
A group leader at @IMBA_Vienna.
Dad x2.
building models and software in genome biology.
3D genome structure in mitosis | DNA repair | meiosis.
A group leader at @IMBA_Vienna.
Dad x2.
Pinned
Anton Goloborodko
@golobor.bsky.social
· Jul 15
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
www.biorxiv.org/content/10.1...
1/
Reposted by Anton Goloborodko
Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳
mrc.tal.net/vx/mobile-0/...
mrc.tal.net/vx/mobile-0/...
Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Medical Research Council
Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55
mrc.tal.net
February 16, 2026 at 12:09 PM
Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳
mrc.tal.net/vx/mobile-0/...
mrc.tal.net/vx/mobile-0/...
🤯🤯🤯
This is a fascinating paper that reveals defined and clear mechanism for a phenomenon that for some seemed unbelievable- the up regulation of genes paralogous to those with specific types of inactivating mutations. This is called transcriptional adaptation 1/ www.science.org/doi/10.1126/...
Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation
Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...
www.science.org
February 16, 2026 at 7:06 AM
🤯🤯🤯
Reposted by Anton Goloborodko
The Faculty has recently opened a wide variety of PhD positions dealing with fascinating physical phenomena, from isotopes to spin waves and carbon nanotubes to low-dimensional materials!
⁉️Want to know more?⁉️ All the information in the link below 👇
🔗 a29.at/3k85aW
⁉️Want to know more?⁉️ All the information in the link below 👇
🔗 a29.at/3k85aW
Vienna Doctoral School in Physics
The Vienna Doctoral School in Physics (VDSP) was created as an intra-faculty physics graduate programme at the University of Vienna to establish faculty wide support and quality assurance in doctoral training, reinforce the spirit of excellence in research and teaching, strengthen synergies between all researchers through enhanced collaboration among the doctoral candidates, and provide international visibility in doctoral training.
a29.at
February 13, 2026 at 2:43 PM
The Faculty has recently opened a wide variety of PhD positions dealing with fascinating physical phenomena, from isotopes to spin waves and carbon nanotubes to low-dimensional materials!
⁉️Want to know more?⁉️ All the information in the link below 👇
🔗 a29.at/3k85aW
⁉️Want to know more?⁉️ All the information in the link below 👇
🔗 a29.at/3k85aW
Reposted by Anton Goloborodko
The demystification of piRNA clusters
if you wonder how cells generate piRNAs specifically against transposons & you are looking for a weekend read
check out @86dominik.bsky.social's opus magna (or Dominik's great thread)
a shared project with the one and only Rippei Hayashi, lab alumnus & friend
if you wonder how cells generate piRNAs specifically against transposons & you are looking for a weekend read
check out @86dominik.bsky.social's opus magna (or Dominik's great thread)
a shared project with the one and only Rippei Hayashi, lab alumnus & friend
How does the piRNA pathway solve the self vs. non-self problem? 🧬
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
A Naïve RNA Sampling Core Enables Adaptive piRNA Specificity Against Transposable Elements https://www.biorxiv.org/content/10.64898/2026.02.07.704324v1
February 13, 2026 at 8:39 PM
The demystification of piRNA clusters
if you wonder how cells generate piRNAs specifically against transposons & you are looking for a weekend read
check out @86dominik.bsky.social's opus magna (or Dominik's great thread)
a shared project with the one and only Rippei Hayashi, lab alumnus & friend
if you wonder how cells generate piRNAs specifically against transposons & you are looking for a weekend read
check out @86dominik.bsky.social's opus magna (or Dominik's great thread)
a shared project with the one and only Rippei Hayashi, lab alumnus & friend
Reposted by Anton Goloborodko
How does the piRNA pathway solve the self vs. non-self problem? 🧬
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
A Naïve RNA Sampling Core Enables Adaptive piRNA Specificity Against Transposable Elements https://www.biorxiv.org/content/10.64898/2026.02.07.704324v1
February 13, 2026 at 3:11 PM
How does the piRNA pathway solve the self vs. non-self problem? 🧬
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
Reposted by Anton Goloborodko
Why hasn't this paper gotten more attention?
A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
www.science.org
February 13, 2026 at 1:40 AM
Why hasn't this paper gotten more attention?
Reposted by Anton Goloborodko
In terms of what cures are being lost:
- Epstein-Barr virus is perhaps the major trigger for multiple sclerosis
- herpes simplex virus causes cold sores, genital herpes, infections in babies, deadly meningitis
- shingles virus causes an intensely painful disease
- Epstein-Barr virus is perhaps the major trigger for multiple sclerosis
- herpes simplex virus causes cold sores, genital herpes, infections in babies, deadly meningitis
- shingles virus causes an intensely painful disease
February 13, 2026 at 5:44 AM
In terms of what cures are being lost:
- Epstein-Barr virus is perhaps the major trigger for multiple sclerosis
- herpes simplex virus causes cold sores, genital herpes, infections in babies, deadly meningitis
- shingles virus causes an intensely painful disease
- Epstein-Barr virus is perhaps the major trigger for multiple sclerosis
- herpes simplex virus causes cold sores, genital herpes, infections in babies, deadly meningitis
- shingles virus causes an intensely painful disease
Reposted by Anton Goloborodko
Interested in transcriptional regulation, enhancers and 3D genome folding?
In this new study we wondered about the role of cohesin loading at enhancers for long-range transcriptional control
www.biorxiv.org/content/10.6...
detailed 🧵👇
In this new study we wondered about the role of cohesin loading at enhancers for long-range transcriptional control
www.biorxiv.org/content/10.6...
detailed 🧵👇
www.biorxiv.org
February 12, 2026 at 9:39 PM
Interested in transcriptional regulation, enhancers and 3D genome folding?
In this new study we wondered about the role of cohesin loading at enhancers for long-range transcriptional control
www.biorxiv.org/content/10.6...
detailed 🧵👇
In this new study we wondered about the role of cohesin loading at enhancers for long-range transcriptional control
www.biorxiv.org/content/10.6...
detailed 🧵👇
Reposted by Anton Goloborodko
Reposted by Anton Goloborodko
Happy birthday to one of my favourite haters, Charles Darwin
February 12, 2026 at 4:31 PM
Happy birthday to one of my favourite haters, Charles Darwin
Reposted by Anton Goloborodko
NOW LIVE!: PhD opening joint with @drjonbaxter.bsky.social at @gdsc-sussex.bsky.social
Get in touch and apply if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
www.sussex.ac.uk/study/fees-f...
Get in touch and apply if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
www.sussex.ac.uk/study/fees-f...
February 12, 2026 at 3:23 PM
NOW LIVE!: PhD opening joint with @drjonbaxter.bsky.social at @gdsc-sussex.bsky.social
Get in touch and apply if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
www.sussex.ac.uk/study/fees-f...
Get in touch and apply if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
www.sussex.ac.uk/study/fees-f...
Reposted by Anton Goloborodko
6th edition of the PSL Soft and Living Matter days, organized by the Grand programme Metasoft Matter, will take place from July 6th to July 8th, 2026 at IPGG.
February 12, 2026 at 9:20 AM
6th edition of the PSL Soft and Living Matter days, organized by the Grand programme Metasoft Matter, will take place from July 6th to July 8th, 2026 at IPGG.
Reposted by Anton Goloborodko
Unpopular opinion here (and I’m not even an AI booster, I’m mostly a skeptic), but I think a whole lot of people are overindexed on AI being the too-many-fingers-and-weird-teeth machine and aren’t accepting or even understanding that its output has generally been continuously improving.
I understand why people are exhausted by AI hype, and why those of us squarely in the corner of "human dignity uber alles" see AI doomerism as self-serving hype, but I *really* think people on the left broadly need to start thinking seriously about the possibiltiy of the hype being...true.
February 11, 2026 at 9:03 PM
Unpopular opinion here (and I’m not even an AI booster, I’m mostly a skeptic), but I think a whole lot of people are overindexed on AI being the too-many-fingers-and-weird-teeth machine and aren’t accepting or even understanding that its output has generally been continuously improving.
Reposted by Anton Goloborodko
Come on join us! We are searching for the next technical associate to join our lab ~Summer 2026.
This could be a great position for someone who is graduating this spring and is looking for 2 more years of research experience before starting their PhD:
careers.peopleclick.com/careerscp/cl...
This could be a great position for someone who is graduating this spring and is looking for 2 more years of research experience before starting their PhD:
careers.peopleclick.com/careerscp/cl...
February 11, 2026 at 9:09 PM
Come on join us! We are searching for the next technical associate to join our lab ~Summer 2026.
This could be a great position for someone who is graduating this spring and is looking for 2 more years of research experience before starting their PhD:
careers.peopleclick.com/careerscp/cl...
This could be a great position for someone who is graduating this spring and is looking for 2 more years of research experience before starting their PhD:
careers.peopleclick.com/careerscp/cl...
Reposted by Anton Goloborodko
And a new paper from the lab. A follow up to a previous study in which we elucidate the mechanism of the nuclear transport. Read the full story: www.nature.com/articles/s41...
February 11, 2026 at 5:12 PM
And a new paper from the lab. A follow up to a previous study in which we elucidate the mechanism of the nuclear transport. Read the full story: www.nature.com/articles/s41...
Reposted by Anton Goloborodko
Aarhus University is seeking a Tenure-Track Assistant/Associate Professor in Bioinformatics/Co… https://nat.au.dk/en/about-the-faculty/vacant-positions-and-career/job/tenure-track-assistant-professor-associate-professor-in-bioinformatics-and-or-computational-biology-at-aarhus-university-denmark #job
Tenure-Track Assistant Professor / Associate Professor in Bioinformatics and/or Computational Biology at Aarhus University, Denmark - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - BiRC - Bioinformatics Research Center, Aarhus University
nat.au.dk
February 7, 2026 at 11:11 PM
Aarhus University is seeking a Tenure-Track Assistant/Associate Professor in Bioinformatics/Co… https://nat.au.dk/en/about-the-faculty/vacant-positions-and-career/job/tenure-track-assistant-professor-associate-professor-in-bioinformatics-and-or-computational-biology-at-aarhus-university-denmark #job
Reposted by Anton Goloborodko
I’m very pleased to share our work looking at what controls condensin II cell-cycle dependant activity; a great collaboration with @eugenekimlab.bsky.social, @damlatetiker.bsky.social, Kyle Muir and Kumiko Samejima
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
February 4, 2026 at 3:57 PM
I’m very pleased to share our work looking at what controls condensin II cell-cycle dependant activity; a great collaboration with @eugenekimlab.bsky.social, @damlatetiker.bsky.social, Kyle Muir and Kumiko Samejima
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Anton Goloborodko
Terrific paper on a new chromosomal
compartment where extensive loop
extrusion isolates domains from
other such domains
compartment where extensive loop
extrusion isolates domains from
other such domains
How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Unique territorial and compartmental organization of chromosomes in the holocentric silkworm - The EMBO Journal
Hallmarks of multicellular eukaryotic genome organization are chromosome territories, compartments, and loop-extrusion-mediated structures, including TADs. However, these have mainly been observed in ...
link.springer.com
February 3, 2026 at 9:55 PM
Terrific paper on a new chromosomal
compartment where extensive loop
extrusion isolates domains from
other such domains
compartment where extensive loop
extrusion isolates domains from
other such domains
Reposted by Anton Goloborodko
Does targeting enzymes and substrates in a condensate lead to rate enhancement? No. Here, we investigate how the condensate environment can inhibit an enzyme reaction.
Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.
doi.org/10.64898/202...
Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.
doi.org/10.64898/202...
February 2, 2026 at 2:25 PM
Does targeting enzymes and substrates in a condensate lead to rate enhancement? No. Here, we investigate how the condensate environment can inhibit an enzyme reaction.
Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.
doi.org/10.64898/202...
Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.
doi.org/10.64898/202...
Reposted by Anton Goloborodko
Still some time to register to this great meeting! Great science and great location for a very affordable registration cost!
Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you
International Symposium on Chromosome Dynamics from Structure to Cellular Function
www.fbs.osaka-u.ac.jp
January 28, 2026 at 1:10 PM
Still some time to register to this great meeting! Great science and great location for a very affordable registration cost!
Reposted by Anton Goloborodko
Seconded. If anything, it has never been a better time to be a biophysicist, a complex system physicists, etc…. And it is a bit sad that much of it now happens *outside* of physics departments (for good and bad reasons…)
At any rate, your usual reminder: when the science media, being less careful than Natalie, asks "Is physics in crisis?", they mean high-energy physics, done by a small proportion of physicists.
January 29, 2026 at 5:24 PM
Seconded. If anything, it has never been a better time to be a biophysicist, a complex system physicists, etc…. And it is a bit sad that much of it now happens *outside* of physics departments (for good and bad reasons…)
Reposted by Anton Goloborodko
Join us at the Evolutionary Biology Centre at Uppsala University. We’re searching for an Assistant Professor in Biology. www.uu.se/en/about-uu/...
January 28, 2026 at 8:28 PM
Join us at the Evolutionary Biology Centre at Uppsala University. We’re searching for an Assistant Professor in Biology. www.uu.se/en/about-uu/...
Reposted by Anton Goloborodko
You have a background in math/physics/computer science/ML and are looking for an interdisciplinary postdoc fellowship in life sciences with free choice of host groups? Then join us at the CSBD as an ELBE postdoc! The application deadline is the 13 of March
January 28, 2026 at 8:19 AM
You have a background in math/physics/computer science/ML and are looking for an interdisciplinary postdoc fellowship in life sciences with free choice of host groups? Then join us at the CSBD as an ELBE postdoc! The application deadline is the 13 of March
Reposted by Anton Goloborodko
Reposted by Anton Goloborodko
it is the same playbook everywhere. “vote for us! we will make you great again by punishing the people you hate! do not pay attention to the fact that we’re also shoveling your money into the pockets of the uber wealthy and building a giant boot to step on your face too (preferably forever)”
The UK version of “Project 2025” by the Reform party includes a British ICE, a concentration camp for 24,000 people, mass surveillance and withdrawing from refugee, anti-torture and anti-trafficking conventions.
It’s on their website. That’s how comfortable fascists are in the UK today.
It’s on their website. That’s how comfortable fascists are in the UK today.
January 28, 2026 at 12:23 AM
it is the same playbook everywhere. “vote for us! we will make you great again by punishing the people you hate! do not pay attention to the fact that we’re also shoveling your money into the pockets of the uber wealthy and building a giant boot to step on your face too (preferably forever)”