Erin E. Cutts
@eecutts.bsky.social
Interdisciplinary biochemist/structural biologist. Works with SMC complexes and their friends. Here for science.
Reposted by Erin E. Cutts
🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...
February 9, 2026 at 12:54 PM
🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...
Reposted by Erin E. Cutts
Structural basis for CTCF-mediated chromatin organization https://www.biorxiv.org/content/10.64898/2026.02.06.704447v1
February 9, 2026 at 3:18 AM
Structural basis for CTCF-mediated chromatin organization https://www.biorxiv.org/content/10.64898/2026.02.06.704447v1
Reposted by Erin E. Cutts
How is Condensin II activated during mitosis? 🧬
@damlatetiker.bsky.social Samejima et al. uncover how Condensin II autoinhibition is relieved by the mitotic activator M18BP1, and reveal that M18BP1 also forms a composite DNA anchor with the NCAPG2–NCAPH2 subcomplex to stabilize DNA loops in vitro.
@damlatetiker.bsky.social Samejima et al. uncover how Condensin II autoinhibition is relieved by the mitotic activator M18BP1, and reveal that M18BP1 also forms a composite DNA anchor with the NCAPG2–NCAPH2 subcomplex to stabilize DNA loops in vitro.
www.biorxiv.org
February 4, 2026 at 3:34 PM
How is Condensin II activated during mitosis? 🧬
@damlatetiker.bsky.social Samejima et al. uncover how Condensin II autoinhibition is relieved by the mitotic activator M18BP1, and reveal that M18BP1 also forms a composite DNA anchor with the NCAPG2–NCAPH2 subcomplex to stabilize DNA loops in vitro.
@damlatetiker.bsky.social Samejima et al. uncover how Condensin II autoinhibition is relieved by the mitotic activator M18BP1, and reveal that M18BP1 also forms a composite DNA anchor with the NCAPG2–NCAPH2 subcomplex to stabilize DNA loops in vitro.
I’m very pleased to share our work looking at what controls condensin II cell-cycle dependant activity; a great collaboration with @eugenekimlab.bsky.social, @damlatetiker.bsky.social, Kyle Muir and Kumiko Samejima
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
February 4, 2026 at 3:57 PM
I’m very pleased to share our work looking at what controls condensin II cell-cycle dependant activity; a great collaboration with @eugenekimlab.bsky.social, @damlatetiker.bsky.social, Kyle Muir and Kumiko Samejima
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Erin E. Cutts
🔬 Calling all early-career researchers (ECRs) for the GRS Single Molecule Approaches to Biology!
🌎 Location: Les Diablerets, Switzerland
📆 Save the date: June 27-28, 2026
🔗 More information: www.grc.org/single-molec...
#biology #biophysics #single-molecule #microscopy #ECR
🌎 Location: Les Diablerets, Switzerland
📆 Save the date: June 27-28, 2026
🔗 More information: www.grc.org/single-molec...
#biology #biophysics #single-molecule #microscopy #ECR
January 22, 2026 at 3:18 PM
🔬 Calling all early-career researchers (ECRs) for the GRS Single Molecule Approaches to Biology!
🌎 Location: Les Diablerets, Switzerland
📆 Save the date: June 27-28, 2026
🔗 More information: www.grc.org/single-molec...
#biology #biophysics #single-molecule #microscopy #ECR
🌎 Location: Les Diablerets, Switzerland
📆 Save the date: June 27-28, 2026
🔗 More information: www.grc.org/single-molec...
#biology #biophysics #single-molecule #microscopy #ECR
Reposted by Erin E. Cutts
Do you have an interest in quantitative microbiology and interdisciplinary research? I'm recruiting a UK PhD student to develop high-throughput ecological screens to help us understand how chemical inputs impact microbial ecosystems: www.findaphd.com/phds/project...
Identifying how chemicals shape microbial diversity through high-throughput ecological screens at University of Sheffield on FindAPhD.com
PhD Project - Identifying how chemicals shape microbial diversity through high-throughput ecological screens at University of Sheffield, listed on FindAPhD.com
www.findaphd.com
January 7, 2026 at 4:00 PM
Do you have an interest in quantitative microbiology and interdisciplinary research? I'm recruiting a UK PhD student to develop high-throughput ecological screens to help us understand how chemical inputs impact microbial ecosystems: www.findaphd.com/phds/project...
Reposted by Erin E. Cutts
New Online! Organization of replicated chromosomes by DNA loops and sister chromatid cohesion
Organization of replicated chromosomes by DNA loops and sister chromatid cohesion
Nature Reviews Molecular Cell Biology, Published online: 02 January 2026; doi:10.1038/s41580-025-00933-1Cohesin complexes regulate genome architecture through DNA loop extrusion and sister chromatid cohesion. The Review discusses how these two cohesin activities mediate the organization of replicated chromosomes and their segregation in mitosis and meiosis, DNA break repair, and age-related aneuploidy in oocytes.
bit.ly
January 2, 2026 at 3:13 AM
New Online! Organization of replicated chromosomes by DNA loops and sister chromatid cohesion
Reposted by Erin E. Cutts
We are looking for a Postdoc at the Center for Gene Expression in Copenhagen. Deadline for applications is the 11th of January. If you are interested in 3D chromatin, SMC complexes, and super-resolution microscopy, join us. www.nature.com/naturecareer...
Postdocs at Center for Gene Expression in Department of Cellular and Molecular Medicine - Copenhagen, Hovedstaden (DK) job with University of Copenhagen | 12849488
We are looking for 2 or more highly motivated postdocs interested in ribosome biology, 3D chromatin organisation, or regulation of protein turnove...
www.nature.com
January 2, 2026 at 8:12 AM
We are looking for a Postdoc at the Center for Gene Expression in Copenhagen. Deadline for applications is the 11th of January. If you are interested in 3D chromatin, SMC complexes, and super-resolution microscopy, join us. www.nature.com/naturecareer...
Reposted by Erin E. Cutts
Read our latest work - a comprehensive review on how DNA secondary structures affect replication.
Very proud of Adi, Maria and Billie for their monumental effort. They've covered a large body of literature while proposing updated models.
Open Access in DNA Repair:
doi.org/10.1016/j.dn...
Very proud of Adi, Maria and Billie for their monumental effort. They've covered a large body of literature while proposing updated models.
Open Access in DNA Repair:
doi.org/10.1016/j.dn...
How DNA secondary structures drive replication fork instability
DNA secondary structures, such as hairpins, cruciforms, triplexes, G-quadruplexes and iMotifs, are common, dynamic features that replication forks rou…
www.sciencedirect.com
December 18, 2025 at 11:19 AM
Read our latest work - a comprehensive review on how DNA secondary structures affect replication.
Very proud of Adi, Maria and Billie for their monumental effort. They've covered a large body of literature while proposing updated models.
Open Access in DNA Repair:
doi.org/10.1016/j.dn...
Very proud of Adi, Maria and Billie for their monumental effort. They've covered a large body of literature while proposing updated models.
Open Access in DNA Repair:
doi.org/10.1016/j.dn...
Only a few days left to apply for this PhD opportunity in my lab! More details and how to apply at: www.findaphd.com/phds/project...
December 1, 2025 at 5:40 PM
Only a few days left to apply for this PhD opportunity in my lab! More details and how to apply at: www.findaphd.com/phds/project...
Reposted by Erin E. Cutts
This alternative view of “condensate” biogenesis is compatible with everything that LLPS claims for itself, including the apparent liquid-like behavior that people a bit ignorant of dynamics find so exciting. I explained this here
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
On the role of phase separation in the biogenesis of membraneless compartments | The EMBO Journal
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
November 29, 2025 at 3:12 PM
This alternative view of “condensate” biogenesis is compatible with everything that LLPS claims for itself, including the apparent liquid-like behavior that people a bit ignorant of dynamics find so exciting. I explained this here
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Erin E. Cutts
We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you.
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Postdoctoral Fellow - H Yardimci Lab
www.crick.ac.uk
November 25, 2025 at 11:55 AM
We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you.
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Reposted by Erin E. Cutts
70 teaspoons placed in tearooms around the institute & observed weekly over 5 months. 80% of spoons disappeared; spoon halflife~81 days. Communal room halflife lower than in specific labs. 250 spoons annually required to maintain 70 spoon population.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
The case of the disappearing teaspoons: longitudinal cohort study of the displacement of teaspoons in an Australian research institute
Objectives To determine the overall rate of loss of workplace teaspoons and whether attrition and displacement are correlated with the relative value of the teaspoons or type of tearoom. Design Longitudinal cohort study. Setting Research institute ...
pmc.ncbi.nlm.nih.gov
November 20, 2025 at 3:44 AM
70 teaspoons placed in tearooms around the institute & observed weekly over 5 months. 80% of spoons disappeared; spoon halflife~81 days. Communal room halflife lower than in specific labs. 250 spoons annually required to maintain 70 spoon population.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted by Erin E. Cutts
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
Biomolecular condensates: organizers of cellular biochemistry - Nature Reviews Molecular Cell Biology
In addition to membrane-bound organelles, eukaryotic cells feature various membraneless compartments, including the centrosome, the nucleolus and various granules. Many of these compartments form thro...
www.nature.com
November 17, 2025 at 7:24 AM
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
I’ve been offline for a while for the reason below. But I’m back in the lab, with more motivation and joy than ever before! The last year has been a wild ride, but everything has worked out brilliantly!
November 5, 2025 at 9:41 AM
I’ve been offline for a while for the reason below. But I’m back in the lab, with more motivation and joy than ever before! The last year has been a wild ride, but everything has worked out brilliantly!
Reposted by Erin E. Cutts
Nominations for the June Almeida award for Mid/Senior-Career Women in Cryo-EM are now open! Submit your nomination via this link www.biophysics.org/awards-fundi... by November 14th to recognize an exceptional woman in our community.
Subgroup Awards - The Biophysical Society
www.biophysics.org
October 16, 2025 at 7:08 PM
Nominations for the June Almeida award for Mid/Senior-Career Women in Cryo-EM are now open! Submit your nomination via this link www.biophysics.org/awards-fundi... by November 14th to recognize an exceptional woman in our community.
Reposted by Erin E. Cutts
I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗
beta.ideas.lego.com/product-idea...
beta.ideas.lego.com/product-idea...
Biological Laboratory | LEGO® Ideas
This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…
beta.ideas.lego.com
October 16, 2025 at 8:07 AM
I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗
beta.ideas.lego.com/product-idea...
beta.ideas.lego.com/product-idea...
Reposted by Erin E. Cutts
We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...
www.jobs.ac.uk/job/DOW912/s...
Senior Research Technician at University of Birmingham
Explore an exciting academic career as a Senior Research Technician. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
www.jobs.ac.uk
October 7, 2025 at 8:51 AM
We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...
www.jobs.ac.uk/job/DOW912/s...
Reposted by Erin E. Cutts
New preprint with @gfudenberg.bsky.social
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
NIPBL dosage shapes genome folding by tuning the rate of cohesin loop extrusion
Cohesin loop extrusion is a major driver of chromosome folding, but how its dynamics are controlled to shape the genome remains elusive. Here we disentangle the contributions of the cohesin cofactors ...
www.biorxiv.org
August 16, 2025 at 3:03 AM
New preprint with @gfudenberg.bsky.social
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
Reposted by Erin E. Cutts
My PhD student @leonielorenz.bsky.social (with Eva Geissen) has made this nice (free) online course to introduce mathematical modelling for biology:
www.ebi.ac.uk/training/onl...
Including both molecular and epidemiological examples
www.ebi.ac.uk/training/onl...
Including both molecular and epidemiological examples
Mathematical modelling for biologists - Modelling concepts in biological research
Mathematical modelling for biologists - Modelling concepts in biological research
www.ebi.ac.uk
August 15, 2025 at 10:39 AM
My PhD student @leonielorenz.bsky.social (with Eva Geissen) has made this nice (free) online course to introduce mathematical modelling for biology:
www.ebi.ac.uk/training/onl...
Including both molecular and epidemiological examples
www.ebi.ac.uk/training/onl...
Including both molecular and epidemiological examples
Reposted by Erin E. Cutts
It's more important than ever for students and educators to stay informed and proactive. That's why you're invited to our upcoming webinar “The Future of Graduate Education in Biophysics"
September 4, 3:30-5:00PM USA Eastern
my.biophysics.org/events/calen...
September 4, 3:30-5:00PM USA Eastern
my.biophysics.org/events/calen...
Meeting Home Page
Displays details of a selected meeting including Date, Time, location, and additional content.
my.biophysics.org
August 7, 2025 at 6:29 PM
It's more important than ever for students and educators to stay informed and proactive. That's why you're invited to our upcoming webinar “The Future of Graduate Education in Biophysics"
September 4, 3:30-5:00PM USA Eastern
my.biophysics.org/events/calen...
September 4, 3:30-5:00PM USA Eastern
my.biophysics.org/events/calen...
Reposted by Erin E. Cutts
Starting off our NAF 2025 meeting with an introduction of the RSC Nucleic Acids Group's new chair, Marco Di Antonio! An exciting new era for our group begins! 🧬
@diantoniogroup.bsky.social
@diantoniogroup.bsky.social
July 11, 2025 at 9:32 AM
Starting off our NAF 2025 meeting with an introduction of the RSC Nucleic Acids Group's new chair, Marco Di Antonio! An exciting new era for our group begins! 🧬
@diantoniogroup.bsky.social
@diantoniogroup.bsky.social
Reposted by Erin E. Cutts
This is a proper tour de force of integrative structural biology and biochem! (Including from our own @eecutts.bsky.social @mcb-sheffield.bsky.social) so many crucial roles for SLiMs in fundamental cellular processes.
Online Now: Condensin II activation by M18BP1 Online now:
Condensin II activation by M18BP1
Borsellini, Conti, Cutts, Harris, et al. identify an interaction between M18BP1 and condensin II that is essential for condensin II activity and chromatin localization. MCPH1 keeps the interphase genome uncondensed by competing with M18BP1. A phosphorylation-driven switch allows M18BP1 to trigger condensation at mitotic onset.
dlvr.it
July 5, 2025 at 6:27 AM
This is a proper tour de force of integrative structural biology and biochem! (Including from our own @eecutts.bsky.social @mcb-sheffield.bsky.social) so many crucial roles for SLiMs in fundamental cellular processes.
Reposted by Erin E. Cutts
Condensin II activation by M18BP1: Molecular Cell www.cell.com/molecular-ce...
Condensin II activation by M18BP1
Borsellini, Conti, Cutts, Harris, et al. identify an interaction between M18BP1 and
condensin II that is essential for condensin II activity and chromatin localization.
MCPH1 keeps the interphase geno...
www.cell.com
July 3, 2025 at 3:03 PM
Condensin II activation by M18BP1: Molecular Cell www.cell.com/molecular-ce...
Reposted by Erin E. Cutts
JOB OPENING for biochemist/-physicst 🧑🔬: This isn't an official job ad yet. We are looking for a postdoc working on large to high throughout single-molecule FRET on protein structures and dynamics. The project will be run in our lab and co-directed jointly with a team from big pharma/biotech. 1/2
June 17, 2025 at 3:05 PM
JOB OPENING for biochemist/-physicst 🧑🔬: This isn't an official job ad yet. We are looking for a postdoc working on large to high throughout single-molecule FRET on protein structures and dynamics. The project will be run in our lab and co-directed jointly with a team from big pharma/biotech. 1/2