Eugene Kim Lab
@eugenekimlab.bsky.social
The Eugene Kim Lab, Max Planck Institute of Biophysics, Germany
https://www.biophys.mpg.de/structure-dynamics-of-chromosomes
https://www.biophys.mpg.de/structure-dynamics-of-chromosomes
Reposted by Eugene Kim Lab
Thanks to all involved in the super exciting work! Happy reading! And happy to answer any questions!
February 4, 2026 at 3:57 PM
Thanks to all involved in the super exciting work! Happy reading! And happy to answer any questions!
Reposted by Eugene Kim Lab
Furthermore, we show a new role for M18BP1 as a condensin II loop stabiliser! Condensin II alone has a short loop lifetime, but when bound by M18BP1, loops are super stable. This is due to a basic region of M18BP1 contributing to DNA binding and loop anchoring!
February 4, 2026 at 3:57 PM
Furthermore, we show a new role for M18BP1 as a condensin II loop stabiliser! Condensin II alone has a short loop lifetime, but when bound by M18BP1, loops are super stable. This is due to a basic region of M18BP1 contributing to DNA binding and loop anchoring!
Reposted by Eugene Kim Lab
I’m very pleased to share our work looking at what controls condensin II cell-cycle dependant activity; a great collaboration with @eugenekimlab.bsky.social, @damlatetiker.bsky.social, Kyle Muir and Kumiko Samejima
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
February 4, 2026 at 3:57 PM
I’m very pleased to share our work looking at what controls condensin II cell-cycle dependant activity; a great collaboration with @eugenekimlab.bsky.social, @damlatetiker.bsky.social, Kyle Muir and Kumiko Samejima
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
How is Condensin II activated during mitosis? 🧬
@damlatetiker.bsky.social Samejima et al. uncover how Condensin II autoinhibition is relieved by the mitotic activator M18BP1, and reveal that M18BP1 also forms a composite DNA anchor with the NCAPG2–NCAPH2 subcomplex to stabilize DNA loops in vitro.
@damlatetiker.bsky.social Samejima et al. uncover how Condensin II autoinhibition is relieved by the mitotic activator M18BP1, and reveal that M18BP1 also forms a composite DNA anchor with the NCAPG2–NCAPH2 subcomplex to stabilize DNA loops in vitro.
www.biorxiv.org
February 4, 2026 at 3:34 PM
How is Condensin II activated during mitosis? 🧬
@damlatetiker.bsky.social Samejima et al. uncover how Condensin II autoinhibition is relieved by the mitotic activator M18BP1, and reveal that M18BP1 also forms a composite DNA anchor with the NCAPG2–NCAPH2 subcomplex to stabilize DNA loops in vitro.
@damlatetiker.bsky.social Samejima et al. uncover how Condensin II autoinhibition is relieved by the mitotic activator M18BP1, and reveal that M18BP1 also forms a composite DNA anchor with the NCAPG2–NCAPH2 subcomplex to stabilize DNA loops in vitro.
Our work on SMC Wadjet is finally out! Congrats to all co-authors!
Happy to see our research on SMC Wadjet published in Molecular Cell. We showed DNA loop extrusion (LE) by a bacterial SMC, confirming LE is conserved across all life forms. Wadjet's LE activity is crucial for recognizing and restricting foreign plasmids, serving as a defense mechanism. 🧬🔬🧪
December 3, 2024 at 8:30 AM
Our work on SMC Wadjet is finally out! Congrats to all co-authors!