Biswajit Pradhan
@bislightyear.bsky.social
Postdoc at MPI Biophysics.
DNA, SMC, Chromosome Organization, Nanoscience, Single-Molecule Biophysics.
https://www.biswajit.de/
DNA, SMC, Chromosome Organization, Nanoscience, Single-Molecule Biophysics.
https://www.biswajit.de/
Pinned
Happy to see our research on SMC Wadjet published in Molecular Cell. We showed DNA loop extrusion (LE) by a bacterial SMC, confirming LE is conserved across all life forms. Wadjet's LE activity is crucial for recognizing and restricting foreign plasmids, serving as a defense mechanism. 🧬🔬🧪
Reposted by Biswajit Pradhan
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
October 30, 2025 at 5:42 PM
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
Reposted by Biswajit Pradhan
Delighted to announce our latest work on how Wadjet loads onto and establishes topological entrapment of plasmid DNA prior to initiating loop extrusion. At @gruberlab.bsky.social, Dubochet Center for Imaging and BSI @igbmc.bsky.social
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
October 9, 2025 at 2:55 PM
Delighted to announce our latest work on how Wadjet loads onto and establishes topological entrapment of plasmid DNA prior to initiating loop extrusion. At @gruberlab.bsky.social, Dubochet Center for Imaging and BSI @igbmc.bsky.social
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Amazing WadjetSMC-DNA gymnastics! fantastic data from @roisnehamelinf.bsky.social , @gruberlab.bsky.social and their team.
How do SMC complexes load onto DNA to get ready for loop extrusion?
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
October 10, 2025 at 12:34 PM
Amazing WadjetSMC-DNA gymnastics! fantastic data from @roisnehamelinf.bsky.social , @gruberlab.bsky.social and their team.
Reposted by Biswajit Pradhan
Our Wadjet-II paper by @roisnehamelinf.bsky.social is out in polished form: www.cell.com/structure/fu...
With a great preview by @kevincorbett.bsky.social & @amardeeep.bsky.social highlighting the potential of Wadjets:
Wadjet—Keeping a watchful eye on circular DNA.
www.cell.com/structure/fu...
With a great preview by @kevincorbett.bsky.social & @amardeeep.bsky.social highlighting the potential of Wadjets:
Wadjet—Keeping a watchful eye on circular DNA.
www.cell.com/structure/fu...
September 5, 2025 at 6:29 AM
Our Wadjet-II paper by @roisnehamelinf.bsky.social is out in polished form: www.cell.com/structure/fu...
With a great preview by @kevincorbett.bsky.social & @amardeeep.bsky.social highlighting the potential of Wadjets:
Wadjet—Keeping a watchful eye on circular DNA.
www.cell.com/structure/fu...
With a great preview by @kevincorbett.bsky.social & @amardeeep.bsky.social highlighting the potential of Wadjets:
Wadjet—Keeping a watchful eye on circular DNA.
www.cell.com/structure/fu...
Reposted by Biswajit Pradhan
Congrats, Max! And big thanks and congratulations to our coauthors at MPI for Marine Microbiology, Bremen, MPI-CBG in Dresden, and in-house at the MPI of Biophysics! It's been great working with you all! @mpimarinemicrobio.bsky.social, @mpicbg.bsky.social sky.social, @hummerlab.bsky.social
Exciting green news! 🦠 Do you know how certain microorganisms make a living by transforming CO2 into useful molecules? Check out our new work on the molecular choreography behind acetyl-CoA synthesis in the CODH/ACS protein complex. 👩🔬 🔗 www.biophys.mpg.de/2844976/micr...
January 31, 2025 at 4:18 PM
Congrats, Max! And big thanks and congratulations to our coauthors at MPI for Marine Microbiology, Bremen, MPI-CBG in Dresden, and in-house at the MPI of Biophysics! It's been great working with you all! @mpimarinemicrobio.bsky.social, @mpicbg.bsky.social sky.social, @hummerlab.bsky.social
Reposted by Biswajit Pradhan
Check out our latest publication in @naturecellbiology.bsky.social on the role of phase separation in selective autophagy initiation! This was done in a fantastic collaboration with
@kraftlabfr.bsky.social
www.nature.com/articles/s41...
Short teaser below 👇👇👇
@kraftlabfr.bsky.social
www.nature.com/articles/s41...
Short teaser below 👇👇👇
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy - Nature Cell Biology
Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub ...
www.nature.com
January 8, 2025 at 3:11 PM
Check out our latest publication in @naturecellbiology.bsky.social on the role of phase separation in selective autophagy initiation! This was done in a fantastic collaboration with
@kraftlabfr.bsky.social
www.nature.com/articles/s41...
Short teaser below 👇👇👇
@kraftlabfr.bsky.social
www.nature.com/articles/s41...
Short teaser below 👇👇👇
Reposted by Biswajit Pradhan
What a great way to end the year! ✨
Today in @cellpress.bsky.social we report the structure and function of the Shedu anti-phage defense system.
tinyurl.com/4crj6dnx
A long 🧵...
Today in @cellpress.bsky.social we report the structure and function of the Shedu anti-phage defense system.
tinyurl.com/4crj6dnx
A long 🧵...
December 31, 2024 at 3:38 PM
What a great way to end the year! ✨
Today in @cellpress.bsky.social we report the structure and function of the Shedu anti-phage defense system.
tinyurl.com/4crj6dnx
A long 🧵...
Today in @cellpress.bsky.social we report the structure and function of the Shedu anti-phage defense system.
tinyurl.com/4crj6dnx
A long 🧵...
Reposted by Biswajit Pradhan
Hi all, I am very excited to share two positions (PhD and PostDoc) in my group on a EU-funded project ProAct.
More about the positions below.
Please share with your colleagues! This will be a great project to work on and also we offer a great environment at the BIOS group
More about the positions below.
Please share with your colleagues! This will be a great project to work on and also we offer a great environment at the BIOS group
December 20, 2024 at 10:45 AM
Hi all, I am very excited to share two positions (PhD and PostDoc) in my group on a EU-funded project ProAct.
More about the positions below.
Please share with your colleagues! This will be a great project to work on and also we offer a great environment at the BIOS group
More about the positions below.
Please share with your colleagues! This will be a great project to work on and also we offer a great environment at the BIOS group
Reposted by Biswajit Pradhan
Chromokinesin KIF4A activation of human condensin I involves a SLiM interfering with auto-inhibitory intramolecular interactions in the condensin complex, exemplifying a conserved mechanism for regulating diverse SMC complexes
@eecutts.bsky.social, Luis Aragon et al
www.embopress.org/doi/full/10....
@eecutts.bsky.social, Luis Aragon et al
www.embopress.org/doi/full/10....
December 18, 2024 at 11:20 AM
Chromokinesin KIF4A activation of human condensin I involves a SLiM interfering with auto-inhibitory intramolecular interactions in the condensin complex, exemplifying a conserved mechanism for regulating diverse SMC complexes
@eecutts.bsky.social, Luis Aragon et al
www.embopress.org/doi/full/10....
@eecutts.bsky.social, Luis Aragon et al
www.embopress.org/doi/full/10....
Reposted by Biswajit Pradhan
Please share: Still plenty of time to apply for PhD projects in my lab using single-molecule methods to look at disordered regions and condensin complexes!
Contact me at e.cutts@sheffield.ac.uk
For details on how to apply: www.findaphd.com/phds/project...
Contact me at e.cutts@sheffield.ac.uk
For details on how to apply: www.findaphd.com/phds/project...
Developing Imaging Solutions to Study the Dynamics of Human Condensin I at University of Sheffield on FindAPhD.com
PhD Project - Developing Imaging Solutions to Study the Dynamics of Human Condensin I at University of Sheffield, listed on FindAPhD.com
www.findaphd.com
December 16, 2024 at 3:37 PM
Please share: Still plenty of time to apply for PhD projects in my lab using single-molecule methods to look at disordered regions and condensin complexes!
Contact me at e.cutts@sheffield.ac.uk
For details on how to apply: www.findaphd.com/phds/project...
Contact me at e.cutts@sheffield.ac.uk
For details on how to apply: www.findaphd.com/phds/project...
Reposted by Biswajit Pradhan
Heartbeat of an early zebrafish embryo. Credit to Drs. Fengzhu Xiong & Sean Megason @harvardmed.bsky.social. #ZebrafishZunday 🧪
December 15, 2024 at 10:22 AM
Heartbeat of an early zebrafish embryo. Credit to Drs. Fengzhu Xiong & Sean Megason @harvardmed.bsky.social. #ZebrafishZunday 🧪
Reposted by Biswajit Pradhan
We have an opening for a 4 yr PhD interested in membrane remodelling and cryo-EM/ET of a minimal cell division machinery: edu.nl/bukan
You will be part of the EVOLF consortium in which 30 leading biochemists/biophysicists work together to explore if and how we can build autonomous synthetic cells.
You will be part of the EVOLF consortium in which 30 leading biochemists/biophysicists work together to explore if and how we can build autonomous synthetic cells.
December 10, 2024 at 2:53 PM
We have an opening for a 4 yr PhD interested in membrane remodelling and cryo-EM/ET of a minimal cell division machinery: edu.nl/bukan
You will be part of the EVOLF consortium in which 30 leading biochemists/biophysicists work together to explore if and how we can build autonomous synthetic cells.
You will be part of the EVOLF consortium in which 30 leading biochemists/biophysicists work together to explore if and how we can build autonomous synthetic cells.
Reposted by Biswajit Pradhan
topology sensing, very cool! another job for loop extrusion!
Happy to see our research on SMC Wadjet published in Molecular Cell. We showed DNA loop extrusion (LE) by a bacterial SMC, confirming LE is conserved across all life forms. Wadjet's LE activity is crucial for recognizing and restricting foreign plasmids, serving as a defense mechanism. 🧬🔬🧪
December 4, 2024 at 10:09 PM
topology sensing, very cool! another job for loop extrusion!
Reposted by Biswajit Pradhan
Delighted to publish my new molecular animation:
DNA Break Repair by Homologous Recombination
youtu.be/Xe-83tBcxhs
DNA Break Repair by Homologous Recombination
youtu.be/Xe-83tBcxhs
DNA Break Repair by Homologous Recombination (2024) Drew Berry wehi.tv
YouTube video by WEHImovies
youtu.be
December 4, 2024 at 12:07 AM
Delighted to publish my new molecular animation:
DNA Break Repair by Homologous Recombination
youtu.be/Xe-83tBcxhs
DNA Break Repair by Homologous Recombination
youtu.be/Xe-83tBcxhs
Reposted by Biswajit Pradhan
Excited to share this work, now out in Molecular Cell.
This was a fun collaboration between the Corbett lab and Kim lab.
This was a fun collaboration between the Corbett lab and Kim lab.
It's awesome that most of the coauthors are on Bluesky! 🤩
I had so much fun learning, collaborating with @amardeeep.bsky.social from @kevincorbett.bsky.social lab.
Thanks to @jessicakoenig.bsky.social and Martin Baaske from @eugenekimlab.bsky.social
I had so much fun learning, collaborating with @amardeeep.bsky.social from @kevincorbett.bsky.social lab.
Thanks to @jessicakoenig.bsky.social and Martin Baaske from @eugenekimlab.bsky.social
Happy to see our research on SMC Wadjet published in Molecular Cell. We showed DNA loop extrusion (LE) by a bacterial SMC, confirming LE is conserved across all life forms. Wadjet's LE activity is crucial for recognizing and restricting foreign plasmids, serving as a defense mechanism. 🧬🔬🧪
December 3, 2024 at 10:30 AM
Excited to share this work, now out in Molecular Cell.
This was a fun collaboration between the Corbett lab and Kim lab.
This was a fun collaboration between the Corbett lab and Kim lab.
It's awesome that most of the coauthors are on Bluesky! 🤩
I had so much fun learning, collaborating with @amardeeep.bsky.social from @kevincorbett.bsky.social lab.
Thanks to @jessicakoenig.bsky.social and Martin Baaske from @eugenekimlab.bsky.social
I had so much fun learning, collaborating with @amardeeep.bsky.social from @kevincorbett.bsky.social lab.
Thanks to @jessicakoenig.bsky.social and Martin Baaske from @eugenekimlab.bsky.social
Happy to see our research on SMC Wadjet published in Molecular Cell. We showed DNA loop extrusion (LE) by a bacterial SMC, confirming LE is conserved across all life forms. Wadjet's LE activity is crucial for recognizing and restricting foreign plasmids, serving as a defense mechanism. 🧬🔬🧪
December 3, 2024 at 8:52 AM
It's awesome that most of the coauthors are on Bluesky! 🤩
I had so much fun learning, collaborating with @amardeeep.bsky.social from @kevincorbett.bsky.social lab.
Thanks to @jessicakoenig.bsky.social and Martin Baaske from @eugenekimlab.bsky.social
I had so much fun learning, collaborating with @amardeeep.bsky.social from @kevincorbett.bsky.social lab.
Thanks to @jessicakoenig.bsky.social and Martin Baaske from @eugenekimlab.bsky.social
Reposted by Biswajit Pradhan
Our work on SMC Wadjet is finally out! Congrats to all co-authors!
Happy to see our research on SMC Wadjet published in Molecular Cell. We showed DNA loop extrusion (LE) by a bacterial SMC, confirming LE is conserved across all life forms. Wadjet's LE activity is crucial for recognizing and restricting foreign plasmids, serving as a defense mechanism. 🧬🔬🧪
December 3, 2024 at 8:30 AM
Our work on SMC Wadjet is finally out! Congrats to all co-authors!
Happy to see our research on SMC Wadjet published in Molecular Cell. We showed DNA loop extrusion (LE) by a bacterial SMC, confirming LE is conserved across all life forms. Wadjet's LE activity is crucial for recognizing and restricting foreign plasmids, serving as a defense mechanism. 🧬🔬🧪
December 2, 2024 at 4:59 PM
Happy to see our research on SMC Wadjet published in Molecular Cell. We showed DNA loop extrusion (LE) by a bacterial SMC, confirming LE is conserved across all life forms. Wadjet's LE activity is crucial for recognizing and restricting foreign plasmids, serving as a defense mechanism. 🧬🔬🧪
Reposted by Biswajit Pradhan
Latest #CDlab paper in Nucleic Acid Research:
academic.oup.com/nar/article/...
Great work by Alejandro Martin-Gonzalez,
@tismaa.bsky.social ea collaboring with @gruberlab.bsky.social, showing the interplay of DNA supercoiling & ParB condensation, 2 processes that set bacterial genome organization.
academic.oup.com/nar/article/...
Great work by Alejandro Martin-Gonzalez,
@tismaa.bsky.social ea collaboring with @gruberlab.bsky.social, showing the interplay of DNA supercoiling & ParB condensation, 2 processes that set bacterial genome organization.
November 27, 2024 at 6:50 PM
Latest #CDlab paper in Nucleic Acid Research:
academic.oup.com/nar/article/...
Great work by Alejandro Martin-Gonzalez,
@tismaa.bsky.social ea collaboring with @gruberlab.bsky.social, showing the interplay of DNA supercoiling & ParB condensation, 2 processes that set bacterial genome organization.
academic.oup.com/nar/article/...
Great work by Alejandro Martin-Gonzalez,
@tismaa.bsky.social ea collaboring with @gruberlab.bsky.social, showing the interplay of DNA supercoiling & ParB condensation, 2 processes that set bacterial genome organization.
Reposted by Biswajit Pradhan
PSFs are just Gaussians, right??
Not when your fluorophore💡is close to a nanoparticle 🟠!
Excited to share our recent ACS Nano paper 🥳 in which we present a novel PSF-fitting approach for localization microscopy near nanoparticles.
pubs.acs.org/doi/full/10....
Main findings below in🧵[1/10]
Not when your fluorophore💡is close to a nanoparticle 🟠!
Excited to share our recent ACS Nano paper 🥳 in which we present a novel PSF-fitting approach for localization microscopy near nanoparticles.
pubs.acs.org/doi/full/10....
Main findings below in🧵[1/10]
November 26, 2024 at 5:58 PM
PSFs are just Gaussians, right??
Not when your fluorophore💡is close to a nanoparticle 🟠!
Excited to share our recent ACS Nano paper 🥳 in which we present a novel PSF-fitting approach for localization microscopy near nanoparticles.
pubs.acs.org/doi/full/10....
Main findings below in🧵[1/10]
Not when your fluorophore💡is close to a nanoparticle 🟠!
Excited to share our recent ACS Nano paper 🥳 in which we present a novel PSF-fitting approach for localization microscopy near nanoparticles.
pubs.acs.org/doi/full/10....
Main findings below in🧵[1/10]
Reposted by Biswajit Pradhan
🧠🔬Using long GRIN lenses and notice that cells look good in the middle, but vague on the sides? My lab developed corrected lenses, which increases the FOV and thus number of neurons recorded! Check out this new publication:
elifesciences.org/reviewed-pre... #microscopy #inscopix
elifesciences.org/reviewed-pre... #microscopy #inscopix
November 26, 2024 at 9:24 AM
🧠🔬Using long GRIN lenses and notice that cells look good in the middle, but vague on the sides? My lab developed corrected lenses, which increases the FOV and thus number of neurons recorded! Check out this new publication:
elifesciences.org/reviewed-pre... #microscopy #inscopix
elifesciences.org/reviewed-pre... #microscopy #inscopix
Reposted by Biswajit Pradhan
We are now on Bluesky!
Follow us for exciting #Science around #CellDivision and nuclear organization, illuminated using advanced #imaging #technology - like our last preprint on mitotic chromosome structure and organization: tinyurl.com/yaznnkku
Follow us for exciting #Science around #CellDivision and nuclear organization, illuminated using advanced #imaging #technology - like our last preprint on mitotic chromosome structure and organization: tinyurl.com/yaznnkku
November 25, 2024 at 1:08 PM
We are now on Bluesky!
Follow us for exciting #Science around #CellDivision and nuclear organization, illuminated using advanced #imaging #technology - like our last preprint on mitotic chromosome structure and organization: tinyurl.com/yaznnkku
Follow us for exciting #Science around #CellDivision and nuclear organization, illuminated using advanced #imaging #technology - like our last preprint on mitotic chromosome structure and organization: tinyurl.com/yaznnkku
Reposted by Biswajit Pradhan
so far, my impression of a few days is that LinkedIn is rather confusing and more business/career related,
and that BlueSky is quite like the old twitter, with a mix of science, news, fun, beauty, etc.
BlueSky looks promising! Lets make it work.
3/
and that BlueSky is quite like the old twitter, with a mix of science, news, fun, beauty, etc.
BlueSky looks promising! Lets make it work.
3/
November 24, 2024 at 8:55 AM
so far, my impression of a few days is that LinkedIn is rather confusing and more business/career related,
and that BlueSky is quite like the old twitter, with a mix of science, news, fun, beauty, etc.
BlueSky looks promising! Lets make it work.
3/
and that BlueSky is quite like the old twitter, with a mix of science, news, fun, beauty, etc.
BlueSky looks promising! Lets make it work.
3/
Reposted by Biswajit Pradhan
I just created a Microscopy feed that tracks anything that has a cute 🔬 emoji on it as well as the simple #microscopy and #imaging tags. Enjoy!
bsky.app/profile/did:...
bsky.app/profile/did:...
November 23, 2024 at 7:48 PM
I just created a Microscopy feed that tracks anything that has a cute 🔬 emoji on it as well as the simple #microscopy and #imaging tags. Enjoy!
bsky.app/profile/did:...
bsky.app/profile/did:...
Reposted by Biswajit Pradhan
Post a non-religious photo you think of as holy.
November 21, 2024 at 5:16 PM
Post a non-religious photo you think of as holy.