The EMBO Journal
@embojournal.org
Non-for-profit publication of research in molecular, cell & organismal biology - as part of @embopress.org
Fast-fair-transparent / Open Access / Open Science
Fast-fair-transparent / Open Access / Open Science
Pinned
Issue 21 highlights:
Paxilin’s nuclear switch in the brain
RING E3s reading & extending ADPr-ubiquitin
Review: Decoding immunometabolism
Nuclear actin limits chromatin leakage upon migratory squeeze
Cover by @syncellbiolab.bsky.social: unlike Odin-archael FtsZ twins
www.embopress.org/toc/14602075...
Paxilin’s nuclear switch in the brain
RING E3s reading & extending ADPr-ubiquitin
Review: Decoding immunometabolism
Nuclear actin limits chromatin leakage upon migratory squeeze
Cover by @syncellbiolab.bsky.social: unlike Odin-archael FtsZ twins
www.embopress.org/toc/14602075...
Reposted by The EMBO Journal
I’m thrilled to share that our latest work, led by PhD scholar Priyanka Das, is published in @embojournal.org!
Using a bacterial mutant library screen, we identified that bacterial-induced ROS extends C. elegans lifespan by disrupting its iron homeostasis. www.embopress.org/doi/full/10....
Using a bacterial mutant library screen, we identified that bacterial-induced ROS extends C. elegans lifespan by disrupting its iron homeostasis. www.embopress.org/doi/full/10....
Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways | The EMBO Journal
imageimageGut microbes are key modulators of host lifespan, yet the underlying mechanisms remain poorly understood. This study shows that gut microbes, which induce oxidative stress in Caenorhabditis elegans, extend the host’s lifespan by ...
www.embopress.org
November 10, 2025 at 2:15 PM
I’m thrilled to share that our latest work, led by PhD scholar Priyanka Das, is published in @embojournal.org!
Using a bacterial mutant library screen, we identified that bacterial-induced ROS extends C. elegans lifespan by disrupting its iron homeostasis. www.embopress.org/doi/full/10....
Using a bacterial mutant library screen, we identified that bacterial-induced ROS extends C. elegans lifespan by disrupting its iron homeostasis. www.embopress.org/doi/full/10....
Reposted by The EMBO Journal
If you work with #scRNAseq, #salivary, #thyroid or #mammary gland #organoids, or are interested in #irradiation and #Notch signaling, you might find this exciting! Our latest paper is now available in @embojournal.org! Check it out! Link below ✨
doi.org/10.1038/s443...
doi.org/10.1038/s443...
November 11, 2025 at 1:15 AM
If you work with #scRNAseq, #salivary, #thyroid or #mammary gland #organoids, or are interested in #irradiation and #Notch signaling, you might find this exciting! Our latest paper is now available in @embojournal.org! Check it out! Link below ✨
doi.org/10.1038/s443...
doi.org/10.1038/s443...
C-reactive protein is a broad-spectrum capsule-binding receptor for hepatic capture of blood-borne bacteria
Chen et al show that CRP binds to a wide variety of bacterial capsule types to facilitate bacterial capture by liver-resident macrophages
www.embopress.org/doi/full/10....
Chen et al show that CRP binds to a wide variety of bacterial capsule types to facilitate bacterial capture by liver-resident macrophages
www.embopress.org/doi/full/10....
November 10, 2025 at 12:28 PM
C-reactive protein is a broad-spectrum capsule-binding receptor for hepatic capture of blood-borne bacteria
Chen et al show that CRP binds to a wide variety of bacterial capsule types to facilitate bacterial capture by liver-resident macrophages
www.embopress.org/doi/full/10....
Chen et al show that CRP binds to a wide variety of bacterial capsule types to facilitate bacterial capture by liver-resident macrophages
www.embopress.org/doi/full/10....
Structural insights into the atypical filament assembly of pyrin domain-containing IFI16
Jungsan Sohn and colleagues
www.embopress.org/doi/full/10....
Jungsan Sohn and colleagues
www.embopress.org/doi/full/10....
November 7, 2025 at 12:53 PM
Structural insights into the atypical filament assembly of pyrin domain-containing IFI16
Jungsan Sohn and colleagues
www.embopress.org/doi/full/10....
Jungsan Sohn and colleagues
www.embopress.org/doi/full/10....
What signaling dependencies underlie cancer transmissability in Tasmanian devils?
Phosphoproteomics & xenograft assays by Richard Moriggl, @andreasbergthaler.bsky.social et al delineate distinct adaptations & sensitivities to tyrosine kinase inhibition strategies
www.embopress.org/doi/full/10....
Phosphoproteomics & xenograft assays by Richard Moriggl, @andreasbergthaler.bsky.social et al delineate distinct adaptations & sensitivities to tyrosine kinase inhibition strategies
www.embopress.org/doi/full/10....
November 7, 2025 at 11:11 AM
What signaling dependencies underlie cancer transmissability in Tasmanian devils?
Phosphoproteomics & xenograft assays by Richard Moriggl, @andreasbergthaler.bsky.social et al delineate distinct adaptations & sensitivities to tyrosine kinase inhibition strategies
www.embopress.org/doi/full/10....
Phosphoproteomics & xenograft assays by Richard Moriggl, @andreasbergthaler.bsky.social et al delineate distinct adaptations & sensitivities to tyrosine kinase inhibition strategies
www.embopress.org/doi/full/10....
Notch signaling is a driver of glandular stem cell activity and regenerative migration after damage
@davidecinat.bsky.social, Lara Barazzuol, Rob Coppes et al
www.embopress.org/doi/full/10....
@davidecinat.bsky.social, Lara Barazzuol, Rob Coppes et al
www.embopress.org/doi/full/10....
November 7, 2025 at 11:05 AM
Notch signaling is a driver of glandular stem cell activity and regenerative migration after damage
@davidecinat.bsky.social, Lara Barazzuol, Rob Coppes et al
www.embopress.org/doi/full/10....
@davidecinat.bsky.social, Lara Barazzuol, Rob Coppes et al
www.embopress.org/doi/full/10....
Stationary-phase E. coli cells exhibit asymmetric division and macromolecule localization due to uneven accumulation of glycogen between the cell poles over divisions
Christine Jacobs-Wagner and coworkers
www.embopress.org/doi/full/10....
Christine Jacobs-Wagner and coworkers
www.embopress.org/doi/full/10....
November 6, 2025 at 4:20 PM
Stationary-phase E. coli cells exhibit asymmetric division and macromolecule localization due to uneven accumulation of glycogen between the cell poles over divisions
Christine Jacobs-Wagner and coworkers
www.embopress.org/doi/full/10....
Christine Jacobs-Wagner and coworkers
www.embopress.org/doi/full/10....
Mechanism of #autophagy initiation by transmembrane selective autophagy receptors
@elias-adriaenssens.bsky.social & @martenslab.bsky.social review emerging mechanistic differences between soluble and transmembrane autophagy receptors
www.embopress.org/doi/full/10....
@elias-adriaenssens.bsky.social & @martenslab.bsky.social review emerging mechanistic differences between soluble and transmembrane autophagy receptors
www.embopress.org/doi/full/10....
November 6, 2025 at 4:20 PM
Mechanism of #autophagy initiation by transmembrane selective autophagy receptors
@elias-adriaenssens.bsky.social & @martenslab.bsky.social review emerging mechanistic differences between soluble and transmembrane autophagy receptors
www.embopress.org/doi/full/10....
@elias-adriaenssens.bsky.social & @martenslab.bsky.social review emerging mechanistic differences between soluble and transmembrane autophagy receptors
www.embopress.org/doi/full/10....
DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation
@reisesousalab.bsky.social et al implicate recruitment of phosphatase SHIP1 by receptor DNGR-1/CLEC9A in uncoupling of cross-presentation from inflammatory induction
www.embopress.org/doi/full/10....
@reisesousalab.bsky.social et al implicate recruitment of phosphatase SHIP1 by receptor DNGR-1/CLEC9A in uncoupling of cross-presentation from inflammatory induction
www.embopress.org/doi/full/10....
November 6, 2025 at 9:02 AM
DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation
@reisesousalab.bsky.social et al implicate recruitment of phosphatase SHIP1 by receptor DNGR-1/CLEC9A in uncoupling of cross-presentation from inflammatory induction
www.embopress.org/doi/full/10....
@reisesousalab.bsky.social et al implicate recruitment of phosphatase SHIP1 by receptor DNGR-1/CLEC9A in uncoupling of cross-presentation from inflammatory induction
www.embopress.org/doi/full/10....
Concurrence of FGFR1 mutations modulates oncogenesis in glioneuronal tumors
Barbara Rivera and coworkers
www.embopress.org/doi/full/10....
Barbara Rivera and coworkers
www.embopress.org/doi/full/10....
November 5, 2025 at 5:19 PM
Concurrence of FGFR1 mutations modulates oncogenesis in glioneuronal tumors
Barbara Rivera and coworkers
www.embopress.org/doi/full/10....
Barbara Rivera and coworkers
www.embopress.org/doi/full/10....
Distinct senotypes in p16+ & p21+ cells across aging human & mouse tissues:
large meta-analysis by Joao Passos, @skhos78.bsky.social et al suggests that senolytic targeting of cells driven into senescence by different CDK inhibitors may require bespoke approaches
www.embopress.org/doi/full/10....
large meta-analysis by Joao Passos, @skhos78.bsky.social et al suggests that senolytic targeting of cells driven into senescence by different CDK inhibitors may require bespoke approaches
www.embopress.org/doi/full/10....
November 5, 2025 at 5:17 PM
Distinct senotypes in p16+ & p21+ cells across aging human & mouse tissues:
large meta-analysis by Joao Passos, @skhos78.bsky.social et al suggests that senolytic targeting of cells driven into senescence by different CDK inhibitors may require bespoke approaches
www.embopress.org/doi/full/10....
large meta-analysis by Joao Passos, @skhos78.bsky.social et al suggests that senolytic targeting of cells driven into senescence by different CDK inhibitors may require bespoke approaches
www.embopress.org/doi/full/10....
Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
November 5, 2025 at 2:45 PM
Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons
Tong Wang and coworkers
www.embopress.org/doi/full/10....
Tong Wang and coworkers
www.embopress.org/doi/full/10....
November 5, 2025 at 6:45 AM
Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons
Tong Wang and coworkers
www.embopress.org/doi/full/10....
Tong Wang and coworkers
www.embopress.org/doi/full/10....
Two alternative isoforms of PRC2 accessory subunit AEBP2 modulate developmental Polycomb functions in opposite ways - with broadly-expressed AEBP2L acting as an intrinsic inhibitor in somatic cells
@adrianbracken.bsky.social @davidovichlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
@adrianbracken.bsky.social @davidovichlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
November 4, 2025 at 12:51 PM
Two alternative isoforms of PRC2 accessory subunit AEBP2 modulate developmental Polycomb functions in opposite ways - with broadly-expressed AEBP2L acting as an intrinsic inhibitor in somatic cells
@adrianbracken.bsky.social @davidovichlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
@adrianbracken.bsky.social @davidovichlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
Non-cell-autonomous control of mouse gastruloid development by the ultra-conserved lncRNA T-UCstem1
Gabriella Minchiotti, @annalisafico.bsky.social and collaborators
www.embopress.org/doi/full/10....
Gabriella Minchiotti, @annalisafico.bsky.social and collaborators
www.embopress.org/doi/full/10....
November 4, 2025 at 11:57 AM
Non-cell-autonomous control of mouse gastruloid development by the ultra-conserved lncRNA T-UCstem1
Gabriella Minchiotti, @annalisafico.bsky.social and collaborators
www.embopress.org/doi/full/10....
Gabriella Minchiotti, @annalisafico.bsky.social and collaborators
www.embopress.org/doi/full/10....
Gut-brain-gut circuitry in C. elegans: intestinal iron depletion upon altered gut microbe metabolism is sensed by the central nervous system and countered by neurotransmitter-induced ferritin expression
Hongyun Tang and coworkers
www.embopress.org/doi/full/10....
Hongyun Tang and coworkers
www.embopress.org/doi/full/10....
November 4, 2025 at 9:02 AM
Gut-brain-gut circuitry in C. elegans: intestinal iron depletion upon altered gut microbe metabolism is sensed by the central nervous system and countered by neurotransmitter-induced ferritin expression
Hongyun Tang and coworkers
www.embopress.org/doi/full/10....
Hongyun Tang and coworkers
www.embopress.org/doi/full/10....
Reposted by The EMBO Journal
Now in @embojournal.org: Researchers in @labgrosshans.bsky.social & UCSC found that similar molecular machineries control daily circadian rhythms & developmental timing—showing that evolution can repurpose core timing systems to coordinate both daily cycles & growth. www.fmi.ch/news-events/...
One clock, two functions: from daily rhythms to development
Scientists at the FMI and the University of California-Santa Cruz have found that similar molecular machineries control daily circadian rhythms and developmental timing. Their work in worms shows that...
www.fmi.ch
November 4, 2025 at 8:28 AM
Now in @embojournal.org: Researchers in @labgrosshans.bsky.social & UCSC found that similar molecular machineries control daily circadian rhythms & developmental timing—showing that evolution can repurpose core timing systems to coordinate both daily cycles & growth. www.fmi.ch/news-events/...
Reposted by The EMBO Journal
We’re on the cover of @embojournal.org
Odin, from Norse mythology, emerges from the Odinarchaeota yellowstonii genome, holding FtsZ1 and FtsZ2 the ancestral twins of tubulin highlighting their evolutionary divergence in Asgard archaea. 👉 shorturl.at/n7iZE
#archaea #evolution #tubulin #cytoskeleton
Odin, from Norse mythology, emerges from the Odinarchaeota yellowstonii genome, holding FtsZ1 and FtsZ2 the ancestral twins of tubulin highlighting their evolutionary divergence in Asgard archaea. 👉 shorturl.at/n7iZE
#archaea #evolution #tubulin #cytoskeleton
November 3, 2025 at 11:54 AM
We’re on the cover of @embojournal.org
Odin, from Norse mythology, emerges from the Odinarchaeota yellowstonii genome, holding FtsZ1 and FtsZ2 the ancestral twins of tubulin highlighting their evolutionary divergence in Asgard archaea. 👉 shorturl.at/n7iZE
#archaea #evolution #tubulin #cytoskeleton
Odin, from Norse mythology, emerges from the Odinarchaeota yellowstonii genome, holding FtsZ1 and FtsZ2 the ancestral twins of tubulin highlighting their evolutionary divergence in Asgard archaea. 👉 shorturl.at/n7iZE
#archaea #evolution #tubulin #cytoskeleton
...and here is the link to this paper!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
🦠 Researchers at #Vetmeduni & #MedUniVienna identified key molecular pathways driving transmissible #cancer in #TasmanianDevils. These insights improve understanding of resistance mechanisms also relevant for human #tumours. 🔬
🔗 Published in @embojournal.org
🔗 Published in @embojournal.org
Research into transmissible cancer in Tasmanian Devils
Read more about the study!
www.meduniwien.ac.at
November 4, 2025 at 8:28 AM
...and here is the link to this paper!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by The EMBO Journal
Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation | The EMBO Journal
imageimageDNGR-1 (CLEC9A) is a C-type lectin receptor of type-1 conventional dendritic cells (cDC1s) with an important role in cross-presentation of dead cell antigens. This study explores how it equips cDC1s with the ability to cross-present such ...
www.embopress.org
November 3, 2025 at 5:23 PM
Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Issue 21 highlights:
Paxilin’s nuclear switch in the brain
RING E3s reading & extending ADPr-ubiquitin
Review: Decoding immunometabolism
Nuclear actin limits chromatin leakage upon migratory squeeze
Cover by @syncellbiolab.bsky.social: unlike Odin-archael FtsZ twins
www.embopress.org/toc/14602075...
Paxilin’s nuclear switch in the brain
RING E3s reading & extending ADPr-ubiquitin
Review: Decoding immunometabolism
Nuclear actin limits chromatin leakage upon migratory squeeze
Cover by @syncellbiolab.bsky.social: unlike Odin-archael FtsZ twins
www.embopress.org/toc/14602075...
November 3, 2025 at 11:23 AM
Issue 21 highlights:
Paxilin’s nuclear switch in the brain
RING E3s reading & extending ADPr-ubiquitin
Review: Decoding immunometabolism
Nuclear actin limits chromatin leakage upon migratory squeeze
Cover by @syncellbiolab.bsky.social: unlike Odin-archael FtsZ twins
www.embopress.org/toc/14602075...
Paxilin’s nuclear switch in the brain
RING E3s reading & extending ADPr-ubiquitin
Review: Decoding immunometabolism
Nuclear actin limits chromatin leakage upon migratory squeeze
Cover by @syncellbiolab.bsky.social: unlike Odin-archael FtsZ twins
www.embopress.org/toc/14602075...
Reposted by The EMBO Journal
Our latest review is now online! 👇
@martenslab.bsky.social
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....
@martenslab.bsky.social
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
October 31, 2025 at 6:24 AM
Our latest review is now online! 👇
@martenslab.bsky.social
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....
@martenslab.bsky.social
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....
Structural insights into selective and dual antagonism of EP2 and EP4 #prostaglandin receptors
#CryoEM structures by H Eric Xu and colleagues reveal interactions of the dual antagonist TG6-129 with EP2 and EP4 via different pharmacophores
www.embopress.org/doi/full/10....
#CryoEM structures by H Eric Xu and colleagues reveal interactions of the dual antagonist TG6-129 with EP2 and EP4 via different pharmacophores
www.embopress.org/doi/full/10....
November 3, 2025 at 8:22 AM
Structural insights into selective and dual antagonism of EP2 and EP4 #prostaglandin receptors
#CryoEM structures by H Eric Xu and colleagues reveal interactions of the dual antagonist TG6-129 with EP2 and EP4 via different pharmacophores
www.embopress.org/doi/full/10....
#CryoEM structures by H Eric Xu and colleagues reveal interactions of the dual antagonist TG6-129 with EP2 and EP4 via different pharmacophores
www.embopress.org/doi/full/10....
Reposted by The EMBO Journal
Happy to have contributed to this interesting study from penengolab.bsky.social! another interesting example of how chromatin modifications and their readers orchestrate replication fork plasticity and protection 👏👇
H2B ubiquitination by RNF20/40 safeguards replication fork dynamics in human cells, by facilitating fork reversal and recruiting RNF169 that protects from excessive degradation of nascent DNA
@penengolab.bsky.social and collaborators
www.embopress.org/doi/full/10....
@penengolab.bsky.social and collaborators
www.embopress.org/doi/full/10....
October 30, 2025 at 1:19 PM
Happy to have contributed to this interesting study from penengolab.bsky.social! another interesting example of how chromatin modifications and their readers orchestrate replication fork plasticity and protection 👏👇
Reposted by The EMBO Journal
Excited to share the peer-reviewed version of our work, now online in @embojournal.org! Big thanks to our reviewers and @hvodermaier.bsky.social for facilitating this process. Looking forward to continuing this fun collaboration with @michaelnadbio.bsky.social!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
October 30, 2025 at 3:33 PM
Excited to share the peer-reviewed version of our work, now online in @embojournal.org! Big thanks to our reviewers and @hvodermaier.bsky.social for facilitating this process. Looking forward to continuing this fun collaboration with @michaelnadbio.bsky.social!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....