The EMBO Journal
@embojournal.org
Non-for-profit publication of research in molecular, cell & organismal biology - as part of @embopress.org
Fast-fair-transparent / Open Access / Open Science
Fast-fair-transparent / Open Access / Open Science
Pinned
In ISSUE 23
Highligh: IL-26 - no guts, no glory
Review: initiating autophagy by selective receptors
Method: 3D-SPARK for spatial mapping of DNA synthesis
Resource: senotypes across aging human and mouse tissues
Cover: Sachin Kotak et al @spindlebehavior.bsky.social
link.springer.com/journal/4431...
Highligh: IL-26 - no guts, no glory
Review: initiating autophagy by selective receptors
Method: 3D-SPARK for spatial mapping of DNA synthesis
Resource: senotypes across aging human and mouse tissues
Cover: Sachin Kotak et al @spindlebehavior.bsky.social
link.springer.com/journal/4431...
ERAD without N-glycosylation?
Yeast screen by Leticia Lemus, Veit Goder et al reveals a novel O-mannosyltransferase complex acting on misfolded secretory substrates that lack N-glycans
link.springer.com/article/10.1...
Yeast screen by Leticia Lemus, Veit Goder et al reveals a novel O-mannosyltransferase complex acting on misfolded secretory substrates that lack N-glycans
link.springer.com/article/10.1...
December 5, 2025 at 1:53 PM
ERAD without N-glycosylation?
Yeast screen by Leticia Lemus, Veit Goder et al reveals a novel O-mannosyltransferase complex acting on misfolded secretory substrates that lack N-glycans
link.springer.com/article/10.1...
Yeast screen by Leticia Lemus, Veit Goder et al reveals a novel O-mannosyltransferase complex acting on misfolded secretory substrates that lack N-glycans
link.springer.com/article/10.1...
Reposted by The EMBO Journal
New paper out!
How can we force HIV genomes out of their capsid shells and what can we learn about HIV biology doing so?
Hint: capsid inhibitors actively re-route nuclear HIV complexes, and expose genomes via intriguing structural effects!
open access:
link.springer.com/article/10.1...
read below
How can we force HIV genomes out of their capsid shells and what can we learn about HIV biology doing so?
Hint: capsid inhibitors actively re-route nuclear HIV complexes, and expose genomes via intriguing structural effects!
open access:
link.springer.com/article/10.1...
read below
Lenacapavir-induced capsid damage uncovers HIV-1 genomes emanating from nuclear speckles - The EMBO Journal
Following cell entry, HIV-1 capsids enter the nucleus by passage through nuclear pores and reach nuclear speckles with subsequent uncoating of the reverse-transcribed genome and its integration into s...
link.springer.com
December 4, 2025 at 1:58 PM
New paper out!
How can we force HIV genomes out of their capsid shells and what can we learn about HIV biology doing so?
Hint: capsid inhibitors actively re-route nuclear HIV complexes, and expose genomes via intriguing structural effects!
open access:
link.springer.com/article/10.1...
read below
How can we force HIV genomes out of their capsid shells and what can we learn about HIV biology doing so?
Hint: capsid inhibitors actively re-route nuclear HIV complexes, and expose genomes via intriguing structural effects!
open access:
link.springer.com/article/10.1...
read below
In ISSUE 23
Highligh: IL-26 - no guts, no glory
Review: initiating autophagy by selective receptors
Method: 3D-SPARK for spatial mapping of DNA synthesis
Resource: senotypes across aging human and mouse tissues
Cover: Sachin Kotak et al @spindlebehavior.bsky.social
link.springer.com/journal/4431...
Highligh: IL-26 - no guts, no glory
Review: initiating autophagy by selective receptors
Method: 3D-SPARK for spatial mapping of DNA synthesis
Resource: senotypes across aging human and mouse tissues
Cover: Sachin Kotak et al @spindlebehavior.bsky.social
link.springer.com/journal/4431...
December 4, 2025 at 7:43 AM
In ISSUE 23
Highligh: IL-26 - no guts, no glory
Review: initiating autophagy by selective receptors
Method: 3D-SPARK for spatial mapping of DNA synthesis
Resource: senotypes across aging human and mouse tissues
Cover: Sachin Kotak et al @spindlebehavior.bsky.social
link.springer.com/journal/4431...
Highligh: IL-26 - no guts, no glory
Review: initiating autophagy by selective receptors
Method: 3D-SPARK for spatial mapping of DNA synthesis
Resource: senotypes across aging human and mouse tissues
Cover: Sachin Kotak et al @spindlebehavior.bsky.social
link.springer.com/journal/4431...
Reposted by The EMBO Journal
Come join us in beautiful Roscoff for this Conference Jacques Monod on Developmental regulation: from molecular to ecological niches
May 18-22, 2026 Roscoff, France
Abstract deadline: January 31, 2026
Apply here: cjm.sb-roscoff.fr/en
May 18-22, 2026 Roscoff, France
Abstract deadline: January 31, 2026
Apply here: cjm.sb-roscoff.fr/en
December 3, 2025 at 8:00 AM
Come join us in beautiful Roscoff for this Conference Jacques Monod on Developmental regulation: from molecular to ecological niches
May 18-22, 2026 Roscoff, France
Abstract deadline: January 31, 2026
Apply here: cjm.sb-roscoff.fr/en
May 18-22, 2026 Roscoff, France
Abstract deadline: January 31, 2026
Apply here: cjm.sb-roscoff.fr/en
and here's the link to the article:
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
👍 Nice work from Sandra Khau and colleagues from CEPR INSERM Lab (Team “ Pathophysiology of lung infections") in @embojournal.org. They propose a didactic review summarizing the cytosolic receptors and the signaling pathways involved in antifungal innate immunity.
December 3, 2025 at 9:14 AM
and here's the link to the article:
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by The EMBO Journal
Wow, researchers from our #SFB1129 are implicated in the Science 2024 Breakthrough of the Year, because they showed that HIV-capsids are flexible and go through nuclear pores. The latest paper on Lenacapavir-induced capsid damage just came out in @embojournal.org
link.springer.com/article/10.1...
link.springer.com/article/10.1...
December 3, 2025 at 7:53 AM
Wow, researchers from our #SFB1129 are implicated in the Science 2024 Breakthrough of the Year, because they showed that HIV-capsids are flexible and go through nuclear pores. The latest paper on Lenacapavir-induced capsid damage just came out in @embojournal.org
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Lysosomal localization impacts their function in neurons:
Jie Luo and coworkers identify ER-linked AREL1 ubiquitin ligase as regulator of lysosome positioning and acidification via V-ATPase ubiquitination
www.embopress.org/doi/full/10....
Jie Luo and coworkers identify ER-linked AREL1 ubiquitin ligase as regulator of lysosome positioning and acidification via V-ATPase ubiquitination
www.embopress.org/doi/full/10....
December 2, 2025 at 2:17 PM
Lysosomal localization impacts their function in neurons:
Jie Luo and coworkers identify ER-linked AREL1 ubiquitin ligase as regulator of lysosome positioning and acidification via V-ATPase ubiquitination
www.embopress.org/doi/full/10....
Jie Luo and coworkers identify ER-linked AREL1 ubiquitin ligase as regulator of lysosome positioning and acidification via V-ATPase ubiquitination
www.embopress.org/doi/full/10....
Lenacapavir-induced capsid damage uncovers HIV-1 genomes emanating from nuclear speckles
By exposing integration-competent genomes, Müller, Kräusslich et al find that reverse transcription can be completed in closed viral capsids without directly inducing uncoating
www.embopress.org/doi/full/10....
By exposing integration-competent genomes, Müller, Kräusslich et al find that reverse transcription can be completed in closed viral capsids without directly inducing uncoating
www.embopress.org/doi/full/10....
December 2, 2025 at 10:47 AM
Lenacapavir-induced capsid damage uncovers HIV-1 genomes emanating from nuclear speckles
By exposing integration-competent genomes, Müller, Kräusslich et al find that reverse transcription can be completed in closed viral capsids without directly inducing uncoating
www.embopress.org/doi/full/10....
By exposing integration-competent genomes, Müller, Kräusslich et al find that reverse transcription can be completed in closed viral capsids without directly inducing uncoating
www.embopress.org/doi/full/10....
ALYREF condensation stabilizes m5C-modified PARP10 mRNA and promotes PI3K-AKT signaling in ovarian cancer
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
December 2, 2025 at 9:20 AM
ALYREF condensation stabilizes m5C-modified PARP10 mRNA and promotes PI3K-AKT signaling in ovarian cancer
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance
@andreasfellas.bsky.social, Alison Pidoux et al @allshire-lab.bsky.social
www.embopress.org/doi/full/10....
@andreasfellas.bsky.social, Alison Pidoux et al @allshire-lab.bsky.social
www.embopress.org/doi/full/10....
December 1, 2025 at 3:21 PM
Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance
@andreasfellas.bsky.social, Alison Pidoux et al @allshire-lab.bsky.social
www.embopress.org/doi/full/10....
@andreasfellas.bsky.social, Alison Pidoux et al @allshire-lab.bsky.social
www.embopress.org/doi/full/10....
Mono-ADP-ribosylation as a degradation mark?
@andriigorelik.bsky.social, Ivan Ahel et al observe increased ADP-ribosylation of aryl hydrocarbon receptor (AHR) & PARP7 upon ubiquitin-proteasome blockage, crosstalk with DTX2 E3, as rapid AHR-transcription off-switch
www.embopress.org/doi/full/10....
@andriigorelik.bsky.social, Ivan Ahel et al observe increased ADP-ribosylation of aryl hydrocarbon receptor (AHR) & PARP7 upon ubiquitin-proteasome blockage, crosstalk with DTX2 E3, as rapid AHR-transcription off-switch
www.embopress.org/doi/full/10....
December 1, 2025 at 3:20 PM
Mono-ADP-ribosylation as a degradation mark?
@andriigorelik.bsky.social, Ivan Ahel et al observe increased ADP-ribosylation of aryl hydrocarbon receptor (AHR) & PARP7 upon ubiquitin-proteasome blockage, crosstalk with DTX2 E3, as rapid AHR-transcription off-switch
www.embopress.org/doi/full/10....
@andriigorelik.bsky.social, Ivan Ahel et al observe increased ADP-ribosylation of aryl hydrocarbon receptor (AHR) & PARP7 upon ubiquitin-proteasome blockage, crosstalk with DTX2 E3, as rapid AHR-transcription off-switch
www.embopress.org/doi/full/10....
Dynein-2 prefers to bind the retrograde-targeted A-tubule in intraflagellar transport - likely because of its tyrosination, suggest cryo-ET data and MD simulations by @ichikawa-lab.bsky.social and coworkers
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
November 28, 2025 at 4:10 PM
Dynein-2 prefers to bind the retrograde-targeted A-tubule in intraflagellar transport - likely because of its tyrosination, suggest cryo-ET data and MD simulations by @ichikawa-lab.bsky.social and coworkers
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
MCM loading onto replication origins: when does it need ORC6 and when not?
AlphaFold-guided structural phylogenetic analyses by @okhay97.bsky.social & @bleichertlab.bsky.social suggests surprising heterogeneity of origin licensing mechanisms across Metazoa
www.embopress.org/doi/full/10....
AlphaFold-guided structural phylogenetic analyses by @okhay97.bsky.social & @bleichertlab.bsky.social suggests surprising heterogeneity of origin licensing mechanisms across Metazoa
www.embopress.org/doi/full/10....
November 28, 2025 at 11:42 AM
MCM loading onto replication origins: when does it need ORC6 and when not?
AlphaFold-guided structural phylogenetic analyses by @okhay97.bsky.social & @bleichertlab.bsky.social suggests surprising heterogeneity of origin licensing mechanisms across Metazoa
www.embopress.org/doi/full/10....
AlphaFold-guided structural phylogenetic analyses by @okhay97.bsky.social & @bleichertlab.bsky.social suggests surprising heterogeneity of origin licensing mechanisms across Metazoa
www.embopress.org/doi/full/10....
Weekend reading:
Judy Lieberman and colleagues reflect on the roles of innate immunity in cancer #immunotherapy, with a focus on how tumors evade immune surveillance and on strategies for enhancing tumor responsiveness
www.embopress.org/doi/full/10....
Judy Lieberman and colleagues reflect on the roles of innate immunity in cancer #immunotherapy, with a focus on how tumors evade immune surveillance and on strategies for enhancing tumor responsiveness
www.embopress.org/doi/full/10....
November 28, 2025 at 11:40 AM
Weekend reading:
Judy Lieberman and colleagues reflect on the roles of innate immunity in cancer #immunotherapy, with a focus on how tumors evade immune surveillance and on strategies for enhancing tumor responsiveness
www.embopress.org/doi/full/10....
Judy Lieberman and colleagues reflect on the roles of innate immunity in cancer #immunotherapy, with a focus on how tumors evade immune surveillance and on strategies for enhancing tumor responsiveness
www.embopress.org/doi/full/10....
New insights into post-translational regulation of maternal-to-zygotic transition in vertebrate development:
Zebrafish screen by @crisprscan.bsky.social , @bazzinilab.bsky.social et al identifies Bckdk role in controlling H3K27 acetylation via Phf10 phosphorylation
www.embopress.org/doi/full/10....
Zebrafish screen by @crisprscan.bsky.social , @bazzinilab.bsky.social et al identifies Bckdk role in controlling H3K27 acetylation via Phf10 phosphorylation
www.embopress.org/doi/full/10....
November 28, 2025 at 7:28 AM
New insights into post-translational regulation of maternal-to-zygotic transition in vertebrate development:
Zebrafish screen by @crisprscan.bsky.social , @bazzinilab.bsky.social et al identifies Bckdk role in controlling H3K27 acetylation via Phf10 phosphorylation
www.embopress.org/doi/full/10....
Zebrafish screen by @crisprscan.bsky.social , @bazzinilab.bsky.social et al identifies Bckdk role in controlling H3K27 acetylation via Phf10 phosphorylation
www.embopress.org/doi/full/10....
Dual interference with host #neuropeptide signaling allows #parasitoid wasp to hijack sugar metabolism of its moth host - involving the help of parasitoid’s symbiotic virus!
Xue-Xin Chen and coworkers
www.embopress.org/doi/full/10....
Xue-Xin Chen and coworkers
www.embopress.org/doi/full/10....
November 27, 2025 at 10:56 AM
Dual interference with host #neuropeptide signaling allows #parasitoid wasp to hijack sugar metabolism of its moth host - involving the help of parasitoid’s symbiotic virus!
Xue-Xin Chen and coworkers
www.embopress.org/doi/full/10....
Xue-Xin Chen and coworkers
www.embopress.org/doi/full/10....
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
November 27, 2025 at 9:12 AM
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
Reposted by The EMBO Journal
Our paper on dynein-2's track recognition mechanism is now published in The EMBO Journal @embojournal.org!!
Cryo-ET and MD simulations reveal that dynein-2 is tuned for binding to the A-tubule of the ciliary doublet | The EMBO Journal www.embopress.org/doi/full/10....
Cryo-ET and MD simulations reveal that dynein-2 is tuned for binding to the A-tubule of the ciliary doublet | The EMBO Journal www.embopress.org/doi/full/10....
Cryo-ET and MD simulations reveal that dynein-2 is tuned for binding to the A-tubule of the ciliary doublet | The EMBO Journal
imageimageDynein-2 is a motor protein essential for retrograde intraflagellar transport (IFT)
on the A-tubule of ciliary doublet microtubules. Here, biochemical and cryo-ET analyses
demonstrate that d...
www.embopress.org
November 26, 2025 at 4:57 PM
Our paper on dynein-2's track recognition mechanism is now published in The EMBO Journal @embojournal.org!!
Cryo-ET and MD simulations reveal that dynein-2 is tuned for binding to the A-tubule of the ciliary doublet | The EMBO Journal www.embopress.org/doi/full/10....
Cryo-ET and MD simulations reveal that dynein-2 is tuned for binding to the A-tubule of the ciliary doublet | The EMBO Journal www.embopress.org/doi/full/10....
Reposted by The EMBO Journal
✨ Happy to share that our work is now published in @embojournal.org ! ✨
Our fantastic collaboration between @crisprscan.bsky.social
@bazzinilab.bsky.social
Here is the updated thread (1/13):
www.embopress.org/doi/full/10....
Our fantastic collaboration between @crisprscan.bsky.social
@bazzinilab.bsky.social
Here is the updated thread (1/13):
www.embopress.org/doi/full/10....
CRISPR-RfxCas13d screening uncovers Bckdk as a post-translational regulator of maternal-to-zygotic transition in teleosts | The EMBO Journal
imageimagePost-translational regulation during the maternal-to-zygotic transition (MZT) remains
largely unexplored. Using an optimized CRISPR-RfxCas13d screening strategy, this study
identifies Bckdk ...
www.embopress.org
November 20, 2025 at 3:14 PM
✨ Happy to share that our work is now published in @embojournal.org ! ✨
Our fantastic collaboration between @crisprscan.bsky.social
@bazzinilab.bsky.social
Here is the updated thread (1/13):
www.embopress.org/doi/full/10....
Our fantastic collaboration between @crisprscan.bsky.social
@bazzinilab.bsky.social
Here is the updated thread (1/13):
www.embopress.org/doi/full/10....
Reposted by The EMBO Journal
Thanks to authors of the News&Views for highlighting the role of NLRP6 in sensing homeostatic disruption
@alexandraboegli.bsky.social @embojournal.org
link.springer.com/article/10.1...
@alexandraboegli.bsky.social @embojournal.org
link.springer.com/article/10.1...
You (bacteria) shall not pass: NLRP6 can sense you! - The EMBO Journal
The EMBO Journal - The ability of intracellular bacteria to spread directly from one cell to the next, avoiding extracellular immune defenses and drugs, is essential for pathogen dissemination and,...
link.springer.com
November 20, 2025 at 3:17 PM
Thanks to authors of the News&Views for highlighting the role of NLRP6 in sensing homeostatic disruption
@alexandraboegli.bsky.social @embojournal.org
link.springer.com/article/10.1...
@alexandraboegli.bsky.social @embojournal.org
link.springer.com/article/10.1...
Reposted by The EMBO Journal
Early registration and abstract deadlines are 15 December for @fusionconf.bsky.social "Mitochondria & Cell Fate Transitions: From Stemness to Senescence Conference". @embojournal.org Senior Editor Daniel Klimmeck is looking forward to this meeting in Malta!
For info & registration: bit.ly/43AaInH
For info & registration: bit.ly/43AaInH
Mitochondria & Cell Fate Transitions: From Stemness to Senescence Conference | Fusion Conferences
Biennial international 2026 Mitochondria and Cell Fate Transitions Conference in Malta. Register now to apply for short talk and poster opportunities.
bit.ly
November 21, 2025 at 11:35 AM
Early registration and abstract deadlines are 15 December for @fusionconf.bsky.social "Mitochondria & Cell Fate Transitions: From Stemness to Senescence Conference". @embojournal.org Senior Editor Daniel Klimmeck is looking forward to this meeting in Malta!
For info & registration: bit.ly/43AaInH
For info & registration: bit.ly/43AaInH
The NLRP6 #inflammasome is activated by sterile or pathogen-induced endolysosomal damage
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
November 21, 2025 at 12:59 PM
The NLRP6 #inflammasome is activated by sterile or pathogen-induced endolysosomal damage
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
Direct and indirect neurogenesis from radial glial progenitor cell clones in the mouse neocortex
Dan Shen et al
www.embopress.org/doi/full/10....
Dan Shen et al
www.embopress.org/doi/full/10....
November 21, 2025 at 7:32 AM
Direct and indirect neurogenesis from radial glial progenitor cell clones in the mouse neocortex
Dan Shen et al
www.embopress.org/doi/full/10....
Dan Shen et al
www.embopress.org/doi/full/10....
Is there a convergent mechanism for triggering PINK1-Parkin-dependent mitophagy?
Derek Narendra and coworkers find that diverse forms of mitochondrial damage are all sensed by a loss of mitochondrial membrane potential (MMP)
www.embopress.org/doi/full/10....
Derek Narendra and coworkers find that diverse forms of mitochondrial damage are all sensed by a loss of mitochondrial membrane potential (MMP)
www.embopress.org/doi/full/10....
November 20, 2025 at 7:01 PM
Is there a convergent mechanism for triggering PINK1-Parkin-dependent mitophagy?
Derek Narendra and coworkers find that diverse forms of mitochondrial damage are all sensed by a loss of mitochondrial membrane potential (MMP)
www.embopress.org/doi/full/10....
Derek Narendra and coworkers find that diverse forms of mitochondrial damage are all sensed by a loss of mitochondrial membrane potential (MMP)
www.embopress.org/doi/full/10....
Now published in peer-reviewed version:
Systematic analysis of immune cell motility leveraging the open intravital microscopy database #Immunemap
www.embopress.org/doi/full/10....
Systematic analysis of immune cell motility leveraging the open intravital microscopy database #Immunemap
www.embopress.org/doi/full/10....
November 20, 2025 at 6:57 PM
Now published in peer-reviewed version:
Systematic analysis of immune cell motility leveraging the open intravital microscopy database #Immunemap
www.embopress.org/doi/full/10....
Systematic analysis of immune cell motility leveraging the open intravital microscopy database #Immunemap
www.embopress.org/doi/full/10....