Ellenberg Lab
@ellenberglab.bsky.social
We systematically elucidate the mechanisms underlying cell division and nuclear organisation and develop advanced imaging technologies
@EMBL.org
@EMBL.org
Our work on NPC biogenesis is now out! Wanlu Zhang investigated the role of FG-Nups in NPC reassembly, pore dilation, and the nuclear envelope remodelling using acute depletions, correlative EM, and MINFLUX imaging 💫.
Thanks, Wanlu and all the collaborators!
Thanks, Wanlu and all the collaborators!
Excited to share the preprint from my postdoc work @ellenberglab.bsky.social! 🌟
During mitotic exit, cells rebuild thousands of nuclear pores within minutes. How do tiny holes expand to selective channels, and how is this coordinated with the nuclear envelope remodeling? 🔗 doi.org/10.1101/2025...
During mitotic exit, cells rebuild thousands of nuclear pores within minutes. How do tiny holes expand to selective channels, and how is this coordinated with the nuclear envelope remodeling? 🔗 doi.org/10.1101/2025...
Hydrophobic interactions of FG-nucleoporins are required for dilating nuclear membrane pores into selective transport channels after mitosis
Nuclear envelope (NE) reformation after mitosis is essential for daughter cell viability and requires tightly coordinated nuclear pore complex (NPC) assembly and nuclear membrane reformation. To revea...
doi.org
September 10, 2025 at 1:14 PM
Our work on NPC biogenesis is now out! Wanlu Zhang investigated the role of FG-Nups in NPC reassembly, pore dilation, and the nuclear envelope remodelling using acute depletions, correlative EM, and MINFLUX imaging 💫.
Thanks, Wanlu and all the collaborators!
Thanks, Wanlu and all the collaborators!
Reposted by Ellenberg Lab
🔬🧬 New in @natcomms.nature.com: Nanoscale 3D DNA tracing in non‑denatured cells maps the #3Dgenome at nm‑resolution and reveals Cohesin‑dependent dynamic loops! 🚀 #OpenAccess
www.nature.com/articles/s41...
@ellenberglab.bsky.social @jungmannlab.bsky.social
#Genomics #SuperResolution
www.nature.com/articles/s41...
@ellenberglab.bsky.social @jungmannlab.bsky.social
#Genomics #SuperResolution
Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ - Nature Communications
A nanoscale 3D DNA tracing workflow visualizes Cohesin-dependent loops in single, structurally well-preserved cells. Computer simulations based on the tracing data give further insight into how Cohesi...
www.nature.com
July 23, 2025 at 12:39 PM
🔬🧬 New in @natcomms.nature.com: Nanoscale 3D DNA tracing in non‑denatured cells maps the #3Dgenome at nm‑resolution and reveals Cohesin‑dependent dynamic loops! 🚀 #OpenAccess
www.nature.com/articles/s41...
@ellenberglab.bsky.social @jungmannlab.bsky.social
#Genomics #SuperResolution
www.nature.com/articles/s41...
@ellenberglab.bsky.social @jungmannlab.bsky.social
#Genomics #SuperResolution
Our new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ - Nature Communications
A nanoscale 3D DNA tracing workflow visualizes Cohesin-dependent loops in single, structurally well-preserved cells. Computer simulations based on the tracing data give further insight into how Cohesi...
www.nature.com
July 21, 2025 at 10:53 AM
Our new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
Reposted by Ellenberg Lab
This seems like a really important paper comparing chromosome tracing methods, demonstrating that classical denaturing DNA-FISH and chromosome tracing leads to substantial distortion of 3D genome structure, likely due to the high-temperatures involved (70-90C):
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 20, 2025 at 7:39 PM
This seems like a really important paper comparing chromosome tracing methods, demonstrating that classical denaturing DNA-FISH and chromosome tracing leads to substantial distortion of 3D genome structure, likely due to the high-temperatures involved (70-90C):
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Check out Andi's #Bluetorial for a summary of our findings 🙌
Mitotic chromosomes form through long, overlapping and self-repelling DNA loops, generated by the Condensin complexes!
Check out our newest paper here, and see below for a short Bluetorial!
www.cell.com/cell/fulltex...
Check out our newest paper here, and see below for a short Bluetorial!
www.cell.com/cell/fulltex...
March 24, 2025 at 3:55 PM
Check out Andi's #Bluetorial for a summary of our findings 🙌
Reposted by Ellenberg Lab
Did you know that DNA must form overlapping loops to give rise to the well-known X-shape of chromosomes? 🧬🧪
New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation.
@ellenberglab.bsky.social
@andibrunner.bsky.social
www.embl.org/news/science...
New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation.
@ellenberglab.bsky.social
@andibrunner.bsky.social
www.embl.org/news/science...
How chromosomes shape up for cell division | EMBL
EMBL scientists have shown how overlapping loops of DNA stack upon each other in dividing cells to give rise to rod-shaped chromosomes
www.embl.org
March 24, 2025 at 3:10 PM
Did you know that DNA must form overlapping loops to give rise to the well-known X-shape of chromosomes? 🧬🧪
New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation.
@ellenberglab.bsky.social
@andibrunner.bsky.social
www.embl.org/news/science...
New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation.
@ellenberglab.bsky.social
@andibrunner.bsky.social
www.embl.org/news/science...
Reposted by Ellenberg Lab
Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social!
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
March 24, 2025 at 3:29 PM
Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social!
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social!
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
March 24, 2025 at 3:29 PM
Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social!
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
We are #hiring!
We have two open postdoc/research scientist positions to join our #ERC funded project MITOFOLD to resolve the organization of mitotic chromosomes!
1) experimental biologist shorturl.at/LjGEM
2) data scientist shorturl.at/nDdhQ
Please share! 🙌
We look forward to your application! 🤩
We have two open postdoc/research scientist positions to join our #ERC funded project MITOFOLD to resolve the organization of mitotic chromosomes!
1) experimental biologist shorturl.at/LjGEM
2) data scientist shorturl.at/nDdhQ
Please share! 🙌
We look forward to your application! 🤩
March 19, 2025 at 11:50 AM
We are #hiring!
We have two open postdoc/research scientist positions to join our #ERC funded project MITOFOLD to resolve the organization of mitotic chromosomes!
1) experimental biologist shorturl.at/LjGEM
2) data scientist shorturl.at/nDdhQ
Please share! 🙌
We look forward to your application! 🤩
We have two open postdoc/research scientist positions to join our #ERC funded project MITOFOLD to resolve the organization of mitotic chromosomes!
1) experimental biologist shorturl.at/LjGEM
2) data scientist shorturl.at/nDdhQ
Please share! 🙌
We look forward to your application! 🤩
Congratulations to @andibrunner.bsky.social
and the team, and many thanks to the lab of Jan-Michael Peters for support!
We found that the interphase and mitotic chromatin loop organization have more in common than previously thought:
In both stages big loops are built first, small ones second
and the team, and many thanks to the lab of Jan-Michael Peters for support!
We found that the interphase and mitotic chromatin loop organization have more in common than previously thought:
In both stages big loops are built first, small ones second
@andibrunner.bsky.social et al. @ellenberglab.bsky.social show that interphase organization into Cohesin-driven loops occurs in a sequential and hierarchical manner - just like the mitotic organization by Condensins. https://buff.ly/426gIEu
@wanluzhang.bsky.social
@wanluzhang.bsky.social
January 9, 2025 at 9:57 PM
Congratulations to @andibrunner.bsky.social
and the team, and many thanks to the lab of Jan-Michael Peters for support!
We found that the interphase and mitotic chromatin loop organization have more in common than previously thought:
In both stages big loops are built first, small ones second
and the team, and many thanks to the lab of Jan-Michael Peters for support!
We found that the interphase and mitotic chromatin loop organization have more in common than previously thought:
In both stages big loops are built first, small ones second
Reposted by Ellenberg Lab
My first own project is published:
Despite major differences in chromosome shape during #interphase and #mitosis, the underlying #loop-extruder based organization is highly similar
A new data resource and new insights into human chromatin biology! 🧬🥳
Despite major differences in chromosome shape during #interphase and #mitosis, the underlying #loop-extruder based organization is highly similar
A new data resource and new insights into human chromatin biology! 🧬🥳
@andibrunner.bsky.social et al. @ellenberglab.bsky.social show that interphase organization into Cohesin-driven loops occurs in a sequential and hierarchical manner - just like the mitotic organization by Condensins. https://buff.ly/426gIEu
@wanluzhang.bsky.social
@wanluzhang.bsky.social
January 9, 2025 at 7:19 PM
My first own project is published:
Despite major differences in chromosome shape during #interphase and #mitosis, the underlying #loop-extruder based organization is highly similar
A new data resource and new insights into human chromatin biology! 🧬🥳
Despite major differences in chromosome shape during #interphase and #mitosis, the underlying #loop-extruder based organization is highly similar
A new data resource and new insights into human chromatin biology! 🧬🥳
Our excellent postdoc Wanlu Zhang is at #CellBio24 and will talk about her unpublished NPC biogensis work tomorrow!
Check it out and say hello 🙌🏼
Check it out and say hello 🙌🏼
December 16, 2024 at 5:35 PM
Our excellent postdoc Wanlu Zhang is at #CellBio24 and will talk about her unpublished NPC biogensis work tomorrow!
Check it out and say hello 🙌🏼
Check it out and say hello 🙌🏼
We are now on Bluesky!
Follow us for exciting #Science around #CellDivision and nuclear organization, illuminated using advanced #imaging #technology - like our last preprint on mitotic chromosome structure and organization: tinyurl.com/yaznnkku
Follow us for exciting #Science around #CellDivision and nuclear organization, illuminated using advanced #imaging #technology - like our last preprint on mitotic chromosome structure and organization: tinyurl.com/yaznnkku
November 25, 2024 at 1:08 PM
We are now on Bluesky!
Follow us for exciting #Science around #CellDivision and nuclear organization, illuminated using advanced #imaging #technology - like our last preprint on mitotic chromosome structure and organization: tinyurl.com/yaznnkku
Follow us for exciting #Science around #CellDivision and nuclear organization, illuminated using advanced #imaging #technology - like our last preprint on mitotic chromosome structure and organization: tinyurl.com/yaznnkku